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World Journal of Gastroenterology 2023年第21期29卷 3257-3268页

作者： federica vernuccio Irene Mercante Xiao-Xiao Tong Filippo Crimì Umberto Cillo Emilio Quaia Department of Radiology University Hospital of PadovaPadova 35128Italy Department of Radiology-DIMED University of PadovaPadova 35128Italy Department of Surgery Hepatobiliary Surgery and Liver Transplant CenterOncology and Gastroenterology(DISCOG)University of PadovaPadova 35128Italy

Biliary complications are the most common complications after liver *** tomography(CT)and magnetic resonance imaging(MRI)are cornerstones for timely diagnosis of biliary complications after liver *** diagnosis of these complications by CT and MRI requires expertise,mainly with respect to identifying subtle early signs to avoid missed or incorrect *** example,biliary strictures may be misdiagnosed on MRI due to size mismatch of the common ducts of the donor and recipient,postoperative edema,pneumobilia,or susceptibility artifacts caused by surgical *** and prompt diagnosis of biliary complications after transplantation allows the timely initiation of appropriate *** aim of this pictorial review is to illustrate various CT and MRI findings related to biliary complications after liver transplantation,based on time of presentation after surgery and frequency of occurrence.

关键词： Liver transplantation Biliary Complications Computed tomography Magnetic resonance imaging Hepatic imaging Biliary tract Cholangiopancreatography Stricture

“Bull’s eye”appearance of hepatocellular adenomas in patients with glycogen storage disease type I-atypical magnetic resonance imaging findings:Two case reports

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World Journal of Clinical Cases 2021年第4期9卷 871-877页

作者： federica vernuccio Stephanie Austin Mathias Meyer Cynthia D Guy Priya S Kishnani Daniele Marin Department of Biomedicine Neuroscience and Advanced DiagnosticsUniversity of PalermoPalermo 90100Italy Departments of Pediatrics Duke University Medical CenterDurhamNC 27710United States Department of Radiology Duke University Medical HospitalDurhamNC 27708United States Department of Pathology Duke UniversityDurhamNC 27710United States Division of Medical Genetics Department of PediatricsDuke University Medical CenterDurhamNC 27710United States Department of Radiology Duke University Medical CenterDurhamNC 27710United States

BACKGROUND Hepatocellular adenomas are rare tumors that can occur in patients with glycogen storage disease type *** SUMMARY We herein report two cases of histologically proven hepatocellular adenomas in patients with glycogen storage disease type *** resonance imaging(MRI)was performed after bolus injection of gadoxetate disodium,a liver-specific gadolinium-based MRI contrast *** the present cases,some of the hepatocellular adenomas showed unexpectedly a“bull’s eye”appearance on T2-weighted and post-contrast images,which was not previously described as imaging findings of hepatocellular adenomas in glycogen storage disease.A bull’s eye appearance on T2-weighted images can be encountered in both benign(i.e.,abscess)or malignant(i.e.,epithelioid hemangioendothelioma,cholangiocarcinoma,and metastases)hepatic *** We present two cases of hepatocellular adenomas in patients with glycogen storage disease type 1,in which gadoxetate disodium-MRI showed atypical imaging findings for hepatocellular *** present there is no systematic study evaluating MRI findings of hepatocellular adenomas in patients with glycogen storage disease,further studies are needed to specifically investigate this issue.

关键词： Glycogen storage disease Hepatocellular adenoma Bull’s eye Magnetic resonance imaging Case report Gadoxetate disodium

Surgical complications after pancreatic transplantation:A computed tomography imaging pictorial review

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World Journal of Gastroenterology 2023年第46期29卷 6049-6059页

作者： Carlo D'Alessandro Matteo Todisco Caterina Di Bella Filippo Crimì Lucrezia Furian Emilio Quaia federica vernuccio Department of Radiology University of PadovaPadova 35128Italy Department of Radiology 2 University Hospital of PadovaPadova 35128Italy Department of Surgical Kidney and Pancreas Transplantation UnitPadova 35128Italy Kidney and Pancreas Transplantation Unit University of PaduaPadova 35128Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Department of Radiology University Hospital of PadovaPadova 35128Italy

Pancreatic transplantation is considered by the American Diabetes Association and the European Association for the Study of Diabetes an acceptable surgical procedure in patients with type 1 diabetes also undergoing kidney transplantation in pre-final or end-stage renal disease if no contraindications are *** transplantation,however,is a complex surgical procedure and may lead to a range of postoperative complications that can significantly impact graft function and patient *** computed tomography(CT)is often adopted to evaluate perfusion of the transplanted pancreas,identify complications and as a guide for interventional radiology *** assessment after pancreatic transplantation should start with the evaluation of the arterial Y-graft,the venous anastomosis and the *** regard to complications,CT allows for the identification of vascular complications,such as thrombosis or stenosis of blood vessels supplying the graft,the detection of pancreatic fluid collections,including pseudocysts,abscesses,or leaks,the assessment of bowel complications(anastomotic leaks,ileus or obstruction),and the identification of *** aim of this pictorial review is to illustrate CT findings of surgical-related complications after pancreatic *** knowledge of surgical techniques is of key importance to understand postoperative anatomic changes and imaging ***,we first provide a short summary of the main techniques of pancreatic ***,we provide a practical imaging approach to pancreatic transplantation and its complications providing tips and tricks for the prompt imaging diagnosis on CT.

关键词： Diabetes mellitus Type 1 Pancreas transplantation Complications Computed tomography Diagnostic imaging

Liver involvement in patients with COVID-19 infection:A comprehensive overview of diagnostic imaging features

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World Journal of Gastroenterology 2023年第5期29卷 834-850页

作者： Davide Ippolito Cesare Maino federica vernuccio Roberto Cannella Riccardo Inchingolo Michele Dezio Riccardo Faletti Pietro Andrea Bonaffini Marco Gatti Sandro Sironi Milano Bicocca School of Medicine and Surgery Milano 20126Italy Fondazione IRCCS San Gerardo dei Tintori Monza 20900Italy Institute of Radiology(DIMED) University Hospital of PadovaPadova 35128Italy Section of Radiology-Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermo 90127Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy Department of Surgical Sciences University of TurinTurin 10126Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalBergamo 24127Italy Department of Diagnostic Radiology University of TurinTurin 10126Italy

During the first wave of the pandemic,coronavirus disease 2019(COVID-19)infection has been considered mainly as a pulmonary ***,different clinical and radiological manifestations were observed over time,including involvement of abdominal ***,the liver is considered one of the main affected abdominal *** involvement may be caused by either a direct damage by the virus or an indirect damage related to COVID-19 induced thrombosis or to the use of different *** clinical assessment,radiology plays a key role in the evaluation of liver ***(US),computed tomography(CT)and magnetic resonance imaging(MRI)may be used to evaluate liver *** is widely available and it is considered the first-line technique to assess liver involvement in COVID-19 infection,in particular liver steatosis and portal-vein *** and MRI are used as second-and third-line techniques,respectively,considering their higher sensitivity and specificity compared to US for assessment of both parenchyma and *** review aims to the spectrum of COVID-19 liver involvement and the most common imaging features of COVID-19 liver damage.

关键词： Liver Fatty liver Hepatomegaly Hepatic infarction Liver diseases Liver failure Biliary tract diseases COVID-19 SARS-CoV-2 Infection X-Ray computed tomography Magnetic resonance imaging Ultrasonography Adults Pediatrics

Radiomics in colorectal cancer patients

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World Journal of Gastroenterology 2023年第19期29卷 2888-2904页

作者： Riccardo Inchingolo Cesare Maino Roberto Cannella federica vernuccio Francesco Cortese Michele Dezio Antonio Rosario Pisani Teresa Giandola Marco Gatti Valentina Giannini Davide Ippolito Riccardo Faletti Unit of Interventional Radiology F.Miulli HospitalAcquaviva delle Fonti 70021Italy Department of Radiology Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Institute of Radiology University Hospital of PadovaPadova 35128Italy Interdisciplinary Department of Medicine Section of Nuclear MedicineUniversity of Bari“Aldo Moro”Bari 70121Italy Department of Surgical Sciences University of TurinTurin 10126Italy

The main therapeutic options for colorectal cancer are surgical resection and adjuvant chemotherapy in non-metastatic ***,the evaluation of the overall adjuvant chemotherapy benefit in patients with a high risk of recurrence is *** images can represent a source of data that can be analyzed by using automated computer-based techniques,working on numerical information coded within Digital Imaging and Communications in Medicine files:This image numerical analysis has been named“radiomics”.Radiomics allows the extraction of quantitative features from radiological images,mainly invisible to the naked eye,that can be further analyzed by artificial intelligence *** is expanding in oncology to either understand tumor biology or for the development of imaging biomarkers for diagnosis,staging,and prognosis,prediction of treatment response and diseases monitoring and *** efforts have been made to develop radiomics signatures for colorectal cancer patient using computed tomography(CT)images with different aims:The preoperative prediction of lymph node metastasis,detecting BRAF and RAS gene ***,the use of delta-radiomics allows the analysis of variations of the radiomics parameters extracted from CT scans performed at different *** published studies concerning radiomics and magnetic resonance imaging(MRI)mainly focused on the response of advanced tumors that under-went neoadjuvant *** status is the main determinant of adjuvant ***,several radiomics model based on MRI,especially on T2-weighted images and ADC maps,for the preoperative prediction of nodes metastasis in rectal cancer has been *** studies mostly focused on the applications of radiomics in positron emission tomogra-phy/CT for the prediction of survival after curative surgical resection and assessment of response following neoadjuvant *** colorectal liver metastase

关键词： Colorectal cancer Radiomics Artificial intelligence Liver metastases Magnetic resonance imaging Computed tomography Positron emission tomography/computed tomography

Drugs to be avoided in patients with long QT syndrome:Focus on the anaesthesiological management

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World Journal of Cardiology 2013年第4期5卷 87-93页

作者： Giovanni Fazio federica vernuccio Giuseppe Grutta Giuseppe Lo Re Poliambulatorio medico Riabiliter S.N.C. Via Oreto90124 PalermoItaly University of Palermo 90124 PalermoItaly

Long QT syndrome incidence is increasing in general population.A careful pre-,peri-and post-operative management is needed for patients with this syndrome because of the risk of Torsades de Pointes and malignant *** available data regarding prevention of lethal Torsades de Pointes during anesthesia in patients with long QT syndrome is scant and conflicting:only case reports and small case series with different outcomes have been ***,there are no definitive guidelines on pre-,peri-and post-operative anesthetic management of congenital long QT *** review focuses on anesthetic recommendations for patients diagnosed with congenital long QT syndrome furnishing some key points for preoperative optimization,intraoperative anesthetic agents and postoperative care plan,which could be the best for patients with c-long QT syndrome who undergo surgery.

关键词： Long QT Syndrome Torsades de pointes Anesthesia QT-prolongation Anesthetic drugs

Magnetic resonance imaging of the cirrhotic liver in the eraof gadoxetic acid

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World Journal of Gastroenterology 2016年第1期22卷 103-111页

作者： Francesco Agnello Marco Dioguardi Burgio Dario Picone federica vernuccio Giuseppe Cabibbo Lydia Giannitrapani Adele Taibbi Antonino Agrusa Tommaso Vincenzo Bartolotta Massimo Galia Roberto Lagalla Massimo Midiri Giuseppe Brancatelli Section of Radiological Sciences DIBIMEDUniversity of Palermo90127 PalermoItaly Section of Gastroenterology DIBIMISUniversity of Palermo90127 PalermoItaly Section of Internal Medicine DIBIMISUniversity of Palermo90127 PalermoItaly Department of General Surgery Urgencyand Organ TransplantationUniversity of Palermo90127 PalermoItaly

Gadoxetic acid improves detection and characterization of focal liver lesions in cirrhotic patients and can estimate liver function in patients undergoing liver *** purpose of this article is to describe the optimal gadoxetic acid study protocol for the liver,the unique characteristics of gadoxetic acid,the differences between gadoxetic acid and extra-cellular gadolium chelates,and the differences in phases of enhancement between cirrhotic and normal liver using gadoxetic *** also discuss how to obtain and recognize an adequate hepatobiliary phase.

关键词： Hepatobiliary contrast materials Gadoxeticacid Cirrhosis Magnetic resonance imaging Liver

Liver metastases:The role of magnetic resonance imaging

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World Journal of Gastroenterology 2023年第36期29卷 5180-5197页

作者： Cesare Maino federica vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco Clara Gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti Department of Radiology Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy University Hospital of Padova Institute of RadiologyPadova 35128Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Unit of Interventional Radiology F Miulli HospitalAcquaviva delle Fonti 70021Italy Department of Surgical Sciences University of TurinTurin 10126Italy School of Medicine University of Milano BicoccaMilano 20100Italy

The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique ***’s well known that liver metastases represent the most common hepatic malignant *** a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall *** the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by *** the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes *** these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best *** the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical *** review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI.

关键词： Liver metastases Magnetic resonance imaging Gadolinium Gd-EOB-DTPA Gadoxetate disodium Liver specific contrast agents Hepatobiliary contrast agents