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Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence

World Journal of Gastroenterology 2018年第5期24卷 641-650页

作者： Pierre Baillet Guillaume Cadiot Marion Goutte felix goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson Université Clermont Auvergne CHU Clermont-Ferrand Service de radiologie CHU de Reims Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm 3iHP CHU Clermont-Ferrand Service d’Hépato-Gastro Entérologie Université Clermont Auvergne Inserm U1071 CH de Bayonne Service d’Hépato-Gastro Entérologie CHU de Reims Service de radiologie CHU Clermont-Ferrand DRCI Unité de Biostatistiques

AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical *** Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high perfor

关键词： Faecal calprotectin Magnetic resonance imaging Postoperative recurrence Crohn’s disease Clermont score Magnetic resonance index of activity

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Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease

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World Journal of Gastroenterology 2016年第21期22卷 5068-5078页

作者： Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte felix goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson Gastroenterology Department University Hospital Estaing 63000 Clermont-Ferrand France DRCI Biostatistics Unit GM Clermont-Ferrand University and Medical Center 63000 Clermont-Ferrand France Pathology Department University Hospital Estaing 63000 Clermont-Ferrand France Microbes Intestine Inflammation and Susceptibility of the Host UMR 1071 Inserm/Universite d'Auvergne USC-INRA 2018 63000 Clermont-Ferrand France Digestive Surgery Department University Hospital Estaing 63000 Clermont-Ferrand France Pediatrics Department University Hospital Estaing 63000 Clermont-Ferrand France

AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative ***: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn’s disease (CD) in our center (1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy (median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of ***: From 205 patients who underwent surgery, 161 patients (follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype (B3) were postoperative risk factors. Previous perianal abscess/fistula (other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management (n = 49/161) prevented clinical (HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence (HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation.

关键词： Crohn’ s disease Postoperative recurrence Endoscopy Prevalence Risk factors

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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The German Energiewende and its roll-out of renewableenergies： An economic perspective

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Frontiers in Energy 2017年第2期11卷 126-134页

作者： Sebastian KREUZ felix MUSGENS Faculty of Mechanical Engineering Electrical and Energy SystemsBrandenburg University of Technology 03046 Cottbus Germany

This paper gives a short overview of the German Energiewende, i.e. the transition of a large and mostly thermal electricity system towards electricity generation from renewable energy source. It discusses both, the motivation of the transitions as future goals and current status. Furthermore, it gives an in-depth view into the changes in economic costs for society as well as electricity price effects, especially for average private households and industrial consumers. It also discusses the benefits of the promotion of renewable energies in Germany.

关键词： electricity system renewable energy cost-benefit analysis

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INFLUENCE OF RARE EARTH DOPING ON MECHANICAL PROPERTY AND MICRO-STRUCTURE OF CHROMIA OXIDE FILM

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Chinese Journal of Mechanical Engineering 2008年第3期21卷 16-19页

作者： JIN Huiming felix Adriana College of Mechanical Engineering Yangzhou University Yangzhou 225005 China College of Materials Engineenng National University of Antiuquia Medellin 23715 Colombia

The isothermal oxidizing kinetics of Co-40Cr alloy and its yttrium ion-implanted samples are studied at 1 000 ℃ in air by thermal-gravity analysis （TGA）. Scanning electronic microscopy （SEM） is used to examine the Cr2O3 oxide film＇s morphology after oxidation. Acoustic emission （AE） method is used in situ for monitoring the cracking and spalling of oxide films formed on both samples during oxidizing and subsequent air-cooling stages. Theoretical model is proposed relating to the film fracture process and is used for analyzing the acoustic emission spectrum both on time domain and on AE-event number domain. It is found that yttrium implantation remarkably reduces the isothermal oxidizing rate of Co-40Cr and improves the anti-cracking and anti-spalling properties of Cr2O3 oxide film. The reasons for the improvement are mainly that the implanted yttrium reduced the grain size of Cr2O3 oxide, increased the high temperature plasticity of oxide film, and remarkably reduced the number and size of Cr2O3/Co-40Cr inteffacial defects.

关键词： Stress Acoustic emission Interface Yttrium Oxidation

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A fast and accurate model for the creation of explosion fragments with improved fragment shape and dimensions

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Defence Technology（防务技术） 2022年第2期18卷 159-169页

作者： David felix Ian Colwill Paul Harris School of Computing Engineering&MathematicsUniversity of BrightonBrightonUK Engineering and Design(Alumni) University of SussexBrightonUK

Explosion models based on Finite Element Analysis(FEA)can be used to simulate how a warhead *** their execution times are *** protection systems need to make very fast predictions,before a fast attacking weapon hits the *** execution times are also needed in real time simulations where the impact of many different computer models is being ***,FEA explosion models are not appropriate for these real-time *** research presented in this paper delivers a fast simulation model based on Mott’s equation that calculates the number and weight of fragments created by an *** addition,the size and shape of fragments,unavailable in Mott’s equation,are calculated using photographic evidence and a distribution of a fragment’s length to its *** model also identifies the origin of fragments on the warhead’s *** results are verified against experimental data and a fast execution time is achieved using uncomplicated simulation *** developed model then can be made available for real-time simulation and fast computation.

关键词： Distribution of fragments Fragment shape Real-time simulation Cylindrical explosion

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Robust Control of a Bevel-Tip Needle for Medical Interventional Procedures

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 244-256页

作者： Surender Hans felix Orlando Maria Joseph Department of Electrical Engineering Indian Institute of Technology RoorkeeRoorkeeUttarakhand 247667India

In minimally invasive surgery, one of the main objectives is to ensure safety and target reaching accuracy during needle steering inside the target organ. In this research work, the needle steering approach is determined using a robust control algorithm namely the integral sliding mode control(ISMC) strategy to eliminate the chattering problem associated with the general clinical scenario. In general, the discontinuity component of feedback control input is not appropriate for the needle steering methodology due to the practical limitations of the driving actuators. Thus in ISMC, we have incorporated the replacement of the discontinuous component using a super twisting control(STC)input due to its unique features of chattering elimination and disturbance observation characteristics. In our study, the kinematic model of an asymmetric flexible bevel-tip needle in a soft-tissue phantom is used to evaluate stability analysis. A comparative study based on the analysis of chattering elimination is executed to determine the performance of the proposed control strategy in real-time needle steering with conventional sliding mode control using vision feedback through simulation and experimental results. This validates the efficacy of the proposed control strategy for clinical needle steering.

关键词： Minimal invasive surgery needle steering nonholonomic system robust control sliding mode control

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Neuronal trafficking as a key to functional recovery in immune-mediated neuropathies

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Neural Regeneration Research 2024年第11期19卷 2331-2332页

作者： felix Kohle Michael Schroeter Department of Neurology University of Cologne and University Hospital CologneCologneGermany

Immune-mediated neuropathies are rare diseases of the peripheral nervous system(PNS),substantially affecting patients’functionality and quality of *** are amenable to immunomodulatory treatments,which in many cases stabilize disease progression,but long-term deficits persist in many *** long-term deficits are particularly observed in monophasic autoimmune neuropathies like Guillain-Barrésyndrome and also in chronic variants,e.g.,chronic inflammatory demyelinating neuropathy(Fadia et al.,2019).

关键词： diseases autoimmune

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LHAASO: A PeVatrons explorer

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Science China(Physics,Mechanics & Astronomy) 2021年第10期64卷 125-126页

作者： felix A.Aharonian Dublin Institute for Advanced Studies Dublin 999015Ireland Max-Planck-Institute for Nuclear Physics Heidelberg 69029Germany

Over the last two decades,we have seen two revolutions in y-ray astronomy-at GeV and TeV *** detection of thousands of GeV and hundreds of TeV y-ray emitters representing more than ten galactic and extragalactic source populations indicates that cosmic ray(CR)factories are distributed throughout the Universe in a wide diversity of forms and scales(see,e.g.,ref.[1]and references therein).These days,we are witnessing a new revolution,this time in the PeV ***,the LHAASO Collaboration[2]reported detection of a dozen ultra-high-energy(UHE;E≥0.1 PeV)y-ray sources,thus opening a new window in the electromagnetic *** y-rays,produced in interactions of charged particles(protons and electrons)with an order of magnitude higher energies,serve as direct messengers of CR PeV atrons.

关键词： spectrum. representing galactic

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Turned Trochoidal Disturbance on a Liquid Jet Surface

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Chinese Journal of Mechanical Engineering 2014年第4期27卷 846-852页

作者： SADIK Shalom KIRZHNER felix KRAMARENKO Denis Department of Mechanical Engineering ORT Braude College Division of Environmental Water and Agricultural Engineering Faculty of Civil and Environmental EngineeringTechnion-IIT Haifa 32000 Israel Biotechnology Engineering ORT Braude College

This paper shows that a turned trochoidal function disturbance may lead to peripheral drops production. The resulting model is used to describe that a turned trochoidal disturbance leads to peripheral drops production on the liquid jet surface without the necessity for superimposed disturbances. The trochoid is a non-unique parametric function. Only non-unique parametric functions disturbances may lead to peripheral drops production. The trochoidal function disturbance is decomposed to Fourier series. Every Fourier element receives an amplification factor in accordance to the Rayleigh inviscid jet model. Peripheral drops are received on the jet surface. The paper shows that all trochoidal disturbance functions, prolate cycloid, cycloid and curtate cycloid have a capability of peripheral drops producing. A limited capability of peripheral drops production is introduced for the trochoidal curtate cycloid. Produced drops size are reduced for increasing the jet velocity and wave number. Smaller drops are also received by transition from the prolate cycloid to curtate cycloid disturbance.

关键词： drops liquid jet trochoidal function

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