Rapid and multimodal in vivo bioimaging of cancer cells through in situ biosynthesis of Zn＆Fe nanoclusters

作     者：Tianyu Du Chunqiu Zhao Fawad ur Rehman Lanmei Lai Xiaoqi Li Yi Sun Shouhua Luo Hui Jiang Matthias Selke Xuemei Wang 

作者机构：State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab) School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Nanjing Foreign Language School Nanjing 210096 China Laboratory of the signal and image processing School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Department of Chemistry and Biochemistry California State University Los Angeles CA 90032 USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2017年第10卷第8期

页      面：2626-2632页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0803[工学-光学工程] 

基　　金：This work is supported by the National High-tech R&D Program of China (No. 2015AA020502) and the National Natural Science Foundation of China (Nos. 81325011  21327902 and 21175020). M. S. acknowledges support from the NSF-PREM program (No  DRM-1523588) 

主　　题：multimodal imaging biosynthesized Zn&Fe oxide nanoclusters cancer diagnosis 

摘      要：Early diagnosis remains highly important for efficient cancer treatment, and hence, there is significant interest in the development of effective imaging strategies. This work reports a new multimodal bioimaging method for accurate and rapid diagnosis of cancer cells by introducing aqueous Fe^2＋ and Zn^2＋ ions into cancer cells （i.e., HeLa, U87, and HepG2 cancer cells）. We found that the biocompatible metal ions Fe^2＋ and Zn^2＋ forced the cancer cells to spontaneously synthesize fluorescent ZnO nanoclusters and magnetic Fe3O4 nanoclusters. These clusters could then be used for multimodal cancer imaging by combining fluorescence imaging with magnetic resonance imaging and computed tomography imaging. Meanwhile, for normal cells （i.e., L02） and tissues, neither fluorescence nor any other obvious difference could be detected between pre- and post-injection. This multimodal bioimaging strategy based on the in situ biosynthesized Zn＆Fe oxide nanoclusters might therefore be useful for early cancer diagnosis and therapy.