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Individualized vaginal applicator for stage IIb primary vaginal adenocarcinoma:A case report

World Journal of Clinical Oncology 2024年第8期15卷 1102-1109页

作者： Saijilafu yan.Jun Gu Ai-Wu Huang Chang-fen.Xu Li-Wen Qian Hangzhou Lin'an Traditional Chinese Medicine Hospital Affiliated HospitalHangzhou City UniversityHangzhou 311300Zhejiang ProvinceChina Department of Radiation Oncology Sir Run Run Shaw HospitalHangzhou 310016Zhejiang ProvinceChina Department of the Gynecology and Obstetrics Hangzhou Lin'an Traditional Chinese Medicine HospitalAffiliated HospitalHangzhou City UniversityHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Primary vaginal cancer is rare and most vaginal tumors are metastatic,often arising from adjacent gynecologic *** vaginal cancers are also more common among postmenopausal women and most of these are squamous cell carcinomas,with adenocarcinomas being relatively *** bleeding is the most common clinical manifestation of vaginal *** 70%of vaginal adenocarcinomas are stage I lesions at the time of diagnosis,for which radical surgery is ***,more advanced vaginal cancers are not amenable to radical surgical treatment and have poor clinical *** treatments modes are still being ***,we report a rare case of stage IIb primary vaginal adenocarcinoma for which an individually designed vaginal applicator for after-loading radiotherapy was used to achieve good tumor *** SUMMARY A 62-year-old woman presented to our clinic after 3 months of abnormal postmenopausal vaginal *** examination,computed tomography(CT),and positron emission tomography-CT showed a large mass(about 5 cm)on the anterior vaginal *** biopsy confirmed adenocarcinoma of vaginal *** three cycles of carboplatin plus paclitaxel chemotherapy,the lesion partially *** patient then received external irradiation of 45 gray(gy)in 25 fractions,which further reduced the vaginal lesion,followed by after-loading radiotherapy of 30 gy in 5 fractions with an individually designed vaginal *** months later,magnetic resonance imaging showed a slight thickening CONCLUSION Primary vaginal adenocarcinoma is rare,and prognosis is poor in most vaginal cancers of locally advanced stages,which cannot be treated with radical *** tumor control can be achieved with an individualized vaginal applicator that allows administration of a higher radical dose to the tumor area while protecting normal tissues.

关键词： Primary vaginal adenocarcinoma After-loading radiotherapy Vaginal applicator Tumor control Case report

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Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu yan.-Zhou Su Hai-Bo yan. fen.Hua Lu yan.yan. Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie Xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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面向月面建造的空间站科学实验研究现状与展望

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华中科技大学学报（自然科学版） 2024年第8期52卷 121-129页

作者：周燕王泽开党芬华中科技大学土木与水利工程学院湖北武汉430074 国家数字建造技术创新中心湖北武汉430074

月壤原位成形技术须借助与月面环境相似的空间站实验平台开展月面环境下的月壤运动性质、月壤成形机理、月壤构件服役性能等相关研究,以认识并阐明空间环境下构件成形及服役性能的演变规律.为此,本文梳理了国际空间站及中国空间站相关... 详细信息

月壤原位成形技术须借助与月面环境相似的空间站实验平台开展月面环境下的月壤运动性质、月壤成形机理、月壤构件服役性能等相关研究,以认识并阐明空间环境下构件成形及服役性能的演变规律.为此,本文梳理了国际空间站及中国空间站相关实验研究,系统综述了空间站代表性的颗粒运动实验、材料凝固实验、舱外暴露实验三方面研究进展,根据月面极端环境与空间站环境的差异,指出了目前空间站实验服务于月面建造的局限性,最后展望了空间站开展科学实验研究的发展方向.以期为月面建造中的月壤采集、月壤成形、月壤构件服役评价等提供借鉴与参考.

关键词：月面建造空间站颗粒凝固舱外暴露

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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi yan.Kai Ding Ya-Lu Cui Bai-Nan Zheng Jin Ding Cheng Luo Xin Zhang Wei-fen.Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen Rui-Ying Jiang Zhan Hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian fen. Jie Luo Wu Ning yan.fen.Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

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TiVNbTa难熔高熵合金的吸放氢动力学

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材料工程 2024年第1期52卷 101-107页

作者：龙雁张李敬杨继荣王芬广东省金属新材料制备与成形重点实验室广州510640 华南理工大学机械与汽车工程学院广州510640

通过真空电磁感应悬浮熔炼技术制备TiVNbTa难熔高熵合金试样,采用多通道储氢性能测试仪测试合金的吸放氢性能,并研究该合金的吸(放)氢行为及其动力学机制。结果表明:单相BCC结构的TiVNbTa难熔高熵合金吸氢后生成TiH_(1.971),Nb_(0.696)V... 详细信息

通过真空电磁感应悬浮熔炼技术制备TiVNbTa难熔高熵合金试样,采用多通道储氢性能测试仪测试合金的吸放氢性能,并研究该合金的吸(放)氢行为及其动力学机制。结果表明:单相BCC结构的TiVNbTa难熔高熵合金吸氢后生成TiH_(1.971),Nb_(0.696)V_(0.304)H和Nb_(0.498)V_(0.502)H_(23)种氢化物新相。氢化高熵合金粉末在519,593 K和640 K分别发生氢化物的分解反应,放氢后恢复单相BCC结构,因此TiVNbTa合金的吸氢反应属于可逆反应。该合金在423~723 K温度区间具有较高的吸(放)氢速率,其吸(放)氢动力学模型分别符合Johnson-Mehl-Avrami(JMA)方程和二级速率方程,吸(放)氢的表观活化能Ea分别为-21.87 J/mol和8.67 J/mol。

关键词：难熔高熵合金吸放氢动力学表观活化能可逆反应

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考虑特殊区域的离散区域划分方法

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系统工程与电子技术 2024年第5期46卷 1656-1664页

作者：蔡畅陈建峰闫青丽刘芬西北工业大学航海学院陕西西安710072 西安邮电大学计算机学院陕西西安710121

基于多机器人系统的区域覆盖中的区域划分问题,分析现有区域覆盖任务发现,在任务区域中存在危险区域或优先级更高的特殊区域。针对特殊区域需要分配给最少的机器人的情况,设计了一种基于Morse分解的离散区域划分方法。该方法用放射状Mo... 详细信息

基于多机器人系统的区域覆盖中的区域划分问题,分析现有区域覆盖任务发现,在任务区域中存在危险区域或优先级更高的特殊区域。针对特殊区域需要分配给最少的机器人的情况,设计了一种基于Morse分解的离散区域划分方法。该方法用放射状Morse分解来定义离散任务区域的空间结构,并提出一种改进回溯法来确定最优分割线,以避免分割特殊区域并保持多机器人工作量均衡。仿真给出了在特殊区域分布不同、机器人数量不同的场景下的区域划分结果,并与两种现有算法进行了比较。结果表明,所提方法能够生成稳定的解,有效减少特殊区域的分割,合理分配多机器人的工作量。

关键词：多机器人区域划分特殊区域 Morse分解回溯法

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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyan. Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao yan.Ni Jun-fen.Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFC

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Journal of Energy Chemistry 2024年第2期89卷 422-433,I0010页

作者： Bin Liu Jiawang Li Bowen yan.Qi Wei Xingyu Wen Huarui Xie Huan He Pei Kang Shen Zhi Qun Tian Collaborative Innovation Center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-C)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-HC)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized S-Fe-N-HC features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-C with soft or graphitic carbon *** unique characteristics endow S-Fe-N-HC with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFC performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near fen.(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-C catalysts,providing a new guidance for developing advanced M-N-C catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction Hard carbon Amide based polymer reaction Proton exchange membrane cells

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轻烧温度及球磨工艺对盐湖Mg(OH)_(2)制备镁砂烧结行为影响

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硅酸盐学报 2024年第9期52卷 3003-3011页

作者：徐义彪李亚伟鄢文周芬武汉科技大学省部共建耐火材料与冶金国家重点实验室武汉430081 武汉钢铁集团耐火材料有限责任公司武汉430082

以盐湖氢氧化镁为原料,经650、750、850℃和950℃保温1 h轻烧,随后将轻烧MgO团聚体球磨(0.5、1.0、3.0、5.0、12.0、24.0 h)破碎,压制成型后于1600℃保温3 h制备了烧结镁砂,探讨了轻烧温度及球磨时间对镁砂显微结构及烧结性能的影响。... 详细信息

以盐湖氢氧化镁为原料,经650、750、850℃和950℃保温1 h轻烧,随后将轻烧MgO团聚体球磨(0.5、1.0、3.0、5.0、12.0、24.0 h)破碎,压制成型后于1600℃保温3 h制备了烧结镁砂,探讨了轻烧温度及球磨时间对镁砂显微结构及烧结性能的影响。结果表明:随轻烧温度由650℃升高到850℃,轻烧MgO团聚体内微晶平均尺寸由138 nm增加至180 nm,尽管微晶活性降低,但残余氢氧化镁减少,镁砂致密性呈增大趋势。轻烧温度升高至950℃,MgO微晶平均尺寸迅速增加至320 nm,活性大幅降低,镁砂晶粒尺寸及致密性显著降低。球磨工艺可以有效破坏轻烧MgO团聚体,其平均尺寸球磨0.5 h后由55.90μm迅速降至2.69μm,并随研磨时间增加至12 h逐渐降至1.72μm,但进一步增加球磨时间团聚体尺寸基本不变。MgO团聚体的破坏减少了生坯中大气孔,提高了晶粒接触程度及传质速率,促进了晶粒长大及样品致密化。850℃制备的轻烧MgO球磨12 h压制的生坯,经1600℃保温3 h烧结,可制备平均晶粒30.4μm,体积密度达3.42 g/cm3的致密镁砂。

关键词：盐湖氢氧化镁烧结镁砂轻烧温度晶粒尺寸致密化

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