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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral Science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai fengyang jing Xuefen Li Jianyun Zhang Heyu Zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

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Genomic alterations in oral multiple primary cancers

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International Journal of Oral Science 2024年第1期16卷 145-153页

作者： Wen Wang Qian Wang Shiying Sun Pengfei Zhang Yuyu Li Weimin Lin Qiwen Li Xiao Zhang Zhe Ma Haiyan Lu Hebei Key Laboratory of Stomatology Hebei Clinical Research Center for Oral DiseasesHebei Medical UniversityShijiazhuangChina Department of Orthodontics School and Hospital of StomatologyHebei Medical UniversityShijiazhuangChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Preventive Dentistry School and Hospital of StomatologyHebei Medical UniversityShijiazhuangHebeiChina

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in ***, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

关键词： alterations metastasis oral

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An amorphous manganese iron oxide hollow nanocube cathode for aqueous zinc ion batteries

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Journal of Energy Chemistry 2023年第12期87卷 314-321,I0008页

作者： fengyang jing Chade Lv Liangliang Xu Yaru Shang Jian Pei Pin Song Yuanheng Wang Gang Chen Chunshuang Yan MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HelongjiangChina Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Engineering Research Center of Carbon NeutralityCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241000AnhuiChina

Aqueous zinc ion batteries(ZIBs) are attracting considerable attentions for practical energy storage because of their low cost and high ***,the traditional manganese oxide cathode materials suffer from the low intrinsic electronic conductivity,sluggish ions diffusion kinetics,and structural collapse,hindering their large-scale ***,we successfully developed a latent amorphous Mn_(1.8)Fe_(1.2)O_(4) hollow nanocube(a-H-MnFeO) cathode material derived from Prussian blue analogue *** amorphous nature endows the cathode with lower diffusion barrier and narrower band gap compared with crystalline counterpart,resulting in the superior Zn^(2+) ions and electrons transport *** structure can furnish abundant surface sites and suppress the structural collapse during the repeated charge/discharge *** virtue of the multiple advantageous features,the a-H-MnFeO cathode exhibits exceptional electrochemical performance,in terms of high capacity,excellent rate capability,and prolonged cycle *** strategy will pave the way for the structural design of emerging cathode materials.

关键词： Aqueous zinc-ion batteries Manganese iron oxide cathode Amorphous structure Hollow nanostructure lons transport kinetics

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基于无线传播环境的无蜂窝大规模MIMO系统接入点部署优化

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电信科学 2024年第2期40卷 11-21页

作者：姜静刘永强严冯洋陶莎 Worakrin Sutthiphan 西安邮电大学陕西省信息通信网络及安全重点实验室陕西西安710121 泰国国家电信有限公司泰国曼谷10700

无蜂窝大规模多输入多输出(MIMO)系统通过在覆盖区域内部署大量的接入点(AP),可以为用户提供均匀、可靠的服务。传统的无蜂窝大规模MIMO系统采用随机部署,未考虑AP周围的路径损耗、阴影衰落散射物以及环境遮挡对覆盖质量的影响。为了考... 详细信息

无蜂窝大规模多输入多输出(MIMO)系统通过在覆盖区域内部署大量的接入点(AP),可以为用户提供均匀、可靠的服务。传统的无蜂窝大规模MIMO系统采用随机部署,未考虑AP周围的路径损耗、阴影衰落散射物以及环境遮挡对覆盖质量的影响。为了考虑实际环境下无蜂窝大规模MIMO能实现均匀、一致的覆盖,提出了基于无线传播环境的AP部署方案。首先,通过混合概率路径损耗模型对无线传播环境进行表征,其次构建了以最大化平均吞吐量为目标的AP部署优化问题,最后将问题转化为马尔可夫博弈过程,并且基于多智能体深度确定性策略梯度(MADDPG)算法得出最优的AP部署策略。仿真结果表明,相比于传统的随机部署和现有AP部署策略,所提方案可明显改善复杂环境下的非均匀覆盖问题,为用户提供良好一致的均匀覆盖。

关键词：无蜂窝大规模MIMO AP部署混合概率路径损耗模型 MADDPG算法

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宁夏地区咸水层CO_(2)封存选区及潜力预测

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水文地质工程地质 2024年第4期51卷 21-32页

作者：杨川枫刘廷程国强刁玉杰马鑫王楠李凤洋杨凌雪马晶虎亭孙建任建国宁夏回族自治区水文环境地质调查院宁夏银川750021 中国地质调查局水文地质环境地质调查中心天津300304

宁夏局部地区高碳排放源集中且碳排量巨大,亟需开展碳封存潜力评价等工作,以支撑未来碳捕集、利用与封存规划与重大示范。文章在宁夏地区碳封存基本地质条件的基础上,采用美国能源部(US-DOE)体积法,评估宁夏地区深部咸水层CO_(2)封存预... 详细信息

宁夏局部地区高碳排放源集中且碳排量巨大,亟需开展碳封存潜力评价等工作,以支撑未来碳捕集、利用与封存规划与重大示范。文章在宁夏地区碳封存基本地质条件的基础上,采用美国能源部(US-DOE)体积法,评估宁夏地区深部咸水层CO_(2)封存预测地质潜力约867.421×10~8 t,预测技术容量约423.34×10^(8) t,主力储层主要集中分布在宁夏东部盐池地区和六盘山盆地。综合封存潜力、盖层封闭性、地质体稳定性、社会环境风险等因素,开展了宁夏地区咸水层封存适宜性初步评价,结果表明:宁夏东部盐池地区储盖层条件良好、构造较稳定、人口密度低,是宁夏地区开展咸水层CO_(2)封存的有利远景区。

关键词：宁夏深部咸水层 CO_(2)地质封存预测潜力远景区

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碎米知风草对不同环境因子的适应性及化学防治药剂的筛选

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草业科学 2024年第6期41卷 1371-1383页

作者：项晶杨飞蒋丽琳范良英范玉洁毕亚玲安徽科技学院资源与环境学院安徽凤阳233100 安徽科技学院农学院安徽凤阳233100

碎米知风草(Eragrostis japonica)是稻田恶性禾本科杂草之一。为明确影响碎米知风草种子萌发的主要环境因子,并筛选有效的化学防除药剂,采用培养皿法和盆钵法分别测定了温度、光照、pH、盐胁迫、渗透势、埋土深度对碎米知风草种子萌发... 详细信息

碎米知风草(Eragrostis japonica)是稻田恶性禾本科杂草之一。为明确影响碎米知风草种子萌发的主要环境因子,并筛选有效的化学防除药剂,采用培养皿法和盆钵法分别测定了温度、光照、pH、盐胁迫、渗透势、埋土深度对碎米知风草种子萌发的影响,并评价了27种稻田除草剂对碎米知风草的活性。结果表明,碎米知风草种子在20~40℃内均能萌发,恒温条件下最适萌发温度为35℃,变温条件下为35℃/25℃;其种子对光照较为敏感,黑暗条件下无法萌发;pH在4~10时种子萌发率在80.67%以上;随着NaCl浓度的升高,种子萌发率呈下降趋势,当NaCl浓度达到160 mmol·L^(-1)时种子停止萌发;碎米知风草种子对水势较为敏感,抑制萌发率50%时水势为-0.35 MPa;当埋土深度达到0.8 cm时可完全抑制种子萌发。活性结果表明,在推荐剂量下,土壤处理乙氧氟草醚、噁草酮、丁草胺、异噁草松、硝磺草酮、丙草胺、莎稗磷、二甲戊灵、仲丁灵、扑草净、环戊噁草酮11种药剂对碎米知风草的抑制效果较强,鲜重抑制率在96.28%以上;茎叶处理药剂噁唑酰草胺、禾草丹、敌稗、吡唑喹草酯、苯丙草酮5种药剂对碎米知风草的鲜重抑制率在92.16%~99.36%。该结果可为稻田碎米知风草的化学防治提供参考依据。

关键词：萌发特性杂草化学防除除草活性种子水稻田胁迫

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120 mm Single-crystalline perovskite and wafers： towards viable applications

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Science China Chemistry 2017年第10期60卷 1367-1376页

作者： Yucheng Liu Xiaodong Ren jing Zhang Zhou Yang Dong Yang fengyang Yu Jiankun Sun Changming Zhao Zhun Yao Bo Wang Qingbo Wei Fengwei Xiao Haibo Fan Hao Deng Liangping Deng Shengzhong (Frank) Liu Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Laboratory for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China iChEM Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Xi'an LONGI Silicon Materials Corporation Xi 'an 710100 China

As the large single-crystalline silicon wafers have revolutionized many industries including electronics and solar cells, it is envisioned that the availability of large single-crystalline perovskite crystals and wafers will revolutionize its broad applications in photovoltaics, optoelectronics, lasers, photodetectors, light emitting diodes(LEDs), etc. Here we report a method to grow large single-crystalline perovskites including single-halide crystals: CH3NH3PbX3(X=I, Br, Cl), and dual-halide ones:CH3NH3Pb(ClxBr1.x)3 and CH3NH3Pb(BrxI1.x)3, with the largest crystal being 120 mm in length. Meanwhile, we have advanced a process to slice the large perovskite crystals into thin wafers. It is found that the wafers exhibit remarkable features:(1)its trap-state density is a million times smaller than that in the microcrystalline perovskite thin films(MPTF);(2) its carrier mobility is 410 times higher than its most popular organic counterpart P3HT;(3) its optical absorption is expanded to as high as910 nm comparing to 797 nm for the MPTF;(4) while MPTF decomposes at 150 °C, the wafer is stable at high temperature up to270 °C;(5) when exposed to high humidity(75% RH), MPTF decomposes in 5 h while the wafer shows no change for overnight;(6) its photocurrent response is 250 times higher than its MPTF counterpart. A few electronic devices have been fabricated using the crystalline wafers. Among them, the Hall test gives low carrier concentration with high mobility. The trap-state density is measured much lower than common semiconductors. Moreover, the large SC-wafer is found particularly useful for mass production of integrated circuits. By adjusting the halide composition, both the optical absorption and the light emission can be fine-tuned across the entire visible spectrum from 400 nm to 800 nm. It is envisioned that a range of visible lasers and LEDs may be developed using the dual-halide perovskites. With fewer trap states, high mobility, broader absorption, and humidity

关键词：硅晶片钙钛矿单晶应用纳米复合薄膜可见光激光器晶体长度太阳能电池

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基于卷积神经网络的葡萄叶病害诊断系统研究与开发

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蚌埠学院学报 2024年第2期13卷 64-70页

作者：吴方婧张华民安徽科技学院机械工程学院安徽凤阳233100 安徽科技学院信息与网络工程学院安徽蚌埠233030

针对当前葡萄叶部病害大数据集匮乏、数据集品质较低等问题,提出一种新型卷积神经网络识别模型。首先,通过3×3的卷积核与池化层的交替结构,实施了一个初步的特征抽取策略。随后,通过空洞卷积技术,构建了一个多分支的模块,旨在捕获多尺... 详细信息

针对当前葡萄叶部病害大数据集匮乏、数据集品质较低等问题,提出一种新型卷积神经网络识别模型。首先,通过3×3的卷积核与池化层的交替结构,实施了一个初步的特征抽取策略。随后,通过空洞卷积技术,构建了一个多分支的模块,旨在捕获多尺度下的病斑特征。在网络的深层,引入了稠密连接策略,进一步完善了葡萄叶片病害的分层识别模型。这个模型不仅可以准确识别常见的葡萄叶片病害,还可以根据病害的严重程度提供相应的治疗建议。最后通过实验及仿真证明,所提新型卷积神经网络识别模型方便了种植户准确地诊断葡萄叶片病害情况,有效减少了经济损失。

关键词：深度学习病害防治特征识别病斑分割神经网络

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奇亚籽凝胶的制备及其抗氧化特性研究

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蚌埠学院学报 2024年第2期13卷 1-4,86页

作者：黄怡王凌晶李雪安徽科技学院食品工程学院安徽凤阳233100

通过单因素实验和正交实验,研究了蒸馏水添加量、凝胶温度、凝胶时间、食盐添加量对奇亚籽凝胶的保水性的影响,同时研究了奇亚籽凝胶对DPPH和羟自由基的清除能力。结果表明:奇亚籽凝胶最佳保水性条件为奇亚籽与蒸馏水的质量比为1∶0.5,... 详细信息

通过单因素实验和正交实验,研究了蒸馏水添加量、凝胶温度、凝胶时间、食盐添加量对奇亚籽凝胶的保水性的影响,同时研究了奇亚籽凝胶对DPPH和羟自由基的清除能力。结果表明:奇亚籽凝胶最佳保水性条件为奇亚籽与蒸馏水的质量比为1∶0.5,在水浴温度为33℃下保温5.5 h,测得保水性为99.70%。奇亚籽凝胶和奇亚籽对DPPH的清除能力分别为34%和27%,对羟自由基的清除能力分别为40%和32%。奇亚籽凝胶对DPPH和羟自由基的清除能力均有提高。

关键词：奇亚籽凝胶保水性抗氧化性自由基

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不同类型除草剂对直播稻田碎米知风草的活性及防效评价

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安徽科技学院学报 2024年第2期38卷 53-58页

作者：项晶王慧熊浩钧李诚程睿毕亚玲安徽科技学院资源与环境学院安徽凤阳233100 安徽科技学院农学院安徽凤阳233100

目的:筛选出防除碎米知风草的高效除草剂,为田间防治碎米知风草提供选药依据。方法:通过整株生物测定法,明确水稻田20种除草剂对碎米知风草的生物活性,并选取其中7种高活性药剂进行田间防效评价。结果:土壤处理药剂丁草胺、丙草胺、莎... 详细信息

目的:筛选出防除碎米知风草的高效除草剂,为田间防治碎米知风草提供选药依据。方法:通过整株生物测定法,明确水稻田20种除草剂对碎米知风草的生物活性,并选取其中7种高活性药剂进行田间防效评价。结果:土壤处理药剂丁草胺、丙草胺、莎稗磷、乙氧氟草醚、噁草酮、环戊噁草酮、二甲戊灵、仲丁灵、硝磺草酮、扑草净和茎叶处理药剂吡唑喹草酯、苯丙草酮、噁唑酰草胺、敌稗、禾草丹对碎米知风草的活性较高,GR90分别为140.47、41.39、92.08、2.92、153.91、34.03、16.76、65.97、7.37、130.30、144.93、68.70、80.46、2520.32、1918.3 g a.i./hm2,均低于各自的田间推荐剂量。结果表明,药后45 d,土壤处理药剂二甲戊灵、丙草胺、仲丁灵及茎叶处理药剂敌稗、苯丙草酮在推荐剂量下对其防效最高,鲜质量防效为82.95%~92.32%。结论:该5种药剂在推荐剂量时对碎米知风草均有较高防效,在田间防除此种杂草时应结合当地用药现状优先选用。

关键词：碎米知风草除草剂除草活性药剂筛选防效

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