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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min li Jiazhi Chen Zhuyong Wang Huantao Wen ming Zhou Minjie Luo Wangming zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Twist-teleportation-based local discrimination of maximally entangled states

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 46-52页

作者： Mao-Sheng li Shao-ming fei zong-Xing Xiong Yan-ling Wang Department of Physics Southern University of Science and TechnologyShenzhen 518055China Department of Physics University of Science and Technology of ChinaHefei 230026China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Max-Planck-Institute for Mathematics in the Sciences Leipzig 04103Germany Department of Mathematics South China University of TechnologyGuangzhou 510640China School of Computer Science and Network Security Dongguan University of TechnologyDongguan 523808China

In this work,we study the local distinguishability of maximally entangled states(MESs).In particular,we are concerned with whether any fixed number of MESs can be locally distinguishable for sufficiently large *** and Tian et *** already obtained two satisfactory results for the generalized Bell states(GBSs)and the qudit lattice states when applied to prime or prime power *** construct a general twist-teleportation scheme for any orthonormal basis with MESs that is inspired by the method used in[***.A 70,022304(2004)].Using this teleportation scheme,we obtain a sufficient and necessary condition for one-way distinguishable sets of MESs,which include the GBSs and the qudit lattice states as special ***,we present a generalized version of the results in[***.A 92,042320(2015)]for the arbitrary dimensional case.

关键词： teleportation local discrimination maximally entangled states

Dynamic prediction of landslide displacement using singular spectrum analysis and stack long short-term memory network

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Journal of Mountain Science 2021年第10期18卷 2597-2611页

作者： li li-min zhang ming-yue WEN zong-zhou College of Electronics and Information Xi’an Polytechnic UniversityXi’an 710048China

An accurate landslide displacement prediction is an important part of landslide warning system. Aiming at the dynamic characteristics of landslide evolution and the shortcomings of traditional static prediction models, this paper proposes a dynamic prediction model of landslide displacement based on singular spectrum analysis(SSA) and stack long short-term memory(SLSTM) network. The SSA is used to decompose the landslide accumulated displacement time series data into trend term and periodic term displacement subsequences. A cubic polynomial function is used to predict the trend term displacement subsequence, and the SLSTM neural network is used to predict the periodic term displacement subsequence. At the same time, the Bayesian optimization algorithm is used to determine that the SLSTM network input sequence length is 12 and the number of hidden layer nodes is 18. The SLSTM network is updated by adding predicted values to the training set to achieve dynamic displacement prediction. Finally, the accumulated landslide displacement is obtained by superimposing the predicted value of each displacement subsequence. The proposed model was verified on the Xintan landslide in Hubei Province, China. The results show that when predicting the displacement of the periodic term, the SLSTM network has higher prediction accuracy than the support vector machine(SVM) and auto regressive integrated moving average(ARIMA). The mean relative error(MRE) is reduced by 4.099% and 3.548% respectively, while the root mean square error(RMSE) is reduced by 5.830 mm and 3.854 mm respectively. It is concluded that the SLSTM network model can better simulate the dynamic characteristics of landslides.

关键词： Landslide Singular spectrum analysis Stack long short-term memory network Dynamic displacement prediction

Local heat transfer properties in co- and counter-current G-L-S magnetically stabilized fluidized beds

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Particuology 2011年第1期9卷 44-50页

作者： Jinli zhang ming zhang Wei li Xiaofang li Xiangkun Meng Baoning zong School of Chemical Engineering Technology Tianjin University Tianjin 300072 China Research Institute of Petroleum Processing SINOPEC Beijing 100083 China

Heat transfer coefficients were measured by immersed probes in co- and counter-current G-L-S magnetically stabilized fluidized beds （MSFBs） using air, water and nickel-alloy particles as the gas, liquid and solid phases. Influences of major factors, including magnetic field intensity, superficial gas and liquid velocities, liquid viscosity and surface tension, on heat-transfer properties were studied experimentally, indicating that both co- and counter-current G-L-S MSFB can provide relatively uniform radial distribution of heat transfer coefficients under appropriate operation conditions, thus controlling operation temperature for highly exothermic multi-phase reaction systems. Two correlations were provided to estimate accurately heat transfer properties in both co- and counter-current G-L-S MSFB systems, with an average error of less than 10%.

关键词： Magnetically stabilized fluidized bed Heat transfer Gas–liquid–solid

Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang zhang Jun-Bang Feng Chuan-ming li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives limitations Neural conduction

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Tungsten 2020年第1期2卷 101-106页

作者： li‑Wen zhang Hai‑Ying Fu zong‑Jian Chai Peng‑fei Zheng Ran Wei ming zhang Ji‑ming Chen Southwestern Institute of Physics Chengdu 610225China

Carbide-dispersion strengthened(CDS)vanadium alloy is a kind of advanced structural material for V/li fusion *** welding technology for the alloy is very important for its application in fusion *** the present study,preliminary investigation on dissimilar-metal bonding by hot isostatic pressing(HIP)was carried out for the CDS V alloy by joining with the conventional V-4Cr-4Ti *** characterization for the bonding interfaces and mechanical tests for bonding property evaluation were analyzed for the HIP *** results show that after the HIP,the grain size of the V-4Cr-4Ti base metal(BM)obviously increases,while the grain size near the interface is much smaller than that in the V-4Cr-4Ti *** is the reason why the hardness near the interface is larger than that of the V-4Cr-4Ti *** shear test evaluation,the HIP joint possesses good bonding property with sound strength and *** there is no phase transformation during HIP,no post-bond heat treatment(PBHT)is necessary for the dissimilar-metal joint.

关键词： Dissimilar-metal bonding Carbide-dispersion strengthened vanadium alloy Hot isostatic pressing Bonding interface Shear strength