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Systematical analysis of sludge treatment and disposal technologies for carbon footprint reduction

Journal of Environmental Sciences 2023年第6期128卷 224-249页

作者： Yingxin Zhao Zhifan Yang Jiaojiao Niu Zihan Du conti federica Zhe Zhu Kaichao Yang Yan Li Baofeng Zhao Thomas Helmer Pedersen Chunguang Liu Mutabazi Emmanuel School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Municipal Engineering Design&Research Institute Co. Ltd.Tianjin 300380China Tianjin International Engineering Institute Tianjin UniversityTianjin 300072China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark School of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China Energy Research Institute of Shandong Academy of Sciences Jinan 250014China Shandong Kailin environmental protection equipment Co. Ltd.Heze 274000China

This study aims to comprehensively analyze the Greenhouse Gases(GHGs)emissions from current sewage sludge treatment and disposal technologies(buildingmaterial,landfill,land spreading,anaerobic digestion,and thermochemical processes)based on the database of Science Citation Index(SCI)and Social Science Citation Index(SSCI)from 1998 to *** general patterns,spatial distribution,and hotspotswere provided by bibliometric analysis.A comparative quantitative analysis based on life cycle assessment(LCA)put forward the current emission situation and the key influencing factors of different *** effective GHG emissions reduction methods were proposed to mitigate climate *** showed that incineration or building materials manufacturing of highly dewatered sludge,and land spreading after anaerobic digestion have the best GHG emissions reduction *** treatment technologies and thermochemical processes have great potential for reducing *** of pretreatment effect,co-digestion,and newtechnologies(e.g.,injection of carbon dioxide,directional acidification)are major approaches to facilitate substitution emissions in sludge anaerobic *** relationship between the quality and efficiency of secondary energy in thermochemical process and GHGs emission still needs further *** sludge products generated by bio-stabilization or thermochemical processes are considered to have a certain carbon sequestration value and can improve the soil environment to control GHG *** findings are useful for future development and processes selection of sludge treatment and disposal facing carbon footprint reduction.

关键词： Bibliometrics Sewage sludge Greenhouse gas Life cycle assessment Sludge management

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Pericyte-like differentiation of human adipose-derived mesenchymal stem cells:An in vitro study

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World Journal of Stem Cells 2020年第10期12卷 1152-1170页

作者： Giuliana Mannino Florinda Gennuso Giovanni Giurdanella federica conti Filippo Drago Salvatore Salomone Debora Lo Furno Claudio Bucolo Rosario Giuffrida Physiology Section Department of Biomedical and Biotechnological SciencesUniversity of CataniaCatania 95123Italy Pharmacology Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy Biochemistry Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy

BACKGROUND Adipose-derived mesenchymal stem cells(ASCs)are characterized by long-term self-renewal and a high proliferation *** adequate conditions,they may differentiate into cells belonging to mesodermal,endodermal or ectodermal *** support endothelial cells and play an important role in stabilizing the vessel wall at the microcirculation *** loss of pericytes,as occurs in diabetic retinopathy,results in a breakdown of the blood-retina barrier(BRB)and infiltration of inflammatory *** this context,the use of pericytelike differentiated ASCs may represent a valuable therapeutic strategy for restoring BRB *** To test in vitro strategies to obtain pericyte-like differentiation of human ASCs(hASCs).METHODS Different culture conditions were tested:hASCs cultured in a basal medium supplemented with transforming growth factorβ1;and hASCs cultured in a specific pericyte medium(PM-hASCs).In a further sample,pericyte growth supplement was omitted from the *** addition,cultures of human retinal pericytes(hRPCs)were used for ***-like differentiation of hASCs was tested by immunocytochemical staining and western blotting to evaluate the expression ofα-smooth muscle actin(α-SMA)and neural/glial antigen 2(NG2).Interactions between human retinal endothelial cells(hRECs)and different groups of hASCs were investigated in co-culture *** these cases,the expression of typical junctional proteins such as vascular endothelial-Cadherin,zonula occludens-1 and Occludin were assessed in *** an in vitro model of the BRB,values of trans-endothelial electrical resistance were measured when hRECs were co-cultured with various groups of pretreated *** values observed were compared with co-cultures of hRECs and hRPCs as well as with cultures of hRECs ***-dimensional co-cultures of hRECs and hRPCs or pericyte-like hASCs in Matrigel were designed to assess their reciprocal *** After 3-6 d of cult

关键词： Adipose-derived mesenchymal stem cells Pericyte-like differentiation Retinal endothelial cells Retinal pericytes Blood-retina barrier Junction proteins

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Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life

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Journal of Geriatric Cardiology 2018年第10期15卷 644-646页

作者： Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto federica conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari Geriatric Unit Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Department of Clinical Sciences and Community Health University of MilanMilanItaly Unit of Epidemiology Fondazione IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanltaly Fellowship in Geriatrics and Gerontology University of MilanMilanItaly

Orthostatic hypotension (OH)is a common condition in older *** to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH.

关键词： Elderly Orthostatic hypotension Prevalence Real-life

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Ultrasound elastographic techniques in focal liver lesions

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World Journal of Gastroenterology 2016年第9期22卷 2647-2656页

作者： Clara Benedetta conti federica Cavalcoli Mirella Fraquelli Dario Conte Sara Massironi Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Department of Pathophysiology and Organ Transplantation Università degli Studi di Milano

Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses.

关键词： Focal liver lesions Acoustic radiation force imaging Transient elastography Elastographic techniques Shear wave imaging

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Non-invasive assessment of liver fibrosis in chronic hepatitis B

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World Journal of Gastroenterology 2014年第40期20卷 14568-14580页

作者： federica Branchi Clara Benedetta conti Alessandra Baccarin Pietro Lampertico Dario Conte Mirella Fraquelli Second Division of Gastroenterology IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano 20122 Milan Italy First Division of Gastroenterology IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano 20122 Milan Italy

The goal of this review is to provide a comprehensive picture of the role,clinical applications and future perspectives of the most widely used non-invasive techniques for the evaluation of hepatitis B virus(HBV)*** the past decade many non-invasive methods have been developed to reduce the need for liver biopsy in staging fibrosis and to overcome whenever possible its limitations,mainly:invasiveness,costs,low reproducibility,poor acceptance by *** techniques conceived to assess liver stiffness,in particular transient elastography,and the most commonly used biological markers will be assessed against their respective role and limitations in staging hepatic *** evidence highlights that both liver stiffness and some bio-chemical markers correlatewith survival and major clinical end-points such as liver decompensation,development of hepatocellular carcinoma and portal *** the non-invasive techniques here discussed can play a major role in the management of patients with chronic HBV-related *** their prognostic value,transient elastography and some bio-chemical markers can be used to better categorize patients with advanced fibrosis and cirrhosis and assign them to different classes of risk for clinically relevant *** recent data indicates that the combined measurements of liver and spleen stiffness enable the reliable prediction of portal hypertension and esophageal varices development.

关键词： Liver fibrosis Cirrhosis Hepatitis B virus Transient elastography Non invasive markers

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Effect of acoustic field on C02 desorption in a fluidized bed of fine activated carbon

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Particuology 2015年第6期13卷 8-15页

作者： federica Raganati Paola Ammendola Riccardo Chirone Department of Chemical Engineering Materials and Industrial Production University of Naples Federico II P. le V. Tecchio 80 80125 Napoli Italy Istituto di Ricerche sulla Combustione CNR P. le K Tecchio 80 80125 Napoli Italy

Adsorption using solid sorbents has the potential to complement or replace current absorption technol- ogy, because of its low energy requirements. Among the commercially available adsorbent materials, attention is focused on activated carbons because they are easily regenerable by reason of their low heat of adsorption. These sorbents are generally available in the form of fine powders. Sound-assisted fluidization can process large amounts of fine powders, promoting and enhancing CO2 capture on fine sorbents, because it maximizes gas-solid contact. Temperature swing adsorption （TSA）, consisting of inducing sor- bent regeneration and CO2 recovery by appropriate temperature increase and gas purge, is one of the most promising techniques. This study investigates the CO2 desorption process by TSA in a sound-assisted flu- idized bed of fine activated carbon. Desorption tests were performed under ordinary and sound-assisted fluidization conditions to assess the capability of sound to promote and enhance the desorption efficiency in terms of CO2 recovery, CO2 purity, and desorption time. The results show that the application of sound results in higher desorption rates, CO2 recovery and purity. Regular and stable desorption profiles can be obtained under sound-assisted fluidization conditions. This stability makes it possible to successfully realize a cyclic adsorption/desorption process.

关键词： Temperature swing adsorption Sound-assisted fluidization CO2 capture Activated carbons Fine powders

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Estimation of the effective properties of two-dimensional cellular materials:a review

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Theoretical & Applied Mechanics Letters 2018年第4期8卷 209-230,298页

作者： federica Ongaro School of Engineering and Materials Science Queen Mary University of LondonLondonUK

In a vast number of engineering fields like medicine,aerospace or robotics,materials are required to meet unusual performances that simple homogeneous materials are often not able to ***,many efforts are currently devoted to develop future generations of materials with enhanced properties and unusual *** many instances,biological systems served as a source of inspiration,as in the case of cellular *** observed in nature,cellular materials offer useful combinations of structural properties and low weight,yielding the possibility of coexistence of what used to be antagonistic physical properties within a single *** to their peculiar characteristics,they are very promising for engineering applications in a variety of industries including aerospace,automotive,marine and ***,their use is conditional upon the development of appropriate constitutive models for revealing the complex relations between the microstructure's parameters and the macroscopic *** this point of view,a great variety of analytical and numerical techniques have been proposed and exhaustively discussed in recent *** contributions,suggesting different assumptions and techniques are critically presented in this review paper.

关键词： Cellular materials Effective properties Computational homogenization Analytical modelling

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NK2 homeobox gene cluster: Functions and roles in human diseases

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Genes & Diseases 2023年第5期10卷 2038-2048页

作者： Catia Mio federica Baldan Giuseppe Damante Dipartimento di Area Medica Universitàdegli Studi di UdineUdine 33100Italy Istituto di Genetica Medica Azienda Sanitaria Universitaria Friuli CentraleUdine 33100Italy

NK2 genes (NKX2 gene cluster in humans) encode for homeodomain-containing transcription factors that are conserved along the phylogeny. According to the most detailed classifications, vertebrate NKX2 genes are classified into two distinct families, NK2.1 and NK2.2 . The former is constituted by NKX2-1 and NKX2-4 genes, which are homologous to the Drosophila scro gene;the latter includes NKX2-2 and NKX2-8 genes, which are homologous to the Drosophila vnd gene. Conservation of these genes is not only related to molecular structure and expression, but also to biological functions. In Drosophila and vertebrates, NK2 genes share roles in the development of ventral regions of the central nervous system. In vertebrates, NKX2 genes have a relevant role in the development of several other organs such as the thyroid, lung, and pancreas. Loss-of-function mutations in NKX2-1 and NKX2-2 are the monogenic cause of the brain-lung-thyroid syndrome and neonatal diabetes, respectively. Alterations in NKX2-4 and NKX2-8 genes may play a role in multifactorial diseases, autism spectrum disorder, and neural tube defects, respectively. NKX2-1 , NKX2-2 , and NKX2-8 are expressed in various cancer types as either oncogenes or tumor suppressor genes. Several data indicate that evaluation of their expression in tumors has diagnostic and/or prognostic value.

关键词： Drosophila melanogaster Evolutionary conservation Homeobox Homeotic genes NK2 genes

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A Drosophila perspective on retina functions and dysfunctions

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Neural Regeneration Research 2022年第2期17卷 341-343页

作者： Elisabetta Catalani federica Silvestri Davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitadegli Studi della Tuscialargo dell’UniversitasncViterboItaly

Due to the high degree of conservation of genes and mechanisms, the fruit fly Drosophila melanogaster is a powerful experimental in vivo tool to investigate complex diseases, thus complementing traditional vertebrate systems. Drosophila is also an advantageous system regarding the animal husbandry and the short generation time and lifespan.

关键词： Drosophila husbandry functions

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Induced pluripotent stem cells for defining Parkinsonian patient subtypes:a further step toward precision medicine

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Neural Regeneration Research 2022年第4期17卷 767-769页

作者： federica Bono Cristina Missale Chiara Fiorentini Division of Pharmacology Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

Introduction:Parkinson's disease PD is a common neurodegenerative disorder mainly characterized by the progressive decline of motor function with a prevalence that is greatly increasing since the pathology is principally driven by *** currently available treatments only mitigate motor symptoms;therefore,a great deal of studies are aimed at finding novel drugs that are able to arrest the evolution of the *** progressive death of nigrostriatal dopaminergic(DA)neurons and the formation of the typical Lewy bodies neuronal inclusions containing misfolded alpha-synuclein are two key histopathological features of the ***,it is now evident that PD has to be considered as a heterogeneous disorder that includes subtypes with distinctive clinical and biological characteristics(Ryden and Lewis,2019).

关键词： drugs progressive finding

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