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Interventional pulmonology for chronic inflammatory airway diseases

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 171-181页

作者： Han Yang Si Chen Jiayuan Sun felix J.f.Herth Department of Respiratory and Critical Care Medicine Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Respiratory Endoscopy Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Engineering Research Center of Respiratory Endoscopy Shanghai 200030China Pneumology and Critical Care Medicine ThoraxklinikUniversity of HeidelbergHeidelberg 69126Germany Translational Lung Research Center Heidelberg German Center for Lung ResearchHeidelberg 69126Germany

Chronic inflammatory airway diseases,such as chronic bronchitis,chronic obstructive pulmonary disease,emphysema,and bronchial asthma,pose significant healthcare *** treatments offer promise as valuable complements to the optimal medical therapy recommended by the Global Initiative for Chronic Obstructive Lung Disease guideline and the Global Initiative for Asthma *** directly accessing the airways,these minimally invasive procedures enable precise *** encompass a wide range of techniques including bronchial thermoplasty and targeted lung denervation for both chronic obstructive pulmonary disease and severe asthma,bronchoscopic lung volume reduction(including the use of endobronchial valves,coils,and bronchoscopic thermal vapor ablation),airway bypass and peripheral stent placement for emphysema,bronchial rheoplasty and spray cryotherapy for chronic bronchitis,and other emerging *** interventional treatments aim to improve patients’symptoms by reducing lung volume,alleviating hyperinflation,eliminating vagal innervation,disrupting hyperplastic goblet cells and thus reducing excessive mucus secretion,and weakening submucosal smooth *** review highlights the potential advantages of interventional treatments for chronic inflammatory airway diseases and discusses relevant techniques tailored to specific disease *** overall aim is to assist interventional pulmonologists in selecting the most appropriate techniques for individual patients.

关键词： Chronic inflammatory airway disease Chronic obstructive pulmonary disease Asthma Emphysema Bronchoscopic lung volume reduction Targeted lung denervation

How does the‘environment’come to the person?The‘ecology of the person’and addiction

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World Journal of Psychiatry 2021年第11期11卷 915-936页

作者： felix Tretter Henriette loeffler-Stastka Bertalanffy Center for the Study of Systems Science Vienna 1040Austria Department of Psychoanalysis and Psychotherapy Medical University ViennaVienna 1090Austria

Currently,psychiatry lacks a field that can be called“theoretical psychiatry”,which uses theoretical concepts and explanatory models:The main stream of research is to collect data of all kinds in the hope that the computational Big Data approach will shed a bright light on the black box of mental ***,the biology-based Research Domain Criteria of the National Institute of Mental Health have been ***,as philosophical analyses of concepts and methods have shown,several epistemological gaps stand in the way of a consistent multilevel understanding of mental ***,the implicit ontological problems in the biological reduction of the psychosocial level and in the integration of so-called hard and soft disciplines are mostly left *** a consequence,a non-reductive psychological theory of mental disorders is sought that also integrates correlating biological and sociological *** this context,one example of promising nonreductive psychiatric research is the option of systems/network *** possibilities for integrating different psychological perspectives are highlighted for the field of addiction research and treatment,where pragmatic behaviorist approaches dominate over the theorybased practice of *** comparing the theoretical constructs of these two approaches,the relevance of the concept of“(social)environment”as the wealth of influential sociocultural factors is discussed at levels superior to the interpersonal micro-level,namely the organizational meso-and societal macro level,which is not sufficiently considered in current *** this basis of argumentation,the usefulness of grounding and framing psychiatry through the field of ecological sciences,especially human ecology,is ***,to this end,an outline of an ecological model of mental health and illness is presented.

关键词： Systems/network psychopathology Theoretical psychiatry Ecology of the person Psychoanalytic object relations theory Addiction Mind Resilience

The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： francesco Chierigo Rocco Simone flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian fred Saad Marcus Graefen Michele Gallucci Alberto Briganti francesco Montorsi felix K.H.Chun Shahrokh f.Shariat Alessandro Antonelli Giovanni Guano Guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

Predicting Purchasing Behavior on E-Commerce Platforms: A Regression Model Approach for Understanding User features that Lead to Purchasing

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International Journal of Communications, Network and System Sciences 2024年第6期17卷 81-103页

作者： Abraham Jallah Balyemah Sonkarlay J. Y. Weamie Jiang Bin Karmue Vasco Jarnda felix Jwakdak Joshua College of Computer Science and Engineering Hunan University Changsha China Department of Health Inspection and Quarantine Xiangya School of Public Health Central South University Changsha China

This research introduces a novel approach to improve and optimize the predictive capacity of consumer purchase behaviors on e-commerce platforms. This study presented an introduction to the fundamental concepts of the logistic regression algorithm. In addition, it analyzed user data obtained from an e-commerce platform. The original data were preprocessed, and a consumer purchase prediction model was developed for the e-commerce platform using the logistic regression method. The comparison study used the classic random forest approach, further enhanced by including the K-fold cross-validation method. Evaluation of the accuracy of the model’s classification was conducted using performance indicators that included the accuracy rate, the precision rate, the recall rate, and the f1 score. A visual examination determined the significance of the findings. The findings suggest that employing the logistic regression algorithm to forecast customer purchase behaviors on e-commerce platforms can improve the efficacy of the approach and yield more accurate predictions. This study serves as a valuable resource for improving the precision of forecasting customers’ purchase behaviors on e-commerce platforms. It has significant practical implications for optimizing the operational efficiency of e-commerce platforms.

关键词： E-Commerce Platform Purchasing Behavior Prediction Logistic Regression Algorithm

Improving the operational stability of perovskite solar cells with cesium-doped graphene oxide interlayer

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Journal of Energy Chemistry 2024年第9期96卷 483-490页

作者： Masaud Almalki Katerina Anagnostou Konstantinos Rogdakis felix T.Eickemeyer Mostafa Othman Minas M.Stylianakis Dimitris Tsikritzis Anwar Q.Alanazi Nikolaos Tzoganakis Lukas Pfeifer Rita Therisod Xiaoliang Mo Christian M.Wolff Aïcha Hessler-Wyser Shaik M.Zakeeruddin Hong Zhang Emmanuel Kymakis Michael Grätzel Laboratory of Photonics and Interfaces École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Electrical and Computer Engineering Hellenic Mediterranean UniversityHeraklionCrete 71410Greece Institute of Electrical and Microengineering(IEM)Photovoltaics and Thin-film Electronics Laboratory(PV-Lab) École Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel 2000Switzerland Department of Nursing Faculty of Health SciencesHellenic Mediterranean UniversityCrete 71410Greece Centre Interdisciplinaire de Microscopie Electronique École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland future Energy Technology Institute King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Saudi Arabia State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionInstitute of OptoelectronicsDepartment of Materials ScienceFudan UniversityShanghai 200433China

Perovskite solar cells(PSCs)have made great advances in terms of power conversion efficiency(PCE),yet their subpar stability continues to hinder their *** interface between the perovskite layer and the charge-carrier transporting layers plays a crucial role in undermining the stability of *** this work,we propose a strategy to stabilize high-performance PSCs with PCE over 23%by introducing a cesium-doped graphene oxide(GO-Cs)as an interlayer between the perovskite and hole-transporting *** GO-Cs treated PSCs exhibit excellent operational stability with a projected T80(the time where the device PCE reduces to 80%of its initial value)of 2143 h of operation at the maximum powering point under one sun illumination.

关键词： Perovskite solar cells Doped graphene oxide Graphene related material Long-term operational stability

Quantifying forest structural diversity based on large-scale inventory data:a new approach to support biodiversity monitoring

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forest Ecosystems 2018年第4期5卷 472-485页

作者： felix Storch Carsten f.Dormann Jurgen Bauhus Chair of Silviculture Tennenbacherstr 4University of FreiburgD-79085 FreiburgGermany Chair of Biometry Tennenbacherstr.4University of FrelburgD-79085FreiburgGermany

Background: The importance of structurally diverse forests for the conservation of biodiversity and provision of a wide range of ecosystem services has been widely recognised. However, tools to quantify structural diversity of forests in an objective and quantitative way across many forest types and sites are still needed, for example to support biodiversity monitoring. The existing approaches to quantify forest structural diversity are based on small geographical regions or single forest types, typically using only small data ***: Here we developed an index of structural diversity based on National forest Inventory(NfI) data of BadenWurttemberg, Germany, a state with 1.3 million ha of diverse forest types in different ownerships. Based on a literature review, 11 aspects of structural diversity were identified a priori as crucially important to describe structural diversity. An initial comprehensive list of 52 variables derived from National forest Inventory(NfI) data related to structural diversity was reduced by applying five selection criteria to arrive at one variable for each aspect of structural diversity. These variables comprise 1) quadratic mean diameter at breast height(DBH), 2) standard deviation of DBH, 3) standard deviation of stand height, 4) number of decay classes, 5) bark-diversity index, 6) trees with DBH ≥ 40 cm, 7) diversity of flowering and fructification, 8) average mean diameter of downed deadwood, 9) mean DBH of standing deadwood, 10) tree species richness and 11) tree species richness in the regeneration layer. These variables were combined into a simple,additive index to quantify the level of structural diversity, which assumes values between 0 and 1. We applied this index in an exemplary way to broad forest categories and ownerships to assess its feasibility to analyse structural diversity in large-scale forest ***: The forest structure index presented here can be derived in a similar way from standard inventor

关键词： Stand structure Structural diversity Structural diversity index Large-scale forest inventory Angle count sampling

Light metal compound casting

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Science China(Technological Sciences) 2009年第1期52卷 46-51页

作者： Konrad J. M. PAPIS Joerg f. loeffler Peter J. UGGOWITZER ETH Zurich Laboratory of Metal Physics and Technology Wolfgang-Pauli-Str. 10

‘Compound casting’simplifies joining processes by directly casting a metallic melt onto a solid metal substrate. A continuously metallurgic transition is very important for industrial applications, such as joint structures of spaceframe constructions in transport industry. In this project, ‘compound casting’ of light metals is investigated, aiming at weight-saving. The substrate used is a wrought aluminium alloy of type AA5xxx, containing magnesium as main alloying element. The melts are aluminium alloys, containing various alloying elements (Cu, Si, Zn), and magnesium. By replacing the natural oxygen layer with a zinc layer, the inherent wetting difficulties were avoided, and compounds with flawless interfaces were successfully produced (no contraction defects, cracks or oxides). Electron microscopy and EDX investigations as well as optical micrographs of the interfacial areas revealed their continu- ously metallic constitution. Diffusion of alloying elements leads to heat-treatable microstructures in the vicinity of the joining interfaces in Al-Al couples. This permits significant variability of mechanical properties. Without significantly cutting down on wettability, the formation of low-melting intermetallic phases (Al3Mg2 and Al12Mg17 IMPs) at the interface of Al-Mg couples was avoided by applying a protective coating to the substrate.

关键词： compound casting aluminium alloys magnesium alloys interface structure

Light metal compound casting

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中国科学:技术科学 2010年第4期 435-435页

作者： Konrad J.M.PAPIS Joerg f.loeffler Peter J.UGGOWITZER ETH Zurich Laboratory of Metal Physics and Technology

"Compound casting"simplifies joining processes by directly casting a metallic melt onto a solid metal substrate.A continuously metallurgic transition is very important for industrial applications,such as joint structures of spaceframe constructions in transport *** this project,"compound casting"of light metals is investigated,aiming at *** substrate used is a wrought aluminium alloy of type AA5xxx,containing magnesium as main alloying element. The melts are aluminium alloys,containing various alloying elements(Cu,Si,Zn) ,and *** replacing the natural oxygen layer with a zinc layer,the inherent wetting difficulties were avoided,and compounds with flawless interfaces were successfully produced(no contraction defects,cracks or oxides) .Electron microscopy and EDX investigations as well as optical micrographs of the interfacial areas revealed their continuously metallic constitution. Diffusion of alloying elements leads to heat-treatable microstructures in the vicinity of the joining interfaces in Al-Al *** permits significant variability of mechanical *** significantly cutting down on wettability,the formation of low-melting intermetallic phases(Al3Mg2 and Al12Mg17 IMPs) at the interface of Al-Mg couples was avoided by applying a protective coating to the substrate.

关键词： compound casting aluminium alloys magnesium alloys interface structure

Editorial for a special issue on graphene and 2D alternative materials:from preparation to potential applications

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Nano Materials Science 2022年第1期4卷 1-2页

作者： Pablo Ares felix Zamora Departamento de fisica de la Materia Condensada and Condensed Matter Physics Center(IfIMAC) Universidad Autonoma de Madrid Madrid28049Spain Departamento de Quimica Inorganica Condensed Matter Physics Center(IFIMAC)and Institute for Advanced Research in Chemical Sciences(IAdChem)Universidad Autonoma de MadridMadrid28049Spain Instituto Madrileno de Estudios Avanzados en Nanociencia(IMDEA-Nanociencia) CantoblancoMadrid28049Spain

The isolation of graphene and subsequent studies showed that obtaining atomically thin crystalline sheets was feasible and possessed extraordinary *** result opened the door to an entirely new family of materials known as two-dimensional or 2D *** in this field is intense:the emergence of new 2D materials,the properties of their combinations and the ability of graphene to reinvent itself,showing novel and exciting properties,make it likely that this field will continue to be one of the leading topics of materials science and condensed matter physics.

关键词： preparation entirely crystalline