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A new cyclopeptide from Dianthus caryophyllus

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Chinese Chemical Letters 2008年第2期19卷 193-195页

作者： fei li feng Mei Zhang Ya Bin Yang Xue Qiong Yang Qiu E. Cao Zhong Tao Ding Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of Education School of Chemical Science and Technology Yunnan University # 2 Green Lake North Road Kunming 650091 China

A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-）（1） and cyclo （-Ala-Gly-Ser-IIe-P... 详细信息

关键词： Caryophyllaceae Dianthus caryophyllus Cyclopeptide Caryophllusin A

Assessment of deep groundwater over-exploitation in the North China Plain

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Geoscience Frontiers 2011年第4期2卷 593-598页

作者： Jiansheng Shi Zhao Wang Zhaoji Zhang Yuhong fei Yasong li feng＇e Zhang Jingsheng Chen Yong Qian Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences Shigang Street 406 ShijiazhuangHebei 050061 China

A series of environmental—geological problems have been caused by over-exploitation of deep groundwater（i.e.,confined aquifer water） in the North China *** order to better understand the status of deep groundwater over-exploitation and the resultant environmental—geological problems on a regional scale,the over-exploitation of groundwater has been assessed by way of the groundwater exploitation potential coefficient（i.e.,the ratio of exploitable amount of deep groundwater to current exploitation）, cumulative land subsidence,and long-term average lowering rate of the groundwater *** is a good correlation among the results calculated by the different *** a regional scale,deep groundwater has been over-exploited and there is no further exploitation potential under the current *** groundwater exploitation degree index takes the exploitation in 2003 as the reference for the calculations, so the results mainly reflect the degree of current groundwater *** results of over-exploitation of deep groundwater obtained by land subsidence data and long-term average rate of depression of the water table mainly reflect environmental—geological problems caused by exploitation of deep groundwater.

关键词： North China Plain Deep groundwater Assessment of over-exploitation Land subsidence Water table depression

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-lin li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

温度响应型PNIPAM/γ-PGA水凝胶正渗透汲取剂的制备及其性能评价

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膜科学与技术 2017年第3期37卷 46-52页

作者：李菲封莉吴言张立秋北京林业大学环境科学与工程学院北京100083

采用N-异丙基丙烯酰胺(NIPAM)和γ-聚谷氨酸(γ-PGA)为合成单体,制备温度响应型半互穿网络聚合二元水凝胶,利用红外光谱和扫描电镜对其结构和形态进行表征,研究不同单体配比条件下水凝胶的溶胀和退溶胀性能,并考察二元水凝胶作为正渗透... 详细信息

采用N-异丙基丙烯酰胺(NIPAM)和γ-聚谷氨酸(γ-PGA)为合成单体,制备温度响应型半互穿网络聚合二元水凝胶,利用红外光谱和扫描电镜对其结构和形态进行表征,研究不同单体配比条件下水凝胶的溶胀和退溶胀性能,并考察二元水凝胶作为正渗透汲取剂的应用效能.结果表明,二元水凝胶具有明显的孔状结构,其平衡溶胀率随γ-PGA单体比例的增加而升高,在NIPAM∶γ-PGA(质量比)=5∶1时,平衡溶胀率为40.3g/g;在40℃下持续脱水6h,脱水率可达80%以上.将所制备的二元水凝胶作为正渗透汲取剂时,0.5h内的水通量为1.1~1.4L/(m^2·h),且重复利用效果较好.随着原料液NaCl浓度不断升高,水通量逐渐降低,当原料液NaCl浓度为2g/L时,0.5h内水通量约为1.0L/(m^2·h).

关键词：温度响应型水凝胶正渗透汲取剂

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan Qin Qiaoyan Wen fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

Effects of an autophagy/lysosomal pathway on the death of dopaminergic cells

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Effects of an autophagy/lysosomal pathway on the death of do...

Copper homeostasis and neurodegenerative diseases

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Xi-feng fei,li ling-Yun,Zheng-Hong QIN,Zhong-Qin liANG Department of Pharmacology,Soochow University School of Medicine,Suzhou 215123,China

＜正＞Objective To study the role of an autophagy/lysosomal pathway in 6-OHDA-induced death of dopaminergic cells in PD *** In this study,we estabUshed two PD models in vivo and in *** model were produced with stereotaxic administration of 6-OHDA into unilateral substantia nigra par compact（SNpc）.SH-SY5Y cells were administrated with *** in SNpc were observed with transmission electronmicro-scopy（TEM）. Autophagosomes in SH-SY5Y cells were observed by MDC *** related to apoptosis and autophagy were determined with immuno-fluorescence（IF） and Western *** of autophagy/lysosome inhibitors on 6-OHDA-induced cathepsin L and NF-kB activation were also *** assay was applied to detect *** TEM revealed mat the formation of autophagosomes in the ipsilateral SNpc after injection of *** staining also showed that autophagosomes appeared in SH-SY5Y cell induced by *** demonstrated that expression of lamp-1,cathepsin B,L and LC3 increased after 6-OHDA *** with inhibitors can potentiated the cytotoxicitiy of 6-OHDA in the earlier stage,while it attenuated 6-OHDA-induced death in the later period. Nuclear-location of Cathepsin L and NF-kB p65was induced by *** with inhibitors downregulated 6- OHDA-induced activation of LC3,cathepsin L and NF-kB,also reduced the number of TUNEL-positive *** The increase of autophagosomes and the activation of lysosomes may be involved in the toxicity induced by 6-OHDA. Autophagy/lysosome pathway may have a crosstalk with apoptosis mediated by *** can be protective in the earlier stage of 6-OHDA administration,while promote the death of dopaminergic cells in the later period by activating autophagy/lysosome-mediated death pathways.

关键词： autophagy lysosome Parkinson’s disease(PD) dopaminergic neurons 6-Hydroxydopamine

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi li Kaifei Xu Guoqing Wang feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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乳腺病灶超声学检查方法的现状与展望

中国医学影像技术 2017年第10期33卷 1562-1565页

作者：靳凤梅马苏美王惠冯菲李金船兰州大学第一医院超声科甘肃兰州730000

乳腺癌是女性生殖系统第二大恶性肿瘤。随着现代医学影像技术的发展,常规超声、乳腺X线摄影是乳腺体检和肿瘤筛查的主要检查手段,CT、MRI、核医学检查是辅助手段,此外,对缺乏影像特征的病灶可行CEUS及穿刺活检。本文对各种影像学检查方... 详细信息

乳腺癌是女性生殖系统第二大恶性肿瘤。随着现代医学影像技术的发展,常规超声、乳腺X线摄影是乳腺体检和肿瘤筛查的主要检查手段,CT、MRI、核医学检查是辅助手段,此外,对缺乏影像特征的病灶可行CEUS及穿刺活检。本文对各种影像学检查方法对乳腺病灶的诊断价值及现状进行综述。

关键词：乳腺肿瘤影像检查