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Synthesis of 3D models by Petri net

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第7期14卷 521-529页

作者： mo-fei SONG Zheng-xing SUN Yan ZHANG fei-qian ZHANG State Key Laboratory for Novel Software Technology Nanjing University

This paper presents a synthesis method for 3D models using Petri net. Feature structure units from the example model are extracted, along with their constraints, through structure analysis, to create a new model using an inference method based on Petri net. Our method has two main advantages: first, 3D model pieces are delineated as the feature structure units and Petri net is used to record their shape features and their constraints in order to outline the model, including extending and deforming operations; second, a construction space generating algorithm is presented to convert the curve drawn by the user into local shape controlling parameters, and the free form deformation (FFD) algorithm is used in the inference process to deform the feature structure units. Experimental results showed that the proposed method can create large-scale complex scenes or models and allow users to effectively control the model result.

关键词： Petri net Inference Interactive modeling model by example

Removal of superior wheat kernels promotes filling of inferior kernels by changing carbohydrate metabolism and sink strength

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The Crop Journal 2021年第6期9卷 1375-1385页

作者： Jian Luo Zhui Li fei mo Yuncheng Liao Yang Liu College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina

Poor filling and low weight of inferior kernels limit the further improvement of wheat yield. Two cultivars, Shuangda 1 and Xinong 538, with different grain weights, were selected to investigate the physiological changes of inferior kernels by removal of superior kernels(RS) at the flowering stage. i TRAQ combined with physiological indexes was used to identify factors limiting the filling of inferior *** of superior kernels significantly increased the mean filling rate of inferior kernels and thus increased their weight. A set of 6012 proteins in inferior wheat kernels were differentially expressed between the RS and control. These differentially expressed proteins were involved mainly in carbon metabolism and energy metabolism. The main reason for the promoting effect of RS on the filling of inferior kernels may be that RS downregulated proteins involved in glycolysis and pyruvate metabolism while upregulating proteins involved in carbon fixation and photosynthesis. Consequently, RS greatly increased the ATP content in inferior kernels, supplying energy for them to absorb photosynthetic assimilates. Removal of superior kernels increased the activities of sucrose synthase, soluble starch synthase,adenosine diphosphate glucose pyrophosphorylase, and starch branching enzyme in inferior kernels and promoted starch accumulation in them. Thus, RS promoted the filling of inferior kernels and increased their weight. The promoting effect of RS on starch synthesis in inferior kernels was associated with their endogenous IAA and ABA levels.

关键词： Inferior grain Grain filling Carbohydrate Sink strength Wheat

Extracting 3D model feature lines based on conditional random fields

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第7期14卷 551-560页

作者： Yao-ye ZHANG Zheng-xing SUN Kai LIU mo-fei SONG fei-qian ZHANG State Key Laboratory for Novel Software Technology Nanjing University

We propose a 3D model feature line extraction method using templates for guidance. The 3D model is first projected into a depth map, and a set of candidate feature points are extracted. Then, a conditional random fields (CRF) model is established to match the sketch points and the candidate feature points. Using sketch strokes, the candidate feature points can then be connected to obtain the feature lines, and using a CRF-matching model, the 2D image shape similarity features and 3D model geometric features can be effectively integrated. Finally, a relational metric based on shape and topological similarity is proposed to evaluate the matching results, and an iterative matching process is applied to obtain the globally optimized model feature lines. Experimental results showed that the proposed method can extract sound 3D model feature lines which correspond to the initial sketch template.

关键词： Nonphotorealistic rendering model feature lines Conditional random fields Feature line metrics Iterative matching

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

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Signal Transduction and Targeted Therapy 2019年第1期4卷 63-101页

作者： Yuan Cheng Cai He Manni Wang Xuelei Ma fei mo Shengyong Yang Junhong Han Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina

Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying *** dysregulation is often linked to human disease,notably *** the development of various drugs targeting epigenetic regulators,epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited viable therapeutic potential for solid tumors in preclinical and clinical *** this review,we summarize the aberrant functions of enzymes in DNA methylation,histone acetylation and histone methylation during tumor progression and highlight the development of inhibitors of or drugs targeted at epigenetic enzymes.

关键词： epigenetic clinical drugs

Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

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World Journal of Gastroenterology 2021年第40期27卷 6888-6907页

作者： mo-fei Wang Song-Song Zhao Dil momin Thapa Yu-Ling Song Zheng Xiang The Second Department of General Surgery The Affiliated Hospital of Inner Mongolia University for the NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Department of Educational Administration The First Affiliated Hospital of Liaoning Medical UniversityJinzhou 121000Liaoning ProvinceChina School of Pharmaceutical Science Liaoning UniversityShenyang 110032Liaoning ProvinceChina

BACKGROUND Fuzi(Radix aconiti lateralis)-Gancao(Radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese *** clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in the treatment of liver diseases such as hepatitis and liver *** To investigate the metabolomics of F-G in CCl4 induced acute liver injury in rats and its regulatory effect on the bile acid *** The pharmacodynamic effect of F-G on CCl4 induced acute liver injury in rats was evaluated,and an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for the simultaneous determination of 92 metabolites from multiple pathways was established to explore the protective metabolic mechanism of F-G in serum on the *** Twenty-four differential metabolites were identified in serum *** primary bile acid biosynthetic metabolic pathway was the major common pathway in the model group and F-G ***,a UPLC-MS/MS method for simultaneous determination of 11 bile acids,including cholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,glycochenodeoxycholic acid,taurocholic acid,glycocholic acid,chenodeoxycholic acid,deoxycholic acid,taurochenodeoxycholic acid,taurocholic acid,and glycinic acid,was established to analyze the regulatory mechanism of F-G in serum.F-G decreased the contents of these 11 bile acids in serum in a dose-dependent manner compared with those in the model control *** F-G could protect hepatocytes by promoting the binding of free bile acids to glycine and taurine,and reducing the accumulation of free bile acids in the liver.F-G could also regulate the compensatory degree of taurine,decreasing the content of taurine-conjugated bile acids to protect hepatocytes.

关键词： Radix aconiti lateralis Radix glycyrrhizae Liver injury Metabolites Bile acid Fuzi-Gancao

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine

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Cellular & molecular Immunology 2021年第9期18卷 2211-2223页

作者： Chunju Fang fei mo Li Liu Jing Du Min Luo Ke Men feifei Na Wei Wang Hanshuo Yang Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan University610041 ChengduP.R.China Department of Oncology Guizhou Provincial People’s Hospital550002 GuiyangGuizhouP.R.China

Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical ***,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully ***,we demonstrate that oxidized mitochondrial DNA(mtDNA)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell *** in ROS and oxidized mtDNA 8-OHG content could be induced in irradiated tumor *** mtDNA derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDNA,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor *** results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines.

关键词： Irradiated tumor cell vaccine Oxidized mitochondrial DNA STING signaling

Biochar induced trade-offs and synergies between ecosystem services and crop productivity

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Journal of Integrative Agriculture 2024年第11期23卷 3882-3895页

作者： Jinxia Wang Qiu Huang Kai Peng Dayang Yang Guozhen Wei Yunfei Ren Yixuan Wang Xiukang Wang Nangia Vinay Shikun Sun Yanming Yang fei mo College of Agronomy Northwest A&F UniversityYangling 712100China Agricultural and Animal Husbandry Technology Extension Center Linzhi 860000China College of Life Sciences Yan’an UniversityYan’an 716000China International Center for Agricultural Research in the Dry Areas(ICARDA) Raba 6299-10112tMorocco College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China College of Agronomy Inner Mongolia Agricultural UniversityHohhot 010019China

Biochar amendment offers a chance for sustainable ***,the effectiveness of biochar relies on its physical and chemical properties,which are heavily affected by biochar production conditions and management ***,substantial uncertainties regarding the use of biochar exist in agricultural systems *** study provides the first quantitative evaluation of the impacts of biochar characteristics and management practices on key ecosystem services by performing a second-order meta-analysis based on 34,628 paired observations in biochar-amended and unamended ***,biochar enhances phytotoxicity alleviation,physiology regulation,soil remediation and carbon sequestration,and microbial functional gene ***,some prominent trade-offs exist between crop productivity and ecosystem service deliveries including for nutrient cycling,microbial function,climate change mitigation,and the soil microbial *** adoption of low C:N biochar produced at high pyrolysis temperatures from sewage sludge-derived feedstock,in combination with a moderate application rate and inorganic fertilizer input,shows potential for achieving synergistic promotion of crop productivity and ecosystem *** outcomes highlight the need for judicious implementation of biochar-based solutions to site-specific soil *** quantified synergy and tradeoff relationships will aid the establishment of a sustainable biochar development framework that strengthens necessary ecosystem services commensurate with food security assurance.

关键词： biochar soil remediation phytotoxicity alleviation carbon sequestration productivity

Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway

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Bone Research 2022年第4期10卷 838-851页

作者： Yu Liu Xiangxian Zhang Wei Wang Ting Liu Jun Ren Siyuan Chen Tianqi Lu Yan Tie Xia Yuan fei mo Jingyun Yang Yuquan Wei Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan 610041PR China Department of Clinical Laboratory The West China Second University Hospital of Sichuan University(WCSUH-SCU)Sichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan 610041PR China Department of Prenatal Diagnosis Center The West China Second University Hospital of Sichuan University(WCSUH-SCU)Sichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan 610041PR China

Ammonia plays an important role in cellular ***,ammonia is considered a toxic *** bone marrow-derived mesenchymal stem cells,multipotent stem cells with high expression of glutamine synthetase(GS)in bone marrow,ammonia and glutamate can be converted to glutamine via glutamine synthetase activity to support the proliferation of *** a major nutritional amino acid for biosynthesis,glutamine can activate the Akt/mTOR/S6k pathway to stimulate cell *** activation of mTOR can promote cell entry into S phase,thereby enhancing DNA synthesis and cell *** studies demonstrated that mesenchymal stem cells can convert the toxic waste product ammonia into nutritional glutamine via GS ***,the Akt/mTOR/S6k pathway is activated to promote bone marrow-derived mesenchymal stem cell *** results suggest a new therapeutic strategy and potential target for the treatment of diseases involving hyperammonemia.

关键词： Ammonia ammonia diseases

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高校ESG信息披露:标准、法治与数字化

中国电化教育 2024年第4期 120-128页

作者：莫菲北京外国语大学国际组织学院北京100089

将新兴的环境、社会与治理(ESG)理念应用于高等教育信息披露领域,有助于推动可持续发展议程在我国高校的主流化,促进我国高等教育的高质量发展。该文讨论了建立高等教育机构ESG信息披露制度的可能性。标准层面,构建环境、社会、治理和... 详细信息

将新兴的环境、社会与治理(ESG)理念应用于高等教育信息披露领域,有助于推动可持续发展议程在我国高校的主流化,促进我国高等教育的高质量发展。该文讨论了建立高等教育机构ESG信息披露制度的可能性。标准层面,构建环境、社会、治理和教育四维度40个指标构成的高校ESG信息披露指标体系,并在应用实例中发现,进行多维度和整体性披露有助于提高ESG信息集中度和能见度。法治层面,探讨了强制披露和自愿披露两种高校ESG信息披露模式,并提出其共性问题。操作层面,在我国高校主要运用网站信息进行ESG信息披露的现实情况下,ESG信息流的每一环节均有数字化空间,并可运用可持续信息门户、仪表盘等数字化架构提高信息透明度和易读性,增强高校可持续教育评价科学性。

关键词：高等教育 ESG 标准体系法治数字化