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Therapeutic Effect of Shenling Baizhu Powder on Primary Nephrotic Syndrome Featuring Damp Abundance Due to Splenic Asthenia

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Medicinal Plant 2020年第5期11卷 76-79页

作者： Yingyuan QIN Youming XIONG Zhimei CUI Xiaowei DENG fengmao zhao Liping FENG Department of Nephrology Guilin Hospital of Traditional Chinese MedicineGuilin 541002China Department of Endocrinology(II) Shijiazhuang Hospital of Traditional Chinese MedicineShijiazhuang 050051China

[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly divided into treatment group(n=19)and control group(n=21).In the treatment group and the control group,methylprednisolone tablets were taken orally and cytoxan(CTX)was given intravenously for treatment;in the treatment group,based on oral administration of methylprednisolone tablets and intravenous drip of cytoxan(CTX),oral administration of traditional Chinese medicine(addition and subtraction of Shenling Baizhu Powder)was *** routine,24-hour urinary protein,renal function and serum albumin were re-examined after 4 weeks of treatment.[Results]The total effective rate of the treatment group was significantly higher than that of the control group(89.47%vs 61.90%,P<0.05).After treatment,both groups could effectively reduce the levels of 24-hour urinary protein(P<0.05),serum creatinine(P<0.05)and urea nitrogen(P<0.05),and increase the level of serum albumin(P<0.05),but the degree of improvement in the treatment group was significantly higher than that in the control group(P<0.05),and the difference was statistically significant(P<0.05).[Conclusions]Methylprednisolone combined with addition and subtraction of Shenling Baizhu Powder could effectively reduce urinary protein,improve edema symptoms,shorten the course of hormone use and reduce adverse reactions in the treatment of PNS featuring damp abundance due to splenic asthenia.

关键词： Primary nephrotic syndrome(PNS) Damp abundance due to splenic asthenia Addition and subtraction of Shenling Baizhu Powder

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儿童非典型脉络丛乳头状瘤的临床特点及疗效观察

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中华神经外科杂志 2022年第9期38卷 895-899页

作者：赵凤毛葛明孙骇浪张楠国家儿童医学中心首都医科大学附属北京儿童医院神经外科北京100045

目的探讨儿童非典型脉络丛乳头状瘤(aCPP)的临床特点、治疗方法及其预后。方法回顾性分析2014年1月至2021年11月首都医科大学附属北京儿童医院神经外科收治的10例aCPP患儿的临床资料。其中,7例肿瘤仅累及一侧侧脑室及其三角区,行单侧三... 详细信息

目的探讨儿童非典型脉络丛乳头状瘤(aCPP)的临床特点、治疗方法及其预后。方法回顾性分析2014年1月至2021年11月首都医科大学附属北京儿童医院神经外科收治的10例aCPP患儿的临床资料。其中,7例肿瘤仅累及一侧侧脑室及其三角区,行单侧三角区入路肿瘤切除术;另2例累及第三脑室及双侧侧脑室,1例累及颞、顶、枕叶,行胼胝体-穹窿间入路肿瘤切除术+硬膜下或脑室外引流术,后期行硬膜下-腹腔或脑室-腹腔分流手术。术后1、3、6个月,1年以及之后每年对患儿进行门诊或电话随访。随访术后是否行放化疗、二次手术治疗,有无新发神经功能障碍等。影像学随访有无肿瘤播散、转移。以术后头颅MRI增强扫描显示颅内瘤腔未见强化为肿瘤全切除。结果10例患儿的中位就诊年龄为1岁(3个月至11岁2个月),其中8例年龄<2岁。所有患儿的病变均位于小脑幕上,均达肿瘤全切除,术后症状改善。10例患儿的病理学分级均为世界卫生组织(WHO)Ⅱ级;免疫组织化学染色结果显示,波形蛋白均为阳性,细胞角蛋白(CK)和S-100均为弱阳性,Ki-67增殖指数为6%~30%。10例患儿的术后中位随访时间为51个月(6个月至8年)。9例患儿术后未行化疗,1例术后2年因急性淋巴细胞白血病行相关化疗。至末次随访,3例后期行分流手术的患儿均未出现分流相关并发症,且肌力均较前进一步改善;另7例患儿中,1例术前合并颅脑外伤的患儿死亡,余6例症状缓解。9例存活患儿的头颅增强MRI结果显示,颅内瘤腔未见强化,无一例发生脑脊液播散、转移或复发。结论儿童aCPP多于2岁前发病,多起源于小脑幕上脑室内脉络丛。经开颅手术治疗,肿瘤可达全切除,总体预后较好。

关键词：脉络丛肿瘤乳头状瘤儿童疾病特征治疗结果

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婴幼儿颅骨生长性骨折的手术治疗

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中华神经外科杂志 2014年第12期30卷 1258-1261页

作者：孙骇浪赵凤毛冀园琦首都医科大学附属北京儿童医院神经外科 100045

目的探讨婴幼儿颅骨生长性骨折的临床特点,强调及早手术,一期自体颅骨修补与硬膜修补同是加速治愈的关键.方法回顾性分析2008年9月至2013年12月间收治的经CT/MRI动态观察的12例3岁以下婴幼儿颅骨生长性骨折的临床资料.结果 5例采用人... 详细信息

目的探讨婴幼儿颅骨生长性骨折的临床特点,强调及早手术,一期自体颅骨修补与硬膜修补同是加速治愈的关键.方法回顾性分析2008年9月至2013年12月间收治的经CT/MRI动态观察的12例3岁以下婴幼儿颅骨生长性骨折的临床资料.结果 5例采用人工脑膜腱修补硬脑膜＋自体骨瓣成型移位固定,成功治愈颅骨生长性骨折,3个月内颅骨均愈合.4例仅行硬脑膜修补,颅骨缺损处未行一期修补,效果尚满意,但术后随访,颅骨愈合时间较长.3例失访.结论婴幼儿颅骨正处于生长发育期,应及早手术,早期清除坏死灶、严密缝合或修补硬脑膜,并采用自体骨瓣成型移位固定,一期还原硬脑膜和颅骨解剖形态,加速生长愈合,疗效确切.

关键词：婴幼儿颅骨生长性骨折自体骨瓣成型

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儿童视路胶质瘤手术前后体重变化的初步观察

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中华神经外科杂志 2021年第12期37卷 1267-1270页

作者：赵凤毛葛明孙骇浪张天蕾国家儿童医学中心首都医科大学附属北京儿童医院神经外科100045

目的初步探讨视路胶质瘤(OPG)患儿手术前后体重的变化。方法回顾性分析2015年7月至2020年12月首都医科大学附属北京儿童医院神经外科收治的36例视路胶质瘤患儿的临床资料。所有患儿均接受肿瘤切除术,基于术中观察及术后复查头颅MRI增强... 详细信息

目的初步探讨视路胶质瘤(OPG)患儿手术前后体重的变化。方法回顾性分析2015年7月至2020年12月首都医科大学附属北京儿童医院神经外科收治的36例视路胶质瘤患儿的临床资料。所有患儿均接受肿瘤切除术,基于术中观察及术后复查头颅MRI增强扫描的结果评估肿瘤的切除程度,其中将肿瘤切除体积为60%~90%定义为大部切除,>90%定义为近全切除。分别于术后1、2周,1、3、6以及9个月对患儿进行门诊复查或网上随访。随访内容包括:患儿的后续治疗情况、肿瘤有无复发、播散转移及体重变化等。根据患儿的性别、出生日期、体重及其测量日期等计算年龄别体重Z评分(WAZ),进一步计算两次随访间患儿WAZ增长速度,即(第n+1次随访时WAZ-第n次随访时WAZ)×1000/随访间隔时间(d)。采用单样本t检验分别比较患儿手术前、后WAZ与国际儿童标准WAZ。采用重复测量方差分析比较患儿术后不同时间点的WAZ以及WAZ的增长速度。结果36例患儿均顺利完成手术,其中28例肿瘤大部切除,8例肿瘤近全切除。病理学结果显示毛细胞型星形细胞瘤11例,毛细胞黏液样星形细胞瘤25例。36例患儿术后中位随访时间(范围)为25个月(9~40个月)。至末次随访,36例患儿均无肿瘤复发及转移,16例术前存在视觉症状的患儿视觉症状均有所好转。36例OPG患儿的术前WAZ为(-0.76±2.32)分,低于国际正常儿童WAZ的总体均值[(0±1.00)分],差异有统计学意义(P=0.024);术后9个月WAZ为(0.82±2.14)分,高于国际正常儿童WAZ的总体均值[(0±1.00)分],差异有统计学意义(P=0.006)。患儿术后WAZ较术前增加,术后1个月时WAZ最高且增长速度最快(均P<0.05)。结论初步观察发现,OPG患儿肿瘤切除术后体重较前增加,且在术后早期增长速度最快。

关键词：神经胶质瘤儿童体重显微外科手术

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儿童结节性硬化症合并室管膜下结节或室管膜下巨细胞星形细胞瘤的治疗体会

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中华神经外科杂志 2020年第5期36卷 470-475页

作者：赵凤毛葛明冀园琦孙骇浪张楠曾津津国家儿童医学中心首都医科大学附属北京儿童医院神经外科100045

目的探讨儿童结节性硬化症(TSC)合并室管膜下结节(SEN)或室管膜下巨细胞星形细胞瘤(SEGA)的治疗方案和预后.方法采用病例系列回顾性研究方法分析2010年4月至2019年3月首都医科大学附属北京儿童医院神经外科收治的12例TSC合并SEN或SEG... 详细信息

目的探讨儿童结节性硬化症(TSC)合并室管膜下结节(SEN)或室管膜下巨细胞星形细胞瘤(SEGA)的治疗方案和预后.方法采用病例系列回顾性研究方法分析2010年4月至2019年3月首都医科大学附属北京儿童医院神经外科收治的12例TSC合并SEN或SEGA患儿的临床资料.所有患儿的影像学均表现为孟氏孔附近的占位性病变特征.12例患儿中,6例考虑为SEN,未行治疗或行药物治疗;6例患儿考虑为SEGA,除1例放弃治疗外,另5例均予肿瘤切除,其中4例采用经额叶皮质造瘘入路,1例采用经胼胝体-穹窿间入路.6例患儿应用哺乳动物雷帕霉素靶蛋白抑制剂西罗莫司治疗.通过临床随访和影像学随访评估患儿的预后.结果 5例行手术治疗的患儿均达到肿瘤全切除,病理学结果提示均为SEGA(世界卫生组织分级为Ⅰ级).1例患儿术后发生脑积水,予脑室-腹腔分流术.12例患儿的随访时间为0.5 ~9.0年.5例患儿术后均无神经功能障碍,至末次随访无复发.6例SEN患儿行影像学复查提示SEN未见增大.6例应用西罗莫司的患儿癫痫发作次数均减少了50%以上.结论儿童TSC合并SEN或SEGA临床鲜见,针对个体情况制定诊疗计划,可获得较好的临床结局,但患儿的远期预后情况仍需随访.

关键词：结节性硬化症儿童室管膜下巨细胞星形细胞瘤室管膜下结节治疗结果

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Significant changes in the physicochemical properties of BC-containing particles during the cold season in Beijing

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Journal of Environmental Sciences 2025年第5期151卷 667-676页

作者： Shuya Hu Linghan Zeng Gang zhao Shiyi Chen Chunsheng zhao Weilun zhao Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Research Center for Atmospheric Research(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China

The ambient air quality has improved significantly under strict emission controls in Beijing,China over the last *** carbon(BC),as a short-lived climate forcer in ambient aerosols,profoundly impacts the air quality and *** studies have demonstrated a decline in the mass concentration of *** this study,we characterized the chemical compositions and size distributions of BC-containing particles during the cold season of 2022 in Beijing using state-of-the-art instruments capable of exclusively measuring BCcontaining *** optical properties of BC-containing particles were further calculated based on the Mie ***,we compared the properties of BC-containing particles in 2022 with the results of previous *** results showed that the diameters of BC cores became larger while the coating thickness of BC-containing particles became thinner in *** the coating materials,the mass fraction of nitrate increased obviously,and even replaced organic matter as the dominant component during the peak of the pollution *** in chemical compositions and size distributions resulted in lower mass absorption cross-sections(MAC)of BC-containing particles from 10.5±1.1 m^(2)/g in 2016 to 7.3±0.8 m^(2)/g in 2022,reduced by 30.5%.Our results demonstrate the synergistic benefits of air pollution control in improving air quality and mitigating climate ***,the MAC of BC adopted in climate models should vary with the changing air pollution *** study emphasizes that it is imperative to conduct long-term observations of BC-containing particles to better estimate BC’s climate effects.

关键词： Black carbon Chemical composition Size distribution Light absorption ability

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Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO_(2)Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The supercritical carbon dioxide(sCO_(2))Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO_(2)Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve(TBV)and the main regulating valve(MGV)to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： sCO_(2)Brayton cycle dynamic model buffer tank startup strategy dynamic characteristic

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Utilizing BP neural networks to accurately reconstruct the tritium depth profile in materials for BIXS

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Nuclear Science and Techniques 2025年第1期36卷 103-114页

作者： Chen zhao Wei Jin Yan Shi Chang-An Chen Yi-Ying zhao Institute of Materials China Academy of Engineering PhysicsJiangyou 621908China

β-ray-induced X-ray spectroscopy(BIXS)is a promising method for tritium detection in solid materials because of its unique advantages,such as large detection depth,nondestructive testing capabilities,and low requirements for sample ***,high-accuracy reconstruction of the tritium depth profile remains a significant challenge for this *** this study,a novel reconstruction method based on a backpropagation(BP)neural network algorithm that demonstrates high accuracy,broad applicability,and robust noise resistance is *** average reconstruction error calculated using the BP network(8.0%)was much lower than that obtained using traditional numerical methods(26.5%).In addition,the BP method can accurately reconstruct BIX spectra of samples with an unknown range of tritium and exhibits wide applicability to spectra with various tritium ***,the BP network demonstrates superior accuracy and stability compared to numerical methods when reconstructing the spectra,with a relative uncertainty ranging from 0 to 10%.This study highlights the advantages of BP networks in accurately reconstructing the tritium depth profile from BIXS and promotes their further application in tritium detection.

关键词： β-ray-induced X-ray spectroscopy Tritium detection BP network Ridge regression Reconstruction problem

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao Qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

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Evaluation of ERA5 reanalysis temperature data over the Qilian Mountains of China

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Journal of Mountain Science 2025年第1期22卷 198-209页

作者： zhao Peng HE Zhibin School of Computer Science Huainan Normal UniversityHuainan 232038China Linze Inland River Basin Research Station Key Laboratory of Inland River Basin ScienceNorthwest Institute of Eco-Environment and ResourceChinese Academy of SciencesLanzhou 730000China

Air temperature is an important indicator to analyze climate change in mountainous ***5 reanalysis air temperature data are important products that were widely used to analyze temperature change in mountainous ***,the reliability of ERA5 reanalysis air temperature over the Qilian Mountains(QLM)is *** this study,we evaluated the reliability of ERA5 monthly averaged reanalysis 2 m air temperature data using the observations at 17 meteorological stations in the QLM from 1979 to *** results showed that:ERA5 reanalysis monthly averaged air temperature data have a good applicability in the QLM in general(R2=0.99).ERA5 reanalysis temperature data overestimated the observed temperature in the QLM in *** mean square error(RMSE)increases with the increasing of elevation range,showing that the reliability of ERA5 reanalysis temperature data is worse in higher elevation than that in lower ***5 reanalysis temperature can capture observational warming rates *** the smallest warming rates of observational temperature and ERA5 reanalysis temperature are found in winter,with the warming rates of 0.393°C/10a and 0.360°C/10a,*** study will provide a reference for the application of ERA5 reanalysis monthly averaged air temperature data at different elevation ranges in the Qilian Mountains.

关键词： ERA5 Reanalysis data Air temperature Qilian Mountains Climate change

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