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Palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylates via direct C(sp^2)-H or C(sp^3)-H bond activation

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Chinese Chemical Letters 2016年第10期27卷 1617-1621页

作者： Jun Ding ying Guo Ling-Yan Shao fei-yi zhao Dao-Hua Liao Hong-Wei Liu Ya-fei Ji School of Pharmacy East China University of Science & Technology

A palladium-catalyzed multi-acetoxylation of 1,3-disubstituted 1H-pyrazole-5-carboxylate derivatives containing multiple potential reactive sites is described. Therein, the sequence of this process has been appropriately investigated. The protocol mainly provides the di- and tri-acetoxylated products for 1,3- diarylpyrazoles. Besides, it is found that the acetoxylation of C（sp3）-H bond is prior to that of C（sp2）-H bond under structurally competitive conditions.

关键词： Palladium catalysisFunctionalized pyrazolesMulti-acetoxylationC-H activationMonodentate directing group

Attention network function of insomniacs improved by manual acupuncture: Evidence from Attention Network Task

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 91-96页

作者： fei-yi zhao Hong XU Yu-fang HONG ying-xia zhao Haixia YAN Qia-yi MA Xing MING Jing HU Yan XU Nursing Department Shanghai Sanda University Shanghai 201209 China Shanghai Municipal Hospital of TCM affiliated to Shanghai TCM University Shanghai 200071 China College of Basic Medicine Shanghai University of TCM Shanghai 201203 China Shanghai Tianshan Hospital of TCM Shanghai 200051 China

Objective:To investigate if manual acupuncture can improve the primary insomnia-induced impairments of attention network function and its ***:Totally 64 eligible participants were enrolled in a randomized controlled trial,with 32 cases allocated to the treatment group and 32 cases allocated to the control group,*** participants in the treatment group received real-acupuncture therapy[acupuncture at 'Five Spirits Acupoints' including Shéntíng(神庭 GV 24),Běnshén(本神 GB 13),Sìshéncōng(四神聪 EX-HN 1),Shéndào(神道 GV11)and Shénmén(神门 HT 7)]whereas participants in control group received sham-acupuncture therapy with Streitberger placebo-needle and same *** were offered every two days and three times a week for total 8 *** Pittsburgh sleep quality index(PSQI)and Attention Network Task(ANT)were employed to assess the changes of sleep quality and attention network function at pretreatment and post-treatment,***,adverse effects were monitored and ***:(1)After 8-week treatment,the total score of PSQI in the treatment group decreased from14.22±3.46 to 8.19±3.34(P<0.001),and the total score of PSQI in the control group decreased from12.84±3.90 to 11.41±3.90(P<0.05).The decrease in the treatment group was more significant than that in the control group(P<0.001).(2)After treatment,the alerting efficiency of both groups increased,the treatment group increased from 40.44±5.62 to 56.44±5.37(P<0.001),and the control group increased from 39.50±6.39 to 40.06±6.14(P<0.05).The increase in the treatment group was more significant than that in the control group(P<0.001).The total reaction time of both groups decreased,the treatment group decreased from 574.94±10.1 to 548.34±15.05(P<0.001),and the control group decreased from578.25±13.26 to 576.78±12.15(P<0.05).The decrease in the treatment group was more significant than that in the control group(P<0.001).(3)No obvious change in orienting efficiency was observed in

关键词： Insomnia Attention network function Acupuncture

SOOJI CHIM (Koryo hand acupuncture) for perimenopausal insomnia:Evidence from actigraphy and serum hormone testing

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 274-278页

作者： fei-yi zhao Jin-Hyeok Kim Li-Ping Yue Hai-Xia Yan Hua-Ling Song Yan Xu Hong Xu Yu-Fang Hong Qiang-Qiang Fu Nursing Department Shanghai SANDA UniversityShanghai 201209China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Municipal Hospital of TCM Affiliated to Shanghai TCM University Shanghai 200071China Research Department Yangpu HospitalTongji UniversityShanghai 200090China

Objective:This study is conducted to determine the effects of SOOJI CHIM(Koryo hand acupuncture,KHA)therapy on sleep structures and perimenopause symptoms among ***:Totally 49 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial,with 24 cases allocated to a real-KHA group and 25 cases allocated to a sham-KHA *** in each group received corresponding treatment every other day,three times a week for total eight *** actigraphy and testing of serum hormones level reflected by biological markers such as follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were performed at pre-and ***,the scores of Pittsburgh sleep quality index(PSQI)was used for assessing the subjective sleep experience of ***,adverse effects were monitored and ***:After eight-week treatment,the global scores of PSQI declined significantly(P0.05).According to the outcomes of actigraphy,a striking increase was observed in both sleep efficiency(SE)and total sleep time(TST)in the real-KHA group(both P0.05).However,no significant changes of sleep awakenings(SA)in both groups was found after treatment(both P>0.05).Meanwhile,FSH and LH in the real-KHA group decreased markedly after intervention(both P0.05).The fluctuation of E2 levels were not significant in both groups(both P>0.05).No serious adverse event was reported in either real-or sham-KHA ***:KHA may be a potential alternative therapy for improving perimenopausal insomnia via down regulating the levels of FSH and LH.

关键词： Perimenopausal insomnia SOOJI CHIM(Koryo hand acupuncture,KHA) Actigraphy Serum hormone testing

Post-schizophrenia comorbid depressive disorder and insomnia treated by acupuncture combined with Chinese medicine:A retrospective case series based on JBI reporting checklist

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World Journal of Acupuncture-Moxibustion 2021年第4期31卷 314-319页

作者： fei-yi zhao Hong XU Hui-ru WANG Qiang-qiang FU Wen-jing ZHANG Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai201209China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai200071China Yangpu Hospital Tongji University School of MedicineShanghaiChina

Background:Acupuncture combined with Chinese herbal medicine was performed on 24 patients with post-schizophrenia comorbid depressive disorder and insomnia admitted to the Psychiatry Department,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine from 2016 to 2020,and provided satisfactory *** post-schizophrenia comorbid depressive disorder and insomnia is not a common clinical disorder in hospital of traditional Chinese medicine,the treatment and follow-up cycle is long,and the dropout rate is high,a retrospective case series based on Joanna Briggs Institute(JBI) reporting checklist were conducted instead of a randomized controlled ***:To retrospectively summary the short-,mid-and long-term effects of acupuncture combined with Chinese herbal medicine for post-schizophrenia comorbid depressive disorder and insomnia,and analyze the principles of the ***:A retrospective analysis based on case series JBI reporting checklist were performed to investigate effects of 24 patients with post-schizophrenia comorbid depressive disorder and insomnia undergoing 12-week combined acupuncture and Chinese herbal medicine treatment(patients did not receive full dosage treatments,or received western medicine or other physical and psychological therapies during the treatment period were excluded).The psychotic symptoms,depression,insomnia,and self-care ability for daily living were measured by the Positive and Negative Syndrome Scale(PANSS),Calgary Depression Scale for Schizophrenia(CDSS),Pittsburgh Sleep Quality Index(PSQI),and Activity of Daily Living Questionnaire(ADL-Q),***-ups were conducted at 8 and 16 weeks after ***,Acupuncture Beliefs Scale(ABS) was assessed at pre-and post-treatment as well as 16-week follow-up to investigate patients’ beliefs and expectations for acupuncture ***:(1) compared with pre-treatment,the PANSS global

关键词： Case series Chailong-Muli decoction Insomnia Joanna Briggs Institute(JBI)reporting checklist Manual acupuncture Post-schizophrenia depressive disorder

The effect of electroacupuncture preconditioning on cognitive impairments following knee replacement among elderly:A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2018年第4期28卷 231-236,309页

作者： fei-yi zhao Zhe-yuan ZHANG ying-xia zhao Hai-xia YAN Yu-fang HONG Xiao-jie XIA Hong XU Shanghai Municipal Hospital of TCM Affiliated to Shanghai University of TCM Shanghai200072China Haiyan People’s Hospital Zhejiang 314300China School of Basic Medical Sciences Shanghai University of TCMShanghai 201203China Department of Education East China Normal UniversityShanghai 200062China

Objective: To investigate if electroacupuncture(EA) preconditioning can mitigate cognitive impairments and reduce the incidence of postoperative cognitive dysfunction(POCD) following knee replacement and its safety among ***: Totally 60 participants met the inclusion criteria were enrolled in a randomized controlled trial a ratio of 1:1, with 30 cases allocated to the treatment group and 30 cases allocated to the control group, respectively. The participants in the treatment group were provided with real-EA therapy whereas participants in control group were provided with placebo-EA therapy(Streitberger Placebo-needle). In both groups, Tou sanshen(头三神)acupoints, including Sìshéncōng(四神聪EX-HN1), Sh6 ntíng(神庭 GV24),and bilateral Běnsh6 n(本神GB13) were adopted as the main acupoints, while Bǎihui(百会GV20), bilateral Hégǔ(合谷Ll4), and bilateral Tàich6 ng(太冲LR3) were adopted as matching acupoints. Interventions were offered 5 days prior to the surgery, once daily, and continued for total 5 days. The global scores of MiniMental State Examination(MMSE), and levels of serum inflammatory cytokines including interleukin 1β(IL-1β) and tumor necrosis factor-α(TNF-α), and S100-β protein were observed at 24 h prior to the surgery, and postoperative 24 and 72 h respectively for assessing the incidence of POCD and the severity of cognitive impairments among patients. Meanwhile, adverse effects were monitored and ***:(1) Compared with baseline, MMSE global scores in both treatment and control groups markedly decreased at postoperative 24 h. MMSE global scores in treatment group decreased from 29.43 ±0.97 to27.10 ±1.95 while that in control group decreased from 29.27 ± 1.01 to 26.83 ± 2.25(all ?P< 0.05), and this trend continued until postoperative 72 h(at postoperative 72 h, MMSE global scores in treatment group was 26.53 ±2.26 versus 24.79 ±3.03 in control group). Moreover, decline in control group was more significant than that in treatment group at postoperati

关键词： Postoperative cognitive dysfunction Electroacupuncture Preconditioning Knee replacement Elderly

Does acupuncture response increase with the increasing dosage:A preclinical study investigating rats with sleep deprivation

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World Journal of Acupuncture-Moxibustion 2020年第3期30卷 207-216页

作者： fei-yi zhao Yan XU Guo-hua WANG Qia-yi MA Qiang-qiang FU Zhi-min LI Hong XU Li-ping YUE Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200071China Shanghai Tianshan Hospital of Traditional Chinese Medicine Shanghai 200051China Research Department Yangpu hospitalTongji University School of MedicineShanghai 200090China

Background:The effectiveness of acupuncture for insomnia and insomnia-related anxiety and depression has been widely investigated in clinical ***,whether higher dosage(more frequent)acupuncture can bring greater responses(a greater size of effect)is less ***:This study is designed to investigate whether a five-times weekly(5 Ts/w)electroacupuncture(EA)treatment is better than a three-times weekly(3 Ts/w)EA in alleviating sleep deprivation,and sleep disturbance-induced cognitive dysfunctions and negative emotions in rats through four various behavioral te ***:Forty-six male Sprague-Dawley rats were randomly divided into control group(n=10),model group(n=12),EA-3 Ts/w group(n=12),and EA-5 Ts/w group(n=12).Except for the control group,the other three groups were established as chronic sleep deprivation models via the modified multi-platform water environment ***,rats in both EA-3 Ts/w group and EA-5 Ts/w group received corresponding dosage of EA therapy,*** modeling and interventions,all four groups received four behavioral tests as follows:(1)sleep behavioral monitoring and evaluation was achieved by Comprehensive Lab Animal Monitoring System(CLAMS).(2)Cognitive functions were assessed by Novel Object Recognition(NOR)test.(3)Depressive-like behaviors was evaluated by Open-Field(OF)test.(4)Anxietylike behaviors was appraised by Elevated Plus-Maze(EPM)*** finishing the behavioral tests,the hippocampus of each rat was removed and its synaptic structure changes were observed under electron ***:(1)CLAMS:two EA groups derived more sleep time within 24 h than the model group(both P0.05).(2)NOR test:NOR ratio in the EA-3 Ts/w group was higher than that of the model group(P<0.05)but lower than that of either the control group(P<0.05)or the EA-5 Ts/w group(P<0.05).(3)OF test:the difference of horizontal movements bet

关键词： Electroacupuncture Sleep deprivation Depressive-like behaviors Anxiety-like behaviors Behavioral test

Manual acupuncture for patients with major depressive disorder and comorbid insomnia:Evidence from polysomnography and serum biomarkers

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World Journal of Acupuncture-Moxibustion 2020年第1期30卷 5-12页

作者： fei-yi zhao Yan XU Li-ping YUE ying-xia zhao ying WANG Hua-ling SONG Hong XU Si-han CHEN Qiang-qiang FU Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Department Meilong Community Healthcare Service CenterShanghai 201100China Shanghai Municipal Hospital of TCM Affiliated to Shanghai TCM University Shanghai 200071China Research Department Yangpu HospitalTongji UniversityShanghai 200090China

Objective:This study is conducted to determine effects of manual acupuncture(MA)in patients with a diagnosis of major depressive disorder(MDD)and comorbid ***:A total of 67 participants who met the inclusion criteria were randomly enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to a real-MA group(patients=34)and a sham-MA group(patients=33).Patients in the real-MA group were treated on‘Five-shen acupoints’,including Sishencong(四神聪EX-HN 1),Shenting(神庭GV 24),Shendao(神道GV 11),bilateral Benshen(本神GB 13),and bilateral Shenmen(神门HT 7).Though being punctured on the same acupoints,patients in the sham-MA group were treated by a placebo acupuncture approach(Streitberger Placeboneedle).Each group received corresponding interventions every other day,three times a week for total eight *** polysomnography(PSG)and testing of serum biological markers such as neuropeptide Y(NPY)and substance P(SP)were performed at pre-and ***,the global scores of Pittsburgh sleep quality index(PSQI)and the global scores of 17-items Hamilton Depression Rating Scale(HAMD17)were used for assessing the subjective sleep and emotion experience of patients,***,adverse effects were monitored and ***:After eight-week treatment,the global scores of PSQI and global scores of HAMD17 declined significantly(both P0.05).According to the parameters of PSG,striking decline were observed in sleep latency(SL)and wake after sleep onset(WASO)and striking climb were observed in total sleep time(TST)and sleep efficiency(SE)in the real-MA group after treatment(P0.05,respectively).Additionally,there were no significant differences in awakening times(ATs)and rapid eyes movement sleep latency(REM-SL)in both two groups after treatment(both P>0.05).Meanwhile,the expression of NPY increased significantly

关键词： Major depressive disorder Insomnia Manual acupuncture Polysomnography Neuropeptide Y Substance P

Occupational therapy with or without combined acupuncture on upper limb pain and hand functions in children with spastic hemiplegic cerebral palsy:A three-arm randomized,placebo-controlled trial

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World Journal of Acupuncture-Moxibustion 2022年第1期32卷 1-8页

作者： fei-yi zhao Yan XU Li-ping YUE Si-han CHEN Xiao-jie XIA Ci HAN Qiang-qiang FU Department of Nursing School of International Medical TechnologyShanghai Sanda UniversityShanghai 201209China Shanghai Xieai TCM Hospital Shanghai University of Traditional Chinese MedicineShanghai 201499China Faculty of Education East China Normal UniversityShanghai 200062China Yangpu Hospital School of MedicineTongji UniversityShanghai 200090China

Objective:This study is conducted to investigate the effects of occupational therapy(OT) with or without combined acupuncture for upper limb pain and hand functions among children with spastic hemiplegic cerebral ***:A total of 90 patients who met the inclusion criteria were enrolled in a three-arm randomized,placebo-controlled trial,and were allocated to mono-occupational therapy(OT) group(patients=30),OT combined with real-acupuncture(ORA) group(patients=30),and OT combined with placeboacupuncture(OPA) group(patients=30),*** addition to receiving the conventional OT program as the basic treatment for total 8 weeks,patients in ORA and OPA group also received corresponding acupuncture treatment 5 days per week for the first two weeks,3 days per week for the next two weeks,2 days per week for another two weeks,and 1 day per week for the last two ***-communicating children’s pain checklist-revised scale(NCCPC-R) was used for assessing the upper limb pain among *** dynamometry,modified Ashworth scale(MAS),manual muscle testing(MMT),JebsenTaylor hand function test(JTHFT) and box and block test(BBT) were used for assessing various aspects of upper limb and hand functions among ***,adverse effects were monitored and ***:After 8-week treatment,NCCPC-R global scores witnessed a dramatic decline in ORA group(P 0.05) or OT group(P> 0.05).Dramatic increases were identified in both squeeze dynamometry scores and MMT scores in all three groups(all P 0.05).The BBT global scores of all three groups significantly increased(all P <0.05) after *** them,the increase of the ORA group was more than that of the other two groups(P <0.05).The 8-week treatment also had a significant impact on

关键词： Occupational therapy Acupuncture Placebo-acupuncture Pain Hand functions Spastic hemiplegic cerebral palsy

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis