Identifying a confused cell identity for esophageal squamous cell carcinoma

作     者：Xiangyu Pan Jian Wang Linjie Guo Feifei Na Jiajia Du Xuelan Chen Ailing Zhong Lei Zhao Lu Zhang Mengsha Zhang Xudong Wan Manli Wang Hongyu Liu Siqi Dai Ping Tan Jingyao Chen Yu Liu Bing Hu Chong Chen 

作者机构：Department of GastroenterologyState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Department of Thoracic OncologyState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041 SichuanChina Dpartment of UrologyInstitute of UrologyWest China HospitalSichuan UniversityChengduChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1692-1702页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：We thank the members of the CC-LY laboratory for their technical support and suggestions,and the Core Facilities of West China Hospital.This work was supported by the National Key R&D Program of China(2017YFA0505600) the National Natural Science Foundation of China(81522003,82170171,81770157,and 82003156) the Sichuan Science and Technology Program(2020YFQ0059,2018JZ0077,2017TJPT0005,2022YFS0171 and 2022YFS0205) 1.3.5.Project for Disciplines of Excellence,West China Hospital,Sichuan University,and the innovation initiative of Sichuan University,Grant no.2018SCUH0060.We thank the Chengdu OrganoidMed Medical Laboratory for their technical support.We also thank BioRender(biorender.com)for providing items for drawing scheme graphs 

主　　题：esophageal SOX2 squamous 

摘      要：The cell identity of malignant cells and how they acquire it are fundamental for our understanding of ***,we report that esophageal squamous cell carcinoma(ESCC)cells display molecular features equally similar but distinct to all three types of normal esophageal epithelial cells,which we term as confused cell identity(CCI).CCI is an independent prognostic marker associated with poor prognosis in ***,we identify tropomyosin 4(TPM4)as a critical CCI gene that promotes the aggressiveness of ESCC in vitro and in *** TPM4 creates CCI through activating the Jak/STAT-SOX2 ***,our study suggests an unrecognized feature of ESCC cells,which might be of value for clinic prognosis and potential interference.