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Gold nanoshells： Contrast agents for cell imaging by cardiovascular optical coherence tomography

Nano Research 2018年第2期11卷 676-685页

作者： Jie Hu Francisco Sanz-Rodríguez fernando rivero Emma Martín Rodríguez Río Aguilar Torres Dirk H. Ortgies José García Solé fernando Alfonso Daniel Jaque Fluorescence Imaging Group Departamento de Física de Materiales Instituto Nicolás Cabrera Facultad de Ciencias Universidad Autónoma de Madrid Madrid Spain Instituto Ramón y Cajal de Investigación Sanitaria Hospital Ramón y Cajal Madrid Spain Departamento de Biología Universidad Autónoma de Madrid Madrid Spain Cardiology Department Hospital Universitario de la Princesa IIS-IP Universidad Autónoma de Madrid Madrid Spain

Optical coherence tomography （OCT） has gained considerable attention in interventional cardiovascular medicine and is currently used in clinical settings to assess atherosclerotic lesions and to optimize stent placement. Artery imaging at the cellular level constitutes the first step towards cardiovascular molecular imaging, which represents a major advance in the development of personalized noninvasive therapies. In this work we demonstrate that cardiovascular OCT can be used to detect individual cells suspended in biocompatible fluids. Importantly, the combination of this catheter-based clinical technique with gold nanoshells （GNSs） as intracellular contrast agents led to a substantial enhancement in the backscattered signal produced by individual cells. This cellular contrast enhancement was attributed to the large backscattering cross-section of GNSs at the OCT laser wavelength （1,300 nm）. A simple intensity analysis of OCT cross-sectional images of suspended cells makes it possible to identify the sub-population of living cells that successfully incorporated GNSs. The generalizability of this method was demonstrated using two different cell lines （HeLa and Jurkat cells）. This work provides novel insights into cardiovascular molecular imaging using specifically modified GNSs.

关键词： optical coherencetomography (OCT)intravascular imaging gold nanoparticles three-dimensional (3D)imaging

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Influence of CFH,HTRA1 and ARMS2 polymorphisms in the response to intravitreal ranibizumab treatment for wet age-related macular degeneration in a Spanish population

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1304-1309页

作者： fernando Cruz-Gonzalez Lucia Cabrillo-Estevez Vanesa rivero-Gutierrez Ana Sanchez-Jara Lourdes De Juan-Marcos Rogelio Gonzalez-Sarmiento Department of Ophthalmology Hospital Universitario Salamanca

AIM：To determine whether gene polymorphisms of the major genetic risk loci for age-related macular degeneration（AMD）：ARMS2（rs10490923）,the complement factor H（CFH）（rs1410996） and HTRA1（rs11200638） influence the response to a treatment regimen with ranibizumab for exudative ***：This study included 100 patients（100 eyes）with exudative *** underwent a treatment with ranibizumab injections monthly during three *** were made when the best corrected visual acuity（BCVA） decrease five letters（ETDRS） or central subfield retinal thickness gained 100 pm in optical coherence tomography ***（rs10490923,rs1410996 and rs11200638） were analyzed using TaqMan probes or polymerase chain reaction-restricted fragment length polymorphisms ***：There were no statistically significant differences in allelic distribution of CFH（rs1410996）,ARMS2（rs10490923） and HTRA1（rs11200638）polymorphisms regarding to response to ranibizumab ***：Ranibizumab treatment response is not related to CFH（rs1410996）,ARMS2（rs10490923） and HTRA1（rs11200638） poymorphisms.

关键词： age-related macular degeneration polymorphisms ARMS2 HTRA1 complement factor H ranibizumab

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Vibrations characterization in milling of low stiffness parts with a rubber-based vacuum fixture

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Chinese Journal of Aeronautics 2021年第6期34卷 54-66页

作者： Antonio RUBIO-MATEOS Mikel CASUSO Asuncion rivero Eneko UKAR Aitzol LAMIKIZ TECNALIA Basque Research and Technology Alliance(BRTA)Paseo Mikeletegi 7Pcirque TecnologicoE-20009 San SebastianSpain University of the Basque Country(UPV/EHU) ETTSII–Department of Mechanical EngineeringC/Alameda de Urquijo s/nE-48013 BilbaoSpain

Fixtures are a critical element in machining operations as they are the interface between the part and the *** components are responsible for the precise part location on the machine table and for the proper dynamic stability maintenance during the manufacturing *** these two features are deeply related,they are usually studied *** the one hand,diverse adaptable solutions have been developed for the clamping of different variable ***,the stability of the part has been long studied to reduce the forced vibration and the chatter effects,especially on thin parts machining operations typically performed in the aeronautic field,such as the skin panels *** present work proposes a commitment between both features by the presentation of an innovative vacuum fixture based on the use of a vulcanized rubber *** solution presents high flexibility as it can be adapted to different geometries while providing a proper damping capacity due to the viscoelastic and elastoplastic behaviour of these ***,the sealing properties of these elastomers provide the perfect combination to transform a rubber layer into a flexible vacuum ***,in order to validate the suitability of this fixture,a test bench is manufactured and tested under uniaxial compression loads and under real finish milling conditions over AA2024 part ***,a roughness model is proposed and analysed in order to characterize the part vibration sources.

关键词： AA2024 aeronautic skin Chatter Damping Finish milling Rubber characterization Vacuum clamping

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Electroconvulsive therapy,catatonia,deep vein thrombosis and anticoagulant treatment:a case report

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General Psychiatry 2021年第6期34卷 73-76,I0008,I0009页

作者： Ana Pérez-Balaguer Irene Sánchez-rivero Department of Psychiatry Hospital Universitario Puerta de Hierro MajadahondaMajadahondaSpain

Electroconvulsive therapy(ECT)is considered an effective treatment for pharmacotherapy-resistant severe mental *** is a complex syndrome characterised by important psychomotor *** vein thrombosis(DVT)and pulmonary embolism(PE)are frequent side effects of prolonged immobility in catatonic ***,it is important to resolve the catatonia as soon as *** is the most effective therapy available and is generally considered a safe ***,its use in patients with DVT or PE and anticoagulant treatment remains *** describe a case of a woman in her 40s with a previous diagnosis of bipolar disorder and dysfunctional personality *** was hospitalised with persecutory and reference delusions,high emotional lability,anxiety,somatisation and regressive *** later developed catatonic *** progress was achieved after a month of hospitalisation,despite several pharmacological *** suffered multiple complications of prolonged bedding,such as an extensive DVT of the left common femoral,the external iliac and the common iliac *** was conducted under treatment with *** the third administration,she showed *** major bleeding or PE was *** safety of ECT while receiving anticoagulant therapy has been documented,though dosage and type of anticoagulant must be *** of DVT(proximal or distal)may be an important topic to take into *** report provides further evidence about the efficacy and safety of undergoing ECT in the context of concomitant serious medical conditions,such as DVT and anticoagulant therapy administration.

关键词： dosage treatment diagnosis

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The affairs of the Falco

The affairs of the Falco

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作者： Melissa rivero.

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Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

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Neural Regeneration Research 2019年第11期14卷 1851-1857页

作者： fernando Lucas-Ruiz Caridad Galindo-Romero David García-Bernal María Norte-Munoz Kristy T. Rodríguez-Ramírez Manuel Salinas-Navarro Jose E. Millán-rivero Manuel Vidal-Sanz Marta Agudo-Barriuso Grupo de Oftalmologia Experimental Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Talmologia Universidad de MurciaMurciaSpain Unidad de Terapia Celular y Trasplante Hematopoyetico Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Medicina Interna Universidad de MurciaMurciaSpain

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e.,Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

关键词： stem cells adipose stem cells umbilical cord bone marrow Wharton's jelly optic nerve axotomy neuroprotection

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In vivo optical quality of posterior-chamber phakic implantable collamer lenses with a central port

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Eye and Vision 2021年第5期8卷 295-302页

作者： Robert Montés-Micó Francisco Pastor-Pascual Enrique Artiaga-Elordi Ramón Ruiz-Mesa Pedro Tañá-rivero Optics and Optometry&Vision Sciences Department University of Valenciac/o Dr Moliner 5046100 ValenciaSpain Oftalvist Clinic ValenciaSpain

Background:The aim of this review is to summarize the optical quality results in patients following the implantation of the V4c implantable collamer lens with a central port(ICL,STAAR Surgical Inc.).Main text:A literature search in several databases was carried out to identify those publications,both prospective,retrospective and/or comparative with other refractive surgery procedures,reporting optical outcomes of patients who were implanted with the V4c ICL model.A total of 17 clinical studies published between 2012 and 2021 were included in this review.A detailed analysis of the available data was performed including number of eyes,follow-up and preoperative spherical ***,the review focused on several optical parameters including higher-order aberrations(HOAs),modulation transfer function(MTF)cut-off frequency and Strehl *** review encompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack,retinal image quality measurement and ray-tracing technologies at different ***:The outcomes found in this review lead us to conclude that the ICL V4c model provides good optical quality,by means of different metrics,when implanted.

关键词： Implantable collamer lens Phakic Optical quality Higher order aberrations Modulation transfer function

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Successful treatment with hysteroscopy for infertility due to isthmocele and hydrometra secondary to cesarean section: A case report

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World Journal of Clinical Cases 2019年第6期7卷 753-758页

作者： Luis Pablo López rivero Miguel Jaimes Felipe Camargo Esther López-Bayghen Instituto de Infertilidad y Genética México SC Departamento de Toxicología Centro de Investigación de Estudios

BACKGROUND An isthmocele is a scar defect in the uterine wall due to a cesarean section. Its prevalence is unknown,but it has been associated with secondary ***,we present a case where the patient suffered from an isthmocele that was associated with persistent hydrometra,which developed during in vitro *** SUMMARY The patient underwent hysteroscopic surgery,which successfully resolved the isthmocele as well as the hydrometra. Afterward,two high-quality,euploid embryos,determined by morphological assessment and pre-implantation genetic diagnostic testing,were transferred. This resulted in uterine pregnancy,as determined byserum β-human chorionic gonadotropin levels on day 14(180 m U/mL) and ultrasound-confirmed presence of a gestational sac with a positive embryocardia at week 6. The pregnancy reached 36 wk without any complications,and the product was born in good health. We report a successful isthmocele treatment in a patient with secondary infertility,in which the isthmocele was the cause of persistent *** Hydrometra caused by secondary cesarean is an infertility factor,which can be corrected by hysteroscopy plus ablation of the isthmocele.

关键词： In vitro fertilization Isthmocele Hydrometra Case report

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Gulliver's travels

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作者： Jonathan Swift edited by Albert J. rivero.

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