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Evolutionary Profile of Severe Acute Ulcerative Colitis in Chronic Inflammatory Bowel Diseases

Open Journal of Gastroenterology 2018年第3期8卷 107-117页

作者： Hakima Abid fatima babakhouya Ihssane Mellouki Mounia El Yousfi Noureddine Aqodad Dafr Allah Benajah Adil Ibrahimi Mohamed El Abkari Hepatogastroenterology Department Hassan II University Hospital of Fez Univesity Sidi Mohamed Ben Abdellah Fez Morocco

Background: Severe acute colitis is a common complication of inflammatory bowel disease (IBD). Their diagnosis is based on clinical, laboratory, endoscopic and radiological. The severe acute colitis is a medical and surgical emergency;its mortality is 1% to 3%. The management should be swift and coordinated, upon admission, between medical and surgical teams. Methods: This is a retrospective study in Gastroenterology Service at the University Hospital HASSAN II Fez, over a period of 10 years (2005-2015). We included all patients admitted for severe acute colitis;all the epidemiological, clinical, endoscopic, histological, and therapeutic monitoring of patients were collected. Results: We collected 123 patients. Their average age was 35 years (16 - 70). It was a female predominance (sex ratio F/M = 1.19). 54 patients were admitted for an inaugural severe acute colitis (43%), while 69 patients were known carriers of IBD (56%). All patients were admitted to an array of severe acute colitis according to the criteria of Truelove and Witts modified. 9 patients were operated urgently because there was the presence of complications (5 cases of perforation, 3 cases of massive rectal bleeding, and one patient with an abscess in the right iliac fossa). Corticosteroids intravenously was administered to 114 patients, 74 patients (64%) had remission. Patients who have not responded to corticosteroids IV (N = 40): 1) 12 patients received treatment with oral cyclosporine: the remission rate was 66%. 2) 8 patients were put under Infliximab: The response rate was 75%. 3) Patients who have not responded to a second-line treatment underwent subtotal colectomy with a dual stoma. 4) The surgery was indicated as a second-line treatment in 20 patients who all received a subtotal colectomy with double stoma;totalizing colectomy and ileoanale anastomosis ware made in 4 patients. The mortality rate is higher in our series (12%) mainly postoperatively;it is due to the delayed admission of pati

关键词： Acute Severe Ulcerative Colitis Infliximab Cyclosporine Colectomy

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A rare complication of measles infection presented with subacute sclerosing panencephalitis: Report of two cases in India

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 184-187页

作者： Razeen fatima Amir Husain Iram Tabish Department of Medicine JN Medical CollegeAMUAligarhIndia

Rationale:Subacute sclerosing panencephalitis(SSPE)is a progressive neurological disorder caused by persistent measles virus *** predominantly affects children and *** symptoms usually develop 6-15 years after measles infection and ultimately leading to death in many *** concerns:Patient 1 presented with cognitive decline and myoclonus and the Patient 2 presented with diminution of vision with myoclonic ***:Based on the clinical features with a characteristic electroencephalogram pattern and the presence of a high titer of anti-measles IgG in serum and cerebrospinal fluid,these patients were diagnosed as ***:Antiepileptics were started for controlling myoclonus along with supportive ***:Both patients were discharged on antiepileptics and supportive ***:Whenever there are unusual clinical manifestations with unknown vaccination status,SSPE can be suspected and the cerebrospinal fluid should be examined for anti-measles *** case study also highlights the importance of universal coverage of measles *** reduce the incidence of measles and associated deaths,it is important to maintain a high level of immunization coverage for the measles vaccine and to strengthen all the integral components of the national immunization program.

关键词： Subacute sclerosing panencephalitis Measles Myoclonus Electroencephalogram Cerebrospinal fluid

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Post processing of additive manufactured Mg alloys:Current status,challenges,and opportunities

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Journal of Magnesium and Alloys 2024年第4期12卷 1283-1310页

作者： Nooruddin Ansari fatima Ghassan Alabtah Mohammad I.Albakri Marwan Khraisheh Mechanical Engineering Program Texas A&M University at QatarP.O.Box 23874DohaQatar

Magnesium(Mg)and its alloys are emerging as a structural material for the aerospace,automobile,and electronics industries,driven by the imperative of weight *** are also drawing notable attention in the medical industries owing to their biodegradability and a lower elastic modulus comparable to *** ability to manufacture near-net shape products featuring intricate geometries has sparked huge interest in additive manufacturing(AM)of Mg alloys,reflecting a transformation in the manufacturing ***,AM of Mg alloys presents more formidable challenges due to inherent properties,particularly susceptibility to oxidation,gas trapping,high thermal expansion coefficient,and low solidification *** leads to defects such as porosity,lack of fusion,cracking,delamination,residual stresses,and inhomogeneity,ultimately influencing the mechanical,corrosion,and surface properties of AM Mg *** address these issues,post-processing of AM Mg alloys are often needed to make them suitable for *** present article reviews all post-processing techniques adapted for AM Mg alloys to date,including heat treatment,hot isostatic pressing,friction stir processing,and surface *** utilization of these methods within the hybrid AM process,employing interlayer post-processing,is also *** post-processing conditions are reported,and their influence on the microstructure,mechanical,and corrosion properties are ***,future prospects and research directions are proposed.

关键词： Magnesium alloy Additive manufacturing Post-processing Heat treatment HIP

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Assessment of phytochemicals, antioxidant, anti-hemolytic, anti-inflammatory and anti-cancer potential of flowers, leaves and stem extracts of Rosa arvensis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 804-812页

作者： Zubaria Tul Ain Iram fatima Sana Naseer Sobia Kanwal Tariq Mahmood Department of Plant Sciences Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biology Allama Iqbal Open UniversityIslamabad 04403Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Pakistan Academy of Sciences Islamabad 04403Pakistan

OBJECTIVE:To evaluate phytochemicals and in vitro biological potential of flowers,leaves and stem extracts of Rosa ***:Presence of twenty secondary metabolites was confirmed and then phenolic and flavonoid contents were quantified *** Transform Infrared spectroscopy was conducted to ascertain functional groups and antioxidant potential was examined using 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant capacity and total reducing power *** erythrocytes were used to assess anti-hemolytic activity and five bacterial strains were examined to determine antibacterial potential of plant *** seeds were used to perform phytotoxic activity and cytotoxic potential was evaluated via brine shrimps and PC3 cell ***:Highest phenolic contents were detected in the methanolic extract of Rosa arvensis flower(RAFM)[(151.635±0.005)gallic acid equivalent mg/g]and highest flavonoid contents in the chloroform leaf extract(RALC)[(108.228±0.004)quercetin equivalent mg/g].Fourier-transform infrared spectroscopy analysis showed the presence of wide range of functional *** antioxidant assays indicated highest DPPH scavenging activity[IC50(23.5±0.6)μg/mL]in the methanolic stem extract(RASM),highest total antioxidant capacity[(265.1±0.9)μg/mL]in RAFM and highest reducing potential[(209.9±0.6)μg/mL]in leaf extract(RALM).Highest antihemolytic activity[(90.0±0.5)μg/mL]was recorded in RAFM and brine shrimp cytotoxicity potential[(52.3±0.3)μg/mL]in *** antimicrobial activity was detected highest[(21.1±0.5)mm inhibition zones]in RALM against Streptococcus *** the end,antiinflammatory and anti-cancer activity results depicted less than 50%inhibition in the methanolic ***:Our findings will be helpful in designing pharmaceutical regimens and therefore,more studies can be recommended to isolate and characterize compounds associated with the biological activities of Rosa arvensis.

关键词： anti-inflammatory agents spectroscopy,fourier transform infrared hemolysis oxidative stress PC-3 cells

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Experimental and numerical study of effecting core configurations on the static and dynamic behavior of honeycomb plate with aluminum material

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DEFENCE TECHNOLOGY 2024年第9期39卷 177-192页

作者： Hamza, Nehad Abid Allah AL-Fatlwe, fatima Mohammed K. Talib, Muna Ali Al Qasim Green Univ Engn Coll Babylon 51013 Iraq Al Furat Al Awsat Tech Univ ATU Engn Tech Coll Al Najaf Najaf 54003 Iraq

The sandwich panel incorporated a honeycomb core, a widely utilized composite structure recognized as a fundamental classification of composite materials. Comprised a core resembling a honeycomb, possessing thickness and softness, and is flank by rigid face sheets that sandwich various shapes and materials. This paper presents an examination of the static and dynamic analysis of lightweight plates made of aluminum honeycomb sandwich composites. Honeycomb sandwich plate samples are 300 mm long, and 300 mm wide, the heights of the core have been varied at four values ranging from 10 to 25 mm. The honeycomb core is manufactured from Aluminum material by using a novel technique namely resistance spot welding (RSW) instead of using adhesive material, which is often used when an industrial flaw is detected. Numerical optimization based on response surface methodology (RSM) and design of experiment software (DOE) was used to verify the current work. A theoretical examination of the crashworthiness behavior (maximum bending load, maximum deflection) and vibration attributes (natural frequency, damping ratio, transient temporal response) of honeycomb sandwich panels with different design parameters was also carried out. In addition, the finite element method-based ANSYS software was used to confirm the theoretical conclusions. The findings of the present work showed that the relationship between the natural frequency, core height, and cell size is direct. In contrast, the relationship between the natural frequency and the thickness of the cell wall is inverse. Conversely, the damping ratio is inversely proportional to the core height and cell size but directly proportional to the thickness of the cell wall. The study indicates that altering the core height within 10-25 mm leads to a significant increase of 82 % in the natural frequency and a notable decrease of 49% in the damping ratio. These findings are based on a specific cell size value of 0.01 m and a cell wall thicknes

关键词： Honeycomb Load Transient response Free vibration Natural frequency SANDWICH PANELS

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Multiple Solutions for an Elliptic Equation with Hardy Potential and Critical Nonlinearity on Compact Riemannian Manifolds

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Journal of Partial Differential Equations 2024年第1期37卷 1-24页

作者： MALIKI Youssef TERKI fatima Zohra Laboratoire Systemes Dynamiques et Applications Department of Mathematics `University Aboubekr Belka¨id of TlemcenTlemcenAlgeria.

We prove the existence of multiple solutions of an elliptic equation with critical Sobolev growth and critical Hardy potential on compact Riemannian manifolds.

关键词： Riemannian manifolds Yamabe equation Hardy potential.

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Corporate Social Responsibility and Brand Community Engagement:Dual Mediating Roleof Brand and Community Identifications in the Chinese Decor Industry

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 51-72页

作者： Moazzam Abbas Zubair Nawaz Andeela Sahar fatima School of Management Huazhong University of Science and TechnologyWuhanChina Leadership and Management Studies National Defence UniversityIslamabadPakistan School of Applied Psychology Social Work and PolicyUniversiti Utara MalaysiaKedahMalaysia

Despite a plethora of studies on how corporate social responsibility(CSR)generates favorable consumer outcomes,the existing literature provides limited insights about how CSR may affect inter-consumer connection and brand community *** consumer engagement in the brand community is one of the key marketing objectives for strengthening the brand-consumer *** study aims to explore the role of corporate social responsibility in enhancing brand community engagement and examines the dual mediating role of brand identification and community *** research was conducted and an adapted questionnaire was *** data were collected from 405 Chinese consumers,and structural equational modeling was used to test the *** demonstrated that CSR motivates consumers to engage with the brand ***,brand identification and community identification perform the role of partial mediators.

关键词： Corporate social responsibility Community engagement Chinese consumers Brand identification Community identification

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Classification and Comprehension of Software Requirements Using Ensemble Learning

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Computers, Materials & Continua 2024年第8期80卷 2839-2855页

作者： Jalil Abbas Arshad Ahmad Syed Muqsit Shaheed Rubia fatima Sajid Shah Mohammad Elaffendi Gauhar Ali School of Computer Science and Technology Anhui UniversityHefei230039China School of Computing Sciences Pak Austria FachhochschuleInstitute of Applied Sciences and TechnologyHaripur22620Pakistan Department of Computer Science and IT University of LahoreLahore55150Pakistan Department of Computer Science Emerson UniversityPunjabMultan60000Pakistan EIAS(Emerging Intelligent Autonomous Systems)Data Science Lab Prince Sultan UniversityRiyad12435Saudi Arabia

The software development process mostly depends on accurately identifying both essential and optional ***,user needs are typically expressed in free-form language,requiring significant time and human resources to translate these into clear functional and non-functional *** address this challenge,various machine learning(ML)methods have been explored to automate the understanding of these requirements,aiming to reduce time and human ***,existing techniques often struggle with complex instructions and large-scale *** our study,we introduce an innovative approach known as the Functional and Non-functional Requirements Classifier(FNRC).By combining the traditional random forest algorithm with the Accuracy Sliding Window(ASW)technique,we develop optimal sub-ensembles that surpass the initial classifier’s accuracy while using fewer *** results demonstrate that our FNRC methodology performs robustly across different datasets,achieving a balanced Precision of 75%on the PROMISE dataset and an impressive Recall of 85%on the CCHIT *** datasets consistently maintain an F-measure around 64%,highlighting FNRC’s ability to effectively balance precision and recall in diverse *** findings contribute to more accurate and efficient software development processes,increasing the probability of achieving successful project outcomes.

关键词： Ensemble learning machine learning non-functional requirements requirement engineering accuracy sliding window

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Sausage Finger Revealed a Bone Sarcoidosis

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International Journal of Dermatology and Venereology 2024年第3期7卷 176-177页

作者： fatima-Zahra Agharbi Abderrahmane Albouzidi Soumiya Chiheb Department of Dermatology Sheikh Khalifa HospitalFaculty of MedicineMohamed VI University of Health SciencesCasablanca 82403Morocco.

Dear Editor,Sarcoidosis is a systemic inflammatory disease of unknown etiology that is characterized by the forma-tion of a giganto-cellular epithelioid granuloma with-out caseous necrosis infiltrating the various *** condition most frequently involves the mediastinal and pulmonary regions,while bone involvement is rare and affects only 1.0%to 13.0%of patients with sarcoid-osis.1 We report a case of an isolated bone sarcoidosis presenting as bull’s finger.

关键词： involvement Sarcoidosis etiology

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MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

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BIOCELL 2024年第3期48卷 403-413页

作者： SHAHID HUSSAIN HABIB BOKHARI XINGXING FAN SHAUKAT IQBAL MALIK SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN fatima Department of Biotechnology Kohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines TaipaMacao Department of Bioinformatics and Biosciences Capital University of Science and TechnologyIslamabadPakistan Department of Microbiology Kohsar University MurreeMurreePakistan

The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal inﬂuence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversiﬁed impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the speciﬁc miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.

关键词： miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy

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