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Optimization of hepatobiliary phase delay time of Gd-EOB-DTPA-enhanced magnetic resonance imaging for identification of hepatocellular carcinoma in patients with cirrhosis of different degrees of severity

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World Journal of Gastroenterology 2018年第3期24卷 415-423页

作者： jian.wei Wu Yue-Cheng Yu Xian-Li Qu Yan Zhang Hong Gao Department of Radiology Bayi HospitalNanjing University of Chinese Medicine Liver Disease Center Bayi HospitalNanjing University of Chinese Medicine

AIM To optimize the hepatobiliary phase delay time(HBPDT) of Gd-EOB-DTPA-enhanced magnetic resonance imaging(GED-MRI) for more efficient identification of hepatocellular carcinoma(HCC) occurring in different degrees of cirrhosis assessed by Child-Pugh(CP) *** The liver parenchyma signal intensity(LPSI), the liver parenchyma(LP)/HCC signal ratios, and the visibility of HCC at HBP-DT of 5, 10, 15, 20, and 25 min(i.e., DT-5, DT-10, DT-15, DT-20, and DT-25) after injection of GdEOB-DTPA were collected and analyzed in 73 patients with cirrhosis of different degrees of severity(including 42 patients suffering from HCC) and 18 healthy adult *** The LPSI increased with HBP-DT more significantly in the healthy group than in the cirrhosis group(F = 17.361, P < 0.001). The LP/HCC signal ratios had a significant difference(F = 12.453, P < 0.001) among various HBP-DT points, as well as between CP-A and CP-B/C subgroups(F = 9.761, P < 0.001). The constituent ratios of HCC foci identified as obvious hypointensity(+++), moderate hypointensity(++), and mild hypointensity or isointensity(+/-) kept stable from DT-10 to DT-25: 90.6%, 9.4%, and 0.0% in the CP-A subgroup; 50.0%, 50.0%, and 0.0% in the CP-B subgroup; and 0.0%, 0.0%, and 100.0% in the CP-C subgroup, *** The severity of liver cirrhosis has significant negative influence on the HCC visualization by GED-MRI. DT-10 is more efficient and practical than other HBP-DT points to identify most of HCC foci emerging in CP-A cirrhosis, as well as in CP-B cirrhosis; but an HBP-DT of 15 min or longer seems more appropriate than DT-10 for visualization of HCC in patients with CP-C cirrhosis.

关键词： Magnetic resonance imaging Gd-EOBDTPA Hepatobiliary phase Delay time Hepatocellular carcinoma Cirrhosis Optimization

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姜风味微胶囊制备与性质研究

食品与发酵工业 2024年第15期50卷 112-118页

作者：金旭冉张剑王文亮宋莎莎王延圣李永生杨正友崔文甲山东省农业科学院山东济南250100 山东农业大学生命科学学院山东泰安271018

为提高姜风味成分的稳定性,以麦芽糊精、阿拉伯胶、β-环糊精为壁材采用喷雾干燥法制备姜风味微胶囊。以包埋率为评价指标优化制备工艺,并对微胶囊颗粒理化性质、微观形态及稳定性进行分析。结果表明,微胶囊的最佳制备工艺:进口温度160... 详细信息

为提高姜风味成分的稳定性,以麦芽糊精、阿拉伯胶、β-环糊精为壁材采用喷雾干燥法制备姜风味微胶囊。以包埋率为评价指标优化制备工艺,并对微胶囊颗粒理化性质、微观形态及稳定性进行分析。结果表明,微胶囊的最佳制备工艺:进口温度160℃、喷雾空气柱45 mm及芯壁质量比1:5。此条件下微胶囊包埋率可达81.32%,呈现完整球形结构,粒径约为15~20μm,其含水量为2.54%,溶解度为95.5%,休止角为42.18°。GC-MS分析表明,贮藏期间姜风味微胶囊比普通姜粉的风味成分更稳定。因此,最佳条件下制备的微胶囊具有良好的流动性、溶解性且风味稳定性较高,可满足一般食品加工条件,为生姜调味产品的研发与改进提供参考。

关键词：生姜微胶囊喷雾干燥理化性质稳定性

Development of an electrochemical immunoassay for detection of gatifloxacin in swine urine

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Journal of Zhejian. University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 118-125页

作者： jian.YI Meng MENG Zhong-qiu LIU jin-fang ZHI Yuan-yang ZHANG jing XU Ya-bin WANG jin-ting LIU Ri-mo XI School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai UniversityTianjin 300071China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100080China

To detect gatifloxacin （GAT） residue in swine urine, an electrochemical immunoassay was established, An indirect competitive immunoassay was developed, in which the coating antigen is immobilized in an enzyme-linked immunosorbent assay （ELISA） plate and GAT residue from the sample competes with the limited binding sites in added anti-GAT antibody. Horseradish peroxidase （HRP） conjugated to goat anti-rabbit IgG was used as the enzymatic label. A carbon fiber working electrode was constructed and current signals were detected by using hydrogen peroxide as a substrate and hydroquinone as an electrochemical mediator. The electrochemical immunoassay was evaluated by analysis of GAT in buffer or swine urine and an average value of half inhibition concentration （IC50） of 8.9 ng/ml was obtained. Excellent specificity of the antibody was achieved with little cross-reaction with Iomefloxacin （3.0%）, ciprofloxacin （3.0%）, and ofloxacin （1.9%） among commonly used （fluoro）quinolones. In conclusion, the im- munoassay system developed in this research can be used as a rapid, powerful and on-site analytical tool to detect GAT residue in foods and food products.

关键词： Gatifloxacin Drug residue Antibody Carbon fiber electrode Electrochemical immunoassay

船舶辅助避碰系统在新明州1868 TEU系列集装箱船上的应用

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航海技术 2024年第3期 13-18页

作者：曲维平殷耀亮姜云博金健林焕泉宁波远洋运输股份有限公司震兑工业智能科技有限公司

为提升船舶避碰效率,辅助驾驶员做出更准确的决策,以新明州1 868 TEU系列集装箱船为例,对智能船舶辅助避碰系统在船上的应用进行探索。该系统通过建立船舶目标感知算法和船舶避碰算法,对水上船舶目标进行视觉捕捉识别和避碰预警,并为船... 详细信息

为提升船舶避碰效率,辅助驾驶员做出更准确的决策,以新明州1 868 TEU系列集装箱船为例,对智能船舶辅助避碰系统在船上的应用进行探索。该系统通过建立船舶目标感知算法和船舶避碰算法,对水上船舶目标进行视觉捕捉识别和避碰预警,并为船舶驾驶员规划避碰航路,结合当前会遇态势推荐避碰建议。多轮试航结果表明,该系统能为有碰撞风险的船舶提供正确的避碰行动规划,符合行业规范和习惯,有效提升船舶航行的安全性,降低海上事故发生概率。

关键词：辅助避碰智能航行智能船舶会遇距离

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王阳明“龙场三卦”诠解

贵州师范学院学报 2024年第2期40卷 1-7页

作者：段剑洪贵州省社会科学院贵州贵阳550005

龙场时期,王阳明居夷处困,精研易道,加上独特的“悟”,其以《恒》《遁》《晋》义理为基础,然后借卦辞、彖辞与象辞呈现出对儒家价值的坚守,现实遭际的自省。具体来说,就是从占卜出发,容纳了义理解释,以占卜预视的吉凶为警醒,将所知的变... 详细信息

龙场时期,王阳明居夷处困,精研易道,加上独特的“悟”,其以《恒》《遁》《晋》义理为基础,然后借卦辞、彖辞与象辞呈现出对儒家价值的坚守,现实遭际的自省。具体来说,就是从占卜出发,容纳了义理解释,以占卜预视的吉凶为警醒,将所知的变化之道引入到自身的德性修养中来。以《恒》《遁》《晋》三卦中包含的道德价值激发自己的理性和生存意志,进而自昭明德和挺立独立人格。

关键词：龙场立恒隐遁明德

信号与系统课程“以学为中心”教学模式探索与实践

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创新创业理论研究与实践 2024年第7期7卷 124-126页

作者：全星慧韩建赵丽华周围吕秀丽东北石油大学物理与电子工程学院黑龙江大庆163318

信号与系统是电子信息类专业的核心基础课。为了激发学生学习的主动性,培养学生的创新能力,进一步提高信号与系统课程的教学质量,该文根据课程特点探索了“以学为中心”的教学模式,通过整合教学内容、增加教学环节、引入教学手段、丰富... 详细信息

信号与系统是电子信息类专业的核心基础课。为了激发学生学习的主动性,培养学生的创新能力,进一步提高信号与系统课程的教学质量,该文根据课程特点探索了“以学为中心”的教学模式,通过整合教学内容、增加教学环节、引入教学手段、丰富评价机制等,实现“以学为中心”,以教为主导,将教学过程纵向延伸,将教学内容横向延伸,培养学生的自主探究、独立思考能力,并取得了较好的教学效果。

关键词：信号与系统创新能力 “以学为中心” 以教为主导教学模式教学质量

Subsumption Checking between Concept Queries in Different Ontologies Based on Mutual Instances

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 68-72页

作者： KANG Da-zhou LU jian.jian. XU Bao-wen WANG Peng ZHOU jin Department of Computer Science and Engineering NmtheastUniversity Nanjing 210096 Jiangsu China jian.su Institute of Software Quality Nanjing 210096 JiangsuChina Institute of Science The People＇s Liberation Army University of Science and Technology Nanjing 210007 Jiangsu China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 Hubei China

This paper proposes a checking method based on mutual instances and discusses three key problems in the method： how to deal with mistakes in the mutual instances and how to deal with too many or too few mutual instances. It provides the checking based on the weighted mutual instances considering fault tolerance, gives a way to partition the large-scale mutual instances, and proposes a process greatly reducing the manual annotation work to get more mutual instances. Intension annotation that improves the checking method is also discussed. The method is practical and effective to check subsumption relations between concept queries in different ontologies based on mutual instances.

关键词： ontology concept query subsumption checking mutual instance

Uncertainty and Sensitivity Analyses of the Simulated Seawater—Freshwater Mixing Zones in Steady-State Coastal Aquifers

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China Ocean Engineering 2015年第4期29卷 489-502页

作者：赵忠伟赵坚辛沛华国芬金光球 State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University College of Water Conservancy and Hydropower Engineering Hohai University

The uncertainty and sensitivity of predicted positions and thicknesses of seawater-freshwater mixing zones with respect to uncertainties of saturated hydraulic conductivity, porosity, molecular diffusivity, longitudinal and transverse dispersivities were investigated in both head-control and flux-control inland boundary systems. It shows that uncertainties and sensitivities of predicted results vary in different boundary systems. With the same designed matrix of uncertain factors in simulation experiments, the variance of predicted positions and thickness in the flux-control system is much larger than that predicted in the head-control system. In a head-control system, the most sensitive factors for the predicted position of the mixing zone are inland freshwater head and transverse dispersivity. However, the predicted position of the mixing zone is more sensitive to saturated hydraulic conductivity in a flux-control system. In a head-control system, the most sensitive factors for the predicted thickness of the mixing zone include transverse dispersivity, molecular diffusivity, porosity, and longitudinal dispersivity, but the predicted thickness is more sensitive to the saturated hydraulic conductivity in a flux-control system. These findings improve our understandings for the development of seawater-freshwater mixing zone during seawater intrusion processes, and give technical support for groundwater resource management in coastal aquifers.

关键词： seawater intrusion mixing zone uncertainty analysis fractional factorial design Morris "s OAT design coastal aquifer

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独立四轨回流系统对埋地管道直流干扰测试

电气化铁道 2024年第1期35卷 79-83页

作者：张坤田庆张豪祖健李松原刘炜中车青岛四方机车车辆股份有限公司西南交通大学电气工程学院

独立四轨回流系统作为一种城市轨道交通牵引供电回流方式,可大幅增加回流轨过渡电阻,减小杂散电流。为研究采用独立四轨回流系统的城市轨道交通杂散电流对周边埋地燃气管道的影响,对郑许线开通前后周边管地电位和地电位梯度进行测试。... 详细信息

独立四轨回流系统作为一种城市轨道交通牵引供电回流方式,可大幅增加回流轨过渡电阻,减小杂散电流。为研究采用独立四轨回流系统的城市轨道交通杂散电流对周边埋地燃气管道的影响,对郑许线开通前后周边管地电位和地电位梯度进行测试。结果表明,郑许线周边管地电位和地电位梯度在线路开通前后变化不大。

关键词：独立四轨回流系统管地电位地电位梯度