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黑河流域土地利用变化特征及其对生境质量的影响

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热带农业工程 2024年第2期48卷 6-13页

作者：张家豪魏菲菲李拉拉王永强郝若男甘肃农业大学管理学院甘肃兰州730070

土地利用与生境质量变化研究是近年来全球环境变化领域的研究热点。以黑河流域这一典型干旱内陆河流域为对象,在研究该流域2000~2020年土地利用变化特征基础上,运用InVEST模型对研究区20年间的生境质量变化情况进行定量评估,并借助贡献... 详细信息

土地利用与生境质量变化研究是近年来全球环境变化领域的研究热点。以黑河流域这一典型干旱内陆河流域为对象,在研究该流域2000~2020年土地利用变化特征基础上,运用InVEST模型对研究区20年间的生境质量变化情况进行定量评估,并借助贡献度方法,进一步分析土地利用变化对生境质量产生的影响。结果表明:(1) 2000~2020年,黑河流域土地利用转变频繁,裸地和草地是主要的转移类型;(2)黑河流域生境质量整体处于较差状态,但在20年间呈现先降后增的变化趋势;(3)草地转林地对流域生境质量的提升具有推动作用,草地转裸地对区域生境质量的下降具有加速影响,加强流域草原生态的治理保护力度是助力黑河流域生物多样性保护的重要推手。

关键词：土地利用变化生境质量影响黑河流域

Time-dependent deviation of bridge pile foundations caused by adjacent large-area surcharge loads in soft soils and its preventive measures

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 184-201页

作者： Shuanglong LI Limin wei Jingtai NIU Zhiping DENG Bangbin WU Wuwen QIAN feifei HE School of Hydraulic Engineering Nanchang Institute of TechnologyNanchang 330099China School of Civil Engineering Central South UniversityChangsha 410075China

Time-dependent characteristics(TDCs)have been neglected in most previous studies investigating the deviation mechanisms of bridge pile foundations and evaluating the effectiveness of preventive *** this study,the stress-strain-time characteristics of soft soils were illustrated by consolidation-creep tests based on a typical engineering *** extended Koppejan model was developed and then embedded in a finite element(FE)model via a user-material subroutine(UMAT).Based on the validated FE model,the time-dependent deformation mechanism of the pile foundation was revealed,and the preventive effect of applying micropiles and stress-release holes to control the deviation was *** results show that the calculated maximum lateral displacement of the cap differs from the measured one by 6.5%,indicating that the derived extended Koppejan model reproduced the deviation process of the bridge cap-pile foundation with *** additional load acting on the pile side caused by soil lateral deformation was mainly concentrated within the soft soil layer and increased with the increase in load *** with t=3 d(where t is surcharge time),the maximum lateral additional pressure acting on Pile 2#increased by approximately 47.0%at t=224 *** bridge pile foundation deviation in deep soft soils,stress-release holes can provide better prevention compared to micropiles and are therefore recommended.

关键词： bridge pile foundation surcharge load soft soil time-dependent deformation interaction mechanism preventive measure

Controlling of cements and physical property of sandstone by fault as observed in well Xia503 of Huimin sag,Linnan sub-depression

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Science China Earth Sciences 2013年第3期56卷 1942-1952页

作者： GAO LiHua HAN ZuoZhen HAN Yu HAN Chao wei feifei QIN Zhen State Key Laboratory of Mining Disaster Prevention and Control Key Laboratory of Depositional Mineralization & Sedimentary Minerals in Shandong Province Shandong University of Science and Technology College of Geological Science and Engineering Shandong University of Science and Technology School of Earth Sciences and Resources China University of Geosciences

Cement content of carbonate in tight sandstone near section is much higher than that of the normal sandstones far away from the fault of well Xia503,in the Huimin sag in Linnan *** order to understand the origin and its impact on fault sealing,analyses of the whole-rock minerals,casting thin sections,cathodoluminescence,isotope and physical properties are conducted on cores from well *** is found that 13C varies from 0.1‰to 0.6‰with the average value of 0.42‰,18O varies from 13.5‰to 12.3‰with the average of 13.1‰,and C–O isotope plotting points are distributed in the low to moderate temperature area of the hydrothermal *** to the occupied relationship,cathodoluminescence,and C–O isotope feature,the carbonate cementation could be divided into four stages:calcites,dolomite,ankerite,and *** is discovered that the carbonate cementation is negatively related to reservoir physical property,with the porosity of 4.8%,permeability of 0.37 mD,and displacement pressure of 1.97 MPa in the tight sandstone,which have increased by almost one order of magnitude compared to the porosity of 14.3%,permeability of 3.73 mD,and displacement pressure of 0.27 MPa in the normal sandstone,which is far away from the *** of the lithology of the counterpart wall of the fault,only the displacement pressure difference caused by carbonate cementation between the tight sandstone and the normal sandstone could seal 41 m high oil column.

关键词：故障控制惠民凹陷临南洼陷物理性质水泥致密砂岩碳氧同位素砂石

c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Animal Models and Experimental Medicine 2024年第2期7卷 136-144页

作者： Yin Ye Xiaojun Yang feifei Li wei Liu Wenqing Zhang Zhibin Huang Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouChina

Background:Despite the success of tyrosine kinase inhibitors in chronic myeloid leukemia(CML)therapy,CML still faces the challenges of drug resistance and progression to blast ***-five percent of patients have imatinib resistance and treatment difficulties due to heterogeneity after progression,but little is known about the mechanism.A key transcription factor in hematopoiesis,MYB,has been reported to increase abnormally in several types of aggressive blood disorders including ***:This study used a zebrafish model to explore the relationship between BCR/ABL1 and c-myb in CML progression.A CML zebrafish model was crossed with a c-myb hyperactivity transgenic ***:It was found that both exogenous BCR/ABL1 and c-myb could up-regulate the expression of neutrophil-related *** seriously,neutrophil accumulation was observed when BCR/ABL1 was combined with c-myb *** studies showed that c-myb may be one of the downstream targets of BCR/ABL1 and the effect of BCR/ABL1 on neutrophils was c-myb *** advantage of this inheritable in vivo model,it was shown that a combination of imatinib and flavopiridol,a cyclin-dependent kinase inhibitor targeting MYB,could more effectively alleviate the aggressive phenotype of the double transgene ***:In summary,this study suggests that c-myb acts downstream of BCR/ABL1 and is involved in CML progression and is therefore a risk factor and a valuable target for the treatment of CML *** model used in the study could be helpful in high-throughput drug screening in CML transformation.

关键词： chronic myeloid leukemia c-myb flavopiridol zebrafish model

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu wei Liu Peng Zhao feifei Lv Jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Single-cell transcriptome sequencing reveals the mechanism regulating rice plumule development

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The Crop Journal 2024年第3期12卷 688-697页

作者： Mingdong Zhu Meng Zhang Kunyong Huang feifei Lu Hong Wang Shaolu Zhao Yinghong Yu Shaoqing Tang Haining Wu Peisong Hu Xiangjin wei State Key Laboratory of Rice Biology and Breeding China National Center for Rice ImprovementChina National Rice Research InstituteHangzhou 310006ZhejiangChina b State Key Laboratory of Hybrid Rice Hunan Rice Research InstituteHunan Academy of Agricultural SciencesChangsha 410125HunanChina Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation College of BiologyHunan UniversityChangsha 410082HunanChina Hubei University Wuhan 430062HubeiChina

Seed plumules comprise multiple developing tissues and are key sites for above-ground plant organ ***,the spatial expression of genes in developing rice seed plumules was characterized by single-cell transcriptome sequencing in Zhongjiazao 17,a popular Chinese indica rice *** 15 cell clusters,13 were assigned to cell types using marker genes and cluster-specific *** genes of multiple cell types were expressed in several clusters,suggesting a complex developmental *** genes for signaling by phytohormones such as abscisic acid were highly expressed in specific *** cis-elements in the promoters of genes specifically expressed in cell clusters were calculated,and some key hormone-related motifs were frequent in certain *** expression patterns of genes involved in rapid seed germination,seedling growth,and development were *** findings enhanced our understanding of cellular diversity and specialization within plumules of rice,a monocotyledonous model crop.

关键词： Rice Plumule Single-cell sequencing Regulatory network

A Study of Electron Beam Induced Deposition and Nano Device Fabrication Using Liquid Cell TEM Technology

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Chinese Journal of Chemistry 2014年第5期32卷 399-404页

作者： Xin Chen Lihui Zhou Ping Wang Hongliang Cao Xiaoli Miao feifei wei Key Laboratory for Ultrafine Materials of Ministry of Education and Shanghai Key Laboratory of Advanced Polymeric MaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China East China University of Science and Technology Shanghai 200237China State Key Laboratory of Bioreactor Engineering Biomedical Nanotechnology CenterEast China University of Science and TechnologyShanghai 200237China

SiCx nano dots and nano wires with sizes from 60 nm to approximately 2μm were fabricated using liquid cell transmission electron microscope(TEM)technology.A SiCl_(4)in CH_(2)Cl_(2)solution was sealed between two pieces of Si_(3)N_(4)window grids in an in situ TEM liquid *** 200 keV electron beams were used to bombard the sealed precursors,which caused decomposition of the precursor materials,and deposition of the nano materials on the Si_(3)N_(4)window *** size of nano dots increased with beam exposure time,following an approximately exponential relationship with the beam *** electrons are attributed as the primary sources for the Si and C reduction.A nano device was formed from a deposited nano wire,with its electrical property characterized.

关键词： electron beam induced deposition in situ TEM nanolithography nanodevices

Effects Associated with Nanostructure Fabrication Using In Situ Liquid Cell TEM Technology

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Nano-Micro Letters 2015年第4期7卷 385-391页

作者： Xin Chen Lihui Zhou Ping Wang Hongliang Cao Xiaoli Miao feifei wei Xia Chen Shanghai Key Laboratory of Advanced Polymeric Materials and Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and Technology State Key Laboratory of Functional Materials for Informatic Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Biomedical Nanotechnology Center East China University of Science and Technology

We studied silicon,carbon,and SiC xnanostructures fabricated using liquid-phase electron-beam-induced deposition technology in transmission electron microscopy *** obtained from fixed electron beam irradiation followed a universal size versus beam dose trend,with precursor concentrations from pure Si Cl4to 0%SiC l4in CH2Cl2,and electron beam intensity ranges of two orders of magnitude,showing good controllability of the *** electrons contributed to the determination of the lateral sizes of the nanostructures,while the primary beam appeared to have an effect in reducing the vertical growth *** results can be used to generate donut-shaped *** a scanning electron beam,line structures with both branched and unbranched morphologies were also *** liquid-phase electron-beaminduced deposition technology is shown to be an effective tool for advanced nanostructured material generation.

关键词： Electron-beam-induced deposition In situ TEM Nanostrucutre Semiconductor Nanolithography

Phase engineering of Ni-Mn binary layered oxide cathodes for sodiumion batteries

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Journal of Energy Chemistry 2024年第4期91卷 501-511页

作者： feifei Hong Xin Zhou Xiaohong Liu Guilin Feng Heng Zhang weifeng Fan Bin Zhang Meihua Zuo Wangyan Xing Ping Zhang Hua Yan wei Xiang College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina College of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina Research Institute for Electronic Science(RIES)and Division of Information Science and Technology Graduate School of Information Science and TechnologyHokkaido UniversityN20W10SapporoHokkaido 001-0020Japan School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Yibin Libode New Materials Co. Ltd.Yibin 644200SichuanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina

Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional *** composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 *** observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 *** systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.

关键词： Phase engineering Ni-Mn layered oxide Cathode Sodium-ion batteries