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Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China

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Molecular Plant 2020年第12期13卷 1733-1751页

作者： Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi fengfeng xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu xueyong Zhang Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture and Rural Affairs/The National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Novogene Bioinformatics Institute Beijing 100083China AgriBio Centre for AgriBioscienceDepartment of Economic DevelopmentJobsTransportand Resources5 Ring RoadLa Trobe UniversityBundooraVIC 3083Australia Department of Agricultural and Food Sciences University of BolognaBolognaItaly

Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant *** than 3000 wheat cultivars have been registered,released,and documented since 1949 in *** this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome *** years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the *** are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern ***,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous *** of more newly assembled genes in newer cultivars implied the potential value of these genes in *** and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were *** or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding *** on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial ***,our study demonstrates the influence of "founder genotypes" on the output of breeding effort

关键词： wheat breeding asymmetric selection founder genotype haplotype block

The biology of bone morphogenetic protein signaling pathway in cerebrovascular system

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Chinese Neurosurgical Journal 2021年第4期7卷 281-288页

作者： Haishuang Tang Xiaoxi Zhang Gaici xue fengfeng xu Qingsong Wang Pengfei Yang Bo Hong Yi xu Qinghai Huang Jianmin Liu Qiao Zuo Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiology the First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China

Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different *** system supplies sufficient oxygen and blood into brain to maintain its normal *** disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern *** recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular *** review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.

关键词： Bone morphogenetic protein Hemodynamic Neovascularization Cerebrovascular diseases

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大型综合医院建筑供配电系统设计

现代建筑电气 2022年第4期13卷 33-38页

作者：徐峰峰筑博设计股份有限公司上海分公司上海200070

结合深圳某大型综合医院建筑,对医院变配电所、柴油发电机房的设置,医疗场所、大型诊疗设备的供配电系统的设计进行分析和梳理,合理地确定供电方案,提高医院建筑的供电可靠性和稳定性。

关键词：综合医院建筑供电措施柴油发电机组医疗设施可靠性

非织造布表面处理对纳米纤维分布及成型的影响

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化工新型材料 2013年第1期41卷 73-75,82页

作者：姚春梅魏取福许凤凤江南大学生态纺织教育部重点实验室无锡214122

采用磁控溅射和等离子体技术处理非织造布,可以明显地改善纳米纤维分布的均匀性;进一步探讨了等离子体处理后对基材表面基团及导电性的影响,结果显示为基材表面产生很多极性基团、导电性增强,相同纺丝条件及纺丝时间下,使其表面沉积的... 详细信息

采用磁控溅射和等离子体技术处理非织造布,可以明显地改善纳米纤维分布的均匀性;进一步探讨了等离子体处理后对基材表面基团及导电性的影响,结果显示为基材表面产生很多极性基团、导电性增强,相同纺丝条件及纺丝时间下,使其表面沉积的纤维直径变小、沉积的纤维数量增加,也进一步减小了复合膜的孔径、孔径分布更加集中,有利于制得高效率、高精度的复合过滤膜。

关键词：非织造布分布磁控溅射等离子体

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非织造基磁控溅射纳米银薄膜导电性能的研究

化工新型材料 2012年第6期40卷 105-107页

作者：许凤凤魏取福孟灵灵江南大学生态纺织教育部重点实验室无锡214122

在室温条件下采用射频磁控溅射在丙纶(PP)、聚乳酸(PLA)熔喷非织造布表面生长纳米银(Ag)薄膜,并且用等离子体预处理样品进行对比。采用扫描电子显微镜(SEM)对其形貌进行表征,采用四探针测试仪对所制备的纳米薄膜的导电性能进行表征。研... 详细信息

在室温条件下采用射频磁控溅射在丙纶(PP)、聚乳酸(PLA)熔喷非织造布表面生长纳米银(Ag)薄膜,并且用等离子体预处理样品进行对比。采用扫描电子显微镜(SEM)对其形貌进行表征,采用四探针测试仪对所制备的纳米薄膜的导电性能进行表征。研究溅射时间、孔隙率及孔径分布和等离子处理对非织造基纳米银薄膜的导电性能的影响。实验表明:随着反应溅射时间的增加,薄膜的方块电阻值下降,导电性能增加;孔径大小也影响薄膜的导电性能,随着孔径的增大,薄膜的导电性能降低;等离子体处理对织物表面进行刻蚀,增加了纤维的比表面积,提高了纤维的润湿性能,改善了织物的导电性能。

关键词：射频磁控溅射非织造导电性纳米银

腹板开孔冷弯薄壁C型钢纯弯构件直接强度法研究

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山西建筑 2017年第32期43卷 40-42页

作者：徐锋锋广东理工学院广东肇庆526100

直接强度法(DSM)是冷弯薄壁型钢稳定设计的主要方法,这种方法对腹板未开孔构件设计可行性强,但是对于腹板开孔构件的适用性还不得而知。选取一定参数的纯弯开孔构件进行了有限元分析,分析表明:纯弯构件发生畸变屈曲的DSM公式在孔高比为0... 详细信息

直接强度法(DSM)是冷弯薄壁型钢稳定设计的主要方法,这种方法对腹板未开孔构件设计可行性强,但是对于腹板开孔构件的适用性还不得而知。选取一定参数的纯弯开孔构件进行了有限元分析,分析表明:纯弯构件发生畸变屈曲的DSM公式在孔高比为0.2,0.4,0.6和0.8下均需要进行修正,并给出了修正公式。

关键词：直接强度法有限元冷弯薄壁C型钢腹板开孔

Underlying mechanism of hemodynamics and intracranial aneurysm

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Chinese Neurosurgical Journal 2022年第2期8卷 120-127页

作者： Haishuang Tang Qingsong Wang fengfeng xu Xiaoxi Zhang Zhangwei Zeng Yazhou Yan Zhiwen Lu Gaici xue Qiao Zuo Yin Luo Jianmin Liu Qinghai Huang Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiology the First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China

In modern society,subarachnoid hemorrhage,mostly caused by intracranial aneurysm rupture,is accompanied by high disability and mortality rate,which has become a major threat to human *** now,the etiology of intracranial aneurysm has not been entirely *** recent years,more and more studies focus on the relationship between hemodynamics and intracranial *** the physiological condition,the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood *** the blood vessels are stimulated by the continuous abnormal blood flow,the functional structure of the blood vessels changes,which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial *** review will focus on the relationship between hemodynamics and intracranial aneurysms,will discuss the mechanism of occurrence and development of intracranial aneurysms,and will provide a new perspective for the research and treatment of intracranial aneurysms.

关键词： Hemodynamics Inflammation Atherosclerosis Intracranial aneurysm

砂质潮间带自由生活海洋线虫对缺氧的响应--微型受控生态系研究

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生态学报 2012年第13期32卷 3975-3986页

作者：华尔李佳董洁徐风风张志南中国海洋大学海洋生命学院青岛266003 东营市海洋与渔业局东营257091

以青岛砂质潮间带自由生活海洋线虫为研究对象,建立微型受控生态系,研究缺氧对海洋线虫群落结构和垂直分布的影响,以及环境复氧后海洋线虫群落的恢复能力。研究结果显示,海洋线虫是耐低氧的小型底栖动物类群,可通过垂直迁移来耐受缺氧... 详细信息

以青岛砂质潮间带自由生活海洋线虫为研究对象,建立微型受控生态系,研究缺氧对海洋线虫群落结构和垂直分布的影响,以及环境复氧后海洋线虫群落的恢复能力。研究结果显示,海洋线虫是耐低氧的小型底栖动物类群,可通过垂直迁移来耐受缺氧造成的不利条件。但是,海洋线虫通过主动迁出而耐受缺氧条件的特性具有种的区别。研究中Pseudosteineria sp1、Rhynchonema sp1等海洋线虫通过向有氧环境的主动迁移耐受缺氧条件;Thalassironus sp1却可通过自身耐受机制抵御缺氧条件,在缺氧生境中仍能保持较高的丰度。此外,研究结果显示,当表层海洋线虫暴露于缺氧环境时,其总丰度显著降低,种类组成发生改变。Pseudosteineria sp1对缺氧环境较为敏感,可暂时性地离开沉积物进入水层;而沉积物溶解氧恢复正常后,该种可以重新回到沉积物中。Daptonema sp1成熟个体及其幼龄个体对缺氧均具有较高的耐受性,是缺氧群落的绝对优势种。***3则表现出对缺氧环境较高的敏感性。环境恢复正常,线虫群落丰度及多样性增加,Neochromadora sp1和Spilophorella sp1等具有机会种的特点,首先表现出丰度和繁殖能力的增加。但是线虫群落种类组成在受测时间内并未能完全恢复,群落结构的恢复需要更长的时间。

关键词：缺氧自由生活海洋线虫微型受控生态系群落结构垂直分布

早期生长反应基因2在肝癌组织的表达及其对细胞增殖能力的影响

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中华实验外科杂志 2016年第5期33卷 1315-1317页

作者：潘康明邓量许峰峰中山大学附属第一医院肝胆外科广州510700

目的观察早期生长反应基因2（EGR2）在肝癌组织中的表达,探讨其对肝癌细胞增殖的影响及作用机制.方法分析肿瘤基因组图谱（TCGA）数据库中50对肝癌组织和癌旁非癌组织中EGR2的mRNA表达水平;用实时荧光定量聚合酶链反应（FQ-PCR）检测... 详细信息

目的观察早期生长反应基因2（EGR2）在肝癌组织中的表达,探讨其对肝癌细胞增殖的影响及作用机制.方法分析肿瘤基因组图谱（TCGA）数据库中50对肝癌组织和癌旁非癌组织中EGR2的mRNA表达水平;用实时荧光定量聚合酶链反应（FQ-PCR）检测8个患者的肝癌组织及配对癌旁非癌组织中EGR2的表达.通过构建重组质粒pQCXIP-EGR2并转染HepG2肝癌细胞,构建稳定高表达EGR2的肝癌细胞株,并采用噻唑蓝（MTT）法和平板克隆形成实验观察稳定高表达EGR2对肝癌细胞增殖能力的影响.同时采用Western blot法和FQ-PCR法检测稳定高表达EGR2对细胞周期相关蛋白细胞周期蛋白D1（Cyclin D1）表达的影响.结果 TCGA数据库分析结果表明EGR2在肝癌组织中的表达量（89.95±16.04）明显低于癌旁非癌组织（440.59±60.60,P＜0.05）.FQ-PCR结果也显示,与癌旁非癌组织比较,来自同一患者的肝癌组织中EGR2基因的mRNA表达水平明显降低（P＜0.05）.MTT实验结果表明显示稳定高表达EGR2的细胞的生长速度明显降低（P＜0.05）.平板克隆形成实验结果显示,与对照细胞比较（177.00±8.18）,高表达EGR2的肝癌细胞的克隆形成数量（86.00±5.51）显著减少,差异有统计学意义（P＜0.05）.Westem blot法和FQ-PCR实验结果表明,稳定高表达EGR2可降低肝癌细胞中Cyclin D1的表达.结论 EGR2在肝癌中表达下调,过表达EGR2可通过调控Cyclin D1的表达进而抑制肝癌细胞的增殖.

关键词：癌肝细胞早期生长反应基因2 增殖细胞周期蛋白D1