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Mitochondrial ATP 6 and 8 polymorphisms in irritable bowel syndrome with diarrhea

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World Journal of Gastroenterology 2013年第24期19卷 3847-3853页

作者： Wei-feng Wang xin Li ming-Zhou Guo jian-De chen Yun-Sheng yang Li-Hua Peng yong-Hua Wang Chun-Yan zhang Hui-Hui Li Department of Gastroenterology and Hepatology Chinese PLA General Hospital Department of Internal Medicine Chinese PLA General Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555-0764 United States Department of Gastroenterology Chinese Navy General Hospital

AIM: To investigate mitochondrial ATP 6 and 8 poly-morphisms in the colon and ileum of patients with ir-ritable bowel syndrome with diarrhea (IBS-D). METHODS: Twenty-eight patients fulfilling the Rome Ⅲ criteria for IBS-D and 28 healthy subjects were in-vestigated. All study participants underwent screening colonoscopy and mucosal biopsies were obtained from the colon and/or terminal ileum. Genomic DNA was ex-tracted from specimens based on standard protocols. Mitochondrial ATP (MT-ATP) 6 and 8 genes in speci-mens were polymerase chain reaction amplified and sequenced. Sequencing data were analyzed via Variant Reporter Software and compared with the reference sequence from Genbank (accession No. NC_012920) to indicate possible polymorphisms. The protocol was registered at *** as NCT01028898. RESULTS: Twenty-five polymorphic sites of MT-ATP 6 and 8 genes were detected and 12 of them were missense mutations. A median of two polymorphic sites in MT-ATP genes was found in colon specimens of controls while a median of three polymorphic sites was noted in patients with IBS-D (Mann-Whitney test, P=0.012). The variants of the colon and ileum speci-mens from the same subjects were identical in all but one case. Symptom duration in IBS was not found to be a significant factor associated with the mtDNA polymorphism (Spearman correlation, P=0.592). The mitochondrial DNA change at 8860 was present in all cases of both groups. The frequency of the 8701 poly-morphism was found to be the second most frequent; however, no statistical difference was noted between the groups (χ2 test, P=0.584). CONCLUSION: Patients with IBS-D have a higher inci-dence of MT-ATP 6 and 8 polymorphisms than healthy subjects, implying that the mtDNA polymorphism may play a role in IBS-D.

关键词： Irritable bowel syndrome Diarrhea Mito-chondrial ATP 6 gene Mitochondrial ATP 8 gene Poly-morphism

Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma:a single-center,single-arm,phase 2 study

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1983-1992页

作者： Guo-ming Shi Xiao-yong Huang Dong Wu Hui-chuan Sun Fei Liang Yuan Ji Yi chen Guo-Huan yang Jia-cheng Lu Xian-long Meng xin-Ying Wang Lei Sun Ning-Ling Ge Xiao-Wu Huang Shuang-jian Qiu xin-Rong yang Qiang Gao Yi-feng He yang Xu jian Sun Zheng-Gang Ren Jia Fan jian Zhou Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Radiology Zhongshan HospitalFudan UniversityShanghaiChina Department of Statistics Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Hepatic Oncology Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Tianjin Medical Laboratory BGI-TianjinBGI ShenzhenTianjinChina

Advanced intrahepatic cholangiocarcinoma(ICC)has a dismal ***,we report the efficacy and safety of combining toripalimab,lenvatinib,and gemcitabine plus oxaliplatin(GEMOX)as first-line therapy for advanced *** patients with pathologically confirmed advanced ICC received intravenous gemcitabine(1 g/m2)on Days 1 and 8 and oxaliplatin(85 mg/m2)Q3W for six cycles along with intravenous toripalimab(240 mg)Q3W and oral lenvatinib(8 mg)once daily for one *** expression of programmed death-ligand 1(PD-L1)and genetic status was investigated in paraffin-embedded tissues using immunohistochemistry and whole-exome sequencing(WES)*** primary endpoint was the objective response rate(ORR).Secondary outcomes included safety,overall survival(OS),progression-free survival(PFS),disease control rate(DCR)and duration of response(DoR).As of July 1,2022,the median follow-up time was 23.5 months,and the ORR was 80%.Twenty-three patients achieved partial response,and one achieved complete ***(21/30)with DNA damage response(DDR)-related gene mutations showed a higher ORR,while patients(14/30)with tumor area positivity≥1(PD-L1 staining)showed a trend of high ORR,but without significant *** median OS,PFS,and DoR were 22.5,10.2,and 11.0 months,*** DCR was 93.3%.Further,56.7%of patients experienced manageable grade≥3 adverse events(AEs),commonly neutropenia(40.0%)and leukocytopenia(23.3%).In conclusion,toripalimab plus lenvatinib and GEMOX are promising first-line regimens for the treatment of advanced ICC.A phase-III,multicenter,double-blinded,randomized study to validate our findings was approved by the National Medical Products Administration(NMPA,No.2021LP01825).

关键词： regimen intrahepatic treatment

M Dwarf catalog of LAMOST general survey data release one

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Research in Astronomy and Astrophysics 2015年第8期15卷 1182-1196页

作者： Yan-xin Guo Zhen-Ping Yi A-Li Luo You-Fen Wang Yu Bai Hai-feng yang Yi-Han Song jian-Jun chen Xiao-Yan chen Fang Zuo Bing Du jian-Nan zhang Yin-Bi Li Xiao Kong Meng-xin Wang Yue Wu Ke-Fei Wu yong-Heng Zhao yong zhang yong-Hui Hou Yue-Fei Wang ming yang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences University of Chinese Academy of Sciences School of Mechanical Electical & Information EngineeringShandong University at Weihai School of Computer Science and Technology Taiyuan University of Science and Technology Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contamination was eliminated using2 MASS photometry and Ca H/TiO molecular indices. For each spectrum, the spectral subtype and values are provided including radial velocity, Hα equivalent width, a series of prominent molecular band indices, and the metal–sensitive parameter ζ, as well as distances and the space motions for high S/N objects. In addition, Hα emission lines are measured to examine the magnetic activity properties of M dwarfs and 7179 active ones are found. In particular, a subsample with significant variation in magnetic activity is revealed through observations from different epochs. Finally, statistical analysis for this sample is performed, including the metallicity classification, the distribution of molecular band indices and their errors.

关键词： catalogs—methods: analytical—stars: statistical—stars : late-type—stars: magnetic-activity—stars

A sample of E+A galaxy candidates in the Second Data Release of LAMOST Survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1414-1423页

作者： Hai-feng yang A-Li Luo Xiao-Yan chen Wen Hou jian-Nan zhang Wei Du Ji-Fu zhang jiang-Hui Cai Yan-xin Guo Shuo zhang yong-Heng Zhao Hong Wu Ting-Gui Wang Shi-Yin Shen ming yang yong zhang yong-Hui Hou Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences School of Computer Science and Technology Taiyuan University of Science and Technology University of Chinese Academy of Sciences Center for Astrophysics University of Science & Technology of China Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

A sample of 70 E＋A galaxies is selected from 37 206 galaxies in the second data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）. This sample is selected according to the criteria for E＋A galaxies defined by Goto, and each of these objects is further visually identified. In this sample, most objects are low redshift E＋A galaxies with z 〈 0.25, and are located in an area of the sky with high Galactic latitude and magnitude from 14 to 18 mag in the g, r and i bands. A stellar population analysis of the whole sample indicates that the E＋A galaxies are characterized by both young and old stellar populations（SPs）, and the metalrich SPs have relatively higher contributions than the metal-poor ones. Additionally, a morphological classification of these objects is performed based on images taken from the Sloan Digital Sky Survey.

关键词： galaxies: evolution—galaxies: formation—galaxies: interactions—galaxies: peculiar—galaxies: starburst

Catheter ablation versus medical therapy for atrial fibrillation with prior stroke history:a prospective propensity score-matched cohort study

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Journal of Geriatric Cardiology 2023年第10期20卷 707-715,I0006页

作者： Wen-Li DAI Zi-Xu ZHAO chao jianG Liu HE Ke-xin YAO Yu-feng WANG ming-yang GAO Yi-Wei LAI Jing-Rui zhang ming-Xiao LI Song ZUO Xue-Yuan GUO Ri-Bo TANG Song-Nan LI chen-Xi jianG Nian LIU De-yong long xin DU Cai-Hua SANG jian-Zeng DONG Chang-Sheng MA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijingChina Heart Health Research Center BeijingChina Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation *** is unclear whether catheter ablation(CA)has further benefits in these *** AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the *** were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity *** primary outcome was a composite of all-cause death or ischemic stroke(IS)/*** During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,P<0.001].There was a significant decreasing risk of all-cause mortality(HR=0.43,95%CI:0.31–0.61,P<0.001),IS/SE(HR=0.73,95%CI:0.54–0.97,P=0.033),cardiovascular mortality(HR=0.32,95%CI:0.19–0.54,P<0.001)and AF recurrence(HR=0.33,95%CI:0.30–0.37,P<0.001)in the CA group compared to that in the MT *** analysis generated consistent results when adjusting for time-dependent usage of *** In AF patients with a prior stroke history,CA was associated with a lower combined risk of all-cause death or IS/*** clinical trials are warranted to confirm the benefits of CA in these patients.

关键词： prospective fibrillation matched

The large-scale modular BGO detection array(LAMBDA)design and test

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Nuclear Science and Techniques 2024年第11期35卷 228-236页

作者： Yao-De Sheng Lu-yang Song Jun Su Shi-Lun Jin Fei Lu yang-Ping Shen Jun-feng chen Li-yong zhang jian-Jun He xin-Yue Li Hong-Na Liu feng-Shou zhang Meng-Lin Qiu Shen Lin Hao zhang Luo-Huan Wang Zi-ming Li Yin-Ji chen xin-Zhi jiang xin chen Zhi-Lin Shen feng-cheng Liu Zhi-Wei Qin Lin Wang Yi-Tong Huang Xiang Li Si-Ze chen You-Bao Wang Zhi-Hong Li Bing Guo Wei-Ping Liu Key Laboratory of Beam Technology of Ministry of Education School of Physics and AstronomyBeijing Normal UniversityBeijing 100875China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MoE) Institute of Modern PhysicsFudan University200433 ShanghaiChina School of Mathematics and Physics Handan UniversityHandan 056005China Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Total absorption gamma-ray spectroscopy(TAGS)is a powerful tool for measuring complexγ transitions,which has been effectively applied to the study of reactor decay *** paper presents the design of a new TAGS detector,the large-scale modular BGO detection array(LAMBDA),tailored for measuringβ-decay intensity distributions of fission *** modular design allows the LAMBDA detectors to be assembled in various *** final version of LAMBDA consists of 102 identical 60 mm×60 mm×120 mm BGO crystals and exhibits a high full-energy peak efficiency exceeding 80%at 0.5∼8 MeV based on a Monte Carlo ***,approximately half of the LAMBDA modules have been *** usingγ-ray sources and nuclear reactions demonstrated favorable energy resolution,energy linearity,and efficiency uniformity across the ***-eight modules have been integrated into the prototype *** capability of LAMBDA-I inβ-delayedγ-decay experiments was evaluated by commissioning measurements using the ^(152)Eu source.

关键词： Total absorption gamma-ray spectroscopy Reactor decay heat Beta-decay BGO detector array LAMBDA

Epidemiological features and temporal trends of the co-infection between HIV and tuberculosis, 1990-2021: findings from the Global Burden of Disease Study 2021

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Infectious Diseases of Poverty 2024年第4期13卷 79-94页

作者： Shun-Xian zhang Ji-Chun Wang jian yang Shan Lv Lei Duan Yan Lu Li-Guang Tian Mu-xin chen Qin Liu Fan-Na Wei xin-Yu feng Guo-Bing yang yong-Jun Li Yu Wang Xiao-Jie Hu ming yang Zhen-Hui Lu Shao-Yan zhang Shi-Zhu Li Jin-xin Zheng longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesShanghai 200025China Department of Science and Technology Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesBeIjing 102206China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghai 200025China Gansu Provincial Center for Disease Control and Prevention Lanzhou 730000China

Background The co-infection of human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS)and tuberculosis(TB)poses a significant clinical challenge and is a major global public health *** study aims to elucidate the disease burden of HIV-TB co-infection in global,regions and countries,providing critical informa-tion for policy decisions to curb the HIV-TB *** The ecological time-series study used data from the Global Burden of Disease(GBD)Study *** data encompass the numbers of incidence,prevalence,mortality,and disability-adjusted life year(DALY),as well as age-standardized incidence rate(ASIR),prevalence rate(ASPR),mortality rate(ASMR),and DALY rate for HIV-infected drug-susceptible tuberculosis(HIV-DS-TB),HIV-infected multidrug-resistant tuberculosis(HIV-MDR-TB),and HIV-infected extensively drug-resistant tuberculosis(HIV-XDR-TB)from 1990 to *** 1990 to *** estimated annual percentage change(EAPC)of rates,with 95%confidence intervals(C/s),was *** In 2021,the global ASIR for HIV-DS-TB was 11.59 per 100,000 population(95%UI:0.37-13.05 per 100,000 population),0.55 per 100,000 population(95%UI:0.38-0.81 per 100,000 population),for HIV-MDR-TB,and 0.02 per 100,000 population(95%UI:0.01-0.03 per 100,000 population)for *** EAPC for the ASIR of HIV-MDR-TB and HIV-XDR-TB from 1990 to 2021 were 4.71(95%CI:1.92-7.59)and 13.63(95%CI:9.44-18.01),*** global ASMR for HIV-DS-TB was 2.22 per 100,000 population(95%UI:1.73-2.74 per 100,000 population),0.21 per 100,000 population(95%UI:0.09-0.39 per 100,000 population)for HIV-MDR-TB,and 0.01 per 100,000 population(95%UI:0.00-0.03 per 100,000 population)for HIV-XDR-TB in *** EAPC for the ASMR of HIV-MDR-TB and HIV-XDR-TB from 1990 to 2021 were 4.78(95%CI:1.32-8.32)and 10.00(95%Cl:6.09-14.05),*** The findings indicate that enhancing diagnostic and treatment strategies,strengthening healthcare infrastructure,increasing a

关键词： Co-infection Tuberculosis HIV/AIDS Epidemiology Global burden of disease 2021

Advanced Space-based Solar Observatory(ASO-S):an overview

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Research in Astronomy and Astrophysics 2019年第11期19卷 3-10页

作者： Wei-Qun Gan cheng Zhu Yuan-yong Deng Hui Li yang Su Hai-Ying zhang Bo chen Zhe zhang jian Wu Lei Deng Yu Huang jian-feng yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen chen cheng Fang Yi-Hua Yan Jun Lin Wei-ming Xiong Bin chen Hai-chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-long chen xin-Yu Li Ye zhang Li feng jiang-Tao Su Ying Li Wei chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China Changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Yunnan Observatories Chinese Academy of SciencesKunming 650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Beijing Special Engineering and Design Institute Beijing 100028China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar *** scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single ***-S is scheduled to be launched into a 720 km Sun-synchronous orbit in *** paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.

关键词： space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray,gamma-rays

Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences

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World Journal of Gastroenterology 2015年第3期21卷 944-952页

作者： Ya-Nan Gong You-ming Li Ning-Min yang Hong-zhang Li feng Guo Lang Lin Qun-Ying Wang Jia-Kun zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-chao Shi Wu-Heng Tang xin-jian Zhu Wei Shao Xiao-feng zhang xing-Hua Wang Yue-feng Tong Mi-Zu jiang Guang-Lan chen Zhi-yong Wang Hui-Min Tu Guo-Fa jiang jian-Sheng Wu Xu-Peng chen Qiu-long Ding Hong Ouyang feng-Zhe Jin Yan-Li Xu jian-Zhong zhang State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of MedicineZhejiang University Zhiyuan Medical Inspection Institute Co. Ltd. Sanmen People’s Hospital The First People’s Hospital of Xiaoshan District The First People’s Hospital of Cangnan Jinhua Municipal Central Hospital The First People’s Hospital of Pingyang The First Hospital of Jiaxing Zhoushan Hospital The First People’s Hospital of Wenling Rui’an People’s Hospital Maternal and Child Health Hospital of Zhoushan City Shangyu People’s Hospital People’s Hospital of Putuo District Zhoushan Hangzhou First People’s Hospital Qingtian People’s Hospital The First People’s Hospital of yongkang The Children’s Hospital Zhejiang University School of Medicine Lishui People’s Hospital The Affiliated Hospital of Hangzhou Normal University Wuxi No.4 Hospital Affiliated to Suzhou University Jinhua Wenrong Hospital The First Affiliated Hospital of Wenzhou Medical College Yueqing People’s Hospital Tiantai People’s Hospital Lin’an people’s Hospital Rui’an City TCM Hospital Medical College of Hebei University of Engineering

AIM:To evaluate the efficacy of centralized culture and possible influencing ***:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(***) infection from 26 hospitals in Zhejiang and jiangsu Provinces in China underwent gastrointestinal *** mucosal biopsies were taken from the antrum for *** biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 *** culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 *** additional 5736 biopsies from ***-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory ***:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the ***-positive quality control *** the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport *** contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter *** samples.

关键词： Centralized isolation Helicobacter pylori Influenc