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从“希腊风”到“开明的品位”——迪朗早期作品设计中的“古典”思想及主导因素转向“类型”原因探析

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世界建筑 2024年第7期 22-33页

作者：赵霖霖钱锋同济大学同济大学建筑与城市规划学院

让-尼古拉-路易·迪朗是18-19世纪法国著名的建筑教育家和理论家。作为巴黎综合理工学院的建筑学教师,他开创了以网格、轴线为方法,以经济、简明为目的的建筑设计教学方法,这套隐含着类型学思想的设计方法体现出了明显的与“古典”的区... 详细信息

让-尼古拉-路易·迪朗是18-19世纪法国著名的建筑教育家和理论家。作为巴黎综合理工学院的建筑学教师,他开创了以网格、轴线为方法,以经济、简明为目的的建筑设计教学方法,这套隐含着类型学思想的设计方法体现出了明显的与“古典”的区别,也因此得到了广泛的关注与讨论。然而,在他成为理工学院教师之前的设计作品得到的关注寥寥无几,关于从“古典”到“类型”转变的原因也莫衷一是。本文将从迪朗1793-1794年间的设计作品入手,结合当时的时代背景分析这些作品诞生的环境、设计的方法及受到的影响,总结他的职业生涯早期是如何受到“希腊风”影响,将建筑与当时的时代精神结合到一起;并以“建筑物—精神”之间的联系为依据分析他从受到希腊风影响转向“开明的品位”的原因。

关键词：迪朗希腊风古典类型 18世纪末期的法国建筑思潮

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

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World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-Yu Shi Xin Che Rui Wen Si-Jia Hou Yu-Jia Xi Yi-qian feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and FH was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(P<0.05).We also found that the immune cell infiltration,mutation,and drug sensitivity were different between the different risk *** highrisk subgroup was associated with lower immune scores and high ***,we found that the combination of the TMB and risk score could stratify patients into three groups with distinct ***-HTMB patients had the worst prognosis,whereas LRisk-LTMB patients had the best prognosis(P<0.0001).Analysis of the scRNAseq data showed that PROM2,SLC7A11,and FANCD2 were significantly differentially expressed,whereas FH was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden Single-cell RNA sequencing Prognosis

Effect of Different Disinfection Methods on Calluses of Amorphophallus albus ***&***

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Agricultural Science & Technology 2024年第2期25卷 26-32页

作者： CHEN Xu-yan LU Yi ZHENG Lin-lin feng Yu-qian HAO Guo-qian Faculty of Agriculture Forestry and Food EngineeringYibin UniversityYibin 644000PRC

This study aimed to examine the effect of different disinfection methods on the callus of Amorphophallus albus in the tissue culture and rapid propagation *** calluses induced from buds of *** were disinfected with benzalkonium bromide,mercury bichloride,sodium hypochlorite,and ethanol,respectively,for different time *** growth of calluses was compared between different treatments and observed in detail by *** results showed that the disinfection with 0.1% mercury bichloride for 5 min and 75% ethanol for 5 s had mild effect on the callus,with the lowest browning rates of 16.32% and 15.46% and the lowest vitrification rates of 3.24% and 9.72%,respectively,after 20 *** disinfection with benzalkonium bromide and sodium hypochlorite had strong effect on the callus cells,with the lowest browning rate of 50.69% and 25.12% and the lowest vitrification rates of 28.47% and 28.43%,*** cytological observation result showed that the calluses disinfected with ethanol and mercury bichloride showcased compact structures,while those disinfected with sodium hypochlorite and benzalkonium bromide exhibited loose *** sum up,it is recommended that 75% ethanol or 0.1% mercury bichloride can be used for disinfection in the tissue culture and rapid propagation of ***,while the use of benzalkonium bromide and sodium hypochlorite should be avoided as much as possible.

关键词： Amorphophallus albus Callus Anatomical observation Disinfection methods

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圆柱直齿渐开线外花键跨棒距坐标测量方法

工具技术 2024年第5期58卷 142-146页

作者：孙玉玖李仕荣汤洁钱丰中航工业北京长城计量测试技术研究所北京市100095 北京工业大学机械与能源工程学院北京市精密测控技术与仪器工程技术研究中心北京市100124

花键是工程领域中传递转矩的重要联结零件,对外花键的齿厚关键参数跨棒距进行测量较为重要。针对圆柱直齿渐开线外花键的坐标测量,建立了外花键坐标测量方法,基于花键齿面模型获取其跨棒距测量的接触点坐标,分析得到花键的跨棒距数值。... 详细信息

花键是工程领域中传递转矩的重要联结零件,对外花键的齿厚关键参数跨棒距进行测量较为重要。针对圆柱直齿渐开线外花键的坐标测量,建立了外花键坐标测量方法,基于花键齿面模型获取其跨棒距测量的接触点坐标,分析得到花键的跨棒距数值。在花键测量中心上开展渐开线外花键跨棒距坐标测量试验,得到的跨棒距测量结果表明,建立的外花键跨棒距坐标测量方法可用于花键快速自动测量。

关键词：渐开线花键跨棒距坐标测量测量中心

超声引导下微波消融治疗多灶性T1N0M0甲状腺乳头状癌的可行性研究

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介入放射学杂志 2024年第5期33卷 495-499页

作者：顾美琴奚静李尊钱丰江苏大学附属武进医院(徐州医科大学武进临床学院)超声科江苏常州213000 苏州大学附属第三医院(常州市第一人民医院)超声科

目的研究超声引导下微波消融治疗多灶性T1N0M0甲状腺乳头状癌(PTC)的可行性、安全性和有效性。方法随机纳入2019年1月至2022年1月我院确诊多灶性T1N0M0(≤3个)PTC患者68例为研究对象,肿瘤最大直径≤2 cm,均采用超声引导下微波消融治疗... 详细信息

目的研究超声引导下微波消融治疗多灶性T1N0M0甲状腺乳头状癌(PTC)的可行性、安全性和有效性。方法随机纳入2019年1月至2022年1月我院确诊多灶性T1N0M0(≤3个)PTC患者68例为研究对象,肿瘤最大直径≤2 cm,均采用超声引导下微波消融治疗。随访至2023年4月,中位时间为30个月,随访包括常规超声、超声造影、甲状腺功能及必要的细针穿刺细胞学检查(FNA)。结果68例患者分为T1a组52例和T1b组16例,T1b组消融时间显著延长,肿瘤最大直径增加,差异有统计学意义(P0.05)。结论超声引导下微波消融治疗多灶性T1N0M0的PTC患者有较好的可行性、安全性和有效性。

关键词：超声微波消融甲状腺乳头状癌肿瘤最大直径甲状腺激素

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基于卷积神经网络的古陶瓷窑口甄别

光谱学与光谱分析 2024年第2期44卷 354-358页

作者：孙合杨周越黎思佳李丽闫灵通冯向前中国科学院高能物理研究所北京100049 中国科学院大学北京100049

古陶瓷作为中华文化的瑰宝,自古以来不仅在国内受到追捧,在国外同样被视若珍宝。伴随着古代商贸的进行,中国古陶瓷遍布全球各地,辗转流传被私人或博物馆收藏,还有部分古陶瓷经墓葬发掘以及沉船打捞后被收藏于博物馆,这类古陶瓷的产地溯... 详细信息

古陶瓷作为中华文化的瑰宝,自古以来不仅在国内受到追捧,在国外同样被视若珍宝。伴随着古代商贸的进行,中国古陶瓷遍布全球各地,辗转流传被私人或博物馆收藏,还有部分古陶瓷经墓葬发掘以及沉船打捞后被收藏于博物馆,这类古陶瓷的产地溯源一直以来都是陶瓷考古的重点,对于研究古代商贸和文化交流有重要的意义。通过便携式数码显微镜、分光光度计、X射线荧光等方法对从越窑后司岙、越窑寺龙口、龙泉枫洞岩窑、耀州窑发掘出土的青釉瓷样品进行分析测量,获得了来自四个窑青釉瓷样品的微观气泡尺寸分布特征、紫外可见近红外光谱特征、釉的成分数据。将来自四个窑青釉瓷样品的这三种特征作为变量建立卷积神经网络分类模型进行训练和验证,结果表明青釉瓷的微观气泡尺寸分布特征、紫外可见近红外光谱特征以及瓷釉成分数据均有效,但是不同特征的分类准确率差异非常明显。三十次随机划分训练集与测试集的模型训练平均准确率:微观气泡尺寸分布特征模型为75%,紫外可见近红外光谱特征模型为89.2%,成分数据模型为92.1%,成分数据模型准确率最高且训练集与测试集准确率相差最小。将基于不同特征训练好的模型参数保存进行融合后再训练发现基于紫外可见近红外光谱特征的模型与基于微观气泡尺寸分布特征模型融合后准确率提升至93.7%,而将三种特征的模型融合后准确率提升至最高的97.4%。五折交叉验证的结果表明多种特征融合后的模型可以有效避免出现单一特征模型对越窑后司岙以及越窑寺龙口样品交叉错判数较多的情况。综合来看基于卷积神经网络探索更多的古陶瓷有效分类特征对于实现古陶瓷的精准溯源是可行的。

关键词：卷积神经网络气泡紫外-可见-近红外光谱 X射线荧光青釉瓷

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清胃泻心汤联合四联疗法治疗胃溃疡临床观察

中国中医药现代远程教育 2024年第5期22卷 121-123页

作者：冯谦薛培培枣庄市中医医院脾胃病科山东枣庄277000 枣庄市立医院肝病科山东枣庄277000

目的探讨清胃泻心汤联合四联疗法对胃溃疡患者效果及对胃黏膜表皮生长因子的影响。方法选取2019年4月—2020年5月在枣庄市中医医院就诊的100例胃溃疡患者,按随机数字表法分为对照组和观察组。对照组45例采用四联疗法,观察组55例采用... 详细信息

目的探讨清胃泻心汤联合四联疗法对胃溃疡患者效果及对胃黏膜表皮生长因子的影响。方法选取2019年4月—2020年5月在枣庄市中医医院就诊的100例胃溃疡患者,按随机数字表法分为对照组和观察组。对照组45例采用四联疗法,观察组55例采用清胃泻心汤联合四联疗法,比较2组胃溃疡患者的疗效、胃黏膜表皮生长因子的变化情况、中医证候积分。结果观察组总有效率为96.36%(53/55),高于对照组的77.78%(35/45),差异有统计学意义(P<0.05);2组胃黏膜表皮生长因子阳性率均显著提高(P<0.05),且观察组阳性率显著高于对照组(P<0.05);2组患者的中医证候积分均低于治疗前(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。结论清胃泻心汤联合四联疗法可有效提高临床效果,减轻幽门螺杆菌感染,有效控制胃溃疡的复发,值得临床推广使用。

关键词：胃溃疡清胃泻心汤胃黏膜表皮生长因子中西医结合疗法

Editorial for Special Issue“Artificial Intelligence Energizes Process Manufacturing”

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Engineering 2021年第9期7卷 1193-1194页

作者： feng qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

Process manufacturing is a pillar of modern economy;it is the dominant mode of production in many industries,including oil and gas,chemicals,nonferrous metals,iron,steel,and *** order to address the problems of resource constraints,energy efficiency,and environmental protection in process manufacturing,it is necessary to develop systems and methods to make process manufacturing more efficient,greener,and *** another perspective,artificial intelligence has been successfully applied in various fields,such as autonomous vehicles,image analysis,robotic manipulators,real-time assistants,and smart recommendation,and has demonstrated its powerful strengths in knowledge representation,cognitive comprehension,and autonomous ***,a deep and tight integration between artificial intelligence and process manufacturing is a promising direction toward“smart process manufacturing.”Smart process manufacturing has become a hot research topic in recent years,and various governments have released strategic plans for smart process manufacturing with the aim of upgrading and transforming the process industry.

关键词： steel autonomous artificial

Improving the off-resonance energy harvesting performance using dynamic magnetic preloading

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Acta Mechanica Sinica 2020年第3期36卷 624-634页

作者： feng qian Shengxi Zhou Lei Zuo Department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

Piezoelectric stack transducers in d33 mode have a much higher mechanical-to-electric energy conversion efficiency compared with d3l mode piezoelectric ***,multilayered piezoelectric stacks usually operate in off-resonance due to the higher stiffness and thereby have a lower power output under low-frequency *** paper proposes to apply the dynamic magnetic pre-loading to a piezoelectric stack transducer to significantly increase the power *** energy harvesting system consists of a multilayered piezoelectric stack with a compliant force amplification frame,a proof mass,and two magnets configured in *** static force-displacement relationship of the magnets is identified from experiments and extended to a dynamic model capable of characterizing the dynamic magnetic *** electromechanical model is developed based on the theoretical derivation and the experimentally identified parameters to predict the voltage outputs under different resistive *** analytical solutions are derived by using the harmonic balance method and show good agreements with the numerical and experimental *** performance of the system is examined and compared with that of the harvester without magnetic *** influences of the distance between the two magnets and the electrical resistive loads on the power output are *** indicate the energy harvesting system with magnetic pre-loading can produce over thousand times more power than the system without magnetic pre-loading at the base excitation of 3 Hz and 0.5 m/s……2,far below the resonance at 243 Hz.

关键词： Energy harvesting Piezoelectric Off-resonance Harmonic balance analysis Magnetic interaction