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Expression and prognosis analyses of Dectin-1 cluster genes in patients with lung adenocarcinoma (LUAD) and the association with immune checkpoint molecules

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BIOCELL 2021年第3期45卷 649-663页

作者： LITING YOU feifei na JUAN ZHOU LIN JIAO YI ZHOU BINWU YING West China School of Medicine West China HospitalSichuan UniversityChengdu610041China Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu610041China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu610041China

Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and *** members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of several ***,little is known about their roles in human lung adenocarcinoma(LUAD).The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA *** evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and *** expression was validated with the EMBL-EBI database,and protein expression was analyzed with the HPA *** addition,protein-protein interaction network,GO,and KEGG analyses were ***,the correlations between CLEC-12A and immune molecules(immune inhibitors and MHC molecules)were investigated via TISIDB and *** expression levels of Dectin-1 cluster genes were downregulated in LUAD tissues compared to those in normal lung *** expression levels of CLEC-12A,CLEC-12B,CLEC-2,and CLEC-9A correlated with tumor stage,and CLEC-12A and CLEC-12B were significantly associated with survival in patients with *** seven genes mostly participated in immune regulation processes and were involved in autoimmune disorders and hematological ***,correlation analyses revealed CLEC-12A expression was associated with most immune inhibitors and ***-12A was positively related to PD-1,PD-L1,PD-L2,CTLA4,TIM3,and *** conclusion,our findings suggest that CLEC-12A and CLEC-12B can be used as prognostic biomarkers in ***-12A expression was associated with immune checkpoint molecules,and CLEC-12A may be a potential assistant target to improve the efficacy of immune checkpoint inhibitors immunotherapy.

关键词： CLEC-12A CLEC-12B Lung cancer Prognosis Immune regulation

Oxidized mitochondrial Dna sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

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Cellular & Molecular Immunology 2021年第9期18卷 2211-2223页

作者： Chunju Fang Fei Mo Li Liu Jing Du Min Luo Ke Men feifei na Wei Wang Hanshuo Yang Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan University610041 ChengduP.R.China Department of Oncology Guizhou Provincial People’s Hospital550002 GuiyangGuizhouP.R.China

Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical ***,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully ***,we demonstrate that oxidized mitochondrial Dna(mtDna)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell *** in ROS and oxidized mtDna 8-OHG content could be induced in irradiated tumor *** mtDna derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDna,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor *** results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines.

关键词： Irradiated tumor cell vaccine Oxidized mitochondrial Dna STING signaling

Novel directions of precision oncology:circulating microbial Dna emerging in cancer-microbiome areas

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Precision Clinical Medicine 2022年第1期5卷 46-62页

作者： Liting You Juan Zhou Zhaodan Xin J.Spencer Hauck feifei na Jie Tang Xiaohan Zhou Zichen Lei Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Pathology Duke University School of MedicineDurhamNC 27710USA Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu 610041China Department of Clinical Laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000China

Microbiome research has extended into the cancer area in the past *** can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect ***-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and ***,the cancermicrobiome has recently been *** identification of intra-tumoral microbes and cancer-related circulating microbial Dna(cmDna)has promoted novel research in the cancer–microbiome *** this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDna as a promising biomarker in cancer liquid *** outline all existing studies on the relationship between cmDna and cancer and the outlook for potential preclinical and clinical applications of cmDna in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field.

关键词： circulating microbial Dna liquid biopsy cancer-microbiome-immunity intra-tumor microbiome cancer precision diagnosis and therapy

Identifying a confused cell identity for esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1692-1702页

作者： Xiangyu Pan Jian Wang Linjie Guo feifei na Jiajia Du Xuelan Chen Ailing Zhong Lei Zhao Lu Zhang Mengsha Zhang Xudong Wan Manli Wang Hongyu Liu Siqi Dai Ping Tan Jingyao Chen Yu Liu Bing Hu Chong Chen Department of Gastroenterology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Department of Thoracic Oncology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041 SichuanChina Dpartment of Urology Institute of UrologyWest China HospitalSichuan UniversityChengduChina

The cell identity of malignant cells and how they acquire it are fundamental for our understanding of ***,we report that esophageal squamous cell carcinoma(ESCC)cells display molecular features equally similar but distinct to all three types of normal esophageal epithelial cells,which we term as confused cell identity(CCI).CCI is an independent prognostic marker associated with poor prognosis in ***,we identify tropomyosin 4(TPM4)as a critical CCI gene that promotes the aggressiveness of ESCC in vitro and in *** TPM4 creates CCI through activating the Jak/STAT-SOX2 ***,our study suggests an unrecognized feature of ESCC cells,which might be of value for clinic prognosis and potential interference.

关键词： esophageal SOX2 squamous

干细胞样CD8^(+)T细胞在抗肿瘤免疫治疗中的地位与演进效应

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中国肿瘤临床 2023年第7期50卷 373-376页

作者：林果姚卓然王徽纳飞飞(综述) 卢铀(审校) 四川大学华西医院肿瘤中心胸部肿瘤病房放疗科四川大学华西医院临床细胞治疗研究室成都市610041

以抗细胞程序性死亡-1/细胞程序性死亡-配体1(programmed cell death-1/programmed cell death-ligand 1,PD-1/PD-L1)为代表的免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)治疗显现了CD8+T细胞在治疗和可能治愈恶性肿瘤方面的潜力。但仅约20%的患者对ICIs治疗获益,因此阐明CD8+T细胞在免疫微环境中的有效抗肿瘤功能,及其分子和空间的决定因素尤为重要。具有自我更新、增殖分化和杀伤肿瘤细胞能力的干细胞样CD8^(+)T细胞亚群,在介导抗肿瘤免疫效应方面扮演极为重要的角色。本文就干细胞样CD8^(+)T细胞在抗肿瘤免疫循环中的地位与演进效应进行综述。

关键词：干细胞样 CD8^(+)T 淋巴细胞免疫治疗肿瘤微环境

BET家族基因表达与恶性肿瘤患者总生存期及临床病理特征的关系

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中国医药导报 2016年第2期13卷 69-72,108页

作者：王婧文唐菲邓磊纳飞飞薛建新卢铀四川大学华西医院华西临床医学院四川成都610041 四川大学华西医院肿瘤中心胸部肿瘤科四川成都610041

目的探讨新兴肿瘤治疗靶点bromodomain and extra—terminal（BET）家族基因表达与多种实体恶性肿瘤患者预后及临床病理特征的关系。方法使用美国Kaplan Meier plotter在线数据库，采集肿瘤样本BET家族基因mRna水平表达数据及患者临床... 详细信息

目的探讨新兴肿瘤治疗靶点bromodomain and extra—terminal（BET）家族基因表达与多种实体恶性肿瘤患者预后及临床病理特征的关系。方法使用美国Kaplan Meier plotter在线数据库，采集肿瘤样本BET家族基因mRna水平表达数据及患者临床数据，在线完成生存分析。结果胃癌中，BRD2／BRD3／BRDT高表达组患者总生存期显著下降（均P〈0．01）。这一相关性在乳腺癌中仅见于Luminal B型及HER2＋型患者。在肺癌中，鳞癌患者生存期与BET家族基因表达无显著相关性，腺癌患者生存与BRD3正相关[风险比95％CI（HR95％CI）：0．22～0．431，与BRDT负相关（HR95％CI：1．08～1．78）。卵巢癌患者预后与BET家族基因表达正相关（BRD2 HR 95％CI：0．70～0．91，BRD3 HR 95％CI：0．76—1．00，BRDT HR 95％CI：0．71～0．93）。结论BET家族基因高表达提示胃癌及部分乳腺癌患者预后不良．但在肺癌及卵巢癌中并不提示生存期下降。

关键词： BET家族胃癌肺癌乳腺癌卵巢癌总生存期

The superhydrophobic sponge decorated with Ni-Co double layered oxides with thiol modification for continuous oil/water separation

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Chinese Journal of Chemical Engineering 2023年第2期54卷 296-305页

作者： Xiaodong Yang na Yang Ziqiang Gong feifei Peng Bin Jiang Yongli Sun Luhong Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

In this paper, the superhydrophobic polyurethane sponge(SS-PU) was facilely fabricated by etching with Jones reagent to bind the nanoparticles of Ni-Co double layered oxides(LDOs) on the surface, and following modification with n-dodecyl mercaptan(DDT). This method provides a new strategy to fabricate superhydrophobic PU sponge with a water contact angle of 157° for absorbing oil with low cost and in large scale. It exhibits the strong absorption capacity and highly selective characteristic for various kinds of oils which can be recycled by simple squeezing. Besides, the as-prepared sponge can deal with the floating and underwater oils, indicating its application value in handling oil spills and domestic oily wastewater. The good self-cleaning ability shows the potential to clear the pollutants due to the ultralow adhesion to water. Especially, the most important point is that the superhydrophobic sponge can continuously and effectively separate the oil/water mixture against the condition of turbulent disturbance by using our designed device system, which exhibit its good superhydrophobicity, strong ***, the SS-PU still maintained stable absorption performance after 150 cycle tests without losing capacity obviously, showing excellent durability in long-term operation and significant potential as an efficient absorbent in large-scale dispose of oily water.

关键词： Superhydrophobic sponge Ni-Co double layered oxides Thiol modification Oil absorption Oil/water separation

CBL结合高仿真电脑模拟人在肺部体格检查教学中的应用研究

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中国病案 2016年第10期17卷 71-73页

作者：魏占云廖秋菊王长远谭菲菲王娜首都医科大学宣武医院北京市100053

目的探讨案例教学法(case-based learning,CBL)结合高仿真电脑模拟人在肺部体格检查教学中应用的有效性。方法将在某医院实习的2012级七年制学生(60人)和2012级五年制学生(30人)共90人为研究对象,随机分为实验组45人和对照组45人,均由3... 详细信息

目的探讨案例教学法(case-based learning,CBL)结合高仿真电脑模拟人在肺部体格检查教学中应用的有效性。方法将在某医院实习的2012级七年制学生(60人)和2012级五年制学生(30人)共90人为研究对象,随机分为实验组45人和对照组45人,均由3名内科脱产带教教师进行肺部体格检查教学,实验组采用CBL结合高仿真电脑模拟人教学方法,对照组采用传统教学方法。两组学生进行统一的肺部查体SP考试和肺部异常体征的考核和问卷调查。结果⑴实验组在肺部查体SP考试成绩和查体手法的规范程度、肺部异常体征考核明显高于对照组,有统计学差异(t值=2.784,P=0.034;t值=2.018,P=0.042;t值=5.385,P=0.016);⑵问卷调查显示实验组在学习兴趣、理论联系实际能力、医患沟通能力、临床思维能力等方面较对照组明显升高(t值=2.186,P=0.037;t值=2.138,P=0.039;t值=2.086,P=0.042;t值=3.038,P=0.019),差异有统计学意义。结论在肺部体格检查教学中应用CBL结合高仿真电脑模拟人教学方法能明显地提高教学质量,有助于医学生熟练掌握肺部体格检查的手法和内容。

关键词：案例教学法教学方法诊断学肺部查体

四川大学华西医院本科生物医药优秀人才培养模式的探索与实践

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华西医学 2023年第10期38卷 1549-1552页

作者：纳飞飞潘翔宇杨洋陈雪兰向明礼陈崇四川大学华西医院生物治疗国家重点实验室成都610041 四川大学华西医院/华西临床医学院成都610041

四川大学2016年创立“华西生物国重创新班”,以探索生物医药领域优秀本科人才培养的新模式。该班级通过组建多学科交叉教师团队、加强早期科研实践、完善评价及激励机制、强化职业认同,培养了具备广阔学科视野、多学科交叉和创新思维的... 详细信息

四川大学2016年创立“华西生物国重创新班”,以探索生物医药领域优秀本科人才培养的新模式。该班级通过组建多学科交叉教师团队、加强早期科研实践、完善评价及激励机制、强化职业认同,培养了具备广阔学科视野、多学科交叉和创新思维的生物医药优秀人才。该文总结了“华西生物国重创新班”的经验与成果,为我国生物医药优秀人才的培养提供了参考,推动高校基础学科拔尖人才培养质量提升。

关键词：生物医药优秀人才多学科交叉

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