检索结果-南通市图书馆

Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin feng Min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

关键词：

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Yuan Dong Li Su Sin Man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

关键词：

1.56 kV/30 A vertical β-Ga2O3 Schottky barrier diodes with composite edge terminations

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年

作者： Yitao feng Hong ZHOU Sami ALGHAMDI Hao FANG Xiaorong ZHANG Yanbo CHEN Guotao TIAN Saud WASLY Yue HAO Jincheng ZHANG Key Lab of Wide Band Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Center of Excellence in Intelligent Engineering Systems (CEIES) King Abdulaziz University China Resources Microelectronics Limited(Wuxi)

In recent years, large-area wide-bandgap (WBG) semiconductor materials have achieved numerous notable breakthroughs [1, 2]. The ultra-WBG semiconductor β-Ga2O3,with its excellent material properties, is ideally suited for the fabrication of power devices. Moreover, it offers easily obtainable large-area substrates, with reported sizes up to 6 inches, produced through melt-grown crystal growth methods. These characteristics make β-Ga2O3 highly attractive for future low-cost commercialization. Despite these advances, most research has focused on low-current and small-size diodes, with few studies addressing high-current and large-size diodes.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

企业数字化转型与全球价值链参与

管理工程学报 2025年第1期39卷 15-31页

作者：李鑫佟岩曹丰北京理工大学管理学院北京100081 湖南大学工商管理学院湖南长沙410082

本文立足“逆全球化”时代数字经济发展迅速的现实背景,利用2010年至2016年中国A股上市公司与中国海关数据库的合并数据,实证检验了企业数字化转型对其全球价值链参与的影响。研究表明,数字化转型能够促进企业更好地融入全球价值链,并... 详细信息

本文立足“逆全球化”时代数字经济发展迅速的现实背景,利用2010年至2016年中国A股上市公司与中国海关数据库的合并数据,实证检验了企业数字化转型对其全球价值链参与的影响。研究表明,数字化转型能够促进企业更好地融入全球价值链,并且该结论在经过一系列稳健性检验后依然成立。影响机制检验发现,企业数字化转型对全球价值链嵌入的提升作用主要通过缓解融资约束和提高生产效率来实现。异质性检验结果表明,当数字化转型基础较好、劳动力需求较高以及成本加成较低时,企业数字化转型对全球价值链参与的影响更为凸显。本文丰富和拓展了企业数字化转型影响机制与经济后果的研究框架,为企业更好地融入全球价值链分工体系、实现高质量发展找到了新的经验证据,对于企业数字化相关政策的制定与调整也具有一定的参考价值。

关键词：数字化转型全球价值链嵌入融资约束生产效率

云南省玉溪市男男性行为者与异性性行为时安全套使用情况及影响因素

在线全文

学校读者我要写书评

暂无评论

中国皮肤性病学杂志 2021年第10期35卷 1146-1151页

作者：董文斌李世福赵金仙朱永芬陈黎跃王晓雯蔡英许杰李泽鲁建波李顺祥罗珠珠` 冯婉君玉溪市疾病预防控制中心性病艾滋病控制科云南玉溪653100 云南省疾病预防控制中心性病艾滋病防制所云南昆明650100 玉溪市急救中心云南玉溪653100 大理大学公共卫生学院流行病学和预防医学系云南大理671000

目的探讨云南省玉溪市男男性行为者(MSM)与异性性行为时安全套使用情况及影响因素。方法根据《全国艾滋病哨点监测方案》要求,在2010-2019年以每年4-7月为监测期,采用横断面调查法对MSM人群的人口学特征、艾滋病知识知晓情况和行为学等... 详细信息

目的探讨云南省玉溪市男男性行为者(MSM)与异性性行为时安全套使用情况及影响因素。方法根据《全国艾滋病哨点监测方案》要求,在2010-2019年以每年4-7月为监测期,采用横断面调查法对MSM人群的人口学特征、艾滋病知识知晓情况和行为学等连续监测,应用累计比数Logit模型分析MSM人群与异性性行为时安全套使用的影响因素。结果878名MSM最近6个月有异性性行为,其中18.79%(165/878)与异性性行为时从未使用安全套,30.52%(268/878)偶尔使用,50.68%(445/878)坚持使用。多因素分析结果显示,年龄越大、已婚/同居、户籍为外省、最近半年与同性发生过无保护性肛交和吸毒的MSM与异性性行为时更倾向于不使用安全套(OR>1,P<0.05);最近半年发生过商业同性性行为的MSM与异性性行为时更倾向于使用安全套(OR=0.551,95%CI:0.328~0.925)。结论MSM人群存在双性性行为,且发生异性性行为时安全套使用率较低,需根据影响MSM与异性性行为时安全套的因素制定相关干预措施,避免MSM人群中的性传播疾病向一般人群传播。

关键词：男男性行为人群性行为安全套使用影响因素

A versatile synthetic strategy towards rare earth based metal-organic frameworks

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

关键词：

新质生产力推动城乡融合发展的作用机理与实现路径

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国流通经济 2025年第1期39卷 39-49页

作者：文丰安重庆大学马克思主义学院重庆市400030

城乡融合发展是中国式现代化的必然要求,是提升中国经济协调性、促进国内大循环、实现高质量发展的重要手段。发展新质生产力是推动高质量发展的内在要求和重要着力点,新质生产力以科技创新为驱动,是推动城乡融合发展的关键选择。目前,... 详细信息

城乡融合发展是中国式现代化的必然要求,是提升中国经济协调性、促进国内大循环、实现高质量发展的重要手段。发展新质生产力是推动高质量发展的内在要求和重要着力点,新质生产力以科技创新为驱动,是推动城乡融合发展的关键选择。目前,我国城乡融合发展仍面临相关机制不健全、要素流动阻碍多、融合发展动力不足、公共资源供给不均衡、居民收入差距较大、乡村产业融合发展相对缓慢等困难。新质生产力作为推动城乡区域发展的重要引擎、加快城乡要素流通的动力支撑、驱动产业转型升级的核心动能,为推动城乡融合发展提供了新的契机。第一,进一步深化户籍制度、土地制度、金融制度等关键领域的改革,打破制约城乡融合发展的体制性障碍,构建科学合理、协调统一的城乡规划引领机制,建立健全城乡统一的市场体系,完善城乡发展机制。第二,推动新型人才流动,加强技术传播,促进信息共享,提高新型劳动者、新型劳动资料在城乡之间的流动效率,减少城乡要素流动障碍,促进城乡要素自由流动,优化生产要素配置。第三,加强城乡基础设施智能化建设,促进城乡公共服务均等化,推动多元化供给和数字化服务。第四,创新产业发展模式,驱动城乡产业无缝对接,协同发展。

关键词：城乡融合发展新质生产力乡村全面振兴高质量发展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

小水电站对赤水河连通性影响评估及恢复对策

湖泊科学 2025年第1期37卷 253-265页

作者：赵文通贺蔚赵先富陈锋张晶金小伟毛丰李正飞河海大学水利水电学院南京210098 水利部中国科学院水工程生态研究所水利部水工程生态效应与生态修复重点实验室武汉430079 中国水利水电科学研究院水生态环境研究所北京100038 中国环境监测总站北京100012 华威大学全球可持续发展研究所考文垂CV47AL 中国科学院水生生物研究所武汉430072

赤水河作为长江上游珍稀特有鱼类国家级自然保护区的重要组成部分,其生态连通性对于长江上游特有鱼类至关重要。但赤水河流域内广泛分布的小水电站严重影响了该区域的连通性。本研究收集了赤水河流域小水电站的空间位置、建设年份、装... 详细信息

赤水河作为长江上游珍稀特有鱼类国家级自然保护区的重要组成部分,其生态连通性对于长江上游特有鱼类至关重要。但赤水河流域内广泛分布的小水电站严重影响了该区域的连通性。本研究收集了赤水河流域小水电站的空间位置、建设年份、装机容量等详细信息,并采用树状水系连通性指数(DCI)、溪流连续性指数(SCI)、河流破碎化指数(CAFI)和新提出的改进的河流破碎化指数(CAFI M)全面评估小水电站对赤水河流域水系连通性影响的时空变化。研究发现,赤水河流域几乎每条河流都建有小水电站,主要分布在低阶河流。DCI和SCI指数表明,随着电站数量的增加,赤水河流域的连通性显著下降,中下游地区连通性低于上游地区。CAFI和CAFI M指数揭示了类似的趋势,随小水电站的建设河流破碎化程度不断加剧,特别是在习水河、大同河和桐梓河流域表现显著。CAFI M指数将小水电站的装机容量因素纳入考虑,能够更加全面准确地评估小水电站的影响。CAFI M指数相较于传统指标,对装机容量变化更为敏感,能有效反映大型电站的影响。根据CAFI M等指数评估结果,研究评估了赤水河流域内各小水电站障碍物的优先级,提出应优先整改位于高阶河流且装机容量大的电站,以最大程度地改善流域连通性。根据各指数评估结果,研究发现电站的位置和装机容量是决定其优先拆除顺序的关键因素,位于高阶河流且装机容量大的电站(如金阳、圆满贯等)的拆除对改善流域连通性效果最为显著。该研究全面评价了赤水河流域的连通性状况,提出了优化小水电站拆除的策略,为该流域生态修复提供了决策依据,对保护长江上游特有鱼类具有重要意义。本研究为小水电站对流域河网连通性的评估及恢复对策提供了理论基础和方法支持。

关键词：河流连通性小水电站改进的河流破碎化指数CAFI M 连通性指数赤水河流域

Reduction in nerve root compression by the nucleus pulposus after feng's Spinal Manipulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第12期8卷 1139-1145页

作者： Yu feng Yan Gao Wendong Yang Tianyou feng Research Center of Manipulative Treatment General Hospital of the Air Force

Ninety-four patients with lumbar intervertebral disc herniation were enrolled in this study. Of these, 48 were treated with feng＇s Spinal Manipulation, hot fomentation, and bed rest （treatment group）. The remaining 46 patients were treated with hot fomentation and bed rest only （control group）. After 3 weeks of treatment, clinical parameters including the angle of straight-leg raising, visual analogue scale pain score, and Japanese Orthopaedic Association score for low back pain were improved. The treatment group had significantly better improvement in scores than the control group. Magnetic resonance myelography three-dimensional reconstruction imaging of the vertebral canal demonstrated that filling of the compressed nerve root sleeve with cerebrospinal fluid increased significantly in the treatment group. The diameter of the nerve root sleeve was significantly larger in the treatment group than in the control group. However, the sagittal diameter index of the herniated nucleus pulposus and the angle between the nerve root sleeve and the thecal sac did not change significantly in either the treatment or control groups. The effectiveness of feng＇s Spinal Manipulation for the treatment of symptoms associated with lumbar intervertebral disc herniation may be attributable to the relief of nerve root compression, without affecting the herniated nucleus pulposus or changing the morphology or position of the nerve root.

关键词： neural regeneration traditional Chinese medicine spinal column rotating reduction manipulation Chinese medicine bone-setting lumbar intervertebral disc herniation intervertebral disc nerve root magnetic resonance imaging biomechanics grants-supported paper neuroregeneration

在线全文

学校读者我要写书评

暂无评论

不同种植密度对夏玉米产量影响分析

农业网络信息 2014年第10期 18-20页

作者：党德宣苏东涛陈朝辉林何莺薄晓峰傅君李兆斌冯婉君山西省农业科学院农业资源与经济研究所山西太原030006 山西省农业科学院棉花研究所山西运城044000 山西省农业科学院农业科技信息研究所山西太原030006

目前山西省复播区市场上销售的玉米品种数量众多,部分品种存在跨区推广现象,对保障夏玉米生产和农民购种造成一定影响。通过进行不同复播玉米品种密度试验,筛选出适宜于当地复播种植的玉米新品种达到增产增效的目的。

关键词：夏玉米密度产量筛选