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The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity

Journal of Molecular Cell Biology 2021年第6期13卷 395-408页

作者： Xueying Wang Wenwen Wang Xiwei Wang Ming Wang Lijuan Zhu fatima garba Chuanhai Fu Barbara Zieger Xu Liu Xing Liu Xuebiao Yao MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics and Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230027China Keck Center for Organoids Plasticity Control AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics&Chemical Biology and CAS Center for Excellence in Molecular Cell Science Hefei 230027China Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and OncologyMedical CenterFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany

Cell polarity is essential for spatially regulating of physiological processes in metazoans by which hormonal stimulation‒secretion coupling is precisely coupled for tissue homeostasis and organ ***,the molecular mechanisms underlying epithelial cell polarity establishment remain ***,we show that septin cytoskeleton interacts with catenin complex to organize a functional domain to separate apical from basal membranes in polarized epithelial *** polarized epithelial cell monolayer as a model system with transepithelial electrical resistance as functional readout,our studies show that septins are essential for epithelial cell *** proteomic analyses discovered a novel septin‒catenin complex during epithelial cell *** functional relevance of septin‒catenin complex was then examined in three-dimensional(3D)culture in which suppression of septins resulted in deformation of apical lumen in cysts,a hallmark seen in polarity-deficient 3D cultures and ***,septin cytoskeleton stabilizes the association of adherens catenin complex with actin cytoskeleton,and depletion or disruption of septin cytoskeleton liberates adherens junction and polarity complexes into the ***,these findings reveal a previously unrecognized role for septin cytoskeleton in the polarization of the apical‒basal axis and lumen formation in polarized epithelial cells.

关键词： septin cytoskeleton cell polarity adherens junction epithelial cells

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Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

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Journal of Molecular Cell Biology 2022年第2期14卷 80-83页

作者： Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen fatima garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao MOE Key Laboratory for Cellular Dynamics University of Science&Technology of China School of Life SciencesHefei 230027China Keck Center for Organoids Plasticity and Department of Surgery Morehouse School of MedicineAtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics&Chemical Biology CAS Center of Excellence in Molecular Cell SciencesHefei 230027China Department of Gastroenterology Beĳing University of Chinese MedicineBeĳing 100081China

Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021).

关键词： acute respiratory

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