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Structural changes in the obese brain

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Neural Regeneration Research 2024年第12期19卷 2561-2562页

作者： Anna R.R.Da conceicao Marcelo N.N.Vieira fernanda g.De Felice D’Or Institute for Research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil centre for Neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies collaboration,2009).

关键词： diseases consequences prevalence

Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2

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Molecular Plant 2024年第6期17卷 884-899页

作者： Liping Zeng Maria fernanda gomez Mendez Jingzhe guo Jishan Jiang Bailong Zhang Hao chen Brandon Le Haiyan Ke Katayoon Dehesh Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideRiversideCA 92521USA School of Medicine University of CaliforniaRiversideRiversideCA 92521USA

Stress-induced retrograde signal transmission from the plastids to the nucleus has long puzzled plant *** address this,we performed a suppressor screen of the ceh1 mutant,which contains elevated 2-c-methyl-d-erythritol-2,4-cyclopyrophosphate(MEcPP)levels,and identified the gain-of-function mutant impα-9,which shows reversed dwarfism and suppressed expression of stress-response genes in the ceh1 background despite heightened *** genetic and biochemical analyses established that the accumulation of MEcPP initiates an upsurge in Arabidopsis SKP1-like 1(ASK1)abundance,a pivotal component in the proteasome degradation *** increase in ASK1 prompts the degradation of IMPα-***,we uncovered a protein-protein interaction between IMPα-9 and TPR2,a transcriptional co-suppressor and found that a reduction in IMPα-9 levels coincides with a decrease in TPR2 ***,the interaction between IMPα-9 and TPR2 was disrupted in impα-9 mutants,highlighting the critical role of a single amino acid alteration in maintaining their *** of their interaction results in the reversal of MEcPP-associated *** immunoprecipitation coupled with sequencing analyses revealed that TPR2 binds globally to stress-response genes and suggested that IMPα-9 associates with the *** function together to suppress the expression of stress-response genes under normal conditions,but this suppression is alleviated in response to stress through the degradation of the suppressing *** biological relevance of our discoveries was validated under high light stress,marked by MEcPP accumulation,elevated ASK1 levels,IMPα-9 degredation,reduced TPR2 abundance,and subsequent activation of a network of stress-response *** summary,our study collectively unveils fresh insights into plant adaptive mechanisms,highlighting intricate interactions among retrograde signaling,the proteasome,and nuclear transport machinery.

关键词： plastidial retrograde signal MEcPP ASK1 impα-9 TPR2

Influence of biological maturation on cardiac autonomic recovery in female volleyball players during&after repeated sprints training:An experimental trial

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Sports Medicine and Health Science 2024年第3期6卷 279-286页

作者： Paulo Francisco de Almeida-Neto fernanda cristina Silva de Oliveira Jose Marcondes de Oliveira-Júnior Júlio cesar Medeiros Alves Matheus de Lima Rocha Iago Medeiros da Silva Roberto Felipe c^amara Rocha Paulo Moreira Silva Dantas Breno guilherme de Araújo Tin^oco cabral Health Sciences center Federal University of Rio Grande do NorteCCS-UFRNNatal59012-570RNBrazil Department of Physical Education Federal University of Rio Grande do NorteDEF-UFRNNatal59078-970RNBrazil

Previously,it was suggested that biological maturation(BM)could be linked to cardiac autonomic recovery(cAR)in the pediatric ***,this influence hasn’t been confirmed *** aim was to investigate the impact of BM on cAR in female volleyball *** study with a sample of 38 volleyball players,comprising 20 girls(age:[11.62.1]years)and 18 women(age:[24.55.5]years),we analyzed BM,comparing maturing subjects(girls)with mature subjects(women).Additionally,we assessed peak height velocity(PHV)in *** conducted a training session involving repeated sprints(3 rounds of 6 sprints interspersed by 5 min[min]of passive rest).Using short-range radio telemetry,we analyzed cAR during(at the end of the 1st and 2nd rounds)and after(following the 3rd round)the training session of repeated sprints by applying the 60-s to 300-s heart rate recovery index(HRR-Index).girls exhibited superior cAR compared to women(round 2:60-s,120-s,240-s,and 300-s,pgroup analyses of BM indicated that individuals in the Late-PHV stage demonstrated superior cAR compared to those in the Early-PHV and During-PHV groups.(60-s to 300-s,η2p>0.4,pcts in the During-PHV stage were superior to those in the Early-PHV stage(240-sa 300-s,η2 p>0.4,pconcluded that biological maturation has a significant impact on cardiac autonomic recovery.

关键词： Exercise Sport Volleyball Heart rate Pediatric

Inosine: a novel treatment for sciatic nerve injury

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Neural Regeneration Research 2021年第1期16卷 127-128页

作者： Fellipe Soares dos Santos cardoso Ana Maria Blanco Martinez fernanda Martins de Almeida Laboratório de Neurodegeneração e Reparo–Departamento de Anatomia Patológica–Hospital Universitário clementino Fraga Filho HUcFF/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil Instituto de ciências Biomédicas–IcB/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil

Trauma to the peripheral nervous system often results in loss of motor and sensory functions of the affected area of the body,leading to a series of functional impairments(Allodi et al.,2012).Injuries to peripheral nerves initiate a series of complex events,known as Wallerian degeneration,which allows the injured axons to regenerate and reinnervate their targets(Allodi et al.,2012).Damage to a nerve induces multiple alterations,which include:axonal degeneration,breakdown of myelin sheath,Schwann cells(Sc)proliferation and conversion to a repair phenotype which express cytokines and chemokines that allow the infiltration and activation of macrophages(Mietto et al.,2015;Jessen and Mirsky,2016).

关键词： al. degeneration alterations

Animal models applied to acute-on-chronic liver failure:Are new models required to understand the human condition?

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World Journal of clinical cases 2022年第9期10卷 2687-2699页

作者： Jaciara fernanda gomes gama Liana Monteiro da Fonseca cardoso Jussara Machado Lagrota-candido LuizAnastacio Alves Laboratory of cellular communication Oswaldo Cruz InstituteOswaldo Cruz FoundationRio de Janeiro 21045900Rio de JaneiroBrazil Laboratory of Immunopathology Department of ImmunobiologyFluminense Federal UniversityNiteroi 24210-200Rio de JaneiroBrazil

The liver is a multifaceted organ;its location and detoxifying function expose this organ to countless ***-on-chronic failure liver(AcLF)is a severe syndrome that affects the liver due to acute decompensation in patients with chronic liver *** infection environment,ascites,increased liver enzymes and prothrombin time,encephalopathy and fast-evolving multiorgan failure,leading to death,usually accompany *** pathophysiology remains poorly *** this context,animal models become a very useful tool in this regard,as understanding;the disease may be helpful in developing novel therapeutic methodologies for ***,although animal models display several similarities to the human condition,they do not represent all AcLF manifestations,resulting in significant *** initial liver cirrhosis framework followed by the induction of an acute decompensation by administering lipopolysaccharide and D-ga IN,potentiating liver damage supports the methodologies applied to induce experimental *** entire methodology has been described mostly for ***,a quick Pub Med database search indicates about 30 studies concerning AcFL models and over 1000 regarding acute liver failure *** findings demonstrate the clear need to establish easily reproducible AcFL models to elucidate questions about this quickly established and often fatal syndrome.

关键词： Liver disease Acute-on-chronic liver failure cirrhosis Acute decompensate event Translational study Animal models

Thulium fiber laser lithotripsy:Is it living up to the hype?

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Asian Journal of Urology 2023年第3期10卷 289-297页

作者： John Denstedt fernanda c.gabrigna Berto Division of Urology Department of SurgeryWestern UniversitySchulich School of Medicine and DentistryLondon Canada

Objective:The holmium:yttrium-aluminium-garnet laser(Ho:YAg)has been the gold standard for laser lithotripsy over the last three *** demonstrating good in vitro efficacy,the thulium fiber laser(TFL)has been recently released in the market and the initial clinical results are *** article aims to review the main technology differences between the Ho:YAg laser and the TFL,discuss the initial clinical results with the TFL as well as the optimal settings for TFL ***:We reviewed the literature focusing on the technological aspects of the Ho:YAg laser and TFL as well as the results of in vitro and in vivo studies comparing both ***:In vitro studies show a technical superiority of TFL compared to the Ho:YAg laser and encouraging results have been demonstrated in clinical ***,as TFL is a new technology,limited studies are currently available,and the optimal settings for lithotripsy are not yet ***:TFL has the potential to be an alternative to the Ho:YAg laser,but more reports are still needed to determine the optimal laser for lithotripsy of urinary tract stones when considering all parameters including effectiveness,safety,and costs.

关键词： Urolithiasis Thulium fiber laser Holmium:yttriumaluminium-garnet laser Laser lithotripsy

Methods and parameters of melting curve analysis for identification of Leishmania species:A scoping review

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Asian Pacific Journal of Tropical Medicine 2021年第12期14卷 528-542页

作者： Juliana J g Ferreira fernanda S Nascimento glaucia E B Marcon Eros A de Almeida Sandra c B costa Laboratório de Diagnóstico de Doenças Infecciosas por Técnicas de Biologia Molecular Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil Fundação Oswaldo cruz Mato grosso do Sul(FIOcRUZ MS) Rua Gabriel Abrão92Jardim das NaçõesCampo Grande79081-746 MSBrazil grupo de Estudos em Doença de chagas Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil

Leishmaniasis is a set of diseases with a worldwide distribution that affects mainly economically underprivileged populations in developing countries. It has a major impact on public health, with a global cost of billions of dollars per year. The treatment and control of leishmaniasis vary according to the Leishmania species involved, which require reliable methods for species identification. Since most of the currently used methods have limitations, there is a need for assays that allow rapid, precise identification of the offending species. Real-time polymerase chain reactions in conjunction with dissociation curve analysis have been used to detect differences in the DNA composition of selected genes of Leishmania spp. Kinetoplast DNA is the main molecular target used because of its high copy number per parasite, but other targets have also been studied. As part of an effort to establish melting temperature standards for each target gene, we have reviewed the pertinent literature available in public databases, including Pub Med, Web of Science, Sci ELO and LILAcS, using the keywords "Leishmania", "leishmaniasis", "realtime PcR", "melting temperature", and "melting curve", alone or in combination. After applying eligibility criteria, 27 articles were selected for analysis. A considerable variation in the methodologies analyzed was found regarding molecular targets, standardization of the methods, reproducibility and specificity. Because of this, statistical analysis was not performed. In most cases, the methods were able to differentiate the parasite at the subgenus level or few species regardless of the target chosen.

关键词： Leishmaniasis Melting temperature Real-time PcR

Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： fernanda Martins de Almeida Suelen Adriani Marques Anne caroline Rodrigues dos Santos caio Andrade Prins Fellipe Soares dos Santos cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

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World Journal of gastroenterology 2010年第6期16卷 728-731页

作者： Keith L Obstein fernanda P Martins gloria Fernández-Esparrach christopher c Thompson gastroenterology Division Brigham and Women's Hospital Federal University of So Paulo Department of gastroenterology Endoscopy UnitHospital Clinic(Spain)

AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(cPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided *** received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were *** abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored ***:EUS-guided cPN was successfully performed in all 6 pigs without immediate *** blue was identified throughout the peritoneal and retroperitoneal cavity in group *** blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group ***:EUS-guided cPN using a reverse phase polymer in a non-survival porcine model was technically *** presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent.

关键词： celiac plexus neurolysis celiac plexus blockade Endoscopic ultrasound Polymer