Therapeutic Effect of Shenling Baizhu Powder on Primary Nephrotic Syndrome Featuring Damp Abundance Due to Splenic Asthenia

作     者：Yingyuan QIN Youming XIONG Zhimei CUI Xiaowei DENG Fengmao ZHAO Liping FENG 

作者机构：Department of NephrologyGuilin Hospital of Traditional Chinese MedicineGuilin 541002China Department of Endocrinology(II)Shijiazhuang Hospital of Traditional Chinese MedicineShijiazhuang 050051China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2020年第11卷第5期

页      面：76-79页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Natural Science Research Project of Guangxi University of Chinese Medicine(2015LX037) 

主　　题：Primary nephrotic syndrome(PNS) Damp abundance due to splenic asthenia Addition and subtraction of Shenling Baizhu Powder 

摘      要：[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly divided into treatment group(n=19)and control group(n=21).In the treatment group and the control group,methylprednisolone tablets were taken orally and cytoxan(CTX)was given intravenously for treatment;in the treatment group,based on oral administration of methylprednisolone tablets and intravenous drip of cytoxan(CTX),oral administration of traditional Chinese medicine(addition and subtraction of Shenling Baizhu Powder)was *** routine,24-hour urinary protein,renal function and serum albumin were re-examined after 4 weeks of treatment.[Results]The total effective rate of the treatment group was significantly higher than that of the control group(89.47%vs 61.90%,P0.05).After treatment,both groups could effectively reduce the levels of 24-hour urinary protein(P0.05),serum creatinine(P0.05)and urea nitrogen(P0.05),and increase the level of serum albumin(P0.05),but the degree of improvement in the treatment group was significantly higher than that in the control group(P0.05),and the difference was statistically significant(P0.05).[Conclusions]Methylprednisolone combined with addition and subtraction of Shenling Baizhu Powder could effectively reduce urinary protein,improve edema symptoms,shorten the course of hormone use and reduce adverse reactions in the treatment of PNS featuring damp abundance due to splenic asthenia.