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具有不同操作工况的装置的热集成

高校化学工程学报 2007年第5期21卷 843-848页

作者：孙艳泽冯霄西安交通大学化工系陕西西安710049

针对具有不同操作工况的连续过程,为了使装置在任一工况下均能达到最大节能潜力,基于夹点技术,根据各工况所对应的夹点位置,扩展了夹点设计原则,提出了一个具有不同操作工况的装置的热集成方法,该方法可以使装置中固定不变部分换热网络... 详细信息

针对具有不同操作工况的连续过程,为了使装置在任一工况下均能达到最大节能潜力,基于夹点技术,根据各工况所对应的夹点位置,扩展了夹点设计原则,提出了一个具有不同操作工况的装置的热集成方法,该方法可以使装置中固定不变部分换热网络结构相同,并且在不同工况下装置的换热网络始终是最大能量回收网络。

关键词：热集成换热网络夹点切换操作工况连续过程

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图像邻域像素分布分析

吉林大学学报（工学版） 2011年第2期41卷 553-558页

作者：谭啸冯久超华南理工大学电子与信息学院广州510641

从数字图像的成像原理出发,对邻域像素的分布进行了分析,进而对邻域像素跳变分布提出了2种新的函数模型。实验采用非线性最小二乘法对从实验图像中得到的分布结果进行函数拟合,并用差值能量函数(DPF)对新提出的函数模型与文献[8,12]的... 详细信息

从数字图像的成像原理出发,对邻域像素的分布进行了分析,进而对邻域像素跳变分布提出了2种新的函数模型。实验采用非线性最小二乘法对从实验图像中得到的分布结果进行函数拟合,并用差值能量函数(DPF)对新提出的函数模型与文献[8,12]的分布函数进行对比分析。结果表明:新提出的函数模型拥有更高的拟合度,更符合邻域像素值的分布情况。

关键词：信息处理分布函数非线性最小二乘法邻域像素跳变

Novel rhino-like SHJH^(hr) mice with thyroid dysfunction

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Zoological Research 2021年第6期42卷 734-738页

作者： Yong-Chao Li Jin-feng Gao Ya-Lun Guan xiao-Yue Wei Xue-Jiao Li Yun-feng Li Zhong-Qiang Huang Shu-Hua Liu Ge Li Ping Xu Guang-Jin Pan Yu Zhang Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouGuangdong 510663China Key Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouGuangdong 510530China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China Shanghai Jihui Laboratory Animal Care Co. Ltd.Shanghai 201611China

A new Hairless(Hr)gene mutant mouse line(SHJH^(hr))was identified,which showed hairless skin in adult individuals as reported in rhino *** Hr gene mutant identification with polymerase chain reaction(PCR)amplification and sequencing,seven mutants were identified,including nonsense mutant site 2134C→T(R467X),which produced a truncated Hr *** activity and heart rate were measured using a metabolic cage and blood pressure instrument,*** SHJH^(hr) mice showed a strong metabolic rate,high heart rate,and low blood *** analysis of the thyroid gland of SHJH^(hr) mice showed abnormal follicular structure and hypertrophic *** to ICR mice,thyroid function in 4-month-old SHJH^(hr) mice showed lower thyroid stimulating hormone(TSH)levels,and in 9-month-old SHJH^(hr) mice showed significantly higher TSH and thyroid hormone *** data indicate that SHJH^(hr) mice may be in a hyperthyroid state with increasing ***,based on the above results,we successfully established a novel mouse model with thyroid dysfunction.

关键词： instrument dysfunction stimulating

Prognostic factors influencing clinical outcomes of glioblastoma multiforme

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Chinese Medical Journal 2009年第11期122卷 1245-1249页

作者： LI shou-wei QIU xiao-guang CHEN Bao-shi ZHANG Wei REN Huan WANG Zhong-cheng JIANG Tao Department of Neurosurgery Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Radiotherapy Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Immunology Harbin Medical University Harbin Heilongjiang 150086 China Beijing-Neurosurgical Institute Beijing 100050 China

Background Glioblastoma multiforme （GBM） is the most malignant kind of astrocytic tumors and is associated with a poor prognosis. In this retrospective study, we assessed the clinical, radiological, genetic molecular and treatment factors that influence clinical outcomes of patients with GBM. Methods A total of 116 patients with GBM who received surgery and radiation between January 2006 and December 2007 were included in this study. Kaplan-Meier survival analysis and Cox regression analysis were used to find the factors independently influencing patients＇ progression free survival （PFS） time and overall survival （OS） time. Results Age, preoperative Karnofsky Performance Scale （KPS） score, KPS score change at 2 weeks after operation, neurological deficit symptoms, tumor resection extent, maximal tumor diameter, involvement of eloquent cortex or deep structure, involvement of brain lobe, Ki-67 expression level and adjuvant chemotherapy were statistically significant factors （P 〈0.05） for both PFS and OS in the univariate analysis. Cox proportional hazards modeling revealed that age 〈50 years, preoperative KPS score 〉80, KPS score change after operation 〉0, involvement of single frontal lobe, non-eloquent area or deep structure involvement, low Ki-67 expression and adjuvant chemotherapy were independent favorable factors （P 〈0.05） for patients＇ clinical outcomes. Conclusions Age at diagnosis, preoperative KPS score, KPS score change at 2 weeks postoperation, involvement of brain lobe, involvement of eloquent cortex or deep structure, Ki-67 expression level and adjuvant chemotherapy correlate significantly with the prognosis of patients with GBM.

关键词： glioblastoma multiforme prognostic factor disease progression survival chemotherapy

Dynamic Sulfur-Rich Polymers from Elemental Sulfur and Epoxides

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Chinese Journal of Polymer Science 2024年第10期42卷 1479-1487,I0010页

作者： Ke-Xiang Chen Chen-Hui Cui Zhen Li Ting Xu Hao-Qing Teng Zhi-Yuan He Yin-Zhou Guo xiao-Qing Ming Zhi-Shen Ge Yan-feng Zhang Tie-Jun Wang School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an710049China State Key Lab for Strength and Vibration of Mechanical Structures Department of Engineering MechanicsXi’an Jiaotong UniversityXi’an710049China

Sulfur-containing dynamic polymers had attracted significant attention due to their unique chemical structures with high *** sulfur, an inexpensive industrial waste product, to synthesize dynamic polysulfide polymers through reverse vulcanization has been a notable approach. However, this method required high temperatures and resulted in the release of unpleasant oders. In this study, we presented a robust method for the preparation of sulfur-rich polymers with dynamic polysulfide bonds from elemental sulfur and inexpensive epoxide monomers via a one-pot strategy at the mild room temperature. Different types of polysulfide molecules and polymers were synthesized by reacting various epoxide compounds with sulfur, along with the investigation of their structures and dynamic behaviors. It was noteworthy that the obatined polymers prepared from m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline and elemental sulfur exhibit multiple dynamic behaviors, including polysulfide metathesis and polysulfide-thiol exchange, enabling their rapid stress relaxation, self-healing, reprocessing and degradable properties of the cross-linked polymer. More importantly, the hydroxyl groups at the side chains from epoxide ring opening exhibited potential transesterification. This work provided a facile strategy for designing dynamic sulfur-rich polymers via a mild synthesis route.

关键词： Elemental sulfur Sulfur-containing polymer Dynamic covalent bond Dynamic polymer

Submonolayer biolasers for ultrasensitive biomarker detection

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Light(Science & Applications) 2023年第12期12卷 2768-2777页

作者： Chaoyang Gong Xi Yang Shui-Jing Tang Qian-Qian Zhang Yanqiong Wang Yi-Ling Liu Yu-Cheng Chen Gang-Ding Peng Xudong Fan Yun-feng xiao Yun-Jiang Rao Yuan Gong Key Laboratory of Optical Fiber Sensing and Communications(Ministry of Education of China) School of Information and Communication EngineeringUniversity of Electronic Science and Technology of ChinaChengduSichuan 611731China Key Laboratory of Optoelectronic Technology and Systems(Ministry of Education of China) School of Optoelectronic EngineeringChongqing UniversityChongqing 400044China State Key Laboratory for Mesoscopic Physics and Frontiers Science Centre for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore School of Electrical Engineering and Telecommunications University of New South WalesSydneyNSW 2052Australia Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Research Centre for Optical Fiber Sensing Zhejiang LaboratoryHangzhouZhejiang 310000China

Biomarker detection is key to identifying health ***,designing sensitive and single-use biosensors for early diagnosis remains a major ***,we report submonolayer lasers on optical fibers as ultrasensitive and disposable *** optical fibers serve as distributed optical microcavities with high Q-factor,great repeatability,and ultralow cost,which enables whispering-gallery laser emission to detect *** is found that the sensing performance strongly depends on the number of gain *** submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection(LOD)when compared to saturated monolayer *** further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker,alpha-synuclein(α-syn),with a lower LOD of 0.32 pM in serum,which is three orders of magnitude lower than theα-syn concentration in the serum of Parkinson's disease *** demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.

关键词： lasers monolayer diagnosis

Enhanced Bombyx genome editing via Cas9 ribonucleoprotein injection

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Insect Science 2019年第6期26卷 1059-1062页

作者： Ling Jia San-Yuan Ma Tong Zhang Wei-Qing Xing Yue Liu Yu-feng Li xiao-Xu Chen Qing-You Xia State Key Laboratory of Silkworm Genome Biology Southwest University Chongqing China Chongqing Engineering and Technology Research Center for Novel Silk Materials Southwest University Chongqing China

Dear Editor, The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system has become a popular and powerful method for manipulating genomes with considerably little effort and high efficiency. It allows for the generation of targeted indels, genomic structure variations, and insertion of foreign fragments. However, increasing concerns have been raised about possible off-target effects.

关键词： Bombyx genome ribonucleoprotein increasing concerns

Identification of a Positive Cis-Element Upstream of Human NKX3.1 Gene

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 773-778页

作者： An-Li JIANG Peng-Ju ZHANG xiao-Yan HU Wei-Wen CHEN feng KONG Zhi-Fang LIU Hui-Qing YUAN Jian-Ye ZHANG Department of Biochemistry,Medical School of Shandong University,Jinan 250012,China Department of Biochemistry Medical School of Shandong UniversityJinan 250012 China

NKX3.1 is a prostate-specific homeobox gene related to prostate development and *** this work,we aimed to identify precisely the functional cis-element in the 197 bp region(from-1032 to -836 bp)of the NKX3.1 promoter(from -1032 to +8bp),which was previously identified topresent positive regulatory activity on NKX3.1 expression,by deletion mutagenesis analysis and electro-phoretic mobility shift assay(EMSA).A 16 bp positive cis-element located between -920 and -905 bpupstream of the NKX3.1 gene was identified by deletion mutation analysis and proved to be a functionalpositive cis-element by *** will be important to further study the functions and regulatory mechanismsof this positive cis-element in NKX3.1 gene expression.

关键词： human NKX3.1 cis-acting element positive regulation mutagenesis

Multiple subtraction method based on a non-causal matching filter

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Applied Geophysics 2011年第1期8卷 27-35,94,95页

作者： Liu Hua-feng Chen xiao-Hong Song Jia-Wen Liu Guo-Chang CNPC Key Lab of Geophysical Exploration China University of Petroleum （Beijing） Beijing 102249 China State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum （Beijing） Beijing 102249 China

The filter operator used in normal multichannel matching filter is physically realizable. This filter operator only delays seismic data in the filtering process. A non- causal multichannel matching filter based on a least squares criterion is proposed to resolve the problem in which predicted multiple model data is later than real data. The differences between causal and non-causal multichannel matching filters are compared using a synthetic shot gather, which demonstrates the validity of the non-causal matching filter. In addition, a variable length sliding window which changes with offset and layer velocity is proposed to solve the count of events increasing with increasing offset in a fixed length sliding window. This variable length sliding window is also introduced into the modified and expanded multichannel matching filter. This method is applied to the Pluto1.5 synthetic data set. The benefits of the non-causal filter operator and variable length sliding window are demonstrated by the good multiple attenuation result.

关键词： multiple matching subtraction non-causal convolution operator variable length window