Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

作     者：Hai-qiong ZHENG Jia-bing RONG Fei-ming YE Yin-chuan XU Hong S.LU Jian-an WANG Hai-qiong ZHENG;Jia-bing RONG;Fei-ming YE;Yin-chuan XU;Hong S. LU;Jian-an WANG

作者机构：Department of Cardiologythe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cardiovascular Key Laboratory of Zhejiang ProvinceHangzhou 310009China Saha Cardiovascular Research CenterUniversity of KentuckyLexingtonKY 40536USA Department of PhysiologyCollege of MedicineUniversity of KentuckyLexingtonKY 40536USA 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2020年第21卷第8期

页      面：603-610页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Project supported by the National Natural Science Foundation of China(Nos.81870292 and 81971860) the National Key Research and Development Program of China(No.2016YFC1301204) 

主　　题：Thoracic aortic dissection(TAD) β-Aminopropionitrile(BAPN) AngiotensinⅡ(AngⅡ) Mouse model Hypertension 

摘      要：Thoracic aortic dissection(TAD)is one of the most lethal aortic diseases due to its acute onset,rapid progress,and high rate of aortic *** pathogenesis of TAD is not completely *** this mini-review,we introduce three emerging experimental mouse TAD models usingβ-aminopropionitrile(BAPN)alone,BAPN for a prolonged duration(four weeks)and then with added infusion of angiotensinⅡ(AngⅡ),or co-administration of BAPN and AngⅡ*** aim to provide insights into appropriate application of these three mouse models,thereby enhancing the understanding of the molecular mechanisms of TAD.