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Chimeric ALT Perforator-Free Flap with Vastus Lateralis Muscle for the Obliteration of the Intrathoracic Dead Space Post-Pneumonectomy: A Case Report

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Modern Plastic Surgery 2023年第3期13卷 63-73页

作者： Nelson Oduor Ouma Daniel Odhiambo Otieno Lee Njagi Munge ferdinand wanjala nang’ole Department of Surgery Plastic Reconstructive and Aesthetic Surgery Thematic Unit College of Health Sciences The University of Nairobi Nairobi Kenya

Chest wall reconstruction is a surgical procedure aimed at restoring the integrity and function of the chest wall, which may be damaged due to trauma, cancer, infection, or congenital defects. The chest wall plays a vital role in protecting the thoracic organs, supporting the respiratory system, and maintaining the shape of the chest. Therefore, any defect or deformity of the chest wall can have significant functional and aesthetic consequences for the patient. The authors present a case report at Kenyatta National Hospital (KNH) of a dyspneic 47-year-old male patient with a right anterolateral chest wall defect post-pneumonectomy previously complicated by bronchopleural fistula. Past attempts at the chest wall reconstruction had utilized the ipsilateral latissimus dorsi muscle, pectoralis major muscle, and the omental pedicled flaps with limited success. A chimeric anterolateral thigh (ALT) perforator-free flap with vastus lateralis (VL) muscle was used to obliterate the post-pneumonectomy intrathoracic dead space and to provide a cutaneous paddle. This case report aims to show the versatility of the ALT flap for chest wall reconstruction to prevent the post-pneumonectomy syndrome associated with tracheal deviation, inspiratory stridor, and exertional dyspnea. In conclusion, chest wall reconstruction with obliteration of intrathoracic dead space post-pneumonectomy is challenging and needs careful planning and execution.

关键词： Chest Wall Reconstruction Bronchopleural Fistula Pneumonectomy Chimeric ALT Flap Intrathoracic Dead Spacepost-Pneumonectomy

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Chimeric ALT Perforator-Free Flap with Vastus Lateralis Muscle for the Obliteration of the Intrathoracic Dead Space Post-Pneumonectomy: A Case Report

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Modern Plastic Surgery（现代整形外科） 2023年第3期

作者： Nelson Oduor Ouma Daniel Odhiambo Otieno Lee Njagi Munge ferdinand wanjala nang’ole

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Antimicrobial Activities of Solanum aculeastrum Fruit Extract against Escherichia coli, Staphylococcus aureus and Candida albicans: Significance of African Traditional Medicine in Combating Infections and Attaining Universal Health Coverage

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Pharmacology & Pharmacy 2023年第5期14卷 176-188页

作者： Christabel nang’andu Hikaambo Phanuel Chilala ferdinand Ndubi Godfrey Mayoka Martin Kampamba Reagan Kabuka Billy Chabalenge Steward Mudenda Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Pharmaceutical Chemistry and Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Department of Pharmacology and Pharmacognosy School of Pharmacy Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Pharmacy School of Health Sciences Levy Mwanawasa Medical University Lusaka Zambia Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia

Solanum aculeastrum, a member of the Solanum genus, has a rich history of traditional use in various populations throughout tropical and southern Africa for treating different ailments. This study investigated the antimicrobial activities of S. aculeastrum fruit extracts grown in Zambia against Escherichia coli (E. coli) (ATCC 25922), Staphylococcus aureus (S. aureus) (ATCC 25923), and Candida albicans (C. albicans). After being dried in an oven at 50°C for eight days, the fruits of S. aculeastrum were pulverised and subjected to extraction using methanol and distilled water as solvents. The resulting crude extract was then filtered, concentrated using a water bath, and packed into airtight containers separately. The disc diffusion method was employed to evaluate the antimicrobial activity of the extracts. The results showed that both the methanolic and aqueous extracts demonstrated antimicrobial activity against S. aureus and C. albicans, but not against E. coli. The zone of inhibition was greater in S. aureus than in C. albicans. This study highlights the importance of researching plants for their medicinal properties, which can pave the way for discovering natural product-based drugs with potential antimicrobial properties. These findings recommend further studies on plants used in African traditional medicine.

关键词： African Traditional Medicine Solanum aculeastrum Phytochemicals Solanum Berries Antimicrobial Activity

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Antimicrobial Activities of Solanum aculeastrum Fruit Extract against Escherichia coli ,Staphylococcus aureus and Candida albicans : Significance of African Traditional Medicine in Combating Infections and Attaining Universal Health Coverage

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Pharmacology & Pharmacy（药理与制药） 2023年第5期

作者： Christabel nang’andu Hikaambo Phanuel Chilala ferdinand Ndubi Godfrey Mayoka Martin Kampamba Reagan Kabuka Billy Chabalenge Steward Mudenda

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