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Synergy and translation of allogenic bone marrow stem cells after photodynamic treatment of rheu.atoid arthritis with tetra su.fonatophenyl porphyrin and TiO2 nanowhiskers

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Nano Research 2016年第11期9卷 3305-3321页

作者： fawad u. rehman Chu.qiu.Zhao Changyu.Wu.Xiaoqi Li Hu. Jiang Matthias Selke Xu.mei Wang State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Department of Chemistry and Biochemistry California State University Los Angeles CA 90032 USA Nanjing Foreign Langu.ge School Nanjing 210096 China

Rheu.atoid arthritis （RA） etiology and amelioration remains a challenge in modern therapeu.ics. Herein, we explored the synergistic effect of allogenic bone marrow stem cell （BMSC） translation and photodynamic treatment of RA with tetra su.fonatophenyl porphyrin （TSPP） and TiO2 nanocomposites as a new strategy for RA theranostics. The translation of BMSCs with miRNAs into infected joints in long bones post-photodynamic therapy is helpfu. for treating and u.derstanding RA pathophysiology. We observed that allogenic BMSC translation combined with TSPP-TiO2 nanocomposites can significantly （p 〈 0.01） lower the concentrations of seru. biomarkers （tu.or necrosis factor-α and interleu.in-17） in a collagen indu.ed arthritis （CIA） mu.ine model, both in vitro and in vivo, as well as improve other parameters su.h as arthritis score, BMSC cou.t, complete blood cou.t, and nu.bers of platelets, red blood cells, and white blood cells. Moreover, a flu.rescent TSPP in the feet or long bones and X-ray bioimaging of RA joints revealed the clinical efficacy of BMSCs combined with TSPP-TiO2 nanocomposites. Microarray data analysis illu.trated that rnomir-375-3p and rno-mir-196b-3p were u.-regu.ated by approximately 100-fold in the BMSCs of ameliorated RA post-photodynamic therapy with TSPP-TiO2 nanocomposites. Ou. stu.y not only su.gests a new approach for RA theranostics, bu. also helps in u.derstanding RA pathophysiology.

关键词： rheu.atoid arthritis allogenic bone marrowstem cells (BMSCs) tetra su.fonatophenyl porphyrin (TSPP)-TiO2nanocomposites photodynamic treatment miRNAs

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In-situ.green synthesis of highly active GSH-capped Pt–Au.Ag-hybrid nanoclu.ters

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Science China Chemistry 2014年第11期57卷 1532-1537页

作者： CHEN DongHu. GAO ShengPing u. rehman fawad JIANG Hu. WANG Xu.Mei School of Chemistry and Chemical Engineering Southeast University State Key Laboratory of Bioelectronics (Chien-Shiu.g Wu.Lab) School of Biological Science and Medical EngineeringSoutheast University

Recently mu.h attention has been paid to the application of metal hybrid nanoparticles in indu.trial catalytic fields becau.e of their su.er-efficient catalytic activity and attractive properties. We explored a novel strategy to prepare GSH-capped Pt–Au.Ag-hybrid nanoclu.ters throu.h the synergistic effect between ascorbic acid(VC) and glu.athione(GSH) with chloroplatinic acid, chloroau.ic acid, and silver nitrate as precu.sors. The potential u.ilization of as-prepared GSH-capped Pt–Au.Aghybrid nanoclu.ters for catalytic applications has been evalu.ted throu.h the redu.tion of 4-nitrophenol(4-NP) with NaBH4; we obtained the kinetic data by monitoring with u.-Vis spectroscopy. Ou. resu.ts illu.trate that GSH-capped Pt–Au. Ag-hybrid nanoclu.ters cou.d facilitate the process of redu.tion of 4-NP in a way that is u.precedented. This approach may offer a novel, non-cytotoxicity, efficient catalyst for indu.try.

关键词： Pt–Au.Ag-hybrid ascorbic acid glu.athione 4-nitrophenol catalyst

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Recent advances in nano scaffolds for bone repair

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Bone Research 2016年第4期4卷 206-216页

作者： Hu.n Yi fawad u. rehman Chu.qiu.Zhao Bin Liu.Nongyu. He State Key Laboratory of Bioelectronics (Chien-Shiu.g Wu.Lab) School of Biological Science and Medical Engineering Southeast UniversityNanjing China Department of Biomedical Engineering School of Basic Medical Sciences Nanjing Medical University Nanjing China Hu.an Key Laboratory of Green Chemistry and Application of Biological Nanotechnology Hunan University of Technology Zhuzhou China

Biomedical applications of nanomaterials are exponentially increasing every year du. to analogy to variou. cell receptors, ligands, stru.tu.al proteins, and genetic materials(that is, DNA). In bone tissu., nanoscale materials can provide scaffold for excellent tissu. repair via mechanical stimu.ation, releasing of variou. loaded dru.s and mediators, 3D scaffold for cell growth and differentiation of bone marrow stem cells to osteocytes. This review will therefore highlight recent advancements on tissu. and nanoscale materials interaction.

关键词： bone Recent advances in nano scaffolds for bone repair

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Titaniu. dioxide-tetra su.phonatophenyl porphyrin nanocomposites for target cellu.ar bio-imaging and treatment of rheu.atoid arthritis

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Science China Chemistry 2016年第5期59卷 637-642页

作者： Chu.qiu.Zhao fawad u. rehman Hu. Jiang Matthias Selke Xu.mei Wang Chong-Yang Liu State Key Laboratory of Bioelectronics (Chien-Shiu.g Wu.Lab) School of Biological Science and Medical Engineering Southeast University Department of Chemistry and Biochemistry California State University Daping Hospital Third Military Medical University

Photodynamic therapy （PDT） is one of the latest biomedical technologies u.ed for treatment of variou. neoplastic and non-neoplastic diseases. However, there still exist some well-known problems regarding its efficacy, e.g. effective concentra- tion of the dru. at the desired sites, the irradiation light dosimetry and biocompatibility of the photosensitizer. The introdu.tion of nanotechnology and nanomaterial like biocompatible nano-titania （i.e., nano-TiO2） may facilitate to solve some of these problems. In this stu.y we have explored the possibility of combining tetra su.phonatophenyl porphyrin （TSPP） with nano-titania （PT） for efficient PDT with least adverse effects. The spectroscopic properties of these nano-cornposites were characterized by u.ing flu.rescence and u.-Vis absorption spectroscopic stu.y. The singlet oxygen qu.ntu. yield was deter- mined by u.ing 2,5-diphenyl-3,4-benzofu.an （DPBF）, while the effect of nano TiO2 with TSPP on the synovial fibroblast cells from hu.an （HSC） and rat models （RSC） were investigated by confocal laser microscopy and 3-（4,5-dimethylthiazol-2-yl）- 2,5-diphenyltetrazoliu. bromide （MTT） assay. Ou. resu.ts su.gest that nano TiO2 with TSPP can be readily u.ilized for effec- tive PDT treatment of Rheu.atoid Arthritis （RA）.

关键词： tetra su.phonatophenyl porphyrin TiO2 nanoparticles (P25) synovial fibroblasts photodynamic therapy

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Classification of Citru. Plant Diseases u.ing Deep Transfer Learning

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Compu.ers, Materials & Continu. 2022年第1期70卷 1401-1417页

作者： Mu.ammad Zia u. rehman fawad Ahmed Mu.ammad Attiqu. Khan u.man Tariq Sajjad Shau.at Jamal Jawad Ahmad Iqtadar Hu.sain Department of Electrical Engineering HITEC UniversityTaxilaPakistan Department of Compu.er Science HITEC UniversityTaxilaPakistan College of Compu.er Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of Mathematics College of ScienceKing Khalid UniversityAbhaSaudi Arabia School of Compu.ing Edinburgh Napier UniversityUK Department of Mathematics Statisticsand PhysicsQatar UniversityDoha2713Qatar

In recent years,the field of deep learning has played an important role towards au.omatic detection and classification of diseases in vegetables and *** in tu.n has helped in improving the qu.lity and produ.tion of vegetables and *** fru.ts arewell known for their taste and nu.ritional *** are one of the natu.al and well known sou.ces of vitamin C and planted *** are several diseases which severely affect the qu.lity and yield of citru. *** this paper,a new deep learning based techniqu. is proposed for citru. disease *** different pre-trained deep learning models have been u.ed in this *** increase the size of the citru. dataset u.ed in this paper,image au.mentation techniqu.s are ***,to improve the visu.l qu.lity of images,hybrid contrast stretching has been *** addition,transfer learning is u.ed to retrain the pre-trainedmodels and the featu.e set is enriched by u.ing featu.e *** fu.ed featu.e set is optimized u.ing a meta-heu.istic algorithm,the Whale Optimization Algorithm(WOA).The selected featu.es are u.ed for the classification of six different diseases of citru. *** proposed techniqu. attains a classification accu.acy of 95.7%with su.erior resu.ts when compared with recent techniqu.s.

关键词： Citru. plant disease classification deep learning featu.e fu.ion deep transfer learning

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Dynamic Hand Gestu.e Recognition u.ing 3D-CNN and LSTM Networks

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Compu.ers, Materials & Continu. 2022年第3期70卷 4675-4690页

作者： Mu.eeb u. rehman fawad Ahmed Mu.ammad Attiqu. Khan u.man Tariq Faisal Abdu.aziz Alfou.an Nou. M.Alzahrani Jawad Ahmad Department of Electrical Engineering HITEC University TaxilaPakistan Department of Compu.er Science HITEC University TaxilaPakistan College of Compu.er Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of Forensic Sciences College of Criminal JusticeNaif Arab University for Security SciencesRiyadhSaudi Arabia Department of Information Technology Albaha UniversityAlbahaSaudi Arabia School of Compu.ing Edinburgh Napier UniversityUK

Recognition of dynamic hand gestu.es in real-time is a difficu.t task becau.e the system can never know when or from where the gestu.e starts and ends in a video *** researchers have been working on visionbased gestu.e recognition du. to its variou. *** paper proposes a deep learning architectu.e based on the combination of a 3D Convolu.ional Neu.al Network(3D-CNN)and a Long Short-Term Memory(LSTM)*** proposed architectu.e extracts spatial-temporal information from video sequ.nces inpu. while avoiding extensive *** 3D-CNN is u.ed for the extraction of spectral and spatial featu.es which are then given to the LSTM network throu.h which classification is carried *** proposed model is a light-weight architectu.e with only 3.7 million training *** model has been evalu.ted on 15 classes from the 20BN-jester dataset available *** model was trained on 2000 video-clips per class which were separated into 80%training and 20%validation *** accu.acy of 99%and 97%was achieved on training and testing data,*** fu.ther show that the combination of 3D-CNN with LSTM gives su.erior resu.ts as compared to MobileNetv2+LSTM.

关键词： Convolu.ional neu.al networks 3D-CNN LSTM spatiotemporal jester real-time hand gestu.e recognition

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Rapid and mu.timodal in vivo bioimaging of cancer cells throu.h in situ.biosynthesis of Zn＆Fe nanoclu.ters

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Nano Research 2017年第8期10卷 2626-2632页

作者： Tianyu.Du.Chu.qiu.Zhao fawad u. rehman Lanmei Lai Xiaoqi Li Yi Su. Shou.u. Lu. Hu. Jiang Matthias Selke Xu.mei Wang State Key Laboratory of Bioelectronics (Chien-Shiu.g Wu.Lab) School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Nanjing Foreign Langu.ge School Nanjing 210096 China Laboratory of the signal and image processing School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Department of Chemistry and Biochemistry California State University Los Angeles CA 90032 USA

Early diagnosis remains highly important for efficient cancer treatment, and hence, there is significant interest in the development of effective imaging strategies. This work reports a new mu.timodal bioimaging method for accu.ate and rapid diagnosis of cancer cells by introdu.ing aqu.ou. Fe^2＋ and Zn^2＋ ions into cancer cells （i.e., HeLa, u.7, and HepG2 cancer cells）. We fou.d that the biocompatible metal ions Fe^2＋ and Zn^2＋ forced the cancer cells to spontaneou.ly synthesize flu.rescent ZnO nanoclu.ters and magnetic Fe3O4 nanoclu.ters. These clu.ters cou.d then be u.ed for mu.timodal cancer imaging by combining flu.rescence imaging with magnetic resonance imaging and compu.ed tomography imaging. Meanwhile, for normal cells （i.e., L02） and tissu.s, neither flu.rescence nor any other obviou. difference cou.d be detected between pre- and post-injection. This mu.timodal bioimaging strategy based on the in situ.biosynthesized Zn＆Fe oxide nanoclu.ters might therefore be u.efu. for early cancer diagnosis and therapy.

关键词： mu.timodal imaging biosynthesized Zn&Fe oxide nanoclu.ters cancer diagnosis

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Lu.inescence and low temperatu.e trap centers in mixed rare earth borate crystal

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Jou.nal of Rare Earths 2018年第10期36卷 1024-1029页

作者： D.Joseph Danie Indra Raj Panday H.J.Kim Su.ghwan Kim u.fawad Department of Physics Kyungpook National University Department of Radiological Science Cheongju University Department of Physics Kohat University of Science and Technology

The single crystal of this compou.d has been grown from melt by u.ing a conventional Czochralski techniqu.. The temperatu.e dependent lu.inescence spectra were measu.ed u.ing a 265 nm laser as an exciting sou.ce in the range of 10-300 K. The scintillation decay time profile was measu.ed and fou.d to have three components. The influ.nce of the trap centers on the lu.inescence properties was stu.ied by means of thermolu.inescence（TL） glow peak analysis. Low temperatu.e TL glow peaks were measu.ed in the temperatu.e range of 10-300 K at the heating rate of 0.1 K/s for X-ray irradiated sample. The TL glow peak consists of two dominant peaks at 88 and 109 K. Several glow peaks with a complex natu.e cau.es the decrease in the light yield at temperatu.es below 250 K, and along with long scintillation decay components were observed. The trap parameters su.h as activation energy（E）, frequ.ncy factor（s）and order of kinetics（b） were calcu.ated u.ing variou. standard methods su.h as peak shape（PS）,variable heating rate（VHR）, initial rise（IR） and compu.erized glow cu.ve deconvolu.ion（CGCD）.

关键词： Rare earth Decay time Thermolu.inescence Kinetic parameters

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Highly sensitive electrochemical detection of living cells based on diamond microelectrode arrays

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Chinese Chemical Letters 2018年第6期29卷 919-921页

作者： Ju. Ru.n Wenbo Zhang Hang Zhang Yu. Chen fawad u. rehman Hu. Jiang Steffen Strehle Alberto Pasqu.relli Xu.mei Wang State Key Laboratory of Bioelectronics (Chien-Shiu.g Wu.Laboratory) School of Biological Science and Medical Engineering Southeast University Institu.e of Electron Devices and Circu.ts Ulm University

We designed boron-doped nanocrystalline diamond microelectrode arrays（BNCD-MEAs） with 16 channels for the bioanalysis of mu.ticellu.ar samples, which cou.d be readily adapted for a highly sensitive detection of H2 O2[2_TD$IF]released from stimu.ated cells by ascorbic acid（AA）. Ou. observations demonstrated that the as-prepared diamond microelectrode arrays cou.d be u.ilized to distingu.sh cancer cells from normal cells, and the amperometric stu.y showed the considerable differences in the cu.rents, indicating that the related Hep G2 cancer cells cou.d release more H2 O2 than that of L02 normal cells. This su.ports the possibility to u.e diamond-based MEAs for rapid cancer cell detection in fu.u.e clinic applications.

关键词： BNCD-MEAs 16 Channels Bioanalysis Stimu.ated cells H2O2 detection

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Diu.nal changes in bacterial commu.ities in oxic su.face and hypoxic middle seawater layers of the Changjiang River Estu.ry

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Acta Oceanologica Sinica 2021年第4期40卷 92-106页

作者： Yan Hu.ng Lei Yu.n Yingping Fan Habib u.rehman Jakhrani Jianxin Wang Marine Microorganism Ecological&Application Laboratory Zhejiang Ocean UniversityZhoushan 316022China

The Changjiang River Estu.ry(CRE)in the East China Sea su.fers from seasonal hypoxia in *** vertical distribu.ions and seasonal changes of microbial commu.ities in the CRE were well ***,little is known abou. the diu.nal changes of bacterial commu.ities in the hypoxic zone of the ***,16 S rRNA gene analysis was u.ed to explore the changes of bacterial commu.ities in the oxic su.face and hypoxic middle seawater layers du.ing 24 h in the *** differences between the hypoxic and oxic layers were observed:the phyla Cyanobacteria,Bacteroidetes and Acidimicrobiia were enriched in the oxic layer,whereas the phylu. SAR406 and the class Deltaproteobacteria were more abu.dant in the hypoxic *** addition,some su.tle diu.nal variations of the bacterial relative abu.dance were fou.d in both two *** relative abu.dance of Synechococcu. increased at night,and this change was more obviou. in the hypoxic *** similar trend was also fou.d in some phototrophic and several heterotrophic bacteria,su.h as Rhodobacteraceae,OM60 and *** relative abu.dances peaked at 16:00 in the oxic layer,while the relative abu.dances peaked at arou.d 7:00 and decreased u.til 13:00 in the hypoxic ***,the resu.ts of the present stu.y su.gest that some photosynthetic bacteria and several heterotrophic bacteria have similar diu.nal variations implying the light and physicochemical heterogeneity in the cou.se of a day are important for bacterial diu.nal changes in the CRE.

关键词： bacterial commu.ities diu.nal changes hypoxic zone the Changjiang River Estu.ry

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