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Is hyperexcitability really guilty in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2015年第9期10卷 1413-1415页

作者： felix Leroy Daniel Zytnicki Centre de Neurophysique Physiologie et Pathologie UMR 8119 Université Paris Descartes UMR 8119 45 rue des Saints-Pères 752070 Paris Cedex 06 France

Amyotrophic lateral sclerosis （ALS） is a lethal disorder char- acterized by the gradual degeneration of brainstem and spinal motoneurons as well as lateral cortico-spinal tracts. The onset generally occurs during the adult age except for some juvenile aggressive forms. Until recently, the vast majority of the cases （90%） were deemed sporadic. Mutations in the SOD1 gene have been for a long time the only ones reported in familiar forms of ALS. However, the recent implication of new genes of little known function cast a new view on this disease. C9ORF72, for example, is now recognized to account for 30% of the familial cases. Overall, ALS has been linked to 20 different genes, many also associated with other degenerative diseases （frontotemporal dementia, Alzheimer or ataxia）. Some of these genes are in- volved in RNA maturation （FUS, TARBD）. Clinical observation of human patients and mouse models suggests that all motor pools and motoneurons are not equally affected （see Kanning et al., 2010）. The disease usually starts in motor pools controlling the limbs or in the bulbar area before expanding to other motor pools, with the exception of a few resistant ones （Onuf＇s and oculomotor nuclei）. Within a vulnerable motor pool, motoneu- tons subtypes also exhibit differential vulnerability and follow an orderly degeneration; starting with the motoneurons innervating fast-contracting fatigable motor units （IZF motoneurons） and followed by the ones innervating fast-contractile fatigue-resistant motor units （FR motoneurons）. The motoneurons in- nervating slow motor units （S motoneurons） appear resistant to the disease. Although the mechanisms leading to the orderly degeneration are not known, many hypotheses have been raised （Ilieva et al., 2009）.

关键词： hyperexcitability amyotrophic sclerosis

Influence of Yttrium Ion-Implantation on the Growth Kinetics and Micro-Structure of NiO Oxide Film

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Plasma Science and Technology 2008年第1期10卷 43-45页

作者：靳惠明 Adriana felix Majorri AROYAVE College of Mechanical Engineering Yangzhou University Yangzhou 225009 China College of Materials Engineering National University of Antiuquia Medellin 23715 Colombia

Isothermal and cyclic oxidation behaviours of pure and yttrium-implanted nickel were studied at 1000℃ in air. Scanning electronic microscopy （SEM） and transmission electronic microscopy （TEM） were used to examine the micro-morphology and structure of oxide scales formed on the nickel substrate. It was found that Y-implantation significantly improved the anti- oxidation ability of nickel in both isothermal and cyclic oxidizing experiments. Laser Raman microscopy was also used to study the stress status of oxide scales formed on nickel with and without yttrium. The main reason for the improvement in anti-oxidation of nickel was that Y- implantation greatly reduced the growing speed and grain size of NiO. This fine-grained NiO oxide film might have better high temperature plasticity and could relieve parts of compressive stress by means of creeping, and maintained a ridge character and a relatively low internal stress level. Hence yttrium ion-implantation remarkably enhanced the adhesion of protective NiO oxide scale formed on the nickel substrate.

关键词： ion-implantation laser Raman stress oxide yttrium

Biaxial versus uniaxial strain tuning of single-layer MoS_(2)

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Nano Materials Science 2022年第1期4卷 44-51页

作者： felix Carrascoso Riccardo Frisenda Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)28049Madrid Spain

Strain engineering has arisen as a powerful technique to tune the electronic and optical properties of twod imensional semiconductors like molybdenum disulfide(MoS_(2)).Although several theoretical works predicted that biaxial strain would be more effective than uniaxial strain to tune the band structure of MoS_(2),a direct experimental verification is still missing in the *** we implemented a simple experimental setup that allows to apply biaxial strain through the bending of a cruciform polymer *** used the setup to study the effect of biaxial strain on the differential reflectance spectra of 12 single-layer MoS_(2)flakes finding a redshift of the excitonic features at a rate between-40 meV/%and-110 meV/%of biaxial *** also directly compare the effect of biaxi al and uniaxial strain on the same single-layer MoS_(2)finding that the biaxial strain gauge factor is 2.3 times larger than the uniaxial strain one.

关键词： finding layer gauge

CHLORAD: Eradicating Translocon Components from the Outer Membrane of the Chloroplast

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Molecular Plant 2019年第4期12卷 467-469页

作者： Venkatasalam Shanmugabalaji felix Kessler Laboratory of Plant Physiology University of Neuchatel 2000 Neuchatel Switzerland

Around 100 proteins are produced inside the chloroplast but the vast majority must be imported. These proteins are synthesized in the cytosol as preproteins with cleavable targeting sequences. Several plastid types other than chloroplasts exist. During plant development, one plastid type may be converted to another, a process referred to as plastid transition (Jarvis and Lopez-Juez, 2013). During plastid transitions, proteome remodeling occurs, and one set of imported proteins is replaced by another that is functionally adapted (Kleffmann et al., 2007). Moreover, plastid proteomes are known to be regulated in an environmentdependent fashion, and chloroplasts may respond to changing light conditions by regulating the composition and abundance of photosynthetic complexes.

关键词： CHLORAD Eradicating Translocon Components Outer Membrane Chloroplast

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2022年第8期14卷 53-66页

作者： Hameed Akbar Jun Cao Dongmei Wang Xiao Yuan Manjuan Zhang Saravanakumar Muthusamy Xiaoyu Song Xu Liu felix aikhionbare Xuebiao Yao Xinjiao Gao Xing Liu MOE Key Laboratory for Cellular Dynamics and School of Life Sciences University of Science and Technology of ChinaHefei 230027China CAS Center for Excellence in Molecular and Cell Sciences Anhui Key Laboratory for Cellular Dynamics and Chemical BiologyHefei 230027China Morehouse School of Medicine AtlantaGA 30310USA

Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome *** eukaryotic cells,nuclear envelope breakdown(NEBD)is required for proper chromosome *** a list of mitotic kinases has been implicated in NEBD,how they coordinate their activity to dissolve the nuclear envelope and protein machinery such as nuclear pore complexes was ***,we identified a regulatory mechanism in which Nup62 is acetylated by TIP60 in human cell ***62 is a novel substrate of TIP60,and the acetylation of Lys432 by TIP60 dissolves nucleoporin Nup62-Nup58-Nup54 complex during entry into ***,this acetylation-elicited remodeling of nucleoporin complex promotes the distribution of Nup62 to the mitotic spindle,which is indispensable for orchestrating correct spindle ***,suppression of Nup62 perturbs accurate chromosome segregation during *** results establish a previously uncharacterized regulatory mechanism in which TIP60-elicited nucleoporin dynamics promotes chromosome segregation in mitosis.

关键词： mitosis spindle Nup62 TIP60 acetylation

Argon: a novel therapeutic option to treat neuronal ischemia and reperfusion injuries?

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Neural Regeneration Research 2015年第7期10卷 1043-1044页

作者： felix Ulbrich Ulrich Goebel Department of Anesthesiology and Intensive Care Medicine University Medical CenterFreiburg Germany

Neuronal injury and neuroprotection：Ischemia and reperfusion injuries in neuronal cells such as acute ischemic stroke-represent the third leading cause of death in the *** therapeutic concepts mainly aim to re-establ... 详细信息

关键词： a novel therapeutic option to treat neuronal ischemia and reperfusion injuries MCAO NDS OGD

Towards an Internet-like Power Grid

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 1-11页

作者： Iasonas Kouveliotis-Lysikatos Nikos Hatziargyriou Yanli Liu felix Wu Department of Electrical Engineering and Computer Science KTH-Royal Institute of TechnologyTeknikringen 3310040StockholmSweden School of Electrical and Computer Engineering National Technical University of Athens15773 AthensGreece School of Electrical and Information Engineering Tianjin UniversityTianjin300072China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA

The great challenges faced by modern power systems require a fresh look at the conventional operation paradigm. The significant challenges faced by modern power systems require an innovative method for the conventional operation paradigm. We claim that the decarbonization of the power grid and extensive electrification of numerous sectors of human activity can only be fostered by a self-adaptable and smart power grid that manifests similar qualities to those of the Internet. The Internet is constructed on a layered architecture that facilitates technology innovations and its intelligence is distributed throughout a hierarchy of networks. In this paper, the fundamental differences between the network data flows and power flows are examined, and the basic requirements for an innovative operation paradigm are highlighted. The current power grid is operated in a highly inflexible, centralized manner to meet increased security goals. A new highly flexible, distributed architecture can be realized by distributing the operation responsibility in smaller areas or even in grid components that can make autonomous decisions. The characteristics of such a power grid are presented, and the key features and advances for the on-going transition to a sustainable power system are identified. Finally, a case study on distributed voltage control is presented and discussed.

关键词： Smart grid Internet distributed intelligence decentralized architecture

Analysis of pneumatic atomizer spray profiles

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Particuology 2016年第6期14卷 80-85页

作者： Walter Schafer Simon Rosenkranz felix Brinckmann Cameron Tropea AOM-Systems GmbH Flughafenstrasse 15 64347 Griesheim Germany LacTec GmbH Otto-Hahn-Strasse 6-8 63110 Rodgau Germany Institute of Fluid Mechanics and Aerodynamics Technische Universitat Darmstadt Alarich-Weiss-Strasse 10 64287 Darmstadt Germany Graduate School of Computational Engineering Technische Universitat Darmstadt Dolivostrasse 15 64287 Darmstadt Germany

Our objective is to analyze the atomization processes of a pneumatic atomizer by measuring the size and velocity distributions of droplets in a liquid paint spray. The droplet size and velocity distributions have been determined at different axial positions in the spray; a mathematical description of how these quan- tities vary throughout the spray is then proposed. Additionally, the relative number density of droplets and the relative local mass flux are estimated.

关键词： Pneumatic atomizer Spray Measurement Droplet size profile Droplet velocity profile Time-shift

Changes in Soil C and N Contents and Mineralization Across a Cultivation Chronosequence of Paddy Fields in Subtropical China

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Pedosphere 2005年第5期15卷 554-562页

作者： LI Zhong-Pei ZHANG Tao-Lin HAN Feng-Xiang P. felix-HENNINGSEN Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Diagnostic Instrumentation and Analysis Laboratory Mississippi State University Starkville MS 39759 （USA） Institute of Soil Science and Soil Conservation Justus-Liebig-University Giessen D-35392 （Germany）

Dynamics of soil organic matter in a cultivation chronosequence of paddy fields were studied in subtropical *** of soil organic matter was determined by measuring CO2 evolution from soil during 20 days of laboratoryincubation. In the first 30 years of cultivation, soil organic C and N contents increased rapidly. After 30 years, 0-10 cmsoil contained 19.6 g kg-1 organic C and 1.62 g kg-1 total N, with the corresponding values of 18.1 g kg-1 and 1.50g kg-1 for 10-20 cm, and then remained stable even after 80 years of rice cultivation. During 20 days incubation themineralization rates of organic C and N in surface soil (0-10 cm) ranged from 2.2% to 3.3% and from 2.8% to 6.7%,respectively, of organic C and total N contents. Biologically active C size generally increased with increasing soil organicC and N contents. Soil dissolved organic C decreased after cultivation of wasteland to 10 years paddy field and thenincreased. Soil microbial biomass C increased with number of years under cultivation, while soil microbial biomass Nincreased during the first 30 years of cultivation and then stabilized. After 30 years of cultivation surface soil (0-10 cm)contained 332.8 mg kg-1 of microbial biomass C and 23.85 mg kg-1 of microbial biomass N, which were 111% and 47%higher than those in soil cultivated for 3 years. It was suggested that surface soil with 30 years of rice cultivation insubtropical China would have attained a steady state of organic C content, being about 19 g kg-1.

关键词： cultivation chronosequence mineralization paddy fields soil C soil N