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Ca.ea.ia.s.lves.ris.Improved Cuta.eous.Burn Repa.r in Dia.etic Ra.s

Journa. of Pha.ma.y a.d Pha.ma.ology 2018年第6期6卷 551-562页

作者： a.ders.n Ma.telli Vivia.e Theodoro Fema.da.O. G. Ga.pi Ma.ia.E. C. a.a.a. Rodrigo a. Da.ia.a.drea.a.a.o Ma.celo a. M. Es.uis.0}to fernanda a. s. mendonca Thia.o a. M. a.dra.e Gla.cia.M. T. s.0}tos Gra.ua.e Progra. of Biomedica. s.iences Herminio Ometto University Center UNIARARAS Araras 13607-339 SP Brazil

Objectives. The burn repa.r a.s.cia.ed with dia.etes.complica.ions.s.owed cons.dera.le cha.ges.in the hea.ing proces. a.d the development of a.terna.ive thera.ies.to fa.or the repa.r is.importa.t. This.s.udy inves.iga.ed the effica.y of the Ca.ea.ia.s.lves.ris.in the burn repa.r in dia.etic a.d non-dia.etic ra.s. Methods. The a.ima.s.were divided into four groups.（n = 20）：（C） non-dia.etics.trea.ed with ca.bopol gel; （G） non-dia.etic trea.ed with C. s.lves.ris.extra.t in ca.bopol gel; （DM-C） dia.etics.trea.ed with ca.bopol gel; （DM-G） dia.etics.trea.ed with C. s.lves.ris.extra.t in ca.bopol gel. Burn wa. induced us.ng a.meta. pla.e （2 cm dia.eter/120 °C/20 s.c）. s.0}ples.were collected on the 3rd, 7th, 14th a.d 21s. da.s.a.ter the injury for his.omorphometric a.a.ys.s.（infla.ma.ory infiltra.e, fibrobla.ts. blood ves.els.a.d colla.en）, MPO （Myeloperoxida.e） a.d Na. （N-a.etilglicos.0}inida.e） dos.0}e, hydroxyproline, glycos.0}inoglyca.s. TGF-β1, VEGF, colla.en I a.d III. Key findings. C. s.lves.ris.decrea.ed the infla.ma.ory proces. during the experimenta. period in dia.etic a.d non-dia.etic a.ima.s.which ha. been demons.ra.ed by MPO, Na. qua.tifica.ion, a.d TGF-β1 expres.ion. C. s.lves.ris.a.s. increa.ed blood ves.els.a.d decrea.ed VEGF expres.ion during the s.udied period in non-dia.etic a.ima.s. Fibropla.ia.a.d colla.ena.e were increa.ed in a.l experimenta. periods.in the DM-G group by mea.s.of de hydroxyproline qua.tifica.ion, colla.en I, colla.en III a.d glycos.0}inoglyca.s. Conclus.ons. C. s.lves.ris.a.plica.ion ca. modula.e fa.ora.ly the time of infla.ma.ion a.d colla.enous.proces. in the repa.r of burn injuries.in dia.etic ra.s.

关键词： Burn hea.ing herba. medicine dia.etes.

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La.erthera.y a. a.s.ra.egy for Trea.ment Hea.ing under Ca.oric Res.riction – s.udy in Ra.s

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Journa. of Pha.ma.y a.d Pha.ma.ology 2018年第7期6卷 647-658页

作者： Lea.dro C. Mos.a.di Ta.ita.P. Es.índola.a.a.da.a. Ferreira.Na.a.a.a.ves.Ma.ia.Es.éria.C. a.a.a. a.dréa.a. a.o Rodrigo a. Da.ia.Ma.celo a. M. Es.uis.0}to fernanda a. s. mendonca Gláucia.M. T. s.0}tos.Thia.o a. M. a.dra.e Gra.ua.e Progra. in Biomedica. s.iences.of the Hermínio Ometto Univers.ty Center UNIARARAS Araras So Paulo 13607-339 Brazilc

Complica.ions.in the hea.ing proces. a.e cha.lenging, es.ecia.ly in clinica. s.tua.ions.of ca.oric res.riction （CR）. The la.erthera.y becomes.a. importa.t s.ra.egy tha. a.ds.the repa.r, es.ecia.ly in CR. Thus. it is.importa.t to inves.iga.e the InGa.lP-660 nm la.er a. a. s.ra.egy to repa.r cuta.eous.wounds.in ra.s.s.bmitted to 30% of CR a.d to unders.a.d the tis.ue repa.r in clinica. s.tua.ions.of CR. Thirty-s.x ma.e Wis.a. ra.s.were us.d, of which ha.f were fed with 30% les. ra.ion, a.d ha.f with a. libitum diet, for 21 da.s. Then, punch les.ons.of 1.5 cm in dia.eter were ma.e on the a.ima.s.ba.ks. which were divided into： NR （no-res.ricted）, R （res.ricted）-both before les.on; C （control）, RC （res.ricted-control）, L （la.er）, RL （res.ricted-la.er）-a.ter les.on. s.0}ples.of the s.in/les.on/s.a. were collected on the 2nd, 7th a.d 14th da.s.pos.-injury for his.ologica., biochemica. a.d molecula. a.a.ys.s. The R group s.owed reduction of body ma.s. epiderma./derma. thicknes., infla.ma.ion, a.giogenes.s. fibropla.ia.a.d colla.enes.s. The RL group s.owed control of infla.ma.ion, oxida.ive da.a.e a.d increa.e of a.tioxida.ts.tha. RC, which proba.ly fa.ored a.giogenes.s. colla.enes.s.a.d reepithelia.iza.ion, s.mila. to C a.d L. Thus. 30% of CR impa.red the s.in （before les.on）. In the les.on, la.erthera.y ha. s.own to be effective in tis.ue repa.r ma.nly in CR s.a.us. being thus. the la.er clinica.ly importa.t s.ra.egy to tis.ue repa.r in critica. s.tua.ions.of ca.oric res.riction.

关键词： Wound hea.ing s.in ca.oric res.riction wound trea.ment thera.eutic s.ra.egy la.erthera.y

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Bruton’s.tyros.ne kina.e inhibitors.in prima.y centra. nervous.s.s.em lymphoma.New hopes.on the horizon

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World Journa. of Clinica. Oncology 2024年第5期15卷 587-590页

作者： Leona.do s.Lino-s.lva.s.0}rina.B Ma.tínez-Villa.icencio Luis.0}fernanda Rivera.Monca.a Depa.tment of Pa.hology Oncology National Cancer Institute(Mexico)TlalpanMexico City 14080Mexico

In this.editoria.,we comment on the a.ticle by Wa.g et *** ma.us.ript explores.the potentia. s.nergis.ic effects.of combining za.ubrutinib,a.novel ora. inhibitor of Bruton’s.tyros.ne kina.e,with high-dos. methotrexa.e(HD-MTX)a. a.thera.eutic intervention for prima.y centra. nervous.s.s.em lymphoma.PCNs.).The s.udy involves.a.retros.ective a.a.ys.s.of 19 PCNs. pa.ients.highlighting clinicopa.hologica. cha.a.teris.ics.trea.ment outcomes.a.d genomic *** res.lts.indica.e the combina.ion’s.good tolera.ce a.d s.rong a.titumor a.tivity,with a. 84.2%overa.l res.ons. *** a.thors.empha.ize the potentia. of za.ubrutinib to modula.e key genomic fea.ures.of PCNs.,pa.ticula.ly muta.ions.in myeloid differentia.ion prima.y res.ons. 88 a.d clus.er of differentia.ion ***,the s.udy inves.iga.es.the role of circula.ing tumor DNa.in cerebros.ina. fluid for dis.a.e s.rveilla.ce a.d trea.ment res.ons. *** es.ence,the s.udy provides.va.ua.le ins.ghts.into the potentia. of combining za.ubrutinib with HD-MTX a. a.frontline thera.eutic regimen for *** findings.unders.ore the importa.ce of exploring a.terna.ive trea.ment moda.ities.a.d monitoring genomic a.d liquid biops. ma.kers.to optimize pa.ient *** the findings.s.gges. promis.,the s.udy’s.limita.ions.s.ould be cons.dered,a.d further res.a.ch is.needed to es.a.lis. the clinica. releva.ce of this.thera.eutic a.proa.h for PCNs..

关键词： Prima.y centra. nervous.s.s.em lymphoma Za.ubrutinib Bruton’s.tyros.ne kina.e Prognos.s Myeloid differentia.ion prima.y res.ons. 88 gene Clus.er of differentia.ion 79B gene

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Protected s.multa.eous.qua.tum remote s.a.e prepa.a.ion s.heme by wea. a.d revers.0} mea.urements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Ma.da. Ma.oj Kuma. Choudhury Bina.a. s. s.0}a.ta.s.umen Depa.tment of Ma.hema.ics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a.qua.tum remote s.a.e prepa.a.ion protocol by which two pa.ties. a.ice a.d Ca.dy, prepa.e a.s.ngle-qubit a.d a.two-qubit s.a.e, res.ectively, a. the s.te of the receiver Bob. The s.ngle-qubit s.a.e is.known to a.ice while the two-qubit s.a.e which is.a.non-ma.ima.ly enta.gled Bell s.a.e is.known to Ca.dy. The three pa.ties.a.e connected through a.s.ngle enta.gled s.a.e which a.ts.a. a.qua.tum cha.nel. We firs. des.ribe the protocol in the idea. ca.e when the enta.gled cha.nel under us. is.in a.pure s.a.e. a.ter tha., we cons.der the effect of a.plitude da.ping(a.) nois. on the qua.tum cha.nel a.d des.ribe the protocol executed through the nois. cha.nel. The decrement of the fidelity is.s.own to occur with the increment in the nois. pa.a.eter. This.is.s.own by numerica. computa.ion in s.ecific exa.ples.of the s.a.es.to be crea.ed. Fina.ly, we s.ow tha. it is.pos.ible to ma.nta.n the la.el of fidelity to s.me extent a.d hence to decrea.e the effect of nois. by the a.plica.ion of wea. a.d revers.0} mea.urements. We a.s. pres.nt a.s.heme for the genera.ion of the five-qubit enta.gled res.urce which we require a. a.qua.tum cha.nel. The genera.ion s.heme is.run on the IBMQ pla.form.

关键词： multi-qubit enta.gled cha.nel qua.tum remote s.a.e prepa.a.ion nois. environments wea. a.d revers.0} mea.urements

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s.ructura. cha.ges.in the obes. bra.n

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Neura. Regenera.ion Res.a.ch 2024年第12期19卷 2561-2562页

作者： a.na.R.R.Da.Conceica. Ma.celo N.N.Vieira.fernanda G.De Felice D’Or Ins.itute for Res.a.ch a.d Educa.ion Rio de JaneiroBrazil Ins.itute of Medica. Biochemis.ry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for Neuros.ience s.udies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obes.ty repres.nts.a.ma.or globa. hea.th concern,with wides.rea. growing preva.ence a.d s.vere cons.quences.for the qua.ity of life a.d life expecta.cy of a.fected individua.s.a.d for the economic burden of hea.thca.e s.s.ems.Pros.ective s.udies.Colla.ora.ion,2009).Obes.ty is.a.well-es.a.lis.ed ris. fa.tor for a.va.iety of conditions.including meta.olic,va.cula.r,a.d hea.t dis.a.es.a.d s.ve ra. types.of ca.cer(Pros.ective s.udies.Colla.ora.ion,2009).

关键词： dis.a.es cons.quences preva.ence

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Ha.ita. a.d food preferences.of Europea. ra.bits.in core a.d edge popula.ions.a.ong the inva.ion front Pa.a.onia.onte,a.gentina

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Current Zoology 2024年第3期70卷 310-319页

作者： s.0}rina.Ya.min Boba.illa.Ma.ía.a.Da.a. Fa.ián M.Ja.s.c Rica.do a.Ojeda.Ma.ía.fernanda Cueva. Ecología.de Ma.íferos.de Tierra. s.ca. IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina La.ora.orio de Filogeogra.ía Taxonomía Integrativa y Ecología(LFTIE)IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Center of a.plied Ecology a.d s.s.a.na.ility(Ca.Es. Pontifcia Universidad Católica de ChileAv.Libertador Bernardo O'Higgins 340Santiago 8320000Región MetropolitanaChile

The Europea. ra.bit Oryctola.us.cuniculus.is.a. exotic herbivorous.ma.ma. undergoing a. a.tive pha.e of geogra.hica. expa.s.on in the a.id ecos.s.ems.of *** a.a.tive Flexibility Hypothes.s.s.a.es.tha. popula.ions.a. the ra.ge edge(new popula.ions.will exhibit grea.er fexibility in the us. of res.urces.compa.ed with popula.ions.loca.ed in the ra.ge core(older popula.ions..The objective of this.work wa. to compa.e the ra.bit’s.us. of s.a.ia. a.d trophic res.urces.in rela.ion to the es.a.lis.ment time of their *** s.0}pling wa. ca.ried out for 2 yea.s.2017 a.d 2018)in s.tes.with different es.a.lis.ment times.for ra.bit *** s.0}pling s.ra.ifed by type of ha.ita. wa. a.plied us.ng 115 fxed s.rip tra.s.cts.of 1,000 m^(2) la.d out a.ros. the s.udy *** ra.bit s.gns.were recorded in ea.h tra.s.ct,a.d environmenta. a.d a.thropic va.ia.les.were *** res.lts.s.ow tha. the individua.s.from the ra.ge edge a.e more s.lective in the us. of ha.ita. tha. thos. from the ra.ge *** the microha.ita. level,we obs.rved a.pa.tern in the pa.ticula. components.of ha.ita. us. by ra.bits.ma.nly linked to food a.a.la.ility a.d proximity to *** a.trophic pers.ective,ra.bits.could s.ow fexible a.jus.ment to novel conditions.a.d environments.in the ra.ge *** va.ia.ility in res.urce us. by the Europea. ra.bit confrms.its.ecologica. fexibility,pivota. for their a.va.ce towa.d new environments.in a.gentina.

关键词： a.id ecos.s.ems inva.ive s.ecies novel environments ra.ge inva.ion s.a.ia. us. trophic us.

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Editoria. for the s.ecia. Is.ue on Emerging Technology a.d a.va.ced a.plica.ion of Nondes.ructive Detection for Power Equipment

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Chines. Journa. of Electrica. Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tia.jin Univers.ty China Ts.nghua.s.enzhen Interna.iona. Gra.ua.e s.hool China La.zhou Jia.tong Univers.ty China

The ra.id development of clea. a.d renewa.le energy technologies.repres.nted by wind a.d s.la. energy,a. well a. the continuous.growth of loa. dema.d,ha.e put forwa.d higher requirements.for the s.0}e opera.ion of the power *** performa.ce of power equipment ba.ed on tra.itiona. dielectric ma.eria.s.is.often limited by va.ious.defects.genera.ed during molding,tra.s.orta.ion,a.s.mbly,a.d opera.ion,which ca.not meet the relia.ility requirements.of power s.s.ems.in the new *** detection is.a. es.entia. technica. method in indus.ria. development,which ca. detect a.d eva.ua.e the defect a.d da.a.e s.a.us.of in-s.rvice equipment,key components.a.d ma.eria.s.without da.a.ing the object.

关键词： s.rvice a.plica.ion opera.ion

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Pa.ticle s.a.m Optimiza.ion-Ba.ed Hyperpa.a.eters.Tuning of Ma.hine Lea.ning Models.for Big COVID-19 Da.a.a.a.ys.s

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Journa. of Computer a.d Communica.ions 2024年第3期12卷 160-183页

作者： Hend s. s.0}em Moha.ed a. Mea. Gha.a.s. El-Ta.eel Depa.tment of Computer s.iences Suez Canal University Ismailia Egypt

a.a.yzing big da.a. es.ecia.ly medica. da.a. helps.to provide good hea.th ca.e to pa.ients.a.d fa.e the ris.s.of dea.h. The COVID-19 pa.demic ha. ha. a.s.gnifica.t impa.t on public hea.th worldwide, empha.izing the need for effective ris. prediction models. Ma.hine lea.ning (ML) techniques.ha.e s.own promis. in a.a.yzing complex da.a.pa.terns.a.d predicting dis.a.e outcomes. The a.cura.y of thes. techniques.is.grea.ly a.fected by cha.ging their pa.a.eters. Hyperpa.a.eter optimiza.ion pla.s.a.crucia. role in improving model performa.ce. In this.work, the Pa.ticle s.a.m Optimiza.ion (Ps.) a.gorithm wa. us.d to effectively s.a.ch the hyperpa.a.eter s.a.e a.d improve the predictive power of the ma.hine lea.ning models.by identifying the optima. hyperpa.a.eters.tha. ca. provide the highes. a.cura.y. a.da.a.et with a.va.iety of clinica. a.d epidemiologica. cha.a.teris.ics.linked to COVID-19 ca.es.wa. us.d in this.s.udy. Va.ious.ma.hine lea.ning models. including Ra.dom Fores.s. Decis.on Trees. s.pport Vector Ma.hines. a.d Neura. Networks. were utilized to ca.ture the complex rela.ions.ips.pres.nt in the da.a. To eva.ua.e the predictive performa.ce of the models. the a.cura.y metric wa. employed. The experimenta. findings.s.owed tha. the s.gges.ed method of es.ima.ing COVID-19 ris. is.effective. When compa.ed to ba.eline models. the optimized ma.hine lea.ning models.performed better a.d produced better res.lts.

关键词： Big COVID-19 Da.a Ma.hine Lea.ning Hyperpa.a.eter Optimiza.ion Pa.ticle s.a.m Optimiza.ion Computa.iona. Intelligence

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Prediction of vertica. dis.la.ement for a.buried pipeline s.bjected to norma. fa.lt us.ng a.hybrid FEM-a.N a.proa.h

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Frontiers.of s.ructura. a.d Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye Ja.a.I Reza.YEGa.EH KHa.s.0} Da.ia. MOHa.Ma.Za.EH s. Na.er Ka.Ba.La.EZa.EH a.ir H.Ga.DOMI Depa.tment of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Depa.tment of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Fa.ulty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Fa.ulty of Engineering&Informa.ion Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.a.ch a.d Innova.ion Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fa.lt movement during ea.thqua.es.is.a.geotechnica. phenomenon threa.ening buried pipelines.a.d with the potentia. to ca.s. s.vere da.a.e to critica. ***,effective prediction of pipe dis.la.ement is.crucia. for preventive ma.a.ement *** s.udy a.ms.to develop a.fa.t,hybrid model for predicting vertica. dis.la.ement of pipe networks.when they experience *** this.s.udy,the complex beha.ior of s.il a.d a.buried pipeline s.s.em s.bjected to a.norma. fa.lt is.a.a.yzed by us.ng a. a.tificia. neura. network(a.N)to genera.e predictions.the beha.ior of the s.il when different pa.a.eters.of it a.e *** this.purpos.,a.finite element model is.developed for a.pipeline s.bjected to norma. fa.lt *** da.a.ba.k us.d for tra.ning the a.N includes.a.l the critica. s.il pa.a.eters.cohes.on,interna. friction a.gle,Young’s.modulus.a.d fa.lting).Furthermore,a.ma.hema.ica. formula.is.pres.nted,ba.ed on bia.es.a.d weights.of the a.N *** res.lts.s.ow tha. the ma.imum error of the pres.nted formula.is.2.03%,which ma.es.the propos.d technique efficiently predict the vertica. dis.la.ement of buried pipelines.a.d hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines norma. Fa.lt finite element method multila.er perceptron neura. network formula.ion

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Improving a.Pa.ient’s.CVD Ris. a.s.s.ment—Upda.ing the Interpreta.ion of the Lipid Profile

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World Journa. of Ca.diova.cula. Dis.a.es 2024年第9期14卷 515-520页

作者： Da.id s. s.ha.e a.len a.olphe Robert Philip Ea.on Depa.tment of Interna. Medicine University of New Mexico Health Sciences Albuquerque USA Depa.tment of Interna. Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile rema.ns.a. importa.t la.ora.ory a.s.s.ment to prevent ca.diova.cula. dis.a.e. Interpreta.ion of the non-fa.ting lipid profile ha. s.gnifica.tly cha.ged ba.ed on new informa.ion concerning the pa.hogenes.s.of a.heros.leros.s. In pa.ticula., the a.s.s.ment of ris. from choles.erol conta.ning pa.ticles.following triglyceride meta.olis. (termed remna.t choles.erol) ca. now be done from a.lipid profile. In a.dition, non-HDL choles.erol a. ca.cula.ed from the lipid profile will provide a.complete a.s.s.ment of tota. circula.ing choles.erol conta.ning pa.ticles. Furthermore, the formula.for mea.urement of LDL choles.erol from a.lipid profile ha. now been revis.d s. tha. triglyceride levels.exert les. interference. Fina.ly, the old concept tha. the “higher the HDL-c, the better” is.no longer tena.le. New da.a.indica.e tha. the optima. high dens.ty lipoprotein level is.below 100 mg/dl for both ma.e a.d fema.e pa.ients. Correct interpreta.ion of the lipid profile will optimize a.ti-a.heros.lerotic thera.y a.d reduce the number one ca.s. of dea.h in the United s.a.es.

关键词： Lipid Profile a.heros.lerotic Ris. Ca.diova.cula. Dis.a.e High Dens.ty Lipoprotein Low Dens.ty Lipoprotein

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