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Liver-spleen axis dysfunction in COVID-19

World Journal of Gastroenterology 2021年第35期27卷 5919-5931页

作者： Sara Cococcia Marco Vincenzo Lenti Giovanni Santacroce Giovanna Achilli federica borrelli de andreis Antonio Di Sabatino First department of Internal Medicine San Matteo Hospital FoundationUniversity of PaviaPavia 27100Italy department of Gastroenterology Royal Free HospitalLondon NW32QGUnited Kingdom

Coronavirus disease 2019(COVID-19),caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is an acute infectious disease that spreads mainly through the respiratory *** interstitial pneumonia,a number of other clinical manifestations were noticed in COVID-19 *** particular,liver and spleen dysfunctions have been described both as complications of COVID-19 and as potential predisposing factors for severe *** damage is rather common in COVID-19 patients,and it is most likely multifactorial,caused by the direct insult of SARS-CoV-2 to the liver by the cytokine storm triggered by the virus,by the use of hepatotoxic drugs,and as a consequence of *** generally mild,liver impairment has been found to be associated with a higher rate of intensive care unit admission.A higher mortality rate was reported among chronic liver disease ***,spleen impairment in patients with COVID-19 has been poorly *** main anatomical changes are the architectural derangement of the B cell compartment,white pulp atrophy,and reduction or absence of lymphoid follicles,while,from a functional point of view,the IgM memory B cell pool is markedly *** outcome of COVID-19 in asplenic or hyposplenic patients is yet to be *** this review,we will summarise the current knowledge regarding the impact of SARS-CoV-2 on the liver and spleen function,as well as the outcome of patients with a pre-existent liver disease or defective spleen function.

关键词： Asplenia Chronic liver disease IgM memory B cell Liver transplantation Transaminase

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Validation of the Italian translation of the perceived stigma scale and resilience assessment in inflammatory bowel disease patients

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World Journal of Gastroenterology 2021年第39期27卷 6647-6658页

作者： Sara Cococcia Marco Vincenzo Lenti Caterina Mengoli Catherine Klersy federica borrelli de andreis Matteo Secco Jihane Ghorayeb Mariangela delliponti Gino Roberto Corazza Antonio Di Sabatino First department of Internal Medicine San Matteo Hospital FoundationUniversity of PaviaPavia 27100LombardiaItaly Service of Biometry&Statistics Foundation IRCCS Policlinico San MatteoPavia 27100LombardiaItaly Psychology Zayed UniversityDubai 00000United Arab Emirates

BACKGROUND Stigmatization is the separation of an individual from a group due to aspects that make them *** may in turn influence the perception of *** with inflammatory bowel disease(IBD)are susceptible to stigma,although data are very *** To validate an Italian translation of the IBD perceived stigma scale(PSS)in relation to patients’*** Consecutive IBD outpatients were prospectively enrolled(december 2018-September 2019)in an Italian,tertiary referral,IBD *** and demographic data were *** and resilience were evaluated through the IBD-PSS and the 25-item Connor-Davidson Resilience Scale,*** International Quality of Life Assessment Project approach was followed to translate the IBD-PSS into Italian and to establish data *** scores represent greater perceived stigma and *** analysis for factors associated with greater stigma was *** Overall,126 IBD patients(mean age 46.1±16.9)were *** International Quality of Life Assessment criteria for acceptable psychometric properties of the scale were satisfied,with optimal data *** was no ceiling effect,whilst floor effect was present(7.1%).The discriminant validity and the internal consistency reliability were good(Cronbach alpha=0.87).The overall internal consistency was 95%,and the test-retest reliability was excellent *** median PSS score was 0.45(0.20-0.85).Resilience negatively correlated with perceived stigma(Spearman’s correlation=-0.18,95%confidence intervals:-0.42-0.08,P=0.03).CONCLUSION We herein validated the Italian translation of the PSS scale,also demonstrating that resilience negatively impacts perceived stigma.

关键词： Crohn’s disease Quality of life Stress Ulcerative colitis

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Anterior capsule contraction syndrome: a successful multimodal therapeutic approach

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1356-1358页

作者： Lisa Toto Pasquale Viggiano Luca Vecchiarino federica Evangelista Enrico borrelli Leonardo Mastropasqua Ophthalmology Clinic Department of Medicine and Science of AgeingUniversity G. D’Annunzio Chieti-Pescara

dear Editor,I am Dr. Lisa Toto, from department of Medicine and Science of Ageing, University G. D’Annunzio ChietiPescara, Chieti, Italy. I write to present a case report of anterior capsule contraction syndrome(ACCS).

关键词： contraction syndrome approach

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Trend in prevalence of uncontrolled total serum cholesterol for cardio-cerebro-vascular disease in a mediterranean area, 1988/89-2008/09

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World Journal of Cardiology 2013年第11期5卷 420-425页

作者： Vincenzo Capuano Norman Lamaida Ernesto Capuano Maria Immacolata borrelli Rocco Capuano Elisabetta Notari Anna Grazia Iannone federica Marchese Matteo Sonderegger Eduardo Capuano department of Cardiovascular Diseases University Hospital of Salerno-Mercato S.Severino Hospital Local Health Authority

AIM: To examine trends of uncontrolled total serum cholesterol, treatment and control in a Mediterranean region(Campania). METHODS: We considered and compared the data collected as part of "Montecorvino Rovella Project" 1988-1989 and cross-sectional data from the two phases of the "VIP Project-Valle dell'Irno Prevenzione": 1998-1999(1stphase) and 2008-2009(2ndphase), in the 35-74-year-old-population. RESULTS: Data show a reduction of mean cholesterolemia in the last twenty years of 7.3 mg/dL for men and unchanged values for women. In the three surveys the mean values for serum cholesterol are in men: 205.2 ±47.1 mg/dL(1988/89), 200 ± 38.9 mg/dL(1998/99) and 197.9 ± 40.2 mg/dL(2008/09); in the women: 203.1 ± 42.5 mg/dL(1988/89), 198.9 ± 37.9 mg/dL(1998/99) and 203.3 ± 39.3 mg/dL(2008/09). Prevalence of uncontrolled high cholesterol ≥ 240 mg/dL for men decreased from 20.8%(1988/89) to 14.3%(1998/99) and 13.9%(2008/9), P = 0.002; for women the values decreased from 19.9%(1988/89), to 18.2%(1998/99) and 18.1%(2008/09), P = 0.007. Is statistically increased the number of patients treated and those treated to target. CONCLUSION: Encouraging increases in awareness, treatment, and control of hypercholesterolemia occurred from 1988 through 2008. Nevertheless, control of hypercholesterolemia remains poor.

关键词： Mediterranean diet Hypercholesterolemia Drug Heart disease Southern Italy

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