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Journal of Ocean Engineering and Science 2023年第2期8卷 181-195页

作者： Shengxia Sun fenghua chen Min Zhao State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringCollaborative Innovation Center for Advanced Ship and Deep-Sea ExplorationShanghai Jiao Tong UniversityShanghai 200240China

Pressure hulls play an important role in deep-sea underwater ***,in the ultra-high pressure environment,a highly destructive phenomenon could occur to them which is called *** study the characteristics of the flow field of the underwater implosion of hollow ceramic pressure hulls,the compressible multiphase flow theory,direct numerical simulation,and adaptive mesh refinement are used to numerically simulate the underwater implosion of a single ceramic pressure hull and multiple linearly arranged ceramic pressure ***,the feasibility of the numerical simulation method is ***,the results of the flow field of the underwater implosion of hollow ceramic pressure hulls in 11000 m depth is *** are the compression-rebound processes of the internal air cavity in the *** the rebound stage,a shock wave that is several times the ambient pressure is generated outside the pressure hull,and the propagation speed is close to the speed of *** pressure peak of the shock wave has a negative exponential power function relationship with the distance to the center of the ***,it is found that the obvious superimposed effect between spheres exists in the chain-reaction implosion which enhances the implosion shock wave.

关键词： Underwater implosion 11000 m depth Hollow ceramic pressure hull Compressible multiphase flow Adaptive mesh refinement Chain-reaction implosion

Comparative Assessment on Microstructure and Properties of in-situ TiC+Ti_(5)Si_(3)Reinforced TiAl-Sn-Zr Matrix Composites by Spark Plasma Sintering and Argon Protected Sintering

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 199-205页

作者：姚辉许晓静 CAI chengbin LI chen chen fenghua LIU Yangguang XIAO Yishui Institute for Advanced Manufacturing and Modern Equipment Technology Jiangsu UniversityZhenjiang 212013China

The effects of SiC particles(SiCp)on high temperature oxidation behavior of titanium matrix composites(TMCs)under different powder metallurgy processes were *** situ Ti C+Ti_(5)Si_(3)reinforced titanium matrix composites were prepared by discharge plasma sintering(SPS)and argon protective sintering(APS).The results show that the two processes have a negligible effect on the composition and hardness of the samples,but the hardness of the two samples is significantly improved by adding *** apparent porosity of SPS process is obviously smaller than that of APS process,whereas,the apparent porosity increases slightly with the addition of *** oxide layer thickness and mass gain of the samples obtained by SPS process are smaller than those obtained by APS *** oxide thickness and mass gain of both processes are further reduced by adding *** SPS composites showed the best high temperature oxidation ***,TMCs with Si Cp by SPS can effectively improve the high-temperature oxidation behavior of the materials.

关键词： powder metallurgy titanium matrix composites High-temperature oxidation TiC and Ti_(5)Si_(3) Ti-Al-Sn-Zr

Barite in omphacite-hosted K-feldspar + quartz poly-crystalline aggregates from the Sulu eclogites and its implications

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Chinese Science Bulletin 2007年第21期52卷 2995-3001页

作者： ZENG LingSen LIU FuLai LIANG fenghua chen FangYuan Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China

K-feldspar + quartz polycrystalline aggregates were found as sub-millimeter-size inclusions with a pseudomorph after coesite (?) in omphacites from a number of Sulu eclogites. In these aggregates, round or subhedral barites occur as tiny inclusions in either K-feldspar or quartz. Energy dispersive spectroscopy (EDS) analyses show that these barites have (1) 33.86%―41.12% SO3, 0%―34.65% SrO, and 24.12%―63.55% BaO, (2) seemingly negative linear correlations between SrO and BaO, indicating that they are ideal solid solutions of barite (BaSO4) and celestite (SrSO4), and (3) highly variable Sr/Ba molar ratios ranging from 0 to 2.1. Presence of barites in the Sulu eclogites not only indicates oxidation of the subducting continental crust, but also very limited and restricted fluids pre- sented during exhumation of the Sulu UHP eclogites.

关键词：重晶石集料变质作用石英石

Synthesis of Co_(4)S_(3)/Co_(9)S_(8) nanosheets and comparison study toward the OER properties induced by different metal ion doping

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Chinese Chemical Letters 2022年第3期33卷 1395-1402页

作者： fenghua chen Zhaoqian Zhang Weiwei Liang Xiaoyun Qin Zhen Zhang Liying Jiang College of Materials and Chemical Engineering Zhengzhou University of Light IndustryZhengzhou 450002China Tianjin Key Laboratory of Molecular Optoelectronic Department of Chemistry School of ScienceTianjin UniversityTianjin 300072China School of Electrical and Information Engineering Zhengzhou University of Light IndustryZhengzhou 450002China

Regulation of chemical composition and nanostructure, such as the introduction of dopant into two-dimensional nanomaterials, is a general and valid strategy for the efficient electrocatalyst design. In this work, Co_(4)S_(3)/Co_(9)S_(8) nanosheets, with an ultrathin layer structure, were successfully synthesized via an efficient solvothermal process combined with ultrasonic exfoliation. Different metal ions (M = Fe^(3+), Cr^(3+), Mn^(2+) and Ni^(2+)) were then doped by a simple cation exchange method and the effects of different dopants on the OER activities of Co_(4)S_(3)/Co_(9)S_(8) NS were further investigated in alkaline media. The corresponding results implied that M-doped Co_(4)S_(3)/Co_(9)S_(8) NS (M = Fe^(3+), Cr^(3+), Mn^(2+) and Ni^(2+)) exhibited different electrocatalytic properties. Evidenced by XPS spectra, the different OER activities were mainly aroused by the redistribution of charge at the interface due to an electronic interaction between the doped metal ions and Co_(4)S_(3)/Co_(9)S_(8) NS.

关键词： Chalcogenides Chemical synthesis Catalytic properties Doping Nanosheets OER

Current research status of tumor cell biomarker detection

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Microsystems & Nanoengineering 2023年第5期9卷 17-34页

作者： Liying Jiang Xinyi Lin fenghua chen Xiaoyun Qin Yanxia Yan Linjiao Ren Hongyu Yu Lingqian Chang ang Wang School of Electrical and Information Engineering Zhengzhou University of Light IndustryZhengzhou 450002China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of Engineering Medicine Beihang UniversityBeijing 100083China

With the annual increases in the morbidity and mortality rates of tumors,the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great *** used for tumor cell detection in body fluids include circulating tumor cells,nucleic acids,protein markers,and extracellular *** them,circulating tumor cells,circulating tumor DNA,and exosomes have high potential for the prediction,diagnosis,and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution;in addition,in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real *** techniques,such as enzyme-linked immunosorbent assays,immunoblotting,and mass spectrometry,have been widely used for the detection of these *** them,the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity,rapid detection and portable ***,we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors,outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells,and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods.

关键词： diagnosis mortality diseases

Observation of magnetic domain evolution in constrained epitaxial Ni–Mn–Ga thin films on MgO(0 0 1) substrate

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Journal of Materials Science & Technology 2022年第7期102卷 56-65页

作者： Bo Yang Ivan Soldatov fenghua chen Yudong Zhang Zongbin Li Haile Yan Rudolf Schäfer Dunhui Wang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China Institute for Metallic Materials Leibniz Institute for Solid State and Materials Research(IFW)DresdenHelmholtzstrasse 2001069 DresdenGermany Institute of Natural Sciences Ural Federal University620002 EkaterinburgRussia Department of Physics School of Applied ScienceTaiyuan University of Science and TechnologyTaiyuan 030024China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux(LEM3) CNRS UMR 7239Universitéde Lorraine57045 MetzFrance Institute for Materials Science Dresden University of Technology01062 DresdenGermany National Laboratory of Solid State Microstructures and Jiangsu Key Laboratory for Nanotechnology and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Epitaxial Ni–Mn–Ga thin films have promising application potential in micro-electro-mechanical sensing and actuation systems. To date, large abrupt magnetization changes have been observed in some epitaxial Ni–Mn–Ga thin films, but their origin-either from magnetically induced martensite variant reorientation(MIR) or magnetic domain evolution-has been discussed controversially. In the present work, we investigated the evolutions of the magnetic domain and microstructure of a typical epitaxial Ni–Mn–Ga thin film through wide-field magneto-optical Kerr-microscopy. It is demonstrated that the abrupt magnetization changes in the hysteresis loops should be attributed to the magnetic domain evolution instead of the MIR.

关键词： Ni–Mn–Ga thin films Magnetic field-induced variant reorientation Magnetic domains Magnetization process Magneto-optical Kerr microscopy

SARS-CoV-2 immunity in animal models

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Cellular & Molecular Immunology 2024年第2期21卷 119-133页

作者： Zhao chen Yaochang Yuan Qingtao Hu Airu Zhu fenghua chen Shu Li Xin Guan Chao Lv Tian Tang Yiyun He Jinling cheng Jie Zheng Xiaoyu Hu Jingxian Zhao Jincun Zhao Jing Sun State Key Laboratory of Respiratory Disease National Clinical Research Centre for Respiratory DiseaseNational Centre for Respiratory MedicineGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510000China Guangzhou National Laboratory GuangzhouGuangdong 510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518005China

The COVID-19 pandemic,which was caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a worldwide health crisis due to its ***-CoV-2 infection results in severe respiratory illness and can lead to significant complications in affected *** complications encompass symptoms such as coughing,respiratory distress,fever,infectious shock,acute respiratory distress syndrome(ARDS),and even multiple-organ *** models serve as crucial tools for investigating pathogenic mechanisms,immune responses,immune escape mechanisms,antiviral drug development,and vaccines against ***,various animal models for SARS-CoV-2 infection,such as nonhuman primates(NHPs),ferrets,hamsters,and many different mouse models,have been *** model possesses distinctive features and *** this review,we elucidate the immune response elicited by SARS-CoV-2 infection in patients and provide an overview of the characteristics of various animal models mainly used for SARS-CoV-2 infection,as well as the corresponding immune responses and applications of these models.A comparative analysis of transcriptomic alterations in the lungs from different animal models revealed that the K18-hACE2 and mouse-adapted virus mouse models exhibited the highest similarity with the deceased COVID-19 ***,we highlighted the current gaps in related research between animal model studies and clinical investigations,underscoring lingering scientific questions that demand further clarification.

关键词： COVID-19 SARS-CoV-2 animal models immune response

Controlled crystallization of guanine crystals

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Controlled crystallization of guanine crystals

中国化学会第十七届全国胶体与界面化学学术会议

作者： Yurong Ma fenghua chen School of Chemistry and Chemical Engineering Beijing Institute of Technology College of Chemistry Peking University

Guanine is one of the most widespread organic crystals existing in organisms, which has superior optical properties and exhibits structural colors. The excellent optical properties of biogenic guanine crystals contribute to the exquisite control on the polymorph, morphology, size and highly-ordered hierarchical microstructure assemblies of guanine crystals and cytoplasm. Controlled crystallization of guanine crystals with particular polymorphs, morphologies, exposing crystal faces was investigated in both water and organic solvents in the presence of additives. Controlled crystallization of guanine monohydrate, anhydrous guanine α and β form in pure phase were realized for the first time under mild conditions in aqueous solution without the presence of additives by changing the guanine concentrations and pH values. Amorphous guanine was synthesized by a one-step synthesis process in large scale, which transformed to anhydrous guanine β form in pure phase. Characterizations using FTIR and ss-NMR showed that anhydrous guanine β and amorphous guanine had similar short-range order structure, which might be the reason for the controlled transformation from amorphous phase to thermodynamically meta-stable anhydrous guanine β form. Anhydrous guanine β form nanoplatelets in pure phase were obtained via amorphous guanine by using polymer additives in organic solvents, which expose（100） face with extremely high refractive index. Guanine analogues had strong influence for the polymorphs and the morphologies of guanine in formamide. Furthermore, a novel crystal phase of anhydrous guanine consisting of N9-G purine ring was obtained by dehydration of guanine monohydrate（GM） at 111 °C, termed as dehydrated-GM, which is the first reported tautomeric polymorph of AG（N7-G purine ring）. The Dehydrated-GM has very good water harvest ability（8 wt%） with a fast rate（ in 30 min） even at relatively low room humidity（below 20 %） and low temperature（40 °C）.

关键词： bioinpired minerlization controlled crystallization guanine amorphous precursor

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金融服务实体经济发展效率的影响因素研究

现代经济探讨 2021年第12期 71-80页

作者：陈丰华苏州大学东吴商学院南京210024

采用DEA-Malmquist指数方法测算了中国2007-2018年金融服务实体经济发展的效率水平及其变动情况,运用动态面板数据模型对金融服务实体经济发展效率的影响因素进行了实证分析。研究发现:2007-2018年间中国金融支持实体经济发展效率整体... 详细信息

采用DEA-Malmquist指数方法测算了中国2007-2018年金融服务实体经济发展的效率水平及其变动情况,运用动态面板数据模型对金融服务实体经济发展效率的影响因素进行了实证分析。研究发现:2007-2018年间中国金融支持实体经济发展效率整体呈现上升趋势,其主要受到技术进步影响,各区域金融支持实体经济发展效率呈现出明显的区域差异性特征;金融业发展水平、金融产业结构和股票融资比重对金融服务实体经济发展效率的影响效应存在着显著的区域差异性,宏观经济发展水平、实体经济产业结构、政府干预程度和对外开放程度等因素也对金融服务实体经济发展效率产生影响。最后,根据研究结论,提出了要完善金融体系、促进金融创新、减少政府干预、优化宏观经济环境等建议。

关键词： Malmquist指数金融实体经济效率

Biotinylated dextran amine tracing of nerve tracts determines regeneration of corticospinal tracts after neural stem cell transplantation

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Neural Regeneration Research 2011年第28期6卷 2183-2187页

作者： Jun Wu fenghua chen Mingyu Zhang Tao Song Jinfang Liu Jiasheng Fang Department of Neurosurgery Xiangya Hospital Central South University Changsha 410008 Hunan Province China

We investigated regeneration of the corticospinal tract and rearrangement of corticospinal nerves after spinal cord injury by biotinylated dextran amine （BDA） nerve tract tracing after neural stem cell transplantation. Neural stem cell transplantation increased motor function scores of rats at 3 weeks after spinal cord transection injury at the thoracic 10 segment. A proportion of BDA-labeled corticospinal tract regenerated through the spinal cord injury site at 12 weeks after transplantation. Electron microscopy revealed that the regenerated BDA-labeled nerve terminals formed new synaptic connections with neurons at the distal end of the injured site. These findings indicate that BDA nerve tract tracing effectively provides anatomic and morphological evidence of recovery after spinal cord injury.

关键词： nerve tract tracing neural stem cells transplantation spinal cord injury corticospinal tract biotinylated dextran amine neural regeneration