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Inflammatory Factor IL1αInduces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca^(2+)/CaMK2b Pathway

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Neuroscience Bulletin 2024年第4期40卷 421-438页

作者： Yu Xia Lu Ding Changlin Zhang Qi Xu Ming Shi Tianshun Gao feng-quan zhou David Y.B.Deng Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Department of Gynecology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Pelvic Floor Disorders Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Big Data Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310016China Orthopaedic and Neurological Repair Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Spinal cord injury(SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocytes usually causes neurological ***,the mechanism underlying astrocyte over-proliferation after SCI is ***2c(glutamate ionotropic receptor type 2c)plays an essential role in cell *** bioinformatic analysis indicated that Grin2c and Ca^(2+)transport functions were inhibited in astrocytes after *** of Grin2c stimulated astrocyte proliferation by inhibiting the Ca^(2+)/calmodulin-dependent protein kinase 2b(CaMK2b)pathway in *** screening different inflammatory factors,interleukin 1α(IL1α)was further found to inhibit Grin2c/Ca^(2+)/CaMK2b and enhance astrocyte proliferation in an oxidative damage *** of IL1αusing neutralizing antibody resulted in increased Grin2c expression and the inhibition of astrocyte proliferation ***,this study suggests that IL1αpromotes astrocyte proliferation by suppressing the Grin2c/Ca^(2+)/CaMK2b pathway after SCI,revealing a novel pathological mechanism of astrocyte proliferation,and may provide potential targets for SCI repair.

关键词： IL1α Grin2c Astrocyte Spinal cord injury

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Signaling pathways that regulate axon regeneration

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Neuroscience Bulletin 2013年第4期29卷 411-420页

作者： Saijilafu Bo-Yin Zhang feng-quan zhou Department of Orthopaedic Surgery The Johns Hopkins University Department of The Solomon H. Snyder Department of Neuroscience The Johns Hopkins University

Neurons in the mammalian central nervous system （CNS） cannot regenerate axons after injury. In contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration.

关键词： axon regeneration axonal growth signal transduction

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Glycogen synthase kinase 3 signaling in neural regeneration in vivo

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Journal of Molecular Cell Biology 2023年第12期15卷 1-11页

作者： Jing Zhang Shu-Guang Yang feng-quan zhou Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China

Glycogen synthase kinase 3(GSK3)signaling plays important and broad roles in regulating neural development in vitro and in ***,we reviewed recent findings of GSK3-regulated axon regeneration in vivo in both the peripheral and central nervous systems and discussed a few controversial findings in the ***,current evidence indicates that GSK3βsignaling serves as an important downstream mediator of the PI3K–AKT pathway to regulate axon regeneration in parallel with the mTORC1 ***,the mTORC1 pathway supports axon regeneration mainly through its role in regulating cap-dependent protein translation,whereas GSK3βsignaling might be involved in regulating N6-methyladenosine mRNA methylation-mediated,cap-independent protein *** addition,GSK3 signaling also plays a key role in reshaping the neuronal transcriptomic landscape during ***,we proposed some research directions to further elucidate the molecular mechanisms underlying the regulatory function of GSK3 signaling and discover novel GSK3 signaling-related therapeutic ***,we hope to provide an updated and insightful overview of how GSK3 signaling regulates neural regeneration in vivo.

关键词： GSK3 neural regeneration protein translation gene transcription

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N6-methyladenine DNA Demethylase ALKBH1 Regulates Mammalian Axon Regeneration

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Neuroscience Bulletin 2021年第6期37卷 809-814页

作者： Qiao Li Cheng Qian Harry feng Tyger Lin Qingsan Zhu Ying Huang feng-quan zhou Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimore 21205USA The Solomon H.Snyder Department of Neuroscience Johns Hopkins University School of MedicineBaltimore 21205USA Department of Spine Surgery The First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130031China

Dear Editor,DNA methylation is a key epigenetic regulatory approach for many biological processes,such as genomic imprinting,epigenetic memory maintenance,aging,and neural *** addition to 5-methylcytosine,DNA methylat... 详细信息

关键词： Regeneration development. adenine

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Peer-to-Peer Trading in Distribution Systems with the Utility's Operation

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 629-638页

作者： Xuanyi Xiao feng Wang Mohammad Shahidehpour Yujia Zhai quan zhou Department of Electrical and Information Engineering Hunan UniversityChangshaChina Robert W.Galvin Center for Electricity Innovation Ilinois Institute of TechnologyChicagoIL60616USA

To realize a liberalized peer-to-peer (P2P) electricity market in distribution systems with network security, this paper develops a general framework for P2P trading in distribution systems with the utility's operation. The model is formulated as a bi-level programming. The utility's operation is an upper level problem, where a calculation method of network usage charges for P2P trading is also proposed. Peers' P2P trading is a lower level problem. An iterative algorithm based on analytical target cascading (ATC) is proposed to solve the model, where the interactions between utility and peers are presented. Numerical results on the IEEE 33-bus system demonstrate that the proposed method realizes a liberalized P2P market and ensures network security in distribution systems.

关键词： Distribution system peer-to-peer trading electricitymarket distributed energyresources(DERs) analytical target cascading(ATC)

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Time course analysis of sensory axon regeneration in vivo by directly tracing regenerating axons

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Neural Regeneration Research 2020年第6期15卷 1160-1165页

作者： Yan Gao Yi-Wen Hu Run-Shan Duan Shu-Guang Yang feng-quan zhou Rui-Ying Wang Guilin Medical University GuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedic Surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedics Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins,representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neurons in the spinal *** recently developed method of in vivo electroporation of plasmid DNA encoding for enhanced green fluorescent protein into adult sensory neurons in the dorsal root ganglia provides a way to directly and specifically measure regenerating sensory axon lengths in whole-mount nerves.A mouse model of sciatic nerve compression was established by squeezing the sciatic nerve with *** DNA carrying enhanced green fluorescent protein was transfected by ipsilateral dorsal root ganglion electroporation 2 or 3 days before *** distribution of dorsal root or sciatic nerve was observed by confocal *** 12 and 18 hours,and 1,2,3,4,5,and 6 days of injury,lengths of regenerated axons after sciatic nerve compression were measured using green fluorescence ***-related protein caspase-3 expression in dorsal root ganglia was determined by western blot *** found that in vivo electroporation did not affect caspase-3 expression in dorsal root *** root ganglia and sciatic nerves were successfully removed and subjected to a rapid tissue clearing *** soma in dorsal root ganglia expressing enhanced green fluorescent protein or fluorescent dye-labeled microRNAs were imaged after tissue *** results facilitate direct time course analysis of peripheral nerve axon *** study was approved by the Institutional Animal Care and Use Committee of Guilin Medical University,China(approval ***201503010)on March 7,2014.

关键词： axon regeneration cell apoptosis dorsal root ganglion in vivo electroporation micro RNAs peripheral nervous system sciatic nerve tissue clearing

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Local manipulation of the growth cone cytoskeleton:new strategies to promote axon regeneration

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Neural Regeneration Research 2015年第12期10卷 1959-1960页

作者： Zi-wei Huang feng-quan zhou Saijilafu Department of Orthopedics the First Affiliated HospitalOrthopedic InstituteSoochow University Department of Orthopedic Surgery and the Solomon H.Snyder Department of Neuroscience the Johns Hopkins University School of Medicine

Thousands of spinal cord injuries occur worldwide as a result of traumatic or non-traumatic *** cord injury usually results in axonal damage,leading to permanent functional deficits and ***,axonal regeneration is the ... 详细信息

关键词： CSPG OMgp CNS

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Supermassive black holes triggered by QCD axion bubbles

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Communications in Theoretical Physics 2024年第5期76卷 134-139页

作者： Hai-Jun Li Ying-quan Peng Wei Chao Yu-feng zhou Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Center for Advanced quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing/HangzhouChina

Supermassive black holes(SMBHs)are ubiquitous in the center of galaxies,although the origin of their massive seeds is still *** this paper,we investigate the formation of SMBHs from the quantum chromodynamics(QCD)axion *** this case,primordial black holes(PBHs)are considered as the seeds of SMBHs,which are generated from the QCD axion bubbles due to an explicit Peccei–Quinn(PQ)symmetry breaking after *** QCD axion bubbles are formed when the QCD axion starts to oscillate during the QCD phase *** consider a general case in which the axion bubbles are formed with the bubble effective angle θ_(eff)∈(0,π],leading to the minimum PBH mass∼■(10^(4)−10^(7))M⊙for the axion decay constant f_(a)∼■(10^(16))*** PBHs at this mass region may account for the seeds of SMBHs.

关键词： supermassive black holes primordial black holes quantum chromodynamics axion

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Roles of nanoparticles in arsenic mobility and microbial community composition in arsenic-enriched soils

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Journal of Environmental Sciences 2024年第4期138卷 301-311页

作者： Ting Luo Qining Zheng Jie Yu Weihao Liang Yan Sun Guixiang quan feng zhou School of Environmental Science and Engineering Yancheng Institute of TechnologyYancheng 224051China Jiangsu Provincial Key Laboratory of Coastal Ecology and Pollution Control Yancheng 224051China School ofEnvironment and Civil Engineering Jiangnan UniversityWuxi 214122China

Environmental effects of nano remediation engineering of arsenic(As)pollution need to be *** this study,the roles of Fe_(2)O_(3)and TiO_(2)nanoparticles(NPs)on the microbial mediated As mobilization from As contaminated soil were *** addition of Fe_(2)O_(3)and TiO_(2)NPs restrained As(V)release,and stimulated As(Ⅲ)***(V)concentration decreased by 94% and 93% after Fe_(2)O_(3)addition,and decreased by 89% and 45% after Ti O_(2)addition compared to the Biotic and Biotic+Acetate(amended with sodium acetate)controls,*** maximum values of As(Ⅲ)were 20.5 and 27.1μg/L at 48 d after Fe_(2)O_(3)and TiO_(2)NPs addition,respectively,and were higher than that in Biotic+Acetate control(12.9μg/L).The released As co-precipitated with Fe in soils in the presence of Fe_(2)O_(3)NPs,but adsorbed on TiO_(2)NPs in the presence of TiO_(2)***,the addition of NPs amended with sodium acetate as the electron donor clearly promoted As(V)reduction induced by *** NPs addition changed the relative abundance of soil bacterial community,while Proteobacteria(42.8%-70.4%),Planctomycetes(2.6%-14.3%),and Firmicutes(3.5%-25.4%)were the dominant microorganisms in *** potential As/Fe reducing bacteria were related to Pseudomonas,Geobacter,Desulfuromonas,and *** addition of Fe_(2)O_(3)and TiO_(2)NPs induced to the decrease of arr A *** results indicated that the addition of NPs had a negative impact on soil microbial population in a long *** findings offer a relatively comprehensive assessment of Fe_(2)O_(3)and TiO_(2)NPs effects on As mobilization and soil bacterial communities.

关键词： Fe_(2)O_(3)and TiO_(2)nanoparticles Arsenic reduction Mobilization Functional gene Microbial community

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Ligation-assisted endoscopic submucosal resection following unroofing technique for small esophageal subepithelial lesions originating from the muscularis propria

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World Journal of Gastroenterology 2024年第32期30卷 3748-3754页

作者： quan Lu quan-zhou Peng Jun Yao Li-Sheng Wang De-feng Li Department of Gastroenterology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Pathology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518020Guangdong ProvinceChina The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518020Guangdong ProvinceChina

BACKGROUND The majority of esophageal subepithelial lesions originating from the muscularis propria(SEL-MPs)are benign in nature,although a subset may exhibit malignant *** endoscopic resection techniques are time-consuming and lack efficacy for small *** To evaluate the efficacy and safety of ligation-assisted endoscopic submucosal resection(ESMR-L)following unroofing technique for small esophageal *** From January 2021 to September 2023,17 patients diagnosed with esophageal SEL-MPs underwent ESMR-L following unroofing technique at the endoscopy center of Shenzhen People’s *** of clinicopathological characteristics and clinical outcomes were collected and *** The mean age of the patients was 50.12±12.65 *** mean size of the tumors was 7.47±2.83 mm and all cases achieved en bloc resection *** average operation time was 12.2 minutes without any *** identified 2 Lesions(11.8%)as gastrointestinal stromal tumors at very low risk,12 Lesions(70.6%)as leiomyoma and 3 Lesions(17.6%)as smooth muscle *** recurrence was found during the mean follow-up duration of 14.18±9.62 *** ESMR-L following roofing technique is an effective and safe technique for management of esophageal SEL-MPs smaller than 20 mm,but it cannot ensure en bloc resection and may require further treatment.

关键词： Subepithelial lesions Muscularis propria Esophagus Ligation Endoscopic submucosal resection

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