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DNA repair and synthetic lethality

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International Journal of Oral Science 2011年第4期3卷 176-179页

作者： Gong-she Guo feng-mei zhang Rui-jie Gao Robert Delsite Zhi-hui feng Simon N. Powell School of Public Health Shandong University Jinan 250012 China Second People＇s Hospital of Weifang Weifang 261041 China Department of Radiation Oncology Washington University in St Louis St Louis MO 63108 USA Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York NY10065 USA

Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination （HR）, are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach, which may lead to new therapeutic strategies. It is well known that poly （adenosine diphosphate （ADP）-ribose） polymerase （PARP） inhibitors show the synthetically lethal effect in tumors defective in BRCA1 or BRCA2 genes encoded proteins that are required for efficient HR. In this review, we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells.

关键词： DNA repair homologous recombination synthetic lethality BRCA Rad52

A new cyclopeptide from Dianthus caryophyllus

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Chinese Chemical Letters 2008年第2期19卷 193-195页

作者： Fei Li feng mei zhang Ya Bin Yang Xue Qiong Yang Qiu E. Cao Zhong Tao Ding Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of Education School of Chemical Science and Technology Yunnan University # 2 Green Lake North Road Kunming 650091 China

A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-）（1） and cyclo （-Ala-Gly-Ser-IIe-P... 详细信息

关键词： Caryophyllaceae Dianthus caryophyllus Cyclopeptide Caryophllusin A

Analysis of microbial community and its correlation with flavor compounds during Congee fermentation

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Food Bioscience 2023年第1期51卷 1287-1300页

作者： Yang Yang You Na Wu Li Ge Er Ce Xi Ge Bu Ren Ge Quan Shuang feng mei zhang Inner Mongolia Agricultural University China Ordos Yidetai Ecological Agriculture and Animal Husbandry Co. LtdChina

We investigated the structural changes in the microbial flora during the fermentation process(with primers added for fermentation)of Congee and its influence on the flavor compounds of Congee using high-throughput sequencing technology.W detected and analyzed the bacterial and fungal community *** addition,gas chromatography-mass spectrometry,electronic nose technology,and electronic tongue technology were used to monitor the changes in the flavor compounds of Congee at different fermentation time points;the correlation between the two was *** Illumina MiSeq sequencing showed bacterial in Congee samples at different fermentation stages belonged mainly to genera Lactobacillus,Kosakonia,and *** major fungal genera were Yarrowia,Dipodascus,and *** chromatography-mass spectrometry(GC-MS)revealed that 90 volatile compounds were detected in the Congee samples during the fermentation process,among which ethyl acetate,eucalyptol,nonanal,heptyl ethyl acid,and acetic acid constituted important aroma compounds in *** addition,16 amino acids were detected from the Congee *** 48 h of fermentation,the content of total amino acids increased to twice that at 0 h of fermentation;the contents of glutamic acid and aspartic acid were the *** electronic nose technology revealed that the W5S(nitrogen oxide),W1S(methyl)and W1W(sulfide sensitive)sensors showed a higher response to Congee *** terms of taste,the response signals of Congee,sweetness,and saltiness were the *** covariance between microbial flora and flavor compounds was analyzed by Spearman’s correlation *** was significantly positive correlation with found with pyridine,butanoic acid,hexanoic acid,and D-limonene(p<0.05),and a significant negative correlation with hexadecanoic acid and ethyl ester(p<0.05).Bacillus exerted a significant positive correlation with heptanoic acid and ethyl ester(p<0.05).Yarrowia was positively correlated with

关键词： Congee Bacterial community structure Fungal community structure Flavor Correlation

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涉自贸区保险合同纠纷司法管辖权规则探析

上海财经大学学报（哲学社会科学版） 2014年第3期16卷 20-27页

作者：冯张美浙江树人大学现代服务业学院浙江杭州310015

中国(上海)自贸区成立后,各类保险机构将陆续进入自贸区发展业务,在区内外销售保险产品或提供相应服务。自贸区的特殊定位将导致各种保险纠纷呈现新特点。文章基于对涉自贸区保险合同纠纷类型的分析,探究可能产生的管辖权冲突,依据地域... 详细信息

中国(上海)自贸区成立后,各类保险机构将陆续进入自贸区发展业务,在区内外销售保险产品或提供相应服务。自贸区的特殊定位将导致各种保险纠纷呈现新特点。文章基于对涉自贸区保险合同纠纷类型的分析,探究可能产生的管辖权冲突,依据地域管辖、协议管辖、专属管辖等基本原则,研究涉自贸区保险合同纠纷司法管辖权规则,以解决保险纠纷案件类型多样化与自贸区保险审判实践经验缺乏之间的矛盾,填补目前区内外保险活动司法管辖及判定的空白,凸显司法进步及自贸区立法与司法齐头并进的趋势。

关键词：自贸区保险合同保险中介特殊地域管辖协议管辖

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： feng zhang Chenyang zhang Linlin Wu Wei Sun Hongliang zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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超高压和热杀菌对枸杞汁品质的影响

中国食品学报 2018年第3期18卷 169-178页

作者：赵凤梅潇张焱廖小军王永涛中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业部果蔬加工重点实验室北京100083

为开发枸杞汁杀菌新技术,采用超高压和热杀菌处理枸杞汁,分析微生物、活性成分、抗氧化活性及色泽等品质指标在处理前、后及贮藏期间的变化。两种处理后枸杞汁微生物均小于10 CFU/m L,而超高压组菌落总数在贮藏结束时为117 CFU/m L,超... 详细信息

为开发枸杞汁杀菌新技术,采用超高压和热杀菌处理枸杞汁,分析微生物、活性成分、抗氧化活性及色泽等品质指标在处理前、后及贮藏期间的变化。两种处理后枸杞汁微生物均小于10 CFU/m L,而超高压组菌落总数在贮藏结束时为117 CFU/m L,超过行业标准要求;p H值、可滴定酸和可溶性固形物含量在两种处理前、后及贮藏期间均无显著变化;处理前、后及贮藏期间枸杞多糖含量基本稳定,而两处理组的总类胡萝卜素和总酚含量在贮藏期间呈下降趋势,超高压能更好保留其含量;在处理前、后及贮藏期间,超高压对枸杞汁抗氧化活性的保持也优于热处理,通过相关性分析发现抗氧化活性与总酚和总类胡萝卜素含量呈显著正相关;通过处理前、后各颜色指标的对比,发现超高压能更好地保持枸杞汁原有的颜色,贮藏期间超高压组L*,a*,b*值降低量高于热处理组,通过PPO及POD活性分析推测酶促色变是引起贮藏期间超高压组颜色变化大于热处理组的重要原因之一。本研究为超高压应用于枸杞汁加工提供理论依据。

关键词：超高压枸杞汁品质贮藏

邢台地区急性细菌性结膜炎病原菌分布及药敏分析

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国际眼科杂志 2014年第11期14卷 2079-2081页

作者：张凤梅尚彦霞中国河北省邢台市眼科医院检验科 054001 中国河北省邢台市眼科医院眼科 054001

目的:了解本地区急性细菌性结膜炎病原菌的种类分布及其对常用药物的敏感性,为临床诊断和治疗提供依据。方法:收集2010-01/2012-12河北邢台眼科医院诊治的急性细菌性结膜炎患者的结膜囊分泌物进行细菌学检查,并对致病菌种类及药敏试验... 详细信息

目的:了解本地区急性细菌性结膜炎病原菌的种类分布及其对常用药物的敏感性,为临床诊断和治疗提供依据。方法:收集2010-01/2012-12河北邢台眼科医院诊治的急性细菌性结膜炎患者的结膜囊分泌物进行细菌学检查,并对致病菌种类及药敏试验结果进行分析。结果:检标本186例中,培养阳性菌150例(80.6%),其中革兰氏阳性菌127例(84.7%),占前三位的分别是表皮葡萄球菌(28.0%),人葡萄球菌(10.0%),溶血葡萄球菌(4.0%)。革兰氏阴性菌23例(15.3%),前四位的分别是:大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、阴沟肠杆菌,均为2.0%。革兰氏阳性菌除对万古霉素敏感率为100%外,对其他抗菌药物均有不同程度的耐药性。革兰氏阴性菌中敏感率最高的是头孢哌酮(87.0%)。结论:表皮葡萄球菌等条件致病菌已成为本地区急性细菌性结膜炎的主要致病菌。无论革兰阳性菌还是革兰阴性菌对临床常用抗菌药物耐药性均较高。尽早获取结膜囊分泌物进行细菌培养和药敏试验,对于临床诊断及合理选择抗生素治疗意义重大。

关键词：结膜炎病原菌药敏分析

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我国少数民族语言转用及对策研究

贵州民族研究 2018年第2期39卷 211-214页

作者：冯红梅张晓传山东大学文学院山东济南250100 东北财经大学新闻传播学院辽宁大连116025

伴随西部大开发及城镇化建设的推进,我国一些少数民族语言的使用功能急剧萎缩甚至处于濒危状态,一些少数民族的部分或大部分成员已转用了汉语。影响语言转用的因素错综复杂,在此重点探讨了语言使用群体的结构、文化基础和文化渗透、国... 详细信息

伴随西部大开发及城镇化建设的推进,我国一些少数民族语言的使用功能急剧萎缩甚至处于濒危状态,一些少数民族的部分或大部分成员已转用了汉语。影响语言转用的因素错综复杂,在此重点探讨了语言使用群体的结构、文化基础和文化渗透、国家语言规划、地区经济发展水平等因素,指出积极应对语言转用的必要性和紧迫性,并提出了减少我国少数民族语言转用的主要策略。

关键词：少数民族濒危语言语言转用语言多样性