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Primary myelofibrosis with concurrent CALR and MPL mutations:A case report

World Journal of Clinical Cases 2020年第22期8卷 5618-5624页

作者： feng-ping zhou Cheng-Cheng Wang Hua-ping Du Shan-Bo Cao Jin Zhang Department of Hematology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Acornmed Biotechnology Co. Ltd.Beijing 100176China

BACKGROUND Primary myelofibrosis(PMF)is a myeloproliferative neoplasm(MPN)characterized by recurrent mutations in the JAK2,CALR,and MPL *** CALR and MPL co-mutation is very *** our knowledge,no more than five cases have been ***,we report a case of PMF in which a CALR and MPL co-mutation was detected by next-generation sequencing(NGS)technology,and a literature review was *** SUMMARY A 73-year-old woman was admitted to our hospital in 2018 due to abdominal *** patient had splenomegaly,lymphadenopathy,leukopenia,anemia,and immature granulocytes in peripheral *** were dacrocytes and atypical megakaryocytes in bone marrow,and megakaryocytic proliferation was very active,accompanied by reticulin fibrosis grade *** NGS analysis of the bone marrow sample,we detected mutations in CALR,MPL,and PIK3RI,while JAK2 V617F and BCR-ABL were ***,the patient was diagnosed with PMF and received oral ***,the spleen and hematologic responses were *** review the literature,analyze previous reports of the mutation sites in our patient and differences between our patient and other reported cases of co-mutated CALR and MPL genes,and discuss the reason why the CALR and MPL co-mutations are rare and possible mechanisms and their impact on the prognosis of *** CALR and MPL mutations can be concurrent in MPN,but they are *** use of NGS may help to identify more patients with co-mutated CALR and MPL *** will help to further explore the mechanism and its impact on these patients to develop appropriate treatment strategies.

关键词： Primary myelofibrosis CALR MPL Co-mutation Next-generation sequencing Case report

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Effect of Heat Treatment on the Mechanical Properties and the Carbide Characteristics of a High Strength Low Alloy Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 143-147页

作者： ZHANG Wen-feng,HU ping,zhou Qiang-guo,YAN Wei,SHAN Yi-yin,YANG Ke (Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110000,Liaoning,China) Chinese Acad Sci Inst Met Res Shenyang 110000 Liaoning Peoples R China

Effect of heat treatment on the mechanical properties and the corresponding morphology changes of carbides such as (NbTi)C and Mo,Cr rich carbides in a high strength steel was studied in the *** was found that the strength depend more on tempering temperature than quenching *** the toughness seemed to be sensitive to both quenching temperature and tempering *** the as water quenched condition,the toughness gave a peak value at the quenching temperature of 860℃.Under the as tempered condition,the toughness showed a temper brittleness at the temperature range of 230℃ to 450℃.The morphology changes of the carbides in the experimental steel were explained from the view of the thermal dynamic behavior.

关键词： ultra high strength steel carbides heat treatment mechanical properties

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Current status of cerebral glioma surgery in China

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Chinese Medical Journal 2011年第17期124卷 2569-2577页

作者： WU Jin-song ZHANG Jie ZHUANG Dong-xiao YAO Cheng-jun QIU Tian-ming LU Jun-feng ZHU feng-ping MAO Ying zhou Liang-fu Glioma Surgery Division Department of Neurosurgery Huashan Hospital Shanghai Medical School Fudan University Shanghai 200040 China

The treatment of gliomas is highly individualized. Surgery for gliomas is essentially for histological diagnosis, to alleviate mass effect, and most importantly, to favor longer survival expectancy. During the past two decades, many surgical techniques and adjuvants have been applied to glioma surgery in China, which lead to a rapid development in the field of cerebral glioma surgery. This article broadly and critically reviewed the existing studies on cerebral glioma surgery and to portrait the current status of glioma surgery in China. A literature search was conducted covering major innovative surgical techniques and adjuvants for glioma surgery in China. The following databases were searched： the Pubmed （January 1995 to date）; China Knowledge Resource Integrated Database （January 1995 to date） and VIP Database for Chinese Technical Periodicals （January 1995 to date）. A selection criterion was established to exclude duplicates and irrelevant studies. The outcome measures were extracted from included studies. A total of 3307 articles were initially searched. After excluded by abstracts and full texts, 69 studies conducted in the mainland of China were included and went through further analysis. The philosophy of surgical strategies for cerebral gliomas in China is undergoing tremendous change. Nowadays Chinese neurosurgeons pay more attention to the postoperative neurofunctional status of the patients. The aim of the glioma surgery is not only the more extensive tumor resection but also the maximal safety of intervention. The well balance of longer overall survival and higher quality of life should be judged with respect to each individual patient.

关键词： glioma neurosurgery China

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Clinical experience of 3T intraoperative magnetic resonance imaging integrated neurosurgical suite in Shanghai Huashan Hospital

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Chinese Medical Journal 2012年第24期125卷 4328-4333页

作者： QIU Tian-ming YAO Cheng-jun WU Jin-song PAN Zhi-guang ZHUANG Dong-xiao XU Gen ZHU feng-ping LU Jun-feng GONG Xiu ZHANG Jie YANG Zhong SHI Jian-bin HUANG feng-ping MAO Ying zhou Liang-fu Glioma Surgery Division Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

Background Intraoperative magnetic resonance imaging （iMRI） dates back to the 1990s and has been successfully applied in neurosurgery but they were low-field iMRI （〈1.0T）. This paper reports the clinical experience with a 3T iMRI-integrated neurosurgical suite in Huashan Hospital, Shanghai, China. Methods From September 2010 through March 2012, 373 consecutive patients underwent neurological surgery under guidance with 3T iMRI. A retrospective analysis was conducted regarding clinical efficiency. Results All surgery in the 373 patients was safe. The ratio of gross total resection for cerebral gliomas （n=161） was increased from 55.90% to 87.58%. The ratio of benefit in extent of resection was 39.13%. One hundred and fifty eight of the 161 glioma patients accomplished follow-up at 3 months postoperatively. Twenty of 161 patients （12.42%） suffered from early motor deficit after surgery. Late motor deficit was however observed in five of 158 patients （3.16%）. Twenty-one of 161 patients （13.04%） had early speech deficit and late speech deficit was only observed in six of 158 patients （3.80%）. The ratio of gross total resection for pituitary adenomas （n=49） was increased from 77.55% to 85.71%. The ratio of benefit in extent of resection was 10.2%. There were no iMRI-related adverse events even for patients who underwent awake craniotomy. Conclusion The 3T iMRI integrated neurosurgical suite provides high-quality intraoperative structural and functional imaging for real-time tumor resection control and accurate functional preservation, resulting in an improvement in maximal safe brain surgery.

关键词： intraoperative magnetic resonance imaging glioma pituitary adenoma

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用硫化氢气体分解硫化钠阳极电解液的热力学分析

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湖南科技大学学报（自然科学版） 2004年第4期19卷 83-87页

作者：易清风刘小平周秀林湖南科技大学化学化工学院湖南湘潭411201

直接电解硫化氢碱性溶液(通常用Na2S溶液表示)产生单质硫和氢气的关键问题是单质硫在阳极表面上沉积而导致的阳极钝化.用硫化氢气体分解Na2S的阳极电解液可以很好地解决这一问题,并对这一方法进行了热力学分析.对简化S H2O系的电势 pH... 详细信息

直接电解硫化氢碱性溶液(通常用Na2S溶液表示)产生单质硫和氢气的关键问题是单质硫在阳极表面上沉积而导致的阳极钝化.用硫化氢气体分解Na2S的阳极电解液可以很好地解决这一问题,并对这一方法进行了热力学分析.对简化S H2O系的电势 pH图的分析表明,多硫化物Sx2-在碱性溶液中稳定,且随着体系中溶解态物质的总硫浓度T(s)的增加,高级多硫化物的优势区增大.当Na2S阳极电解液与硫化氢气体反应时,固相硫稳定存在于pH较低和H2S分压较小的环境中.分析表明,当H2S分压为1atm,溶液pH值小于8时,大多数多硫化物分解为单质硫S、S2-,HS-或H2S(aq.).分析结果对电解产生多硫化物以及用H2S气体分解多硫化物的实际过程具有重要指导意义.图6,表1,参10.

关键词：硫化氢气体硫化钠阳极电解液热力学分析化合物分解

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脉冲等离子爆炸工艺表面改性H13钢

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钢铁 2017年第2期52卷 71-77页

作者：邹晋付青峰陆德平周喆刘成成陆磊江西省铜钨新材料重点实验室江西南昌330029 上海市现代冶金与材料制备重点实验室上海200444 南昌航空大学材料科学与工程学院江西南昌330063

为研究脉冲等离子爆炸工艺制备H13钢(4Cr5Mo Si V1)表面改性层的组织和性能,通过对显微组织形貌、相结构、残余应力、硬度和耐磨性的分析,对脉冲等离子爆炸工艺的改性机制和影响进行了讨论。结果表明,脉冲等离子爆炸工艺使H13钢表面发... 详细信息

为研究脉冲等离子爆炸工艺制备H13钢(4Cr5Mo Si V1)表面改性层的组织和性能,通过对显微组织形貌、相结构、残余应力、硬度和耐磨性的分析,对脉冲等离子爆炸工艺的改性机制和影响进行了讨论。结果表明,脉冲等离子爆炸工艺使H13钢表面发生快速熔凝和快速淬火过程,在材料表面形成厚度均匀、组织致密、高硬度的改性层;改性层中马氏体细化,同时由于不同物理变化过程分别形成残余奥氏体和逆变奥氏体;随着脉冲次数的增加,材料表面的残余应力经历了由压应力先增大后减小然后转变成拉应力的过程;改性层的厚度和硬度随脉冲次数的增加而提高,但同时表面熔化程度加剧,表层低硬度熔凝区厚度增加。当脉冲次数为8次时,H13钢具有最优的耐磨损性能。

关键词：脉冲等离子爆炸表面改性耐磨性 H13钢

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji feng-Ying Zhang ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Trigonometric Series with a Generalized Monotonicity Condition

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Acta Mathematica Sinica,English Series 2014年第8期30卷 1289-1296页

作者： Lei feng Vilmos TOTIK Song ping zhou Institute of Mathematics Zhejiang Sci-Tech University MTA-SZTE Analysis and Stochastics Research Group Bolyai InstituteUniversity of Szeged Department of Mathematics and Statistics University of South Florida

In this paper,we consider numerical and trigonometric series with a very general monotonicity ***,a fundamental decomposition is established from which the sufficient parts of many classical results in Fourier analysis can be derived in this general *** the second part of the paper a necessary and sufficient condition for the uniform convergence of sine series is proved generalizing a classical theorem of Chaundy and Jolliffe.

关键词： Uniform convergence monotonicity mean value bounded variation decomposition

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High-extensible scene graph framework based on component techniques

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1247-1252页

作者： LI Qi-cheng WANG Guo-ping zhou feng Department of Computer Science ＆ Technology Peking University Beijing 100871 China

In this paper, a novel component-based scene graph is proposed, in which all objects in the scene are classified to different entities, and a scene can be represented as a hierarchical graph composed of the instances of entities. Each entity contains basic data and its operations which are encapsulated into the entity component. The entity possesses certain behaviours which are responses to rules and interaction defined by the high-level application. Such behaviours can be described by script or behaviours model. The component-based scene graph in the paper is more abstractive and high-level than traditional scene graphs. The contents of a scene could be extended flexibly by adding new entities and new entity components, and behaviour modification can be obtained by modifying the model components or behaviour scripts. Its robustness and efficiency are verified by many examples implemented in the Virtual Scenario developed by Peking University.

关键词： Scene graph Entity Entity component Behaviour script Behaviour model

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Inerting characteristics of entrained atomized water on premixed methane-air flame

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International Journal of Mining Science and Technology 2015年第6期25卷 997-1002页

作者： Cai feng Wang ping zhou Jiebo Li Chao Key Laboratory of Mining Coal Safely and Efficiently Constructed by Anhui Province and Ministry of Education Anhui Universigty of Science and Technology School of Resource and Safety Engineering Anhui University of Science and Technology State Key Laboratory of Fire Science China University of Science and Technology Academy of Coal Methane Huainan Mining Industry (Group) Co.Ltd.

A combustion tube experiment platform was designed and used to study the inerting conditions and capacity of entrained atomized water on premixed methane–air flame. The structure of a laminar flame of premixed methane–air gas and the process of interaction between atomized water and flame was recorded, and the rules of combustion velocity, stability and strength rate of laminar flame were experimentally studied. The inerting process and mechanism was analyzed, and the characteristics of inerting premixed methane–air gas within explosion limits by atomized water were acquired. The research results show that: for the premixed methane–air gas with a concentration of 7%, the minimum inerting atomized water flux is 20.8 m L/(m2min); for the premixed methane–air gas with a concentration of 9%, the minimum inerting atomized water flux is 32.9 m L/(m2min); for the premixed methane–air gas with a concentration of 11%, the minimum inerting atomized water flux is 44.6 m L/(m2min). The research results are significant for extinguishing methane flame and inhibiting of methane explosion using atomized water.

关键词： Atomized water Methane-air gas Premixed methane-air flame lnertion

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