检索结果-南通市图书馆

Journal of Thermal Science 2021年第6期30卷 2223-2240页

作者： JIANG Kaijun wang fengli KONG Yanqiang XU Chao DU Xiaoze MOE Key Laboratory of Power Station Energy Transfer Conversion and System North China Electric Power UniversityBeijing 102206China School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China

A novel particle solar receiver(PSR)with gas-solids countercurrent fluidized bed(CCFB)was *** cold-mold prototype was set up to investigate the gas-solids flow structure by using optical fiber *** local solids holdup distribution,its evolution with various operating conditions and the fluctuations of the local flow structures were investigated *** results show that the novel CCFB can achieve much higher solids holdup(~9%)compared to the traditional downer ones(~l%).The solid particles are mainly distributed in the near-wall region and the particles are more difficult to get a fully developed state in the near-wall *** excellent gas-solids mixing and contacting demonstrated by the standard deviation and intermittency index means a better wall-to-bed heat transfer *** distribution of the solid particles in the CCFB transport tube is revealed,which can provide a significant reference for the structure design of the hot-mold ***,the research can fill in the research gap in the gas-solids counterflow field.

关键词： concentrated solar power particle solar receiver countercurrent fluidized bed optical fiber probe local solids holdup

Experimental Investigation on the Hydrodynamic Characteristics of Fluidized Bed Particle Solar Receiver with Gas-Solid Countercurrent Flow Pattern

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2021年第6期30卷 2241-2253页

To design a particle solar receiver(PSR),a vital energy conversion system,is still a bottleneck for *** study presents a novel PSR based on countercurrent fluidized bed(CCFB)technology,named CCFB *** this design,downward-moving particles are subjected to the action of an up-flow gas to reduce the falling speed and enhance the radial disturbance,and hence increase the residence time of particles and improve the heat transfer.A cold-mold visual experimental setup is *** influence factors are investigated experimentally,including the superficial gas velocity,solid flux,aeration gas,particle size and transport tube *** results indicate that the maximum solid holdup can exceed 9%or so with fine particles of diameter d_(p)=113.5 μm and a tube diameter of 40 *** is proved that the CCFB can operate stably and adjust the solid flux *** results of this study provide a new structure for PSRs in the concentrated solar power field and could fill the research insufficiency in the gas-solid counterflow field.

关键词： particle solar receiver gas-solid two-phase flow countercurrent fluidized bed solid holdup

Modelling and analysis of hybrid stochastic timed Petri net

在线全文

学校读者我要写书评

暂无评论

Journal of Control and Decision 2019年第2期6卷 90-110页

作者： Ruimin Cao Lina Hao fengli wang Qiang Gao School of Mechanical Engineering&Automation Northeastern UniversityShenyangChina Key Laboratory of Manufacturing Industrial Integrated Automation Shenyang UniversityShenyangChina

In this paper,an interesting Hybrid Stochastic Timed Petri Net(HSTPN)is proposed for a class of hybrid *** proposed HSTPN can be adopted to represent hybrid systems with discrete,continuous,conflicting,time-delay and stochastic characteristics *** proposed HSTPN outperforms conventional hybrid Petri net models in terms of describing the scalability and immediacy of hybrid *** of the HSTPN on describing hybrid system are verified by establishing some equivalent models of HPN and its derived models.

关键词： Hybrid stochastic timed Petri net hybrid dynamic system structural equivalence equivalence rules scalability

Chemical composition,energy and amino acid digestibility in double-low rapeseed meal fed to growing pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2015年第4期6卷 445-454页

作者： Peili Li fengli wang Fei Wu Jinrong wang Ling Liu Changhua Lai State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural University College of Bio-engineering Henan University of Technology

Background： The nutritional value of rapeseed meal may be variable due to the variation of its chemical composition. And a precise understandin9 of the nutritional value of an ingredient is beneficial for the accurate diet formulation and reduction of feed costs. This study was conducted to determine the chemical composition, dicjestible energy （DE） and metabolizable enercjy （ME） content, and apparent ileal digestibility （AID） and standardized ileal dicjestibility （SID） of amino acids （AA） for growincj pigs. Thirteen solvent-extracted double-low rapeseed meal （DLIRSM） samples were obtained from the main double-low rapeseed producing areas in China. Methods： The DE and ME contents of the 13 DLRSM samples were measured in cjrowin9 pigs （six pigs per DLRSM sample, average initial body weicjht （BW） =48.3 kg）. The AID and SID of AA of 10 DLRSM samples were determined in 12 crossbred barrows （average initial BW = 35.3 kcj） by using two 6 x 6 Latin square designs. Each Latin square comprised one N-flee diet and 5 DLRSM test diets. Results： The chemical composition of DLRSM varied among samples, and the coefficient of variation was greater than ]0 % for ether extract （EE）, neutral detergent fiber （NDF）, acid detergent fiber （ADF）, calcium （Ca）, and total 91ucosinolates. The AA content of DLRSM varied among samples especially for lysine （Lys） and methionine （Met）. On a dry matter （DM） basis, the apparent total tract digestibility （ATFD） of gross energy （GE）, the DE and ME and the ME：DE ratio of DLRSM averaged 62.39 %, 2862 kcal/k9 and 2723 kcal/kcj, and 94.95 %, respectively. The mean value of S1D of Lys was 70.52 % which varied from 66.54-76.54 %. The SID of crude protein （CP）, Met, and threonine （Thr） averaged 72.81%, 82.41%, and 69.76 %, respectively. Conclusions： There was great variability in chemical composition especially in the concentration of EE, NDF and ADF, but no significant differences in energy content of the DLIRSM samples were observed. In addition, the AID

关键词： Digestible energy Double-low rapeseed meal Growing pigs Ileal digestibility of amino acids,Metabolizable energy

Design,fabrication and characterization of the X-ray supermirrors

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2005年第5期48卷 559-574页

作者： wang Zhanshan wang fengli ZHANG Zhong CHENG Xinbin QIN Shuji CHEN Lingyan Institute of Precision Optical Engineering Department of PhysicsTongji UniversityShanghai 20092China

The design,fabrication and characterization of the X-ray supermirrors are discussed in this *** the local optimization method of simplex algorithm and the global one of simulated annealing algorithm with different initial multilayer structures,we designed the broad angular band supermirrors with different grazing incidence angle intervals at the energy of 8.0 keV(the Kαline of Cu)and the broad energetic band supermirrors with different energy intervals at fixed grazing incidence *** fabricating techniques for depositing non-periodic multilayers are also *** W/C and W/Si supermirrors are deposited on silicon substrates and characterized by a high resolution X-ray D1 diffractometer from Bede Company,*** the interface roughness and the densities of the materials as independent variables,some measured reflectivity curves are fitted using the Debye-Waller factor with interface *** experimental results show that the optical performances of the fabricated supermirrors are in agreement with the designed ones.

关键词： X-ray supermirror magnetron sputter multilayer reflectivity.

The role of PARP1 in the DNA damage response and its application in tumor therapy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2012年第2期6卷 156-164页

作者： Zhifeng wang fengli wang Tieshan Tang Caixia Guo Laboratory of Disease Genomics and Individual Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Single-strand break repair protein poly(ADP-ribose)polymerase 1(PARP1)catalyzes the poly(ADPribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNA damage response pathways,rendering it a promising target in cancer *** tumor-suppressor effects of PARP inhibitors have attracted significant interest for development of novel cancer ***,recent evidence indicated that the underlying mechanism of PARP inhibitors in tumor therapy is more complex than previously *** present review will focus on recent progress on the role of PARP1 in the DNA damage response and PARP inhibitors in cancer *** emerging resistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA damage and *** recent research advances will inform the selection of patient populations who can benefit from the PARP inhibitor treatment and development of effective drug combination strategies.

关键词： PARP1 synthetic lethality PARP inhibitor DNA repair cancer NHEJ

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2023年第4期2023卷 671-688页

作者： fengli wang Lingjuan wang Shiming Gan Shenglei Feng Sijin Ouyang Xiaoli wang Shuiqiao Yuan Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Laboratory of Animal Center Huazhong University of Science and TechnologyWuhan 430030China

Stress granules(SGs)are membraneless cytoplasmic condensates that dynamically assemble in response to various stressors and reversibly disassemble after stimulus removal;however,the mechanisms underlying SG dynamics and their physiological roles in germ cell development are ***,we show that SERBP1(SERPINE1 mRNA binding protein 1)is a universal SG component and conserved regulator of SG clearance in somatic and male germ ***1 interacts with the SG core component G3BP1 and 26S proteasome proteins PSMD10 and PSMA3 and recruits them to *** the absence of SERBP1,reduced 20S proteasome activity,mislocalized valosin containing protein(VCP)and Fas associated factor family member 2(FAF2),and diminished K63-linked polyubiquitination of G3BP1 during the SG recovery period were ***,the depletion of SERBP1 in testicular cells in vivo causes increased germ cell apoptosis upon scrotal heat ***,we propose that a SERBP1-mediated mechanism regulates 26S proteasome activity and G3BP1 ubiquitination to facilitate SG clearance in both somatic and germ cell lines.

关键词： G3BP1 depletion absence

Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第2期18卷 487-489页

作者： Xixiang Ma Chuhuai Guan Rong Chen Yunyun wang Shenglei Feng Rongshuai wang Guoqiang Qu Sijia Zhao fengli wang Xiaoli wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430030China Department of Pathology Wuhan Jinyintan HospitalWuhanHubei430023China Hubei Chongxin Judicial Expertise Center WuhanHubei430415China Research Center for Translational Medicine Wuhan Jinyintan HospitalWuhanHubei430023China Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology and Wuhan Jinyintan HospitalChinese Academy of SciencesWuhanHubei430023China

In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(https://***/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are *** two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male *** the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy.

关键词： patients infection damage

Targeting histone deacetylases for cancer therapy: Trends and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第6期13卷 2425-2463页

作者： Tao Liang fengli wang Reham M.Elhassan Yongmei Cheng Xiaolei Tang Wengang Chen Hao Fang Xuben Hou Department of Pharmacy the Second Hospital Affiliated Wannan Medical CollegeWuhu 241000China Department of Science and Education Translational Medicine Center&Vascular Disease Research Centerthe Second Hospital Affiliated Wannan Medical CollegeWuhu 241000China Clinical Pathogens Detection Engineering Center of Wuhu Wuhu 241000China Department of Medicinal Chemistry and Key Laboratory of Chemical Biology(Ministry of Education) School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Dysregulation of histone deacetylases(HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great deal of research interests and two decades of effort has led to the approval of five HDAC inhibitors(HDACis). However, currently traditional HDACis, although effective in approved indications, exhibit severe off-target toxicities and low sensitivities against solid tumors, which have urged the development of next-generation of HDACi. This review investigates the biological functions of HDACs, the roles of HDACs in oncogenesis, the structural features of different HDAC isoforms, isoform-selective inhibitors, combination therapies, multitarget agents and HDAC PROTACs. We hope these data could inspire readers with new ideas to develop novel HDACi with good isoform selectivity, efficient anticancer effect, attenuated adverse effect and reduced drug resistance.

关键词： HDACs Oncogenesis Selective inhibitor Combination therapy Multitarget agent PROTAC

Miro2 supplies a platform for Parkin translocation to damaged mitochondria

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2019年第11期64卷 730-747页

作者： Jiu-Qiang wang Shu Zhu Yihan wang fengli wang Chaoqiang An Dongfang Jiang Lijie Gao Yingfeng Tu Xuefei Zhu Yun wang Hongmei Liu Juanjuan Gong Zhongshuai Sun Xi wang Leimei Liu Keyan Yang Caixia Guo Tie-Shan Tang State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Key Laboratory of Genomics and Precision Medicine Beijing Institute of GenomicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Department of Foresight and Evaluation Research Chinese Academy of Science and Technology for DevelopmentBeijing 100038China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

PINK1/Parkin-mediated mitophagy is an important process in selective removal of damaged mitochondria, in which translocation of Parkin to damaged mitochondria is recognized as an initiation step. At present, how the damaged mitochondria are selectively recognized and targeted by Parkin is not fully understood. Here we show that Miro2, an outer mitochondrial membrane protein, undergoes demultimerization from a tetramer to a monomer and alteration in mitochondrial localization upon CCCP treatment, suggesting a CCCP-induced realignment of Miro2. The realignment of Miro2 is tightly regulated by PINK1-mediated phosphorylation at Ser325/Ser430 and by Ca^2+binding to EF2 domain, which are both essential for the subsequent Parkin translocation. Interestingly, ablation of Miro2 in mouse causes delayed reticulocyte maturation, lactic acidosis and cardiac disorders. Furthermore, several Miro2 mutations found in the congenital lactic acidosis patients also disable its realignment and Parkin translocation. These findings reveal an important role of Miro2 to mediate Parkin translocation by sensing both depolarization and Ca^2+release from damaged mitochondria to ensure the accuracy of mitophagy.

关键词： Miro2 Parkin Mitochondria Ca^2+ Mitophagy PINK1