Antimicrobial Activities of Solanum aculeastrum Fruit Extract against Escherichia coli, Staphylococcus aureus and Candida albicans: Significance of African Traditional Medicine in Combating Infections and Attaining Universal Health Coverage
Antimicrobial Activities of Solanum aculeastrum Fruit Extract against Escherichia coli, Staphylococcus aureus and Candida albicans: Significance of African Traditional Medicine in Combating Infections and Attaining Universal Health Coverage作者机构：Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Pharmaceutical Chemistry and Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Department of Pharmacology and Pharmacognosy School of Pharmacy Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Pharmacy School of Health Sciences Levy Mwanawasa Medical University Lusaka Zambia Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia
出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)
年 卷 期：2023年第14卷第5期
页 面：176-188页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：African Traditional Medicine Solanum aculeastrum Phytochemicals Solanum Berries Antimicrobial Activity
摘 要：Solanum aculeastrum, a member of the Solanum genus, has a rich history of traditional use in various populations throughout tropical and southern Africa for treating different ailments. This study investigated the antimicrobial activities of S. aculeastrum fruit extracts grown in Zambia against Escherichia coli (E. coli) (ATCC 25922), Staphylococcus aureus (S. aureus) (ATCC 25923), and Candida albicans (C. albicans). After being dried in an oven at 50°C for eight days, the fruits of S. aculeastrum were pulverised and subjected to extraction using methanol and distilled water as solvents. The resulting crude extract was then filtered, concentrated using a water bath, and packed into airtight containers separately. The disc diffusion method was employed to evaluate the antimicrobial activity of the extracts. The results showed that both the methanolic and aqueous extracts demonstrated antimicrobial activity against S. aureus and C. albicans, but not against E. coli. The zone of inhibition was greater in S. aureus than in C. albicans. This study highlights the importance of researching plants for their medicinal properties, which can pave the way for discovering natural product-based drugs with potential antimicrobial properties. These findings recommend further studies on plants used in African traditional medicine.
维普期刊数据库
