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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI Maria DI roSA Luca PANDOLFI Michele marroni Dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** D1 phase was testified by rare isoclinal *** D2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** D3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the D1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** D2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

Cerebral and muscle tissue oxygenation during exercise in healthy adults: A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 459-471,F0003页

作者： Diego Orcioli-Silva Victor Spiandor Beretta Paulo Cezar rocha Santos fe.ipe.marroni raste.ro Anita Brum Marostegan rodrigo Vitorio Claudio Alexandre Gobatto Fulvia Barros Manchado-Gobatto Laboratory of Applied Sport Physiology(LAFAE) School of Applied Sciences(FCA)University of Campinas(UNICAMP)Limeira 13484-350Brazil Posture and Gait Studies Laboratory(LEPLO) Institute of BiosciencesSao Paulo State University(UNESP)Rio Claro 13506-900Brazil Physical Education Department School of Technology and SciencesSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Computer Science&Applied Mathematics Weizmann Institute of ScienceRehovot 7610001Israel Center of Advanced Technologies in Rehabilitation Sheba Medical CenterRamat Gan 5265601Israel Department of Sport Exercise and RehabilitationNorthumbria UniversityNewcastle upon Tyne NE18STUK

Background:Near-infrared spectroscopy(NIRS)technology has allowed for the measurement of cerebral and skeletal muscle oxygenation simultaneously during *** this technology has been growing and is now successfully used in laboratory and sports settings,this systematic review aimed to synthesize the evidence and enhance an integrative understanding of bloodﬂow adjustments and oxygen(O_(2))changes(i.e.,the balance between O_(2) delivery and O_(2) consumption)within the cerebral and muscle systems during ***:A systematic review was conducted using PubMed,Embase,Scopus,and Web of Science databases to search for relevant studies that simultaneously investigated cerebral and muscle hemodynamic changes using the near-infrared spectroscopy system during *** review considered manuscripts written in English and available before february 9,*** step of screening involved evaluation by 2 inde-pendent authors,with disagreements resolved by a third *** Joanna Briggs Institute Critical Appraisal Checklist was used to assess the methodological quality of the ***:Twenty studies were included,of which 80%had good methodological quality,and involved 290 young or middle-aged *** types of exercises were used to assess cerebral and muscle hemodynamic changes,such as cycling(n=11),treadmill(n=1),knee extension(n=5),isometric contraction of biceps brachii(n=3),and duet swim routines(n=1).The cerebral hemodynamics anal-ysis was focused on the frontal cortex(n=20),while in the muscle,the analysis involved vastus lateralis(n=18),gastrocnemius(n=3),biceps brachii(n=5),deltoid(n=1),and intercostal muscle(n=1).Overall,muscle deoxygenation increases during exercise,reaching a plateau in voluntary exhaustion,while in the brain,oxyhemoglobin concentration increases with exercise intensity,reaching a plateau or declining at the exhaustion ***:Muscle and cerebral oxygenation respond differently to exercise,with muscle

关键词： Near-infrared spectroscopy Hemodynamic Blood flow Brain Muscle metabolism

The evolution of available pharmacological treatments for variceal bleeding secondary to portal hypertension: A scope review

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iLIVER 2023年第3期2卷 170-176页

作者： Eduarda Raisa Coser Raphael Bernardo Neto Izabel Cristina Meister Martins Coelho Norma Possa marroni Claudio Augusto marroni Camila Moraes Marques Faculdades Pequeno Principe Brazil Universidade federal de Ciencias da Saude de Porto Alegre Brazil

The texts analyzed in full totaled 110,of which 36 articles published between 2001 and 2020 were selected,with quantitative approaches,case reviews,liter-ature reviews,meta-analyses,and *** is concluded that beta-blockers are the drugs of choice for primary prophylaxis of variceal *** for secondary prophylaxis,there is an association of these with nitrates and endoscopic *** regard to acute bleeding,the use of vasoactive drugs is chosen,especially ***,it is important to emphasize that there is a shortage of clinical studies and a need for investment in new therapies.

关键词： Portal hypertension Clinical treatment pharmacology and variceal bleeding

Deformation history and processes during accretion of seamounts in subduction zones:The example of the Durkan Complex(Makran,SE Iran)

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Geoscience Frontiers 2023年第2期14卷 182-203页

作者： Edoardo Barbero Maria Di rosa Luca Pandolfi Morteza Delavari Asghar Dolati federica Zaccarini Emilio Saccani Michele marroni Dipartimento di Fisica e Scienze della Terra Universitàdi Ferrara44123 FerraraItaly Istituto di Geoscienze e Georisorse Consiglio Nazionale delle Ricerche(CNR)10125 TorinoItaly Dipartimento di Scienze della Terra Universitàdi Pisa56126 PisaItaly Istituto di Geoscienze e Georisorse Consiglio Nazionale delle Ricerche(CNR)56124 PisaItaly Faculty of Earth Sciences Kharazmi UniversityTehran 15719-19911Iran Department of Applied Geological Sciences and Geophysics University of Leoben8700 LeobenAustria

The Durkan Complex is a tectonic element of the Makran Accretionary Prism(SE Iran)that includes fragments of Late Cretaceous *** this paper,the results of map-to micro-scale structural studies of the western Durkan Complex are presented with the aim to describe its structural and tectonometamorphic *** Durkan Complex consists of several tectonic units bordered by mainly NNW-striking *** main deformation phases(D_(1),D_(2),and D_(3))are distinguished and likely occurred from the Late Cretaceous to the Miocene–Pliocene.D_(1) is characterized by sub-isoclinal to close and W-verging folds associated with an axial plane foliation and shear zone along the fold *** phase records the accretion of fragments of the seamount within the Makran at blueschist facies metamorphic conditions(160–300℃ and 0.6–1.2 GPa).D_(2) is characterized by open to close folds with subhorizontal axial plane that likely developed during the exhumation of previously accreted seamount *** upper Paleocene–Eocene siliciclastic succession unconformably sealed the D_(1) and D_(2) structures and is,in turn,deformed by W-verging thrust faults typical of D_(3).The latter likely testifies for a Miocene–Pliocene tectonic reworking of the accreted seamount fragments with the activation of out of sequence *** results shed light on the mechanism of accretion of seamount materials in the accretionary prisms,suggesting that seamount slope successions favour the localization and propagation of the basal dé*** study further confirms that the physiography of the subducting plates plays a significant role in the tectonic evolution of the subduction complexes.

关键词： Underplated seamount Makran Accretionary Prism Tectono-sedimentary evolution Tectono-metamorphic evolution Cretaceous Iran

Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats

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World Journal of Gastroenterology 2022年第3期28卷 348-364页

作者： Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A marroni Norma P marroni Medical Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Marilda S BrasilNorma Biological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Cellular and Molecular Biology Program Lutheran University of Brazil(ULBRA)Canoas 92425-900Brazil Pneumological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Brazil Posgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil

BACKGroUND Cirrhosis is an important health problem characterized by a significant change in liver *** animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant *** To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary *** Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+*** was administered(20 mg/kg)daily beginning on day 15 after biliary *** day 29 the animals were *** samples,liver tissue,and bone marrow were collected for further *** BDL caused changes in biochemical and histological parameters and markers of inflammatory *** acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(Proups that received *** damage was also lower(Proups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(Pfectively restored the evaluated parameters.

关键词： Antioxidants Secondary biliary cirrhosis Oxidative stress Melatonin Bile duct ligation

Melatonin restores zinc levels,activates the Keap1/Nrf2 pathway,and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第2期13卷 11-22页

作者： Silvia Bona Sabrina Alves fernandes Andrea C Janz Moreira Graziella rodrigues Elizângela G Schemitt Fabio Cangeri Di Naso Cláudio A marroni Norma P marroni Medical Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Posgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90040-001Rio Grande do SulBrazil Biological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90000-000Rio Grande do SulBrazil

BACKGroUND Melatonin(MLT)is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations,due to its action against free *** To evaluate the effect of MLT on carbon tetrachloride(CCl_(4))induced liver injury in rats in terms of oxidative stress,reticular stress,and cell *** Twenty male Wistar rats(230-250 g)were divided into four groups:Control rats,rats treated with MLT alone,rats treated with CCl_(4)alone,and rats treated with CCl_(4)plus ***_(4)was administered as follows:Ten doses every 5 d,ten every 4 d,and seven every 3 *** was administered intraperitoneally at a dose of 20 mg/kg from the 10th wk to the end of the experiment(16th wk).RESULTS MLT was able to reduce the release of liver enzymes in the bloodstream and to decrease oxidative stress in CCl_(4)treated rats by decreasing the level of thiobarbituric acid reactive substances and increasing superoxide dismutase activity,with a lower reduction in serum zinc levels,guaranteeing a reduction in liver damage;additionally,it increased the expression of nuclear factor(erythroid-derived 2)-like 2 and decreased the expression of Kelch-like ECH-associated protein *** also decreased the expression of the proteins associated with endoplasmic reticulum stress,i.e.,glucose-regulated protein 78 and activating transcription factor 6,as well as of heat shock factor 1 and heat shock protein *** MLT has a hepatoprotective effect in an experimental model of CCl_(4)-induced liver injury,since it reduces oxidative stress,restores zinc levels,and modulates endoplasmic reticulum stress.

关键词： Liver injury Cell damage Antioxidant Melatonin Carbon tetrachloride

Assessment of resting energy expenditure in patients with cirrhosis

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World Journal of Hepatology 2022年第4期14卷 802-811页

作者： Shaiane ferreira Cláudio Augusto marroni Jessica Taina Stein roberta Rayn Ana Cristhina Henz Natália P Schmidt Randhall B Carteri Sabrina Alves fernandes Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Nutrition Centro Universitário Metodista-IPAPorto Alegre 90420-060Brazil Department of Health and Behavior Catholic University of PelotasPelotas 96015-560Brazil

BACKGroUND Malnutrition affects 20%to 50%of patients with *** may be associated with serious complications and has a direct impact on *** energy expenditure(REE)is an important parameter to guide the optimization of therapy and recovery of nutritional status in patients with ***,the REE of patients with cirrhosis is still unclear,casting doubt upon the optimal nutritional management *** To identify the best method that predicts the REE of cirrhotic patients,using indirect calorimetry(IC)as the gold *** An observational study was performed on 90 patients with *** was assessed by IC,bioelectrical impedance analysis(BIA),and predictive formulas,which were compared using Bland-Altman plots and the Student’s *** REE values measured by IC(1607.72±257.4 kcal)differed significantly from those determined by all other methods(BIA:1790.48±352.1 kcal;Harris&Benedict equation:2373.54±254.9 kcal;IOM equation:1648.95±185.6 kcal;Cunningham equation:1764.29±246.2 kcal),except the Food and Agriculture Organization of the United Nations,World Health Organization,and United Nations University(FAO/WHO/UNU)(1616.07±214.6 kcal)and McArdle(1611.30±241.8 kcal)*** found no significant association when comparing IC and 24-h dietary recall among different Child-Pugh classes of *** The IOM and FAO/WHO/UNU equations have the best agreement with the *** results indicate a possibility of different tools for the clinical practice on cirrhotic patients.

关键词： Liver cirrhosis Calorimetry Indirect Energy metabolism Malnutrition

Machine learning approaches using blood biomarkers in nonalcoholic fatty liver diseases

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Artificial Intelligence in Gastroenterology 2022年第3期3卷 80-87页

作者： Randhall B Carteri Mateus Grellert Daniela Luisa Borba Claudio Augusto marroni Sabrina Alves fernandes Department of Nutrition Methodist University Center-IPAPorto Alegre 90420-060Rio Grande do SulBrazil Department of Health and Behaviour Catholic University of PelotasPelotas 96015-560Rio Grande do SulBrazil Department of Informatics and Statistics Federal University of Santa CatarinaFlorianópolis 88040-900Santa CatarinaBrazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Department of Gastroenterology and Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil

The prevalence of nonalcoholic fatty liver disease(NAFLD)is an important public health *** diagnosis of NAFLD and potential progression to nonalcoholic steatohepatitis(NASH),could reduce the further advance of the disease,and improve patient *** to support patient diagnostic and predict specific outcomes,the interest in artificial intelligence(AI)methods in hepatology has dramatically increased,especially with the application of lessinvasive *** this review,our objective was twofold:Firstly,we presented the most frequent blood biomarkers in NAFLD and NASH and secondly,we reviewed recent literature regarding the use of machine learning(ML)methods to predict NAFLD and NASH in large ***,these studies provide insights into ML application in NAFLD patients'prognostics and ranked blood biomarkers are able to provide a recognizable signature allowing cost-effective NAFLD prediction and also differentiating NASH *** studies should consider the limitations in the current literature and expand the application of these algorithms in different populations,fortifying an already promising tool in medical science.

关键词： Artificial intelligence Liver diseases Healthcare Hepatology Prognosis Diagnostics

Protective action of glutamine in rats with severe acute liver failure

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World Journal of Hepatology 2019年第3期11卷 273-286页

作者： Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A marroni Norma P marroni Laboratory of Experimental Hepatology and Gastroenterology Hospital de Clínicas de Porto Alegre Laboratory of Oxidative Stress and Antioxidants Universidade Luterana do Brasil

BACKGroUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver ***(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative *** To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced *** Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory *** TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P roup(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decr

关键词： Thioacetamide Cytokines Oxidative stress Inflammation Liver failure Chemical and drug induced liver injury Glutamine

The Intra-Pontide ophiolites in Northern Turkey revisited:From birth to death of a Neotethyan oceanic domain

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Geoscience Frontiers 2020年第1期11卷 129-149页

作者： Michele marroni M.Cemal Goncüoglu Chiara Frassi Kaan Sayit Luca Pandolfi Alessandro Ellero Giuseppe Ottria Dipartimento di Scienze della Terra Universita di Pisavia S.Maria 5356126PisaItaly Istituto di Geoscienze e Georisorse-CNR Via G.Moruzzi 156124PisaItaly Department of Geological Engineering Middle East Technical University06531 AnkaraTurkey

The Anatolian peninsula is a key location to study the central portion of the Neotethys Ocean(s)and to understand how its western and eastern branches were *** of the lesser known branches of the Mesozoic ocean(s)is preserved in the northern ophiolite suture zone exposed in Turkey,namely,the Intra-Pontide suture *** is located between the Sakarya terrane and the Eurasian margin(i.e.,Istanbul-Zonguldak terrane)and consists of several metamorphic and non-metamorphic units containing ophiolites produced in supra-subduction settings from the Late Triassic to the Early *** preserved in the metamorphic units recorded pervasive deformations and peak metamorphic conditions ranging from blueschist to eclogite *** the nonmetamorphic units,the complete oceanic crust sequence is preserved in tectonic units or as olistoliths in sedimentary ***,structural,metamorphic and geochronological investigations performed on ophiolite-bearing units allowed the formulation of a new geodynamic model of the entire"life"of the IntraPontide oceanic basin(s).The reconstruction starts with the opening of the Intra-Pontide oceanic basins during the Late Triassic between the Sakarya and Istanbul-Zonguldak continental microplates and ends with its closure caused by two different subductions events that occurred during the upper Early Jurassic and Middle *** continental collision between the Sakarya continental microplate and the Eurasian margin developed from the upper Early Cretaceous to the *** presented reconstruction is an alternative model to explain the complex and articulate geodynamic evolution that characterizes the southern margin of Eurasia during the Mesozoic era.

关键词： Intra-Pontide suture zone Central Pontides Northern Turkey Ophiolites Neotethys Ocean Geodynamics