Current role in facial allograft transplantation:what have we learned?

作     者：Pedro Infante-Cossio Fernando Barrera-Pulido Tomas Gomez-Cia Domingo Sicilia-Castro Alberto Garcia-Perla-Garcia Purificacion Gacto-Sanchez Jose Maria Hernandez-Guisado Araceli Lagares-Borrego Rocio Narros-Gimenez Juan-David Gonzalez-Padilla 

作者机构：Department of Oral and Maxillofacial SurgeryVirgen del Rocio University Hospital41013 SevilleSpain Department of Plastic and Reconstructive SurgeryVirgen del Rocio University Hospital41013 SevilleSpain 

出 版 物：《Plastic and Aesthetic Research》 (整形与美容研究（英文版）)

年 卷 期：2016年第3卷第1期

页      面：211-218页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Face transplantation composite tissue transplantation facial allograft transplantation facial reconstruction outcomes and complications of face transplantation 

摘      要：Face transplant(FT)has evolved enormously in the last 10 years since the successful completion of the first facial *** procedure has become a new reconstructive option for complex facial deformities to restore the anatomy of patients with severely disfigured *** authors review the literature and discuss the main surgical,immunological,and ethical aspects as well as the results described in patients undergoing *** date there have been more than thirty FT *** main indication was post-traumatic *** all cases a standard immunosuppression was performed with three drugs,although acute rejection episodes were observed,that could be controlled with conventional immunosuppressive ***,functional and aesthetic results have been excellent at short-term and high satisfaction rate exceeded initial expectations,although long-term data are still *** complications were opportunistic *** deaths that occurred have reopened the ethical debate about the potential complications and concerns of providing informed consent to *** progresses in microsurgical techniques and preoperative planning have promoted the evolution from partial to full *** these are on the basis of accurate and careful selection of well-motivated *** next challenge will be getting new immunosuppressive treatment *** clinical experience has demonstrated the FT viability,it is still considered an experimental procedure in which we have much to learn to define its true role in the current reconstructive surgery and resolve major technical,medical and ethical problems involved.