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The arousal effects of alarm pheromonesand their neural pathways involved

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The arousal effects of alarm pheromonesand their neural path...

Surface-confined persistent luminescence with amplified FRET efficiency for cell-cell communication monitoring

第五届中国西部睡眠医学大会暨重庆市心理卫生协会睡眠医学学术年会

作者： Yu-feng Shao Can Wang Chao-Yu Cong Le Xin Jun-Fan Xie Hai-Lin Chen Guang-Fu Cui Yu-Nong Chen fen-qiu dai Yi-Ping Hou Departments of Neuroscience AnatomyHistologyand EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou University

Objective:Alarm pheromones(APs) are important chemical communicating molecules which signal danger,injury,distress,or the presence of predators to *** is unclear as yet whether APs could wake up rodent during sleep period to avoid dangerousness,through a sufficient sleep is required for their ***:Free Moving Olfaction-Sleep Recording System(FMOSRS) was used to analyze sleepwake states in this ***(collected from mice with electrical stimulation) or their main component(2-sec-butyl-4,5-dihydrothiazole,SBT) were directly delivered to the mouse’s nasal cavity during the period of non-rapid eye movement(NREM) or rapid eye movement(REM) sleep determined by EEC/EMC and digital *** of axons of the Cr(u|¨)eneberg ganglion(CCAxo) or excision of the vomeronasal organ(VNOX) were used to identify the sensory organ of *** addition,microinjection of herpes simplex virus(HSV) was employed to reveal the neural pathways involved in APs-induced ***:(1) Both of APs and SBT deliveries immediately induced an arousal from NREM or REM sleep compared to air in *** SBT-induced awakening efficiency was higher than APs-induced.(2) GG neurons degenerated by GGAxo,and showed an attenuation of the arousal effects of SBT mainly in post-odor stimulate period.(3) VNOX blocked the arousal effects of SBT mainly in odor stimulate period.(4) HSV labeling neurons in the basal forebrain(BF) and locus coeruleus(LC) were found following olfactory bulb(OB) *** percentage of HSV neurons in the LC that also display staining for tyrosine hydroxylase(TH) were 75.70%± 3.20%,whereas,HSV neurons in the BF were not cholinergic ***:Nasal delivery of APs or SBT arouses mice from NREM and REM *** and VNO are sensory organs for detecting APs,because the arousal effects of SBT are blocked by GGAxo and ***,HSV injection into the OB markedly labeled LC neurons,most of them also express *** results suggest that APs ar

关键词： alarm pheromones 2-sec-butyl-4,5-dihydrothiazole non-rapid eye movement sleep rapid eye movement sleep arousal Grueneberg ganglion vomeronasal organ locus coeruleus

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Science China Chemistry 2025年

作者： Ziyun Miao Wenjing dai Yubin Jin Bing Qi Jiayi Chen Lingling qiu Yurong Wei Jie Wang The Key Lab of Health Chemistry&Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering&Materials ScienceSoochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections,and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent ***, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr（ZGGO@ZGGO:Cr） persistent luminescence nanoparticles（PLNPs） with amplified FRET efficiency for the detection of azoreductase（AzoR） that participates in bacterial communication. ZGGO@ZGGO:Cr nanoparticles were functionalized with an azo black hole quencher（ZGGO@ZGGO:Cr-BHQ-3）. Due to the proximity of surface-confined persistent luminescence with the surface-bound BHQ-3,ZGGO@ZGGO:Cr-BHQ-3 exhibited a FRET efficiency up to 1.6 times that of traditional ZGGO:Cr-BHQ-3. Further, the specific catalytic reduction of azo bonds in BHQ-3 by bacterial extracellular AzoR recovers the persistent luminescence of ZGGO@ZGGO:Cr. ZGGO@ZGGO:Cr-BHQ-3 displayed superior sensitivity and speed in detecting extracellular AzoR over ZGGO:Cr-BHQ-3, attributed to its surface-confined persistent luminescence. We found that the peak secretion of AzoR occurs during the exponential growth period of bacteria including S. aureus and E. coli based on the persistent luminescence recovery rate of ZGGO@ZGGO:Cr-BHQ-3. Furthermore, ZGGO@ZGGO:Cr-BHQ-3 was used to probe the communication between different bacterial species. R. palustris is a kind of lycopene-production bacteria. We found that the cohabitation of R. palustris and S. putrefaciens boosted both AzoR secretion and lycopene production. Moreover, the secretion and activity of AzoR positively correlated with lycopene production, suggesting that AzoR may participate in the communication between R. palustris and S. putrefaciens to promote lycopene production. This study offers a robust method to enhance PLNP-based biosensing sensitivity and provides a promising strategy for microbial communication monitoring.

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Application of the Störmer–Verlet-Like Symplectic Method to the Wave Equation

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Chinese Physics Letters 2013年第8期30卷 9-12页

作者： qiu Yu-fen WU Xin School of Science Nanchang UniversityNanchang 330031

A fourth-order three-stage symplectic integrator similar to the second-order Störmer–Verlet method has been proposed and used before[***.28(2011)070201;*** 126(2011)73].Continuing the work initiated in the publications,we investigate the numerical performance of the integrator applied to a one-dimensional wave equation,which is expressed as a discrete Hamiltonian system with a fourth-order central difference approximation to a second-order partial derivative with respect to the space *** is shown that the Störmer–Verlet-like scheme has a larger numerical stable zone than either the Störmer–Verlet method or the fourth-order Forest–Ruth symplectic algorithm,and its numerical errors in the discrete Hamiltonian and numerical solution are also smaller.

关键词： Hamiltonian symplectic numerical

Faber-Krahn Inequality for Robin Problems Involving p-Laplacian

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Acta Mathematicae Applicatae Sinica 2011年第1期27卷 13-28页

作者： qiu-yi dai Yu-xia Fu Department of Mathematics Hunan Normal University Changsha 410081 China Group of Mathematics Dongguan Polytechinic College Dongguan 523808 China

The eigenvalue problem for the p-Laplace operator with Robin boundary conditions is considered in this paper. A Faber-Krahn type inequality is proved. More precisely, it is shown that amongst all the domains of fixed ... 详细信息

关键词： Robin problem p-Laplacian Faber-Krahn type inequality

Existence and Nonexistence of Global Classical Solutions to Porous Medium and Plasma Equations with Singular Sources

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Acta Mathematica Sinica,English Series 2006年第2期22卷 485-496页

作者： qiu Yi dai Li Hui PENG Department of Mathematics Hunan Normal University Department of Mathematics Zhejiang University

Let Ω be a bounded or unbounded domain in R~n. The initial-boundary value problem for the porous medium and plasma equation with singular terms is considered in this paper. Criteria for the appearance of quenching phenomenon and the existence of global classical solution to the above problem are established. Also, the life span of the quenching solution is estimated or evaluated for some domains.

关键词： Initial-boundary value problem Porous medium and plasma equation Quenching phenomenon Global classical solution

Testing Lorentz violation using propagating UHECRs

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Chinese Journal of Astronomy and Astrophysics 2009年第4期9卷 409-421页

作者： Cong-Xin qiu Zi-Gao dai Department of Astronomy Nanjing University Nanjing 210093 China

Lorentz invariant violation （LIV） test is important for studying modem physics. All the known astrophysical constraints either have a very small examinable parameter space or are only suitable for some special theoretical models. Here, we suggest that it is possible to directly detect the time-delay of ultra-high-energy cosmic-rays （UHECRs）. We discuss some difficulties in our method, including the intergalactic magnetic fields. It seems that none of them are crucial, hence this method could give a larger examinable parameter space and a stronger constraint on LIV.

关键词： cosmic rays-gamma rays bursts-ISM magnetic fields-relativity

Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer

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World Journal of Gastroenterology 2007年第43期13卷 5692-5698页

作者： Jian-feng Wang Dong-qiu dai Department of Surgical Oncology the FirstAffiliated Hospital China Medical University Dalian UniversityAffiliated Xinhua Hospital Shenyang 110001 Liaoning ProvinceChina Department of Surgical Oncology the FirstAffiliated Hospital China Medical University Shenyang 110001Liaoning Province China

AIM: To screen out the differentially methylated DNA sequences between gastric primary tumor and metastatic lymph nodes, test the methylation difference of gene PTPRG between primary gastric tumor and metastatic lymph nodes, and test the regulatory function of 5-aza- 2-deoxycytidine which is an agent with suppression on methylation and the level of methylation in gastric cancer cell line. METHODS: Methylated DNA sequences in genome were enriched with methylated CpG islands amplification (MCA) to undergo representational difference analysis (RDA), with MCA production of metastatic lymph nodes as tester and that of primary tumor as driver. The obtained differentially methylated fragments were cloned and sequenced to acquire the base sequence, which was analyzed with bioinformatics. With methylation-specific PCR (MSP) and RT-PCR, methylation difference of gene PTPRG was detected between primary tumor and metastatic lymph nodes in 36 cases of gastric cancer. Methylation of gene PTPRG and its regulated expression were observed in gastric cancer cell line before and after being treated with methylation-suppressive agent. RESULTS: Nineteen differentially methylated sequences were obtained and located at 5' end, exons, introns and 3' end, in which KL59 was observed to be located at 9p21 as the first exon of gene p16 and KL22 to be located at promoter region of PRPRG . KL22, as the probes, was hybridized with driver, tester and 3-round RDA products respectively with all positive signals except with the driver. Significant difference was observed in both methylation rate of gene PTPRG and PTPRG mRNA expression rate between primary tumor and metastatic lymph nodes. Demethylation of gene PTPRG, with recovered expression of PTPRG mRNA, was observed after gastric cancer cell line being treated with methylation-suppressive agent. CONCLUSION: Difference exists in DNA methylation between primary tumor and metastatic lymph nodes of gastric cancer, with MCA-RDA as one of the good anal

关键词： Gastric cancer Methylated CpG islandsamplification Representational difference analysis DNA methylation gene PTPRG

Comparison between P25 and anatase-based TiO_2 quasi-solid state dye sensitized solar cells

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Chinese Science Bulletin 2008年第6期53卷 954-957页

作者： LUO fen WANG LiDuo qiu Yong Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Tsinghua University Beijing 100084China

Pure anatase TiO2 films have been made via hydration of titanium isopropoxide using a sol-gel tech- nique, while mixed TiO2 films which contained both anatase and rutile TiO2 were made from commercial P25 powder. Quasi-solid state dye-sensitized solar cells were fabricated with these two kinds of mesoporous films and a comparison study was carried out. The result showed that the open-circuit photovoltages (Voc) for both kinds of cells were essentially the same, whereas the short-circuit photo- currents (Isc) of the anatase-based cells were about 33% higher than that of the P25-based cells. The highest photocurrent intensity of the anatase-based cell was 6.12 mA/cm2 and that of the P25-based cell was 4.60 mA/cm2. Under an illumination with the light intensity of 30 mW/cm2, the corresponding en- ergy conversion efficiency was measured to be 7.07% and 6.89% for anatase-based cells and P25-based cells, respectively.

关键词：太阳能电池锐钛矿二氧化钛光电流

Microstructure and mechanical properties of friction stir welding joint during post weld heat treatment with different zigzag lines

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Rare Metals 2019年第11期38卷 1070-1077页

作者： Zhi-Li Hu qiu Pang Ming-Liang dai Hubei Key Laboratory of Advanced Technology of Automobile Components Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China School of Mechanical and Electrical Engineering Wuhan Donghu UniversityWuhan 430212China

Zigzag line is a common defect in friction stir welding(FSW) *** formation mechanism of the zigzag line in Al-Cu alloy FSW joint and its influence on the microstructure and mechanical properties during post weld heat treatment(PWHT) were studied by scanning electron microscopy(SEM),microhardness and tensile *** is found that the occurrence of zigzag line for PWHT joint is determined by PWHT process which in nature depends on residual stress and thermal stress of FSW *** optimization of PWHT process to reduce the residual and thermal stress can trigger for the deterioration of mechanical properties of PWHT joints with zigzag *** obvious decrease of tensile properties is observed for T6-450 and T6-495 joints although zigzag line appears in the *** determines the sizes of zigzag line cracks and consequently determines the fracture location and characteristics of FSW joint.

关键词： Friction stir welding Post weld heat treatment Zigzag line Mechanical properties