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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-ming Yuan Guo-Da Zhang Chao Wang Shu-Juan Sun Peng-fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-ming Wu Lin He Lin-Sen ye Xiao-Feng Yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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新建大学物理实验室建设的实践与探索

实验室研究与探索 2006年第10期25卷 1313-1314,1321页

作者：刘传先滕琴费业铭上海第二工业大学理学院上海201209

通过对一所新建本科院校非物理专业大学物理实验室建设实践的分析,探索了实验项目设置、先进设备申购、原实验仪器改造利用、实验室人文环境创建、实验室规范管理和分层次等方面的建设模式。期待对同类院校物理实验室建设能有借鉴作用。

关键词：新建本科院校物理实验室建设模式

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基于图像处理的齿轮啮合面积计算

汽车科技 2017年第1期 26-29页

作者：费明德叶波陈永华郭剑东风商用车有限公司技术中心十堰442001

在驱动桥齿轮印迹试验中,利用图像处理技术,用迭代法对图像进行二值化处理,再进行杂质去除和孔洞填充,得到齿轮啮合区域;再对像素点标定,得到像素点单位面积。计算齿轮啮合区域像素点点数,二者相乘计算得到齿轮啮合面积。对没有形成封... 详细信息

在驱动桥齿轮印迹试验中,利用图像处理技术,用迭代法对图像进行二值化处理,再进行杂质去除和孔洞填充,得到齿轮啮合区域;再对像素点标定,得到像素点单位面积。计算齿轮啮合区域像素点点数,二者相乘计算得到齿轮啮合面积。对没有形成封闭齿轮啮合区域的印迹,用膨胀腐蚀的方法进行计算。

关键词：图像处理啮合面积孔洞填充杂质去除

Tsallis relativeαentropy of coherence dynamics in Grover′s search algorithm

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Communications in Theoretical Physics 2023年第8期75卷 87-99页

作者： Linlin ye Zhaoqi Wu Shao-ming fei Department of Mathematics Nanchang UniversityNanchang 330031China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

Quantum coherence plays a central role in Grover’s search *** study the Tsallis relative a entropy of coherence dynamics of the evolved state in Grover’s search *** prove that the Tsallis relative a entropy of coherence decreases with the increase of the success probability,and derive the complementarity relations between the coherence and the success *** show that the operator coherence of the first H■relies on the size of the database N,the success probability and the target ***,we illustrate the relationships between coherence and entanglement of the superposition state of targets,as well as the production and deletion of coherence in Grover iterations.

关键词： quantum coherence Grover's search algorithm Tsallis relativeαentropy of coherence

Analysis of irregular repetition spatially-coupled slotted ALOHA

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Science China(Information Sciences) 2019年第8期62卷 22-34页

作者： Hanxiao YU Zesong fei Congzhe CAO ming XIAO Dai JIA Neng ye School of Information and Electronics Beijing Institute of Technology Department of Electrical and Computer Engineering University of Alberta School of Electrical Engineering KTH Royal Institute of Technology

Contention-based access is a promising technology for massive and sporadic transmissions. In this paper, we propose a novel contention-based multiple access scheme, named irregular repetition spatiallycoupled slotted ALOHA(IRSC-SA), motivated by the spatial coupling and irregular repetition *** are different classes of users and slots in IRSC-SA, which result in unequal protection for different users. Considering that, we derive a novel density evolution(DE) method, which deals with unequal packet protection and introduces Bayesian reasoning to analyze the throughput threshold of the proposed *** analysis and simulation results show that the proposed scheme achieves better asymptotic threshold and system packet throughput performance than the conventional spatially-coupled slotted ALOHA.

关键词： spatial coupling coded slotted ALOHA contention-based access density evolution irregular repetition

Effect of cooling rate during quenching on the microstructure and creep property of nickel-based superalloy FGH96

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International Journal of Minerals,Metallurgy and Materials 2019年第4期26卷 493-499页

作者： ye-fei Feng Xiao-ming Zhou Jin-wen Zou Gao-feng Tian Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The effect of cooling rate during quenching on the microstructure and creep property of nickel-based superalloy FGH96 was investigated. Three groups of samples were quenched continuously with three fixed cooling rates, respectively, then subjected to a creep test under a constant load of 690 MPa at 700℃. Clear differences in size of secondary γ′ precipitates, creep properties and substructure of creep-tested samples were observed. The quantitative relationship among cooling rate, the size of secondary γ′ precipitates, and steady creep rate was constructed. It was found that with increasing cooling rate, the size of secondary γ′ precipitates decreases gradually, showing that the relationship between the size of secondary γ′ precipitates and the cooling rate obeys a power law, with an exponent of about –0.6, and the creep rate of steady state follows a good parabola relationship with cooling γ′ precipitate size. For 235℃/min, FGH96 alloy exhibited very small steady creep rate. The density of dislocation was low, and the isolated stacking fault was the dominant deformation mechanism. With decreasing cooling rates, the density of dislocation increased remarkably, and deformation microtwinning was the dominant deformation process. Detailed mechanisms for different cooling rate were discussed.

关键词： quantitative relationship cooling rate secondaryγ′precipitates steady creep rate deformation mechanism

The uncertainty and quantum correlation of measurement in double quantum-dot systems

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Frontiers of physics 2022年第6期17卷 211-218页

作者： Long-Yu Cheng fei ming Fa Zhao Liu ye Dong Wang School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China

In this work,we study the entropic uncertainty and quantum discord in two double-quantum-dot(DQD)system coupled via a transmission line resonator(TLR).Explicitly,the dynamics of the systemic quantum correlation and measured uncertainty are analysed with respect to a general Xtype state as the initial ***,it is found that the different parameters,including the eigenvalueαof the coherent state,detuning amountδ,frequencyωand the coupling constant g,have subtle effects on the dynamics of the entropic uncertainty,such as the oscillation period of the *** is clear to reveal that the quantum discord and the lower bound of the entropic uncertainty are anti-correlated when the initial state of the system is the Werner-type state,while quantum discord and the lower bound of the entropic uncertainty are not anti-correlated when the initial state of the system is the Bell-diagonal ***,we claim that the current investigation would provide an insight into the entropic uncertainty and quantum correlation in DQDs system,and are basically of importance to quantum precision measurement in practical quantum information processing.

关键词： uncertainty relations quantum correlation quantum dot