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Non-invasive imaging of pathological scars using a portable handheld two-photon microscope

Chinese Medical Journal 2024年第3期137卷 329-337页

作者： yang Han Yuxuan Sun feili yang Qingwu Liu Wenmin Fei Wenzhuo Qiu Junjie Wang Linshuang Li Xuejun Zhang Aimin Wang Yong Cui Graduate School Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China College of Engineering Peking UniversityBeijing 100871China School of Chemical Biology and Biotechnology State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Department of Dermatology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Future Technology Peking UniversityBeijing 100871China Beijing Transcend Vivoscope Biotech Beijing 100085China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230001China Institute of Dermatology Anhui Medical UniversityHefeiAnhui 230001China School of Electronics Peking UniversityBeijing 100871China

Background:Pathological scars are a disorder that can lead to various cosmetic,psychological,and functional problems,and no effective assessment methods are currently *** and treatment of pathological scars are based on cutaneous manifestations.A two-photon microscope(TPM)with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in *** study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar ***:Fifteen patients with pathological scars and three healthy controls were *** was performed using a portable handheld *** indexes were extracted from two dimensional(2D)and three dimensional(3D)perspectives,including collagen depth,dermo-epidermal junction(DEJ)contour ratio,thickness,orientation,and occupation(proportion of collagen fibers in the field of view)of *** depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D *** assessed index differences between scar and normal skin and changes before and after ***:Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen *** indexes were employed to distinguish between normal skin and scar *** significant differences were found in average depth(t=9.917,P<0.001),thickness(t=4.037,P<0.001),occupation(t=2.169,P<0.050),orientation of collagen(t=3.669,P<0.001),and the DEJ contour ratio(t=5.105,P<0.001).Conclusions:Use of portable handheld TPM can distinguish collagen from skin tissues;thus,it is more suitable for scar imaging than reflectance confocal ***,a TPM may be an auxiliary tool for scar treatment selection and assessing treatment efficacy.

关键词： Scars Two-photon microscope Two-photon excitation fluorescence Second harmonic generation microscopy

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Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides

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Nano Research 2024年第3期17卷 1473-1481页

作者： Yue Ouyang Xiaoxiao Li Jiexin Zhu Wei Zong Yuhang Dai Xuan Gao Wei Zhang Shengyuan yang Roohollah Bagherzadeh feili Lai Yue-E Miao Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Advanced Fibrous Materials LAB Institute for Advanced Textile Materials and Technologies(ATMT)School of Advanced Materials and ProcessesAmirkabir University of TechnologyTehran 15914Iran Christopher Ingold Laboratory Department of ChemistryUniversity College London20 Gordon StreetLondon WC1H 0AJUK Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)***,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur *** the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur ***,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume *** expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 ***,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions.

关键词： interface-induced polymerization electrospun porous nanofibers lithium-sulfur(Li-S)batteries high sulfur loading lithium polysulfides(LiPSs)immobilization

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Shear behavior and off-fault damage of saw-cut smooth and tension-induced rough joints in granite

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1216-1230页

作者： Fanzhen Meng feili Wang Louis Ngai Yuen Wong Jie Song Muzi Li Chuanqing Zhang Liming Zhang College of Science Qingdao University of TechnologyQingdao266033China Department of Earth Sciences The University of Hong KongPokfulamHong KongChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Cooperative Innovation Center of Engineering Construction and Safety Shandong Peninsula Blue Economic Zone Qingdao266033China

The damage of rock joints or fractures upon shear includes the surface damage occurring at the contact asperities and the damage beneath the shear surface within the host *** latter is commonly known as off-fault damage and has been much less investigated than the surface *** main contribution of this study is to compare the results of direct shear tests conducted on saw-cut planar joints and tension-induced rough granite joints under normal stresses ranging from 1 MPa to 50 *** shear-induced off-fault damages are quantified and compared with the optical microscope *** results clearly show that the planar joints slip stably under all the normal stresses except under 50 MPa,where some local fractures and regular stick-slip occur towards the end of the *** post-peak stress drop and stick-slip occur for all the rough *** residual shear strength envelopes for the rough joints and the peak shear strength envelope for the planar joints almost *** root mean square(RMS)of asperity height for the rough joints decreases while it increases for the planar joint after shear,and a larger normal stress usually leads to a more significant decrease or increase in ***,the extent of off-fault damage(or damage zone)increases with normal stress for both planar and rough joints,and it is restricted to a very thin layer with limited micro-cracks beneath the planar joint *** comparison,the thickness of the damage zone for the rough joints is about an order of magnitude larger than that of the planar joints,and the coalesced micro-cracks are generally inclined to the shear direction with acute *** findings obtained in this study contribute to a better understanding on the frictional behavior and damage characteristics of rock joints or fractures with different roughness.

关键词： Planar joint Rough joint Shear behavior Off-fault damage Micro-cracks

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d-d Orbital coupling induced by crystal-phase engineering assists acetonitrile electroreduction to ethylamine

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Journal of Energy Chemistry 2024年第2期89卷 216-225,I0006页

作者： Honggang Huang Yao Chen Hui Fu Cun Chen Hanjun Li Zhe Zhang feili Lai Shuxing Bai Nan Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122JiangsuChina Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina

The d-d orbital coupling induced by crystal-phase engineering can effectively adjust the electronic structure of electrocatalysts,thus showing significant catalytic performance,while it has been rarely explored in electrochemical acetonitrile reduction reaction(ARR)to ***,we successfully realize the structural transformation of Pd Cu metallic aerogels(MAs)from face-centered cubic(FCC)to body-centered cubic(BCC)through annealing ***,the BCC Pd Cu MAs exhibit excellent ARR performance with high ethylamine selectivity of 90.91%,Faradaic efficiency of 88.60%,yield rate of 316.0 mmol h^(-1)g^(-1)_(Pd+Cu)and long-term stability for consecutive electrolysis within 20 h at-0.55 V *** hydrogen electrode,outperforming than those of FCC Pd Cu *** the membrane electrode assembly system,BCC Pd Cu MAs also demonstrate excellent ethylamine yield rate of 389.5 mmol h^(-1)g^(-1)_(Pd+Cu).Density functional theory calculation reveals that the d-d orbital coupling in BCC Pd Cu MAs results in an evident correlation effect for the interaction of Pd and Cu sites,which boosts up the Cu sites electronic activities to enhance ARR *** work opens a new route to develop efficient ARR electrocatalysts from the perspective of crystalline structure transformation.

关键词： d-d Orbital coupling Crystal-phase engineering Metallic aerogels Acetonitrile electroreduction reaction Ethylamine

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一种基于安装式标准电能表的智能电能表误差在线检测比对方法研究

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电测与仪表 2022年第3期59卷 181-186页

作者：杨芾藜侯兴哲国网重庆市电力公司营销服务中心重庆401123 国网重庆电力公司电力科学研究院重庆401123

文章针对不同厂家生产的单相智能电能表在线使用时计量准确性问题,在相同实际负载条件下进行相关试验。通过一种新型的高精度单相安装式标准电能表模拟用户实际使用情况,采用多种不同功率的负载对单相智能电能表在实际运行中的基本误差... 详细信息

文章针对不同厂家生产的单相智能电能表在线使用时计量准确性问题,在相同实际负载条件下进行相关试验。通过一种新型的高精度单相安装式标准电能表模拟用户实际使用情况,采用多种不同功率的负载对单相智能电能表在实际运行中的基本误差、电量走字误差进行测试。与实验室参比条件下检定装置测试的数据进行比对,验证分析单相智能电能表在参比条件下检定装置测试数据的可靠性和一致性。通过实验数据分析表明,该方法可以真实反映单相智能电能表在实际使用中基本误差和电量误差的情况,可以作为单相智能电能表在线检测的一种新的方法。

关键词：安装式标准电能表误差在线检测电量在线比对

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单相智能电能表现场检测与寿命评估

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电测与仪表 2022年第4期59卷 41-48页

作者：杨芾藜郑可邹波张兵周谭杰国网重庆电力公司营销服务中心重庆401123

文章针对现场使用中已经达到设计使用寿命的单相智能电能表,选取使用环境不同的多个现场网点,采用现场校验仪、现场检定装置、精密稳定电源等设备对运行中的单相智能电能表进行现场误差检测、现场日计时检测、现场电量比对等测试;然后... 详细信息

文章针对现场使用中已经达到设计使用寿命的单相智能电能表,选取使用环境不同的多个现场网点,采用现场校验仪、现场检定装置、精密稳定电源等设备对运行中的单相智能电能表进行现场误差检测、现场日计时检测、现场电量比对等测试;然后将单相智能电能表拆回实验室在参比条件下通过电能表检定装置进行检测。将两种测试数据和单相智能电能表挂网前的测试数据进行比对,分析单相智能电能表在达到设计使用寿命后各项功能的衰减情况,评估单相智能电能表继续延寿运行的可靠性。通过对测试数据的分析表明,可对达到使用寿命的智能电能表进行适当延期,但延期的时间要根据智能电能表不同的安装使用环境分别进行评估。

关键词：单相智能电能表现场检测单相智能电能表延寿安装式标准电能表

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Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA

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Chinese Medical Journal 2024年第6期137卷 729-736页

作者： Lin Yuan Zhiying Liu Xin Zhang feili Wei Shan Guo Na Guo Lifeng Liu Zhenglai Ma Yunxia Ji Rui Wang Xiaofan Lu Zhen Li Wei Xia Hao Wu Tong Zhang Bin Su Beijing Key Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Background:Total human immunodeficiency virus(HIV)DNA and integrated HIV DNA are widely used markers of HIV *** digital polymerase chain reaction(ddPCR)can be used for absolute quantification without needing a standard ***,we developed duplex ddPCR assays to detect and quantify total HIV DNA and integrated HIV ***:The limit of detection,dynamic ranges,sensitivity,and reproducibility were evaluated by plasmid constructs containing both the HIV long terminal repeat(LTR)and human CD3 gene(for total HIV DNA)and ACH-2 cells(for integrated HIV DNA).Forty-two cases on stable suppressive antiretroviral therapy(ART)were assayed in total HIV DNA and integrated HIV *** coefficient analysis was performed on the data related to DNA copies and cluster of differentiation 4 positive(CD4^(+))T-cell counts,CD8^(+)T-cell counts and CD4/CD8 T-cell ratio,*** assay linear dynamic range and lower limit of detection(LLOD)were also ***:The assay could detect the presence of HIV-1 copies 100%at concentrations of 6.3 copies/reaction,and the estimated LLOD of the ddPCR assay was 4.4 HIV DNA copies/reaction(95%confidence intervals[CI]:3.6-6.5 copies/reaction)with linearity over a 5-log_(10)-unit range in total HIV DNA *** the integrated HIV DNA assay,the LLOD was 8.0 copies/reaction(95%CI:5.8-16.6 copies/reaction)with linearity over a 3-log 10-unit *** HIV DNA in CD4^(+)T cells was positively associated with integrated HIV DNA(r=0.76,P<0.0001).Meanwhile,both total HIV DNA and integrated HIV DNA in CD4^(+)T cells were inversely correlated with the ratio of CD4/CD8 but positively correlated with the CD8^(+)T-cell ***:This ddPCR assay can quantify total HIV DNA and integrated HIV DNA efficiently with robustness and *** can be readily adapted for measuring HIV DNA with non-B clades,and it could be beneficial for testing in clinical trials.

关键词： Human immunodeficiency virus HIV Integrated HIV-1 DNA Total HIV DNA Droplet digital polymerase chain reaction HIV reservoir Antiretroviral therapy

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核电站用重要厂用水泵试验台架的选择

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水泵技术 2019年第A1期 70-76页

作者：杨飞力上海阿波罗机械股份有限公司上海201401

从泵设计角度,根据不同项目参数及布置,分析重要厂用水泵在核电现场运行与厂内试验的差异及重要厂用水泵试验的布置需求,根据实践经验及结果,提出重要厂用水泵厂内试验的优选方案。

关键词：核电站用泵重要厂用水泵试验优选

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40.5kV充气柜的智能化思考

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电工技术 2024年第S1期 299-301页

作者：程飞骊许继电气股份有限公司河南许昌461000

由于开关柜的结构具有密封性、绝缘性特点,断路器在柜内的试验位置并不明确,在运行过程中,很有可能会发生断路器动静触头接触不良的情况,从而引发运行故障,不利于电网安全、稳定的运行。如何提高40.5kV充气柜智能化水平,是该领域研究的... 详细信息

由于开关柜的结构具有密封性、绝缘性特点,断路器在柜内的试验位置并不明确,在运行过程中,很有可能会发生断路器动静触头接触不良的情况,从而引发运行故障,不利于电网安全、稳定的运行。如何提高40.5kV充气柜智能化水平,是该领域研究的热点。为此,对40.5kV充气柜的智能化方案设计进行了分析与探讨。

关键词： 40.5kV充气柜智能化研究

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整体感知视域下的英语小说导读课设计探究——以The Canterville Ghost为例

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英语教师 2024年第1期24卷 26-29页

作者：邹飞丽广东肇庆中学广东肇庆526060

介绍整体感知及整体感知视域下的导读课。以《黑布林英语阅读》高二年级The Canterville Ghost为例,以整体感知为导向,探索英语小说导读课设计,即明确导读课的教学内容,制订导读课的教学目标(学习理解、应用实践、迁移创新),梳理导读课... 详细信息

介绍整体感知及整体感知视域下的导读课。以《黑布林英语阅读》高二年级The Canterville Ghost为例,以整体感知为导向,探索英语小说导读课设计,即明确导读课的教学内容,制订导读课的教学目标(学习理解、应用实践、迁移创新),梳理导读课教学活动设计要点(导入、过程、评价),从而帮助学生养成自主阅读、规划阅读任务的习惯。

关键词：整体感知英语小说导读课

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