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车载激光点云纠正技术研究

测绘与空间地理信息 2022年第2期45卷 103-106页

作者：杨飞飞上海市测绘院上海200063

随着智慧城市建设发展需求的不断扩大,移动扫描技术在项目应用中的频率不断提升,车载三维激光扫描技术以其高效率、高精度的特点已在项目实践中占有一席之地。但车载三维激光扫描技术受限于卫星信号等情况影响,点云数据为确保达到高精度... 详细信息

随着智慧城市建设发展需求的不断扩大,移动扫描技术在项目应用中的频率不断提升,车载三维激光扫描技术以其高效率、高精度的特点已在项目实践中占有一席之地。但车载三维激光扫描技术受限于卫星信号等情况影响,点云数据为确保达到高精度,通常需进行远超车载扫描本身工作量的点云精度改善工作,即点云纠正,本文使用多个实例数据,通过对不同纠正策略的对比,对车载激光扫描技术的纠正点布设数量和位置进行研究,摸索最优的纠正点布设方法,以期能减少纠正点布设工作,并提出了以轨迹质量为依据的点云纠正策略,提高大批量获取高精度道路点云数据的效率。

关键词：车载激光扫描技术点云纠正纠正点布设轨迹质量虚拟纠正点

笑声疗法改善护理本科生主观幸福感及应对方式的效果

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护理研究 2022年第11期36卷 2042-2046页

作者：杨菲非李莉宋丽萍山西医科大学护理学院山西030001 山西医科大学第一医院

目的:探讨笑声疗法对护理本科生主观幸福感及应对方式的影响,为在校护生精神科护理教学及心理健康教育提供理论与实践依据。方法:选择某医学院校3年级护理本科生为研究对象,以班级为单位,采用掷硬币法将10个班级分为对照组132人和试验组... 详细信息

目的:探讨笑声疗法对护理本科生主观幸福感及应对方式的影响,为在校护生精神科护理教学及心理健康教育提供理论与实践依据。方法:选择某医学院校3年级护理本科生为研究对象,以班级为单位,采用掷硬币法将10个班级分为对照组132人和试验组148人。试验组护生进行为期24 d、每天30 min的笑声疗法干预,对照组护生嘱其睡前随机聆听音乐10 min。比较两组护生干预前后主观幸福感、应对方式及正念得分情况。结果:干预24 d后试验组护生主观幸福感、正念总分分别为(136.43±17.63)分、(126.70±10.51)分,对照组护生主观幸福感、正念总分分别为(116.95±19.44)分、(119.28±7.76)分,两组比较差异均有统计学意义(P<0.01)。干预后试验组护生积极应对评分高于对照组(P<0.01),消极应对评分低于对照组(P<0.01)。结论:笑声疗法可以有效提高护理本科生积极应对方式及正念水平,促使其积极面对日常学习、生活中的各种应激源,提升护生主观幸福感。

关键词：护理本科生笑声疗法主观幸福感应对方式生活质量护理干预

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黑龙江某数据中心空调节能改造设计

洁净与空调技术 2022年第4期 67-69页

作者：杨菲菲北京中环世纪工程设计有限公司北京市100000

对黑龙江某数据中心空调进行空调节能改造,旨在改善机房气流组织,解决局部热点问题,提高空调系统的利用效率,降低机房空调用电量,实现节能增效;实现温湿度独立控制,提高数据中心运行安全系数。

关键词：数据中心空调节能改造安全

中药穴位注射联合骶管注射治疗腰椎间盘突出症的临床观察

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反射疗法与康复医学 2022年第8期3卷 34-36,40页

作者：杨扉扉贵州省骨科医院骨内科贵州贵阳 550002

目的探究中药穴位注射联合骶管注射治疗腰椎间盘突出症的效果.方法选取2018年1月—2021年9月我院收治的92例腰椎间盘突出症患者为研究对象,随机分成两组,每组46例.对照组采用单一骶管注射治疗,研究组采用中药穴位注射联合骶管注射治疗... 详细信息

目的探究中药穴位注射联合骶管注射治疗腰椎间盘突出症的效果.方法选取2018年1月—2021年9月我院收治的92例腰椎间盘突出症患者为研究对象,随机分成两组,每组46例.对照组采用单一骶管注射治疗,研究组采用中药穴位注射联合骶管注射治疗.对比两组的临床治疗效果、日本骨科学会评定(JOA)评分、疼痛视觉模拟(VAS)评分及生活质量综合评定问卷(GQOLI-74)评分.结果研究组的治疗总有效率为93.48%,高于对照组的73.91%,差异有统计学意义(P<0.05).研究组治疗后的JOA评分为(24.63±3.05)分,高于对照组的(18.44±1.22)分,VAS评分为(2.32±0.13)分,低于对照组的(4.64±0.47)分,组间差异有统计学意义(P<0.05).研究组治疗后的各项GQOLI-74评分均高于对照组,组间差异有统计学意义(P<0.05).结论采用中药穴位注射联合骶管注射治疗腰椎间盘突出症的临床疗效理想,可大幅度缓解患者疼痛,恢复腰腿功能,提高生活质量,值得推广应用.

关键词：中药穴位注射骶管注射腰椎间盘突出症生活质量腰腿功能疼痛

基于阴囊超声参数及机器学习的中重度生精功能障碍风险评分系统的构建与验证

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中华生殖与避孕杂志 2024年第7期44卷 723-727页

作者：吴萌李学峰李鑫焱刘菲菲杨洁崔广和滨州医学院附属医院超声医学科滨州滨州医学院附属医院生殖医学科滨州

目的建立基于阴囊超声参数及机器学习的中重度生精功能障碍风险评分系统并探讨其价值。方法回顾性队列分析2021年6月至2022年12月期间在滨州医学院附属医院生殖医学科确诊无精子症、中重度少、弱精子症患者112例及同期在本院因不孕而就... 详细信息

目的建立基于阴囊超声参数及机器学习的中重度生精功能障碍风险评分系统并探讨其价值。方法回顾性队列分析2021年6月至2022年12月期间在滨州医学院附属医院生殖医学科确诊无精子症、中重度少、弱精子症患者112例及同期在本院因不孕而就诊的116例生精功能正常男性的阴囊超声参数。分别使用随机森林、支持向量机、逻辑回归、K-最近邻算法、XGBoost构建模型。综合各模型各参数的平均沙普利可加性模型解释方法值构建风险评分系统。通过受试者工作特征曲线评估模型的预测效能, 临床决策曲线评估模型的临床应用价值。结果评分系统包括双侧睾丸总体积、睾丸回声是否均匀, 右侧精索静脉内径及精索静脉曲张血液反流时间。风险评分系统训练集的曲线下面积(area under the curve, AUC)为0.757, 测试集AUC为0.718, 决策曲线显示该评分系统具有较高的临床价值。结论基于阴囊超声参数及机器学习建立风险评分系统可有效预测中重度生精功能障碍, 对此类患者的早发现有着积极意义。

关键词：生精功能障碍机器学习 SHAP 阴囊超声

Phase engineering of Ni-Mn binary layered oxide cathodes for sodiumion batteries

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Journal of Energy Chemistry 2024年第4期91卷 501-511页

作者： feifei Hong Xin Zhou Xiaohong Liu Guilin Feng Heng Zhang Weifeng Fan Bin Zhang Meihua Zuo Wangyan Xing Ping Zhang Hua Yan Wei Xiang College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina College of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina Research Institute for Electronic Science(RIES)and Division of Information Science and Technology Graduate School of Information Science and TechnologyHokkaido UniversityN20W10SapporoHokkaido 001-0020Japan School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Yibin Libode New Materials Co. Ltd.Yibin 644200SichuanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina

Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional *** composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 *** observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 *** systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.

关键词： Phase engineering Ni-Mn layered oxide Cathode Sodium-ion batteries

Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

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Bone Research 2024年第2期12卷 314-333页

作者： Chengjun Li Tian Qin Jinyun Zhao Yuxin Jin Yiming Qin Rundong He Tianding Wu Chunyue Duan Liyuan Jiang feifei Yuan Hongbin Lu Yong Cao Jianzhong Hu Department of Sports Medicine Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceXiangya Road 87Changsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Department of Spine Surgery and Orthopaedics Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China

Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory *** extensive investigations into vascular senescence associated with aging and degenerative diseases,the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress,particularly its involvement in senescence-induced inflammation,remain insufficiently *** this study,we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury(SCI).Lysine demethylase 6A(Kdm6a),commonly known as UTX,emerges as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells(SCMECs).Upregulation of UTX induces senescence in SCMECs,leading to an amplified release of proinflammatory factors,specifically the senescenceassociated secretory phenotype(SASP)components,thereby modulating the inflammatory ***,the deletion of UTX in endothelial cells shields SCMECs against senescence,mitigates the release of proinflammatory SASP factors,and promotes neurological functional recovery after *** forms an epigenetic regulatory axis by binding to calponin 1(CNN1),orchestrating trauma-induced SCMECs senescence and SASP secretion,thereby influencing neuroinflammation and neurological functional ***,local delivery of a senolytic drug reduces senescent SCMECs and suppresses proinflammatory SASP secretion,reinstating a local regenerative microenvironment and enhancing functional repair after *** conclusion,targeting the UTX-CNN1 epigenetic axis to prevent trauma-induced SCMECs senescence holds the potential to inhibit SASP secretion,alleviate neuroinflammation,and provide a novel treatment strategy for SCI repair.

关键词： inflammation epigenetic neurological

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao feifei Lv Jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Cranial ultrasound in perioperative period of acute severe traumatic brain injury

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中国医学影像技术 2024年第8期40卷 1156-1159页

作者： WANG yangang LYU Zhenpu ZHENG Xianzhao QIN Zheng LI Jianxin GE Ran ZHAO feifei Department of Neurosurgery Jiaozuo People's HospitalJiaozuo 454000China Department of Neurology Jiaozuo People's HospitalJiaozuo 454000China

Objective To observe the value of cranial ultrasound for perioperative patients with acute severe traumatic brain injury(sTBI).Methods Data of 55 sTBI patients who underwent craniotomy were retrospectively *** patients were divided into observation group(n=15)and control group(n=40)according to received perioperative cranial ultrasound or *** general data and surgical data were compared between groups,and ultrasonic data of observation group were *** The proportions of good prognosis 1 and 6 months after operation in observation group were both higher than those in control group,while the incidence of cerebral infarction in observation group was lower than that in control group(all P0.05).Acute encephalocele occurred in 1 case in observation group during operation,and cranial ultrasound accurately showed the contralateral secondary epidural *** intracranial pressure in different degrees were found in all 15 cases(15/15,100%)in observation group after operation with transcranial color coded Doppler(TCCD)or transcranial Doppler(TCD),while cerebral vascular spasm was observed in 5 cases(5/15,33.33%),among them 4 cases(4/5,80.00%)were diagnosed cerebral infarction based on CT *** Cranial ultrasound could be used to evaluate changes of sTBI in perioperative period and guide adjusting treatment strategy in time,being valuable for reducing risk of postoperative cerebral infarction and improving prognosis.

关键词： craniocerebral trauma perioperative period ultrasonography

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