检索结果-南通市图书馆

Pollen-Inspired Photonic Barcodes with Prickly Surface for Multiplex Exosome Capturing and Screening

在线全文

学校读者我要写书评

暂无评论

Research 2023年第1期2022卷 111-119页

作者： Ning Li feika bian Xiaowei Wei Lijun Cai Hongcheng Guu Yuanjin Zhao Luoran Shang Department of Rheumatology and Immunology Institute of Translational MedicineNanjing Drum Tower HospitalSchoolof Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine VisionAnd Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Shanghai Xuhui Central Hospital Zhongshan-Xuhui HospitalAnd the Shanghai Key Laboratory of Medical EpigeneticsThe International Co-Laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghaiChina

Exosomes,which play an important role in intercellular communication,are closely related to the pathogenesis of ***,their effective capture and multiplex screening are still ***,inspired by the unique structure of pollens,we present novel photonic crystal(PhC)barcodes with prickly surface by hydrothermal synthesis for multiplex exosome capturing and *** pollen-inspired PhC barcodes are imparted with extremely high specific surface area and excellent prickly surface nanostructures,which can improve the capture rate and detection sensitivity of *** the internal periodic structures are kept during the hydrothermal synthesis process,the pollen-inspired PhC barcodes exhibit obvious and stable structural colors for identification,which enables multiplex detection of ***,the pollen-inspired PhC barcodes can not only effectively capture and enrich cancer-related exosomes but also support multiplex screening of exosomes with high *** features make the prickly PhC barcodes ideal for the analysis of exosomes in medical diagnosis.

关键词： Exosome enable synthesis

Stomatocyte structural color-barcode micromotors for multiplex assays

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2020年第3期7卷 644-651页

作者： Lijun Cai Huan Wang Yunru Yu feika bian Yu Wang Keqing Shi Fangfu Ye Yuanjin Zhao Precision Medicine Center Laboratory The First Affiliated Hospital of Wenzhou Medical University Wenzhou Institute University of Chinese Academy of Sciences State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Artificial micromotors have a demonstrated value in the biomedical area. Attempts to develop this technology tend to impart micromotors with novel functions to improve the values. Herein, we present novel structural color-barcode micromotors for the multiplex assays. We found that, by rapidly extracting solvent and assembling monodispersed nanoparticles in droplets, it could form stomatocyte colloidal crystal clusters, which not only showed striking structural colors and characteristic reflection peaks due to their ordered nanoparticles arrangement, but also provided effective cavities for the integration of functional elements. Thus, the micromotors with catalysts or magnetic elements in their cavities, as well as with the corresponding structural color coding, could be achieved by using the platinum and ferric oxide dispersed pre-gel to fill and duplicate the stomatocyte colloidal crystal clusters. We have demonstrated that the self-movement of these structural color-barcode micromotors could efficiently accelerate the mixing speed of the detection sample and greatly increase the probe–target interactions towards faster and more sensitive single or multiplex detection, and the magnetism of these barcode micromotors enables the flexible collection of the micromotors, which could facilitate the detection processes. These features make the stomatocyte structural color-barcode micromotors ideal for biomedical applications.

关键词： structural color micromotor sensor photonic crystal multiplex assay

具有光电双响应特性的仿生器官芯片用于激素测试

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2023年第9期68卷 938-945,M0004页

作者：孙灵钰汪雨卞非卡许冬雨赵远锦 Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

心脏芯片能够在体外重现心脏组织的动态微环境和生理相似性,有望取代传统的细胞和动物模型,为心脏病理学研究和药物开发等应用提供更可靠的测试平台.目前该领域的研究方向包括改善其微生理可视化特性、增强其仿生性能以及拓展其生物医... 详细信息

心脏芯片能够在体外重现心脏组织的动态微环境和生理相似性,有望取代传统的细胞和动物模型,为心脏病理学研究和药物开发等应用提供更可靠的测试平台.目前该领域的研究方向包括改善其微生理可视化特性、增强其仿生性能以及拓展其生物医学应用等.受孔雀羽毛绚丽色彩的启发,本研究制备了一种明亮的MXene结构色水凝胶用于心肌细胞培养,并由此构建了具有光电双响应特性的仿生器官芯片用于激素测试.MXene不仅能够增强结构色的对比度,而且能够赋予该复合水凝胶体系良好的导电性,从而促进其表面培养的心肌细胞的协同搏动.在心肌细胞的驱动下,MXene结构色水凝肢会发生同步的形变,并产生相应的光子带隙和结构色的变化用于反馈心肌细胞的力学行为.研究结果表明了双响应器官芯片在激素毒性测试中的实用价值,为测试模型的开发提供了新的思路.

关键词：响应特性测试模型生物医学应用心肌细胞光子带隙毒性测试复合水凝胶仿生

MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2021年第1期2021卷 1236-1244页

作者： Lingyu Sun Lu Fan feika bian Guopu Chen Yuetong Wang Yuanjin Zhao Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School210008 NanjingChina State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Wound healing is a complex physiological process that involves coordinated phases such as inflammation and *** to promote the healing process tend to construct an effective delivery system based on different drugs and *** this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound *** to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle *** from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury *** vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing *** applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound *** features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.

关键词： materials boron bonding

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

仿生包裹钙钛矿量子点纤维的微流控制备

Science China Materials 2021年第11期64卷 2858-2867页

作者：余筠如郭佳慧卞非卡张大淦赵远锦 Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

由于钙钛矿量子点诸多的优良特性,基于其的功能材料已经得到了广泛开发.本文受蜘蛛纺丝工艺启发,通过多相流微流控方式制备了具有可控形态和功能的包裹钙钛矿量子点的超细纤维.将钙钛矿量子点前驱液引入内相毛细管阵列的通道中并将它们... 详细信息

由于钙钛矿量子点诸多的优良特性,基于其的功能材料已经得到了广泛开发.本文受蜘蛛纺丝工艺启发,通过多相流微流控方式制备了具有可控形态和功能的包裹钙钛矿量子点的超细纤维.将钙钛矿量子点前驱液引入内相毛细管阵列的通道中并将它们在其中混合,而外部通道中通入聚偏二氟乙烯(PVDF)的N,N-二甲基甲酰胺溶液作为壳层纤维的反应溶液.在此过程中,随着外部PVDF纤维的形成,内部钙钛矿量子点前驱液中阴阳离子原位合成,并能够很好地包封在纤维核层中,从而免受外部环境对于结构的破坏.微流控制备纤维的过程高度可控,除了直纤维外,也能制备螺旋纤维,并且还能调节这些纤维的荧光颜色即内部包裹量子点的发射峰.此外,我们探究了这些纤维作为荧光材料在条形码中的应用,以及作为柔性光电探测器的潜在应用,证明了这类纤维在不同领域中具有广泛而灵活的应用潜能.

关键词：纺丝工艺超细纤维荧光材料光电探测器条形码微流控反应溶液毛细管阵列

A Case Study on Sierra Leone Brewery Limited's Motivation of Employees

在线全文

学校读者我要写书评

暂无评论

A Case Study on Sierra Leone Brewery Limited's Motivation of...

作者： KALIFA feika 广东外语外贸大学

学位级别：硕士

This study investigates employee motivation in *** focus of this study is to determine staff motivational practices and the need for personnel policies in *** motivational practices at the Sierra Leone Brewery Limited,for example,have made the job of the Human Resource Management very difficult and challenging in efficiently motivating employees to maximize *** the numerous motivational strategies introduced like the recognition of staff for performance,the improvement in Service Condition,Staff Training and *** company continues to experience a serious problem with staff *** personnel policies covered areas relating to recruitment,selection,promotion,training,and development of employees,where people management utilization performance becomes *** data obtained is analysed by frequency counts,followed by the tabulation of the data *** responses are also *** indicate that the whole motivational strategies together with the Human Resource Policies at the Sierra Leone Brewery Limited are a bench mark for other leading organizations so as to attract,retain and motivate employees to prevent the huge attrition rate from the *** the level of bureaucracy in the establishment is reduced to establish a more flexible structure for prompt delivery of services to overcome problems with the operations with a clear policy drawn on internal communication for the attention of ***,it is suggested that a detail study on the application of a monitoring system for the enhancement of staff development should be done to ensure staff development motivation at the Sierra Leone Brewery Limited.

关键词： motivation,Sierra,staff,Staff,motivated,private,retention,Motivation,工商管理硕士,attractive,

老年慢性心力衰竭合并肌少症发病机制的研究进展

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

老年医学与保健 2023年第6期29卷 1377-1381页

作者：杨启瑞吴方李菲卡上海交通大学医学院附属瑞金医院全科医学科上海交通大学医学院附属瑞金医院老年病科上海200025

慢性心力衰竭(chronic heart failure,CHF)指因多种病因导致心肌结构和功能的变化,引起以呼吸困难、体液潴留、乏力纳差为特征的临床综合征,属于心脏疾病的终末期状态。我国1项流行病学调查结果显示,65岁及以上老年人CHF患病率为5.3%[1]... 详细信息

慢性心力衰竭(chronic heart failure,CHF)指因多种病因导致心肌结构和功能的变化,引起以呼吸困难、体液潴留、乏力纳差为特征的临床综合征,属于心脏疾病的终末期状态。我国1项流行病学调查结果显示,65岁及以上老年人CHF患病率为5.3%[1],对人群健康和社会经济产生巨大影响和负担。

关键词：老年人慢性心力衰竭肌少症发病机制炎症营养不良

在线全文

学校读者我要写书评

暂无评论

老年功能受损风险简易预测模型构建

内科理论与实践 2023年第3期18卷 177-182页

作者：白婷婷李菲卡徐刚蒋倩雯吴方上海交通大学医学院附属瑞金医院老年病科上海200025 上海交通大学医学院公共卫生学院上海200025

目的:构建老年功能受损风险预测模型。方法:选取2019年12月至2020年12月间入住上海交通大学医学院附属瑞金医院等4所三级甲等医院的住院老年患者共481例,收集基本资料、共病情况、老年综合征、检验结果等,根据国际功能、残疾和健康分类(... 详细信息

目的:构建老年功能受损风险预测模型。方法:选取2019年12月至2020年12月间入住上海交通大学医学院附属瑞金医院等4所三级甲等医院的住院老年患者共481例,收集基本资料、共病情况、老年综合征、检验结果等,根据国际功能、残疾和健康分类(International Classification of Functioning,Disability and Health,ICF)及功能受损评估量表(function impairment screening tool,FIST)评估,共231例患者存在功能受损。采用最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)及Logistic回归筛选预测因素,构建Nomogram图。采用校准曲线、决策分析曲线、一致性指数(concordance index,C指数)等进行评价。结果:筛选并纳入年龄段、性别、社交活动、脑卒中、糖尿病、焦虑、认知障碍、衰弱、白蛋白共9项预测因素构建老年功能受损Nomogram图,校准曲线和决策分析曲线验证模型具有良好的预测能力和临床效益。C指数=0.938[95%置信区间(confidence interval,CI)=0.917~0.959]提示区分度良好。结论:本研究建立的老年功能受损Nomogram图具有良好的预测能力、临床效益和区分性,可简易快速评估老年功能受损风险,为临床预测老年功能受损提供了直观有效的指导工具。

关键词：功能受损老年人预测模型 Nomogram图

基于德尔菲专家咨询法构建的老年肌少症评估初始量表

在线全文

学校读者我要写书评

暂无评论

内科理论与实践 2022年第3期17卷 238-242页

作者：李菲卡杨文丽蒋倩雯方芳白婷婷徐刚吴方何清上海交通大学医学院附属瑞金医院老年医学科上海200025 上海交通大学医学院公共卫生学院上海200025

目的:构建适合我国老年人群肌少症全面评估量表(包括自评与他评2个部分)的初始量表。方法:通过检索和复习文献,选取与肌少症相关的量表,形成初步条目池后,经国内16名相关领域的专家2轮德尔菲咨询问卷筛选条目,通过统计专家积极系数、专... 详细信息

目的:构建适合我国老年人群肌少症全面评估量表(包括自评与他评2个部分)的初始量表。方法:通过检索和复习文献,选取与肌少症相关的量表,形成初步条目池后,经国内16名相关领域的专家2轮德尔菲咨询问卷筛选条目,通过统计专家积极系数、专家权威程度、专家意见重要性的协调系数、各指标得分平均值、变异系数和满分率,形成老年人肌少症评估初始量表。结果:经文献收集及专家小组讨论,首先形成了包括3个一级指标、5个二级指标、21个三级指标(条目)的自评部分初步条目池,和包括2个一级指标、4个二级指标、17个三级指标(条目)的他评部分初步条目池。第1轮德尔菲咨询的专家积极系数为100%,专家权威系数Cr=0.956。自评和他评部分,专家对所有条目的重要性Kendall协调系数分别为0.424和0.449,^(2)分别为133.534(P<0.001)和114.591(P<0.001);第2轮德尔菲咨询的专家积极系数为100%,专家权威系数Cr=0.968。自评和他评部分,专家对所有条目的重要性Kendall协调系数分别为0.350和0.400,χ^(2)分别为84.119(P<0.001)和67.546(P<0.001)。根据2轮的得分情况及专家修改意见,最终形成3个一级指标、5个二级指标、10个三级指标(条目)的自评部分条目池,和包括2个一级指标、4个二级指标、13个三级指标(条目)的他评部分条目池初始量表。结论:通过德尔菲专家咨询法构建的老年人肌少症全面评估初始量表,专家积极参与,权威度高,专家意见集中程度和协调度好。

关键词：德尔菲法老年肌少症评估量表