Liver-spleen axis dysfunction in COVID-19
作者机构：First Department of Internal MedicineSan Matteo Hospital FoundationUniversity of PaviaPavia 27100Italy Department of GastroenterologyRoyal Free HospitalLondon NW32QGUnited Kingdom
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第35期
页 面：5919-5931页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Università degli Studi di Pavia
主 题：Asplenia Chronic liver disease IgM memory B cell Liver transplantation Transaminase
摘 要：Coronavirus disease 2019(COVID-19),caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is an acute infectious disease that spreads mainly through the respiratory *** interstitial pneumonia,a number of other clinical manifestations were noticed in COVID-19 *** particular,liver and spleen dysfunctions have been described both as complications of COVID-19 and as potential predisposing factors for severe *** damage is rather common in COVID-19 patients,and it is most likely multifactorial,caused by the direct insult of SARS-CoV-2 to the liver by the cytokine storm triggered by the virus,by the use of hepatotoxic drugs,and as a consequence of *** generally mild,liver impairment has been found to be associated with a higher rate of intensive care unit admission.A higher mortality rate was reported among chronic liver disease ***,spleen impairment in patients with COVID-19 has been poorly *** main anatomical changes are the architectural derangement of the B cell compartment,white pulp atrophy,and reduction or absence of lymphoid follicles,while,from a functional point of view,the IgM memory B cell pool is markedly *** outcome of COVID-19 in asplenic or hyposplenic patients is yet to be *** this review,we will summarise the current knowledge regarding the impact of SARS-CoV-2 on the liver and spleen function,as well as the outcome of patients with a pre-existent liver disease or defective spleen function.
维普期刊数据库