Non-invasive assessment of liver fibrosis in chronic hepatitis B
Non-invasive assessment of liver fibrosis in chronic hepatitis B作者机构：Second Division of Gastroenterology IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano 20122 Milan Italy First Division of Gastroenterology IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano 20122 Milan Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第40期
页 面：14568-14580页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Liver fibrosis Cirrhosis Hepatitis B virus Transient elastography Non invasive markers
摘 要：The goal of this review is to provide a comprehensive picture of the role,clinical applications and future perspectives of the most widely used non-invasive techniques for the evaluation of hepatitis B virus(HBV)*** the past decade many non-invasive methods have been developed to reduce the need for liver biopsy in staging fibrosis and to overcome whenever possible its limitations,mainly:invasiveness,costs,low reproducibility,poor acceptance by *** techniques conceived to assess liver stiffness,in particular transient elastography,and the most commonly used biological markers will be assessed against their respective role and limitations in staging hepatic *** evidence highlights that both liver stiffness and some bio-chemical markers correlatewith survival and major clinical end-points such as liver decompensation,development of hepatocellular carcinoma and portal *** the non-invasive techniques here discussed can play a major role in the management of patients with chronic HBV-related *** their prognostic value,transient elastography and some bio-chemical markers can be used to better categorize patients with advanced fibrosis and cirrhosis and assign them to different classes of risk for clinically relevant *** recent data indicates that the combined measurements of liver and spleen stiffness enable the reliable prediction of portal hypertension and esophageal varices development.
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