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Rare Metals 2023年第2期42卷 399-405页

作者： Ai-Ji wang Liang Yang Jian Ge Gong-Xun Deng Yu-Ben Yang Jing-Di Lu Yue-Lin Zhang Yin-Shu wang Hai-Ming Yu ling-fei wang Ce-Wen Nan Jin-Xing Zhang Department of Physics Beijing Normal UniversityBeijing100875China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei230026China Fert Beijing Institute MIIT Key Laboratory of SpintronicsSchool of Integrated Circuit Science and EngineeringBeihang UniversityBeijing100191China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Electric-field control of topological magnetic states in thinfilm heterostructures is promising for applications in nextgeneration memory or logic devices with ultrahigh density and low-power *** materials,where spin and polar degrees of freedom coexist,provide a versatile playground to manipulate magnetism(converse magnetoelectric effect).Here,we report that the topological spin textures can be controlled by electric field in rhombohedral BiFeO_(3)/monoclinic La_(0.67)Sr_(0.33)MnO_(3)thin-film heterostructure at room temperature.

关键词： temperature textures field

PKC and PKA mediate LPS-induced release of CGRP in DRG neurons of neonatal rats

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Acta Pharmacologica Sinica 1999年第5期 87-88页

作者： HOU ling-fei, wang Xian(Institute of Vascular Medicine, Third Hospital, Beijing MedicalUniversity, Beijing 100083 , China)

Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is produced in dorsal root ganglia (DRG) neurons, which extend nerves peripherally to different organs and centrally to the spinal *** have previously reported that plasma levels of CGRP are significantly elevated in rats after injection of lipopolysaccharide (LPS) in *** triggers CGRP release from capsaicin-sensitive sensory nerves in the isolated mesenteric arteial bed of the *** this work, we used the cultured DRG neurons of neonatal mrs to detemine whether or not LPS could trigger CGRP release and if it did so, what cellular signaling pathway was involved in the CGRP *** were disassociated from the DRG of 5- 7-d neonatal rat using

关键词： CGRP DRG PKC and PKA mediate LPS-induced release of CGRP in DRG neurons of neonatal rats PKA

Theoretical Studies on Nb2Bx–（x = 1–6） Clusters

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Theoretical Studies on Nb2Bx–（x = 1–6） Clusters

His bundle pacing versus left bundle branch pacing on ventricular function in atrial fibrillation patients referred for pacing:a prospective crossover comparison

中国化学会第十二届全国量子化学会议

作者： ling-fei wang Chan-Juan Xia Yong-Fan Zhang Xin Huang Department of Chemistry Fuzhou University

Because of the electron deficiency for boron,bulk boron and metal borides possess unusual chemical bonding and physicochemical properties,and have attracted sustained research interests over the past *** boride clusters can be used as models to provide fundamental insights into molecular structures and chemical *** the current work,we are interested in investigating the structural and electronic properties of di-niobium boride clusters Nb2Bx–/0（x=1–6）.Extensive DFT calculations were performed at the BP86 level to locate the ground states of Nb2Bx–/0（x=1–6）.The fascinated structural evolution is observed in Nb2Bx–（x=1–6）clusters,which shows the equatorial boron chain extends around the Nb-Nb dimer with x increasing and an enclosed planar B6 ring emerges in *** ground state of Nb2B6-cluster（Figure 1a）is found to be a hexagonal bipyramid structure with D6h（2A2u）*** ground state of Nb2B6（D6h,1A1g）（Figure 1b）is similar to the anion in term of atomic *** electron detachment energies（VDEs）are calculated using the generalized Koopmans’*** first VDE（Figure 1c）of Nb2B6-is calculated to be 1.31 e *** orbitals are performed to elucidate the chemical bonding and electronic properties in these clusters.

关键词：

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Journal of Geriatric Cardiology 2023年第1期20卷 51-60页

作者： Yang YE Bo GAO Yuan LV Tian-Tian XU Si-Si ZHANG Xiao-Li LU Ying YANG Dong-Mei JIANG Yi-Wen PAN Xia SHENG Bei wang Yan-Kai MAO Zu-Wen ZHANG Shi-Quan CHEN Jie-Fang ZHANG Li wang Jiang-Fen JIANG Ya-Xun SUN Yan MA fei-ling wang Min wang Hong HE Chen-Yang JIANG Guo-Sheng FU Department of Cardiology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Cardiology Zhejiang Rongjun HospitalJiaxingZhejiang ProvinceChina Department of Cardiology Lishui People’s HospitalLishuiZhejiang ProvinceChina Department of Cardiology Ningbo Ninth HospitalNingboZhejiang ProvinceChina Department of Cardiology Anji people’s HospitalNingboZhejiang ProvinceChina Department of Diagnostic Ultrasound and Echocardiography Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

BACKGROUND His bundle pacing(HBP)and left bundle branch pacing(LBBP)both provide physiologic pacing which maintain left ventricular *** both improve heart failure(HF)symptoms in atrial fibrillation(AF)*** aimed to assess the intra-patient comparison of ventricular function and remodeling as well as leads parameters corresponding to two pacing modalities in AF patients referred for pacing in intermediate *** Uncontrolled tachycardia AF patients with both leads implantation successfully were randomized to either *** measurements,New York Heart Association(NYHA)classification,quality-of-life assessments and leads parameters were obtained at baseline and at each 6-month follow *** ventricular function including the left ventricular endosystolic volume(LVESV),left ventricular ejection fraction(LVEF)and right ventricular(RV)function quantified by tricuspid annular plane systolic excursion(TAPSE)were all *** Consecutively twenty-eight patients implanted with both HBP and LBBP leads successfully were enrolled(69.1±8.1 years,53.6% male,LVEF 59.2%±13.7%).The LVESV was improved by both pacing modalities in all patients(n=23)and the LVEF was improved in patients with baseline LVEF at less than 50%(n=6).The TAPSE was improved by HBP but not LBBP(n=23).CONCLUSION In this crossover comparison between HBP and LBBP,LBBP was found to have an equivalent effect on LV function and remodeling but better and more stable parameters in AF patients with uncontrolled ventricular rates referred for atrioventricular node(AVN)*** could be preferred in patients with reduced TAPSE at baseline rather than LBBP.

关键词： ventricular patients bundle

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren fei Zheng Tingwei Cao Qiang wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： fei Lv Longjie Liu Jiazhe Wu Pengfei wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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基于PCA的水质紫外吸收光谱分析模型研究

光谱学与光谱分析 2016年第11期36卷 3592-3596页

作者：赵友全李霞刘潇董鹏飞王伶俐王先全天津大学精密仪器与光电子工程学院天津300072 重庆理工大学电子信息与自动化学院重庆400054

利用紫外光谱分析水中有机污染物已成为水质实时在线监测的重要方法之一,水样组分复杂且不稳定是影响其测量结果的主要因素。利用主成分分析法(PCA)结合欧氏距离分析水样紫外吸收光谱,对水样分类,效果良好。分别用主成分分析结合偏最小... 详细信息

利用紫外光谱分析水中有机污染物已成为水质实时在线监测的重要方法之一,水样组分复杂且不稳定是影响其测量结果的主要因素。利用主成分分析法(PCA)结合欧氏距离分析水样紫外吸收光谱,对水样分类,效果良好。分别用主成分分析结合偏最小二乘法回归(PCA-PLSR)和直接利用多波长吸光度结合偏最小二乘法回归(MWA-PLSR)建立分析模型,并对比分析了不同浓度的COD标准液的实验数据。结果表明,采用第一、二主成分作为回归参数的PLSR模型的测量误差在5%以内,偏差最小。利用本文方法可同时实现水样分类和水质参数的精确定量。

关键词：紫外吸收光谱水质分析 PCA PLSR 水样分类

微小RNA-126与冠心病发生发展关系的研究进展

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内蒙古医科大学学报 2016年第4期38卷 361-365页

作者：滕菲王玲内蒙古医科大学内蒙古呼和浩特010059 内蒙古自治区人民医院心血管内科

微小RNA(miRNAs)是一类高度保守的内源性非编码小分子单链RNA,能通过特异性识别靶基因mRNA,在翻译水平调节基因表达,从而调节细胞分化、生长发育、增殖与凋亡、激素分泌等各种过程。现已经发现多种miRNA,其中微小RNA-126(miR-126)主要... 详细信息

微小RNA(miRNAs)是一类高度保守的内源性非编码小分子单链RNA,能通过特异性识别靶基因mRNA,在翻译水平调节基因表达,从而调节细胞分化、生长发育、增殖与凋亡、激素分泌等各种过程。现已经发现多种miRNA,其中微小RNA-126(miR-126)主要存在于血管内皮细胞和血小板当中,与血管的生成、发育、修复功能密切相关,与高血压、冠心病、心力衰竭等心血管疾病密切相关。其中,冠心病即将成为危害全人类健康的头号致死杀手,其诊断和治疗备受关注。本文就miR-126在冠心病发生发展过程中的作用进行系统综述。

关键词：微小RNA-126 冠心病内皮功能障碍动脉粥样硬化血管生成血管修复生物标志物

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu ling Zhang Meng wang Zhiying He Yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors