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Current role in facial allograft transplantation:what have we learned?

Plastic and Aesthetic Research 2016年第1期3卷 211-218页

作者： Pedro Infante-Cossio fernando barrera-pulido Tomas Gomez-Cia Domingo Sicilia-Castro Alberto Garcia-Perla-Garcia Purificacion Gacto-Sanchez Jose Maria Hernandez-Guisado Araceli Lagares-Borrego Rocio Narros-Gimenez Juan-David Gonzalez-Padilla Department of Oral and Maxillofacial Surgery Virgen del Rocio University Hospital41013 SevilleSpain Department of Plastic and Reconstructive Surgery Virgen del Rocio University Hospital41013 SevilleSpain

Face transplant(FT)has evolved enormously in the last 10 years since the successful completion of the first facial *** procedure has become a new reconstructive option for complex facial deformities to restore the anatomy of patients with severely disfigured *** authors review the literature and discuss the main surgical,immunological,and ethical aspects as well as the results described in patients undergoing *** date there have been more than thirty FT *** main indication was post-traumatic *** all cases a standard immunosuppression was performed with three drugs,although acute rejection episodes were observed,that could be controlled with conventional immunosuppressive ***,functional and aesthetic results have been excellent at short-term and high satisfaction rate exceeded initial expectations,although long-term data are still *** complications were opportunistic *** deaths that occurred have reopened the ethical debate about the potential complications and concerns of providing informed consent to *** progresses in microsurgical techniques and preoperative planning have promoted the evolution from partial to full *** these are on the basis of accurate and careful selection of well-motivated *** next challenge will be getting new immunosuppressive treatment *** clinical experience has demonstrated the FT viability,it is still considered an experimental procedure in which we have much to learn to define its true role in the current reconstructive surgery and resolve major technical,medical and ethical problems involved.

关键词： Face transplantation composite tissue transplantation facial allograft transplantation facial reconstruction outcomes and complications of face transplantation

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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comIntraspecific variation in heritable secondary metabolites and defensive strategies in a relict tree

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Journal of Plant Ecology 2018年第2期11卷 256-265页

作者： Adara Pardo Yonatan Cáceres fernando pulido Institute for Dehesa Research(INDEHESA) University of ExtremaduraPlasenciaSpain

Aims Key herbivory interaction traits such as plant defensive compounds may differ among populations of a single species due to the spatial variation in herbivore feeding guilds and the strength of the ***,the genealogy of population lineages could represent an additional source of variation interacting with the predominant eco-clinal *** tested for the existence of genetically based intraspecific variation in chemical defence profiles across the range of the relict tree Prunus lusitanica ***,we investigated geographical variation in defence inducibility and tested for the exist-ence of a trade-off between qualitative and quantitative *** We conducted a greenhouse experiment where 210 plants were grown under a common environment,comprising 10 different pop-ulations throughout the distribution range of the species and span-ning three separate regions:iberia,Morocco and *** test for the inducibility of defences,we artificially defoliated *** treatments were established within each population:undam-aged,defoliated and sampled after 2 h,and defoliated and sampled after 72 *** concentration of cyanogenic glycosides(prunasin)and phenolics was determined in leaf samples for all *** findings Basal levels of cyanogenics and phenolics significantly differed among populations and regions across the range of ***,with this variation having a heritable ***(pruna-sin)were significantly higher in ancient Macaronesian populations,while phenolic concentrations were larger in *** higher cyanogenic levels found in Macaronesia could be a consequence of the known stronger herbivory pressure in the islands than in iberia or the likely longer coevolutionary history with herbivores in this *** findings indicate that the geographical variation of key ecological traits such plant chemical defences can be imprinted by phylogeographical signals,particularly in relict spe

关键词： herbivory intraspecific variation phylogeography plant defences relict flora

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Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2795-2814页

作者： Alvaro barrera-Ocampo Facultad de Ingenierıa Diseno y Ciencias AplicadasDepartamento de Ciencias Farmaceuticas y QuimicasGrupo NaturaUniversidad IcesiCali 760031Colombia

Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and *** cure for AD has not been found yet and the treatments available until recently were only *** of multidisciplinary approaches and efforts made by pharmaceutical companies,it was only in the past two years that new drugs were approved for the treatment of the *** beta(Aβ)immunotherapy is at the core of this therapy,which is one of the most innovative approaches looking to change the course of *** technology is based on synthetic peptides or monoclonal antibodies(mAb)to reduce Ab levels in the brain and slow down the advance of ***,this article reviews the state of the art about AD neuropathogenesis,the traditional pharmacologic treatment,as well as the modern active and passive immunization describing approved drugs,and drug prototypes currently under investigation in different clinical *** addition,future perspectives on immunotherapeutic strategies for AD and the rise of the aptamer technology as a non-immunogenic alternative to curb the disease progression are discussed.

关键词： Aβ Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning

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Resource manipulation reveals flexible allocation rules to growth and reproduction in a Mediterranean evergreen oak

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Journal of Plant Ecology 2014年第1期7卷 77-85页

作者： fernando pulido Gerardo Moreno Eustolia García José J.Obrador Raúl Bonal Mario Díaz Grupo de Investigación Forestal Ingeniería Forestal y del Medio NaturalUniversidad de ExtremaduraE-10600 PlasenciaCáceresSpain Colegio de Postgraduados Campus TabascoMX-86500 CárdenasTabascoMexico Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM-JCCM)University of Castilla-La ManchaCiudad RealSpain Department of Biogeography and Global Change(BCG-MNCN) Museo Nacional de Ciencias NaturalesCSICE-28006 MadridSpain

Aims In plants,resource allocation to growth and reproduction may depart from trade-off expectations if(i)investment in growth and reproduction relies on different resource pools,(ii)allocation to reproduction is dependent upon reaching some growth threshold or(iii)reproduction is developmentally linked to growth,both functions relying on the same resource *** examined the effects of enhanced resource level on patterns of resource allocation to growth and reproduction in holm oak(Quercus ilex ***),a Mediterranean evergreen *** In the experimental year(2003),we manipulated the amount of soil nutrients in autumn(to increase nutrient uptake during shoot elongation in the following spring)and soil water in summer(to increase water uptake during acorn growth).Indicators of growth and male and female reproduction were estimated in the preexperimental(2002),experimental(2003)and post-experimental(2004)*** Findings Fertilized trees produced significantly longer shoots,but the number of female flowers per shoot was not affected by *** production of male catkins was also enhanced by *** did not affect the production of female flowers or abortion *** and female reproduction showed no consistent relationship in untreated trees,but resource addition elicited a growth-female reproduction trade-off in the experimental *** sign of this significant relationship changed in the post-experimental year,indicating the existence of lagged effects of resource manipulation on acorn ***,patterns of allocation to growth and reproduction varied as a function of sex,resource availability and year,a result consistent with extreme allocational plasticity in holm oak.

关键词： acorn abortion allocational plasticity dehesa growthreproduction trade-offs nutrient addition Quercus ilex resource allocation

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Gene transcription profiting of astheno-and normo-zoospermic sperm subpopulations

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Asian Journal of Andrology 2020年第6期22卷 608-615页

作者： Pedro Caballero-Campo Saul Lira-Albarran David barrera Elizabeth Borja-Cacho Hector S Godoy-Morales Claudia Rangel-Escareno fernando Larrea Mayel Chirinos Department of Reproduction Biology National Institute of Medical Sciences and Nutrition Salvador ZubiranMexico City 14080Mexico Tambre Foundation Madrid 28002Spain Reproductive Medicine Unit Angeles del Ped regal HospitalMexico City 10700Mexico Computational Genomic and Integrative Biology Laboratory National Institute of Genomic MedicineMexico City 14610Mexico

Spermatozoa contain a repertoire of RNAs considered to be potential functional fertility *** this study,the gene expression of human sperm subpopulations with high(F1)and low(F2)motility from healthy normozoospermic(N)and asthenozoospermic(A)individuals was evaluated using RNA microarray followed by functional genomic analysis of differentially expressed *** from A-F1 versus N-F1,A-F2 versus N-F2,N-F1 versus N-F2,and A-F1 versus A-F2 comparisons showed a considerably larger set of downregulated genes in tests versus *** ontology(GO)analysis of A-F1 versus N-F1 identified 507 overrepresented biological processes(BPs),several of which are associated with sperm *** addition,gene set enrichment analysis of the same contrast showed 110 BPs,36 cellular comp on ents,and 31 molecular functions,several of which are involved in sperm motility.A leadi ng・edge analysis of selected GO terms resulted in several down regulated genes encoding to dyn eins and kin esins,both related to sperm ***,the predicted activation state of asthenozoospermia was increased,while fertility,cell movement of sperm,and gametogenesis were ***,several downregulated genes characteristic of the canonical pathway protein ubiquitination were involved in asthenozoospermia ***,GO analysis of A-F2 versus N-F2 did not identify overrepresented BPs,although the gene set enrichment analysis detected six enriched BPs,one cellular component,and two molecular ***,the results show differences in gene transcription between sperm subpopulations from asthenozoospermic and normozoospermic semen samples and allowed the identification of gene sets relevant to sperm physiology and reproduction.

关键词： asthenozoospermia male in fertility microarray sperm transcriptome

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New Insights into Plant Isoprenoid Metabolism

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Molecular Plant 2012年第5期5卷 964-967页

作者： Pablo pulido Catalina Perello Manuel Rodriguez-Concepcion Department of Molecular Genetics Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB Campus UAB Bellaterra 08193 BarcelonaSpain

Isoprenoids are a hugely diverse family of compounds derived from the C5 precursors isopentenyl diphosphate （IPP） and dimethylallyl diphosphate （DMAPP）. Although all free-living organisms synthesize isoprenoids, they are particularly abun- dant and diverse in plants, with tens of thousands structures known to date. The highest variety of plant isoprenoids are specialized （secondary） metabolites that participate in the interaction of plants with their environment. These include pigments, volatiles, and defense compounds, some of which have applications in industry and agriculture.

关键词： Metabolism Insight Plant

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Extra dimensions and atomic transition frequencies

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Chinese Physics B 2008年第1期17卷 70-75页

作者：李志刚倪维斗 Antonio pulido Patón Center for Gravitation and Cosmology Purple Mountain ObservatoryChinese Academy of Sciences

New unification theories predict large extra dimensions （LEDs）. If that is the case, gravity would be stronger at short ranges than what Newtonian gravity predicts. LEDs could also have effects at atomic level. In this paper we propose a new method to constrain the size of ‘gravity-only’ LEDs by analysing how these LEDs modify the energy of the atomic transitions 1s-2s and 2s-2p （Lamb shift）, in the particular case of the hydrogen and muonium atoms. We estimate these effects by using Bethe＇s non-relativistic treatment of Lamb shift. In the particular case of three LEDs, which may be a candidate to explain the interaction mechanism of dark matter particles, we have found that current knowledge in atomic spectroscopy could constrain their sizes to less than 10 μm. Although our contributions do not reach the sensitivity given by SN1987a, they are still slightly better than recent constraints given by Inverse Square Law tests of the Eoet-Wash group at Washington University, which gave R3 〈 36.6 μm.

关键词： large extra dimensions Lamb shift atomic spectroscopy

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Bird Monitoring to Conserve Salitre Wetland in Bogotá： Strengthening Local Efforts in Conservation

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Journal of Environmental Science and Engineering(B) 2012年第10期1卷 1162-1166页

作者： Abril-pulido Elizabeth Pachón Carlos Barragán-barrera Dalia Akuaippa Association Jorge Tadeo Lozano Univesity Bogotá 111221 Colombia

Abstract： The Bogota Savannah was great Lake Humboldt 20,000 years ago. In the early 20th century, there were 50,000 ha of wetlands in Bogotá, but now this area has reduced to around 800 ha, due principally to human activities like industry, city-planning expansion, and agriculture. Actually, there are 13 wetlands and two lakes in Bogotá. SW （Salitre wetland） is an aquatic area that contains migratory and resident bird＇s species. Around this wetland, there are some urbanization and recreational areas that affect this natural habitat. Due to city-planning expansion, the city government wanted to build a great area to perform massive public events on the Salitre area. From June 2009 to June 2010, the researchers have made bird monitoring and recorded the SW as a very important habitat for birds; they demonstrated that this site offered them food and protection. Migratory species like Dendroica striata, Porzana carolina, Porphyrio martinica, Actitis macularia, Piranga rubra, Contopus cooperi and Contopus virens, inhabit this area. Most of the birds in SW use the area primarily for feeding and roosting, and the authors have recorded presence of eggs and chicks. In this way, the authors have demonstrated that this area is very important for migratory and resident birds. Currently, SW is in process to be officially designated as a wetland after many efforts. However, conservation and educational efforts should be taken into consideration for the protection and conservation of this wetland.

关键词： SW (Salitre wetland) bird species conservation.

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Influence of microbial priming and seeding depth on germination and growth of native wildflowers

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Ecological Processes 2021年第1期10卷 266-273页

作者： Daniela barrera Juan Luera Kaitlynn Lavallee Pushpa Soti Mathematics and Science Academy University of Texas-Rio Grande ValleyEdinburg 78539USA Sharyland Pioneer High School MissionTX 78573USA. Department of Biology University of Texas-Rio Grande ValleyEdinburgTX 78539USA. School of Earth Environmentand Marine SciencesUniversity of Texas-Rio Grande ValleyEdinburgTX 78539USA.

Background:Using native wildflowers for restoring marginal lands has gained considerable *** of wildflowers can be challenging due to several environmental *** the microbial community in degraded habitats can potentially result in the native plant performance and habitat *** study was conducted to investigate the impact of native soil microbes and seeding depth on germination of south Texas native *** wildflower species,Ratibida columnifera(Nutt.)(Mexican Hat)and Verbesina encelioides(Cav.)(cowpen daisy),were treated with microbial wash extracted from native soils,and germination rate was recorded for 14-day *** further analyzed the growth,biomass allocation,and root colonization by mycorrhizal fungi in these two plants growing them in a plant growth chamber for 6 *** determine the impact of seeding depth,we planted the seeds of the two plant species at 2-cm,6-cm,and 12-cm depth and monitored germination and plant ***:The two species responded differently to the seeding depth and microbial wash *** wash treatment resulted in higher germination rate in *** compared to control,while it did not have any impact on *** seed *** microbial treatment did not influence the total biomass,it had a significant impact on the biomass allocation in both the plant *** seeds germinated at both 2-cm and 6-cm depth and did not germinate at 12 cm,while the *** seeds germinated only at 2 cm and did not germinate at 6-cm or 12-cm seeding ***:While our results are species specific,our results indicate that native soil microbes can potentially improve the seed germination and growth of *** results also indicate the importance of specific seeding depth when sowing wildflower seeds for habitat restoration.

关键词： Habitat restoration Soil microbes Seeding depth Wildflowers Root endophytes

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