Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

作     者：Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao 

作者机构：MOE Key Laboratory for Cellular DynamicsUniversity of Science&Technology of China School of Life SciencesHefei 230027China Keck Center for Organoids Plasticity and Department of SurgeryMorehouse School of MedicineAtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics&Chemical BiologyCAS Center of Excellence in Molecular Cell SciencesHefei 230027China Department of GastroenterologyBeijing University of Chinese MedicineBeijing 100081China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2022年第14卷第2期

页      面：80-83页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by NIH grants(DK56292 DK115812 U54MD007602-33S3 S21MD000101 and CA164133) 

主　　题：acute respiratory 

摘      要：Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021).